...L-MYC and LIN28 pCXLE-hOCT3/4-shp53-F 27077 OCT3/4 and shRNA against p53 pCXWB-EBNA1 37624 transient...efficiency through the expression of a shRNA against p53, a modified reprogramming factor cocktail, and viral...completely understood, the addition of an shRNA for P53 and replacing C-MYC with L-MYC in the episomal reprogramming... induced pluripotent stem cell generation by the p53-p21 pathway. Nature, 2009. 460(7259): p. 1132-5. ...It has been shown previously that suppression of TP53 enhances iPSC generation as does replacing C-MYC...

...fragment Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Gaglia G,...

...includes interactive maps for the Ras, mTor, and p53 pathways. The curation project continues to evolve...

... epitope tags into the endogenous alleles of the p53 and PTEN tumor suppressor genes in human cells (Kim...