...amyloidosis (hATTR) hATTR is caused by a variety of single nucleotide polymorphisms (SNPs) in the TTR gene and... the liver. Thus, it has been used for hATTR therapy, since TTR is primarily made in the liver. Similarly...is molecularly characterized by misfolding of the TTR protein, which contributes to the disease phenotype...phenotype. Intellia initiated a CRISPR therapy for hATTR with the first-ever systemic CRISPR therapy. They ... expected soon on how this therapy is affecting hATTR patient outcomes. Bacterial infection and HIV Most...

... (attL-left- and attR-right-, Figure 1). Under certain conditions, the attL and attR sites can recombine...attB2 only with attP2, attL1 only with attR1; attL2 only with attR2, and so on. Take a look at some of the...Recombination of attP and attB sites creates attL and attR sites.   Gateway vectors contain modified versions... attL sites of the generated entry clone and the attR sites of the destination vector. This reaction is...or the doxycycline-inducible pLIX_402. The chosen attR destination vector will recombine with the attL-...cloning or by Restriction Cloning Destination vector attR sites for recombination; ccdB gene for negative ...

...thrive in laboratory settings. One of its most attractive features is its stability and easily obtainable...is far from perfect. One of the most limiting attributes of rats is their difficult to manipulate genome...ability to regenerate, the axolotl has several attractive characteristics that make them an ideal model...for human disease research. One of their most attractive features are their eggs. Frog eggs are large,...making them useful for in vivo studies. These attributes make frog eggs some of the most useful tools ...

...resulting in faint signals (Schwab et al., 1979; Buttry & Goshgarian, 2015). Nevertheless, the use of these...polysynaptic spreading. AAV vectors cover some of these attributes and their use has allowed for the visualization...PMID: 21825165. PubMed Central PMCID: PMC3174680. Buttry, J.L., and Goshgarian, H.G. (2015). WGA-Alexa Transsynaptic...Roberts, T. F., Hisey, E., Tanaka, M., Kearney, M., Chattree, G., Yang, C. F., Shah, N.M., and Mooney, R. (...

...of support and structure, prevent science from attracting and keeping diverse talent in science related...prioritize ongoing work.  If we’re going to continue attracting and launching science talent we must ensure that...

...Queensland, whose outstanding marine photography has attracted much attention over the past few years, including...is easy to see how these incredible images are attracting so much attention. When I spoke with Daniel about...

...and digital articles where it’s easier to give attribution, than for journal publications. Google Image ...includes images that can’t be reused without attribution, despite filtering for images labeled for reuse...

...a DNA/RNA cargo into their targets makes them attractive and tractable tools for genome engineering. Scientists... into an organism. This feature makes them an attractive tool for human subject delivery, as immunogenicity...

...Beatty et al., 2012). These features make AdV an attractive candidate for in vivo delivery of advanced genome...editing (Maggio et al., 2014). Gonçalves said they attribute this phenomenon to the presence of terminal proteins...

...with AAV sgRNA delivery make the SPH mouse an attractive tool to probe gene-function relationships in ...cell populations makes Cre-dependent SPH mice an attractive alternative. Whatever your application, first...

... 2013, Figure 1. Used under Creative Commons Attribution License. Within the nervous system, remember... 2019, Figure 4. Used under Creative Commons Attribution 4.0 International License.   Inducible promoters...

... that almost all off-target expression can be attributed to spontaneous recombination between homologous...the amount of leaky expression can largely be attributed to the level of spontaneous recombination between...

...surveillance. Dormancy of certain cancers can be attributed to the concept of immunoediting, by way of favorably...endothelial growth factors (VEGF) in tumors is attributed to a signaling cascade, where lack of oxygen ...

...biology work in Ghana - Building a bioresource to attract research funding. Using current resources to develop...

... be tested carefully to ensure it retains the attributes of the native protein. Since this process takes...

... of the credit, the success of the company is attributed to the entire Addgene family; the depositors ...

...have: working to deadlines, writing up clear and attractive reports, being good at presentations and of course...

...plasmids to self-replicate within a cell make them attractive tools for the life scientist or bioengineer. ...

...members. We also find that, as a nonprofit, we attract partnerships with organizations that share our ...

...signals in ultrasound imaging. Ultrasound is an attractive imaging platform for in vivo imaging experiments...