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PX552 Citations (29)

Plasmid Article: In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9.
Swiech L, Heidenreich M, Banerjee A, Habib N, Li Y, Trombetta J, Sur M, Zhang F Nat Biotechnol. 2014 Oct 19. doi: 10.1038/nbt.3055.
PubMed Journal

Articles Citing PX552

Articles
The CRISPR/Cas9-created MDM2 T309G enhances vitreous-induced expression of MDM2 and proliferation and survival of cells. Duan Y, Ma G, Huang X, D'Amore PA, Zhang F, Lei H. J Biol Chem. 2016 May 31. pii: jbc.M116.729467. PubMed

Associated Plasmids

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo. Hung SS, Chrysostomou V, Li F, Lim JK, Wang JH, Powell JE, Tu L, Daniszewski M, Lo C, Wong RC, Crowston JG, Pebay A, King AE, Bui BV, Liu GS, Hewitt AW. Invest Ophthalmol Vis Sci. 2016 Jun 1;57(7):3470-6. doi: 10.1167/iovs.16-19316. PubMed

Associated Plasmids

The Development of a Viral Mediated CRISPR/Cas9 System with Doxycycline Dependent gRNA Expression for Inducible In vitro and In vivo Genome Editing. de Solis CA, Ho A, Holehonnur R, Ploski JE. Front Mol Neurosci. 2016 Aug 18;9:70. doi: 10.3389/fnmol.2016.00070. eCollection 2016. PubMed

Associated Plasmids

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Suzuki K, Tsunekawa Y, Hernandez-Benitez R, Wu J, Zhu J, Kim EJ, Hatanaka F, Yamamoto M, Araoka T, Li Z, Kurita M, Hishida T, Li M, Aizawa E, Guo S, Chen S, Goebl A, Soligalla RD, Qu J, Jiang T, Fu X, Jafari M, Esteban CR, Berggren WT, Lajara J, Nunez-Delicado E, Guillen P, Campistol JM, Matsuzaki F, Liu GH, Magistretti P, Zhang K, Callaway EM, Zhang K, Belmonte JC. Nature. 2016 Dec 1;540(7631):144-149. doi: 10.1038/nature20565. Epub 2016 Nov 16. PubMed

Associated Plasmids

Genome editing abrogates angiogenesis in vivo. Huang X, Zhou G, Wu W, Duan Y, Ma G, Song J, Xiao R, Vandenberghe L, Zhang F, D'Amore PA, Lei H. Nat Commun. 2017 Jul 24;8(1):112. doi: 10.1038/s41467-017-00140-3. PubMed
MANF regulates hypothalamic control of food intake and body weight. Yang S, Yang H, Chang R, Yin P, Yang Y, Yang W, Huang S, Gaertig MA, Li S, Li XJ. Nat Commun. 2017 Sep 18;8(1):579. doi: 10.1038/s41467-017-00750-x. PubMed
Site-directed RNA repair of endogenous Mecp2 RNA in neurons. Sinnamon JR, Kim SY, Corson GM, Song Z, Nakai H, Adelman JP, Mandel G. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9395-E9402. doi: 10.1073/pnas.1715320114. Epub 2017 Oct 16. PubMed
Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina. Hung SS, Li F, Wang JH, King AE, Bui BV, Liu GS, Hewitt AW. Methods Mol Biol. 2018;1715:113-133. doi: 10.1007/978-1-4939-7522-8_9. PubMed
Mental Illnesses-Associated Fxr1 and Its Negative Regulator Gsk3beta Are Modulators of Anxiety and Glutamatergic Neurotransmission. Khlghatyan J, Evstratova A, Chamberland S, Marakhovskaia A, Bahremand A, Toth K, Beaulieu JM. Front Mol Neurosci. 2018 Apr 12;11:119. doi: 10.3389/fnmol.2018.00119. eCollection 2018. PubMed

