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TypeBlog PostPublishedDec. 23, 2015, 3:30 p.m....widely used luciferase reporter gene plasmid pGL3 pGL3 luciferase reporter gene plasmids have been ... and Woods in the nineties. However, reliance on pGL3 has not been without problems due to the high rate...pXPG, which shows lower background expression than pGL3, enabling its use for the study of promoters with...pXPG contains the Luc+ luciferase gene derived from pGL3 but has a distinct advantage over the latter plasmid... the synthetic polyadenylation signal present in pGL3. This appears to contribute to more efficient blocking...