Deciphering the Mysteries of Behavior with Viral Vectors
Type
Blog Post
...neurons (Drd1) in mPFC is responsible for the antidepressant effect. To specifically activate the Drd1 neurons...neurons, they injected AAV2 particles into a Drd1-Cre transgenic mouse to deliver Cre-dependent expression... upon light stimulation. When they activated the Drd1 neurons 24 hours before the forced swim test, they...Optogenetic stimulation of medial prefrontal cortex Drd1 neurons produces rapid and long-lasting antidepressant...