Plasmid Collections
Plasmids for Stem Cell Research

Plasmids for Stem Cell Research

Stem cells are proliferative, unspecialized cells with the capacity to differentiate into many different cell types in the body during development. Unlike other cell types, each stem cell has the potential to either remain a stem cell or become another type of cell with a more specialized function. They also have the unique potential to continuously divide while maintaining an undifferentiated state. Stem cells are classified as pluripotent or multipotent, based on their ability to generate different cell lineages. Pluripotent stem cells, such as embryonic cells, can potentially give rise to any other cell type in the body. Multipotent stem cells, such as adult (or somatic) stem cells, can differentiate into multiple cell types, but are typically limited to related cell lineages.

Pluripotent embryonic and multipotent adult stem cells have been studied for over 30 years. All of this research led to Kazutoshi Takahashi and Shinya Yamanaka’s breakthrough development of induced pluripotent stem cells (iPSCs) in both mouse and human cells in 2006 and 2007, respectively. To create iPSCs, fully-differentiated adult somatic cells are returned to a pluripotent state using a cocktail of factors (Oct3/4, Sox2, c-Myc, and Klf4) that are known to maintain pluripotency during embryonic development. This “reprogramming” of the cell to an embryonic state holds immense potential for drug development, disease modeling, and regenerative medicine.

iPSCs, much like their ES cell cousins, have the hallmarks of pluripotent cells--they are capable of differentiating into every other cell type in the body and have the capacity to give rise to an entire organism. iPSC technology removes the possible ethical concerns related to embryonic stem cell use and has the major advantage that iPSCs can potentially be derived from patient-specific or disease-specific cells. For this reason, iPSCs have become an excellent unlimited stem cell source for therapeutic use.

Since 2006, scientists have developed many approaches to generate iPSCs. The generation of iPSCs is relatively simple in concept: ectopically express a cocktail of stem cell reprogramming factors and wait for cells to de-differentiate. However it may be difficult to decide which method to use. Addgene's blog post Delivery Methods for Generating iPSCs provides an overview of several different reprogramming methods with the goal of helping readers choose a strategy suited to their research. Once you know which method you would like to use, browse Addgene's collection of Reprogramming Plasmids in the table below.

Once iPSCs have been created they can be directly differentiated into specific somatic stem cells or fully differentiated cell types. Browse Addgene's collection of Differentiation Plasmids below.

Alternatively, it is also possible to directly differentiate one differentiated somatic cell into another via transdifferentiation. This method of cell lineage conversion can be faster, bypasses intermediate pluripotent stages, and can occur without cell division, all of which lower the risk of mutation and minimize tumorigenicity, an inherent disadvantage of iPS cell technology. Browse Addgene's collection of Transdifferentiation Plasmids below.

Many of the techniques for reprogramming, differentiation, and transdifferentiation utilize plasmids to increase expression of key factors. The tables below will help you find plasmids available from Addgene that can be used to create iPSCs or another cell type. You can also browse Addgene’s entire collection of Stem Cell Research Plasmids. For more information on stem cells, visit the NIH Stem Cell information page.

Reprogramming Plasmids

Browse the table below for plasmids used to create induced pluripotent stem cells (iPSCs). Sort the table by delivery method, species, or PI and then select the article link to find more information.