Associated Plasmids

Inhibition of PKCdelta reduces amyloid-beta levels and reverses Alzheimer disease phenotypes. Du Y, Zhao Y, Li C, Zheng Q, Tian J, Li Z, Huang TY, Zhang W, Xu H. J Exp Med. 2018 Jun 4;215(6):1665-1677. doi: 10.1084/jem.20171193. Epub 2018 May 8. PubMed
CRISPR/Cas9 Mediated Disruption of the Swedish APP Allele as a Therapeutic Approach for Early-Onset Alzheimer's Disease. Gyorgy B, Loov C, Zaborowski MP, Takeda S, Kleinstiver BP, Commins C, Kastanenka K, Mu D, Volak A, Giedraitis V, Lannfelt L, Maguire CA, Joung JK, Hyman BT, Breakefield XO, Ingelsson M. Mol Ther Nucleic Acids. 2018 Jun 1;11:429-440. doi: 10.1016/j.omtn.2018.03.007. Epub 2018 Mar 16. PubMed
Nucleus of the Solitary Tract Serotonin 5-HT2C Receptors Modulate Food Intake. D'Agostino G, Lyons D, Cristiano C, Lettieri M, Olarte-Sanchez C, Burke LK, Greenwald-Yarnell M, Cansell C, Doslikova B, Georgescu T, Martinez de Morentin PB, Myers MG Jr, Rochford JJ, Heisler LK. Cell Metab. 2018 Oct 2;28(4):619-630.e5. doi: 10.1016/j.cmet.2018.07.017. Epub 2018 Aug 23. PubMed
Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z. Mol Cell. 2018 Nov 15;72(4):650-660.e8. doi: 10.1016/j.molcel.2018.09.007. Epub 2018 Nov 1. PubMed
The Development of an AAV-Based CRISPR SaCas9 Genome Editing System That Can Be Delivered to Neurons in vivo and Regulated via Doxycycline and Cre-Recombinase. Kumar N, Stanford W, de Solis C, Aradhana, Abraham ND, Dao TJ, Thaseen S, Sairavi A, Gonzalez CU, Ploski JE. Front Mol Neurosci. 2018 Nov 13;11:413. doi: 10.3389/fnmol.2018.00413. eCollection 2018. PubMed
Induction of Brain Arteriovenous Malformation Through CRISPR/Cas9-Mediated Somatic Alk1 Gene Mutations in Adult Mice. Zhu W, Saw D, Weiss M, Sun Z, Wei M, Shaligram S, Wang S, Su H. Transl Stroke Res. 2018 Dec 3. pii: 10.1007/s12975-018-0676-1. doi: 10.1007/s12975-018-0676-1. PubMed
Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling. Hamnett R, Crosby P, Chesham JE, Hastings MH. Nat Commun. 2019 Feb 1;10(1):542. doi: 10.1038/s41467-019-08427-3. PubMed
Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant. Tran MTN, Khalid MKNM, Pebay A, Cook AL, Liang HH, Wong RCB, Craig JE, Liu GS, Hung SS, Hewitt AW. Mol Vis. 2019 Mar 16;25:174-182. eCollection 2019. PubMed
Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina. Li F, Hung SSC, Mohd Khalid MKN, Wang JH, Chrysostomou V, Wong VHY, Singh V, Wing K, Tu L, Bender JA, Pebay A, King AE, Cook AL, Wong RCB, Bui BV, Hewitt AW, Liu GS. Hum Gene Ther. 2019 Nov;30(11):1349-1360. doi: 10.1089/hum.2019.021. Epub 2019 Oct 25. PubMed
High levels of AAV vector integration into CRISPR-induced DNA breaks. Hanlon KS, Kleinstiver BP, Garcia SP, Zaborowski MP, Volak A, Spirig SE, Muller A, Sousa AA, Tsai SQ, Bengtsson NE, Loov C, Ingelsson M, Chamberlain JS, Corey DP, Aryee MJ, Joung JK, Breakefield XO, Maguire CA, Gyorgy B. Nat Commun. 2019 Sep 30;10(1):4439. doi: 10.1038/s41467-019-12449-2. PubMed
Neuronal programming by microbiota regulates intestinal physiology. Obata Y, Castano A, Boeing S, Bon-Frauches AC, Fung C, Fallesen T, de Aguero MG, Yilmaz B, Lopes R, Huseynova A, Horswell S, Maradana MR, Boesmans W, Vanden Berghe P, Murray AJ, Stockinger B, Macpherson AJ, Pachnis V. Nature. 2020 Feb;578(7794):284-289. doi: 10.1038/s41586-020-1975-8. Epub 2020 Feb 5. PubMed

