...Neuromodulators like dopamine and norepinephrine have important functions in the brain but have been ... activity. In 2019, the first generation of norepinephrine sensors was developed, named GRABNE, which ...which helped researchers visualize norepinephrine (Feng et al., 2019). But this first generation of tools ...limitations by developing and depositing two new norepinephrine indicators: nLightG and nLightR (Kagiampaki...indicators are more sensitive to and selective for norepinephrine and faster to respond than GRABNE. While GRABNE... provide inhibitory feedback in response to norepinephrine release, and clinically-used drugs targeting...major advantages of this next generation of norepinephrine sensors is their speed. nLightG is activated...

...De-jargonizer.   Academic Phrasebank  The Academic Phrasebank is a resource for phrases commonly used in research...introduction, methods, results; or phrases are categorized by the goal of the phrase, such as being cautious, being... being critical, or defining terms. The phrases in Phrasebank are generic, so they need to be edited to...research papers or dissertations. Phrases are categorized either based on the section of a manuscript they...

...and triggering release of the stress hormone norepinephrine to promote vigilance. A recent study investigated...those neurons are chemogenetically activated, norepinephrine release causes a freezing response, a form ...associated with psychiatric diseases such as schizophrenia or bipolar disorder. In both diseases, animals...

...high spatiotemporal measurements of norepinephrine. These norepinephrine sensors include GRAB_NE1h (high ...from recent months: New GPCR activation-based norepinephrine (GRABNE) sensors allow for sensitive and high...

...activator - the CRY2 photolyase homology region (CRY2PHR) fused to a transcriptional activator domain (VP64...as directed by the guide RNA (gRNA), while the CRY2PHR-activator fusion floats freely, depicted in the...performing combination was NLS-dCas9-trCIB1 and NLSx3-CRYPHR-p65 - it had the lowest background activity in ...

... is said to be hyperpolarized. The chloride pump NpHR brings in negative chloride ions which hyperpolarize... have shown that some channels, such as ChR2 and NpHR, can even be expressed simultaneously and still ...

...pAAV-Ef1a-fDIO-GCaMP6s Neurotransmitter sensors: Dopamine and norepinephrine Neuroscience research relies on accurate monitoring...measurements of dopamine (113049, 113050) or norepinephrine (123308). The two dopamine sensors offer different...

...(Pyrophorus plagiophthalmus), railroad worm (Phrixothrix hirtus), and a variety of marine crustaceans....544-593 64 Luciferin ATP No Railroad worms(Phrixothrix hirtus) 630 64 Luciferin ATP No Common uses...

...of matches: exact words, partial words, phrases, partial phrases, or numerical identifiers. We also combine...

... an AAV vector to express ChR2(H134R) in A2 norepinephrine expressing neurons. We tested four serotypes...dopamine beta-hydroxylase (DBH, magenta) to label norepinephrine (NE) expressing neurons and GFP (green) to ...

...Labeling in the Phrenic Motor System of Adult Rats: Intrapleural Injection versus Intradiaphragmatic Injection...

...CRISPR is a sleek acronym for a real mouthful of a phrase: Clustered Regularly Interspaced Short Palindromic...

...cited below. Scientists can obtain dCas9-trCIB1, CRY2PHR-p65, and other plasmids from this article through... labs of Jeffrey Chao, Robert Singer, and Anne Ephrussi allows researchers to observe when and where translation...

...session were words from Eric Hendrickson, loosely paraphrased in the tweet below. The complexity and challenges...

...broad simple overview, learn some jargon and key phrases and understand enough to relate it to the position...

...antidiabetic properties that can ameliorate diabetics nephropathy, one of the major pathophysiological complications...

...In a lab, you may have heard the phrase gram negative or positive being used to describe a species of...

... AP, Askari JA, Byron A, Takada Y, Jowitt TA, Humphries MJ (2016) Ligand-induced Epitope Masking. Journal...

...thing’ could be a neurotransmitter, such as norepinephrine, or an electrolyte such as calcium. This varied...

...quiz! What pops into your head when you hear the phrase “action potential?” Firing neurons are likely the...