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TypeGuide...Molecular Therapy — Methods & Clinical Development , 28 , 116–128. https://doi.org/10.1016/j.omtm.2022.12.006... to reduce the chance of creating replication-competent retroviruses. For a summary of all gamma-retroviral...: The potential for generation of replication-competent gamma-retroviral vectors The potential for oncogenesis...oncogenesis The potential for generation of replication-competent gamma-retroviral vectors is very low thanks to...to alter infectivity and tropism. Replication-competent The ability of a virus (or viral vector) to replicate...