Associated Plasmids

Factors Impacting Efficacy of AAV-Mediated CRISPR-Based Genome Editing for Treatment of Choroidal Neovascularization. Chung SH, Mollhoff IN, Nguyen U, Nguyen A, Stucka N, Tieu E, Manna S, Meleppat RK, Zhang P, Nguyen EL, Fong J, Zawadzki R, Yiu G. Mol Ther Methods Clin Dev. 2020 Jan 23;17:409-417. doi: 10.1016/j.omtm.2020.01.006. eCollection 2020 Jun 12. PubMed
In vivo CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy. Colasante G, Qiu Y, Massimino L, Di Berardino C, Cornford JH, Snowball A, Weston M, Jones SP, Giannelli S, Lieb A, Schorge S, Kullmann DM, Broccoli V, Lignani G. Brain. 2020 Mar 1;143(3):891-905. doi: 10.1093/brain/awaa045. PubMed
Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form. Yang H, Yang S, Jing L, Huang L, Chen L, Zhao X, Yang W, Pan Y, Yin P, Qin ZS, Li S, Li XJ. Nat Commun. 2020 May 22;11(1):2582. doi: 10.1038/s41467-020-16318-1. PubMed
Loss of Hap1 selectively promotes striatal degeneration in Huntington disease mice. Liu Q, Cheng S, Yang H, Zhu L, Pan Y, Jing L, Tang B, Li S, Li XJ. Proc Natl Acad Sci U S A. 2020 Aug 18;117(33):20265-20273. doi: 10.1073/pnas.2002283117. Epub 2020 Aug 3. PubMed
D1 receptors in the anterior cingulate cortex modulate basal mechanical sensitivity threshold and glutamatergic synaptic transmission. Darvish-Ghane S, Quintana C, Beaulieu JM, Martin LJ. Mol Brain. 2020 Sep 5;13(1):121. doi: 10.1186/s13041-020-00661-x. PubMed
AAV-mediated in vivo genome editing in vascular endothelial cells. Wu W, Yang Y, Yao F, Dong L, Xia X, Zhang S, Lei H. Methods. 2020 Dec 9. pii: S1046-2023(20)30263-2. doi: 10.1016/j.ymeth.2020.12.001. PubMed
The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons. Sertel SM, von Elling-Tammen MS, Rizzoli SO. J Neurosci. 2021 Feb 10;41(6):1157-1173. doi: 10.1523/JNEUROSCI.0921-20.2020. Epub 2020 Dec 11. PubMed
Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study. Liu H, Zhang C, Xu J, Jin J, Cheng L, Miao X, Wu Q, Wei Z, Liu P, Lu H, van Zijl PCM, Ross CA, Hua J, Duan W. Brain. 2021 May 27. pii: 6286941. doi: 10.1093/brain/awab190. PubMed
Generation of Transgenic Rat Embryonic Stem Cells Using the CRISPR/Cpf1 System for Inducible Gene Knockout. Sherstyuk VV, Zakian SM. Biochemistry (Mosc). 2021 Jul;86(7):843-851. doi: 10.1134/S0006297921070051. PubMed

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