Delivery Method	Species	Description	Article	PI
Lentivirus	Human	Expression of human Oct4, Sox2, Klf4, Myc, and Brd3R from five separate lentiviral plasmids	The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun. 2016 Mar 7;7:10869.	Hu
CRISPRa	Human	CRISPR activator system for reprogramming human cells to pluripotency by activating enogenous genes	Human pluripotent reprogramming with CRISPR activators. Nat Commun. 2018 Jul 6;9(1):2643.	Otonkoski
Lentivirus	Human	Expression of human Sox2, Nanog, Oct4, and Lin28 from four separate lentiviral plasmids	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Dec 21;318(5858):1917-20.	Thomson
Lentivirus	Human	Doxycycline-inducible expression of human Oct4, Sox2, Klf4, and c-Myc from four separate lentiviral plasmids	A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 2008 Sep 11. 3(3):346-53.	Jaenisch
Lentivirus	Human	Single polycistronic lentiviral vector for the expression of human Oct4, Sox2, and Klf4	Polycistronic lentiviral vector for "hit and run" reprogramming of adult skin fibroblasts to induced pluripotent stem cells. Stem Cells. 2009 May . 27(5):1042-9.	Townes
Lentivirus	Human	Single polycistronic lentiviral vector for the expression of human Oct4, Klf4, Sox2, and c-Myc	Human Induced Pluripotent Stem Cells Produced Under Xeno-Free Conditions. Stem Cells Dev. 2010 Aug;19(8):1221-9.	Cibelli
Lentivirus	Human	Single polycistronic, doxycycline-inducible lentiviral vector for the expression of human Oct4, Klf4, c-Myc, and Sox2	Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 2015 Jul 16;162(2):412-24.	Mikkelsen
Lentivirus	Human	Expression of human Klf4, Oct4, c-Myc, and Sox2 as VP-16 transcriptional activating fusions in single lentiviral vectors for human iPSC generation	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596.	Ptashne
Minicircle	Human	Non-integrating mini-intronic plasmid (MIP) polycistronic expression of human Oct4, Klf4, Sox2, c-Myc and hairpin RNA p53 for single plasmid reprogramming	Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep. 2015 Jan 28;5:8081.	Kay and Wu
MMLV-derived Retrovirus	Human	Yamanaka factors for generating human iPS cells; retroviral expression of human Sox2, Oct3/4, Klf4, and c-Myc from four separate plasmids	Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30. 131(5):861-72.	Yamanaka
Plasmid	Human	Non-integrating transient expression of human L-Myc, Lin28, Sox2, Klf4, Oct3/4, Glis1, and EBNA1 from separate plasmids	An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells. 2012 Nov 29.	Yamanaka
Replicating EBNA1 episome	Human	Non-integrating EBNA1-mediated polycistronic expression of human Sox2, KLF4, L-Myc, Lin28, OCT3/4, and shRNA against p53 in different gene/insert combinations.	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 May;8(5):409-12.	Yamanaka
Replicating EBNA1 episome	Human	Non-integrating polycistronic expression of human Oct4, Klf4, Sox2, c-Myc, Nanog, Lin28, NR5A2, and microRNA 302/367 in three different combinations of reprogramming factors	Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83.	Capecchi
Replicating EBNA1 episome	Human	Fluorescent-tagged EBNA1-mediated expression of human Oct3/4, shp53, Klf4, Sox2, L-Myc, Lin28 from separate non-integrating episomes to allow sorting and dosage tracking of reprogramming factors	Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 5;8(1):132.	Zovein
Replicating EBNA1 episome	Human	Non-integrating EBNA1-mediated polycistronic expression of human Oct4, Sox2, Myc, Klf4, BCL2L1, and EBNA1 from three separate plasmids	A Facile Method to Establish Human Induced Pluripotent Stem Cells From Adult Blood Cells Under Feeder-Free and Xeno-Free Culture Conditions: A Clinically Compliant Approach. Stem Cells Transl Med. 2015 Mar 5. pii: sctm.2014-0214.	Cheng
RNA	Human	Reprogramming factors for delivering synthetic mRNAs encoding human Klf4, Oct4, Sox2, c-Myc, and Lin28A to somatic cells from separate plasmids	Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Nov 5;7(5):618-30.	Rossi
RNA	Human	Non-integrating, polycistronic, self-replicating VEE RNA species expressing human Oct4, Klf4, Sox2, with either c-Myc or Glis1	Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1;13(2):246-54.	Dowdy
Adenovirus	Mouse	Non-integrating expression of mouse Sox2, Oct4, c-Myc, and Klf4 from four separate adenoviral plasmids	Induced Pluripotent Stem Cells Generated Without Viral Integration. Science. 2008 Nov 7;322(5903):945-9.	Hochedlinger
Lentivirus	Mouse	Doxycycline-inducible expression of mouse Oct4, Sox2, Klf4, and c-Myc from four separate lentiviral plasmids	Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2008 Feb 7. 2(2):151-9.	Jaenisch
Lentivirus	Mouse	Polycistronic, doxycycline-inducible lentiviral vectors for the expression of mouse Oct4, Klf4, c-Myc, and Sox2	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.	Jaenisch
Lentivirus	Mouse	Doxycycline-inducible lentiviral expression of mouse Oct4, Sox2, Klf4, and c-Myc from four separate plasmids	Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 6. 2(3):230-40.	Hochedlinger
MMLV-derived Retrovirus	Mouse	Original set of Yamanaka factors for generating mouse iPS cells; retroviral expression of mouse Sox2, Oct3/4, Klf4, and c-Myc from separate plasmids	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.	Yamanaka
PiggyBac	Mouse	Doxycycline-inducible piggyBac transposon reprogramming system; expression of mouse Oct4, Sox2, Klf4, and c-Myc from polycistronic cassettes	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43.	Woltjen
Plasmid	Mouse	Non-integrating polycistronic expression of mouse Oct4, Klf4, Sox2, and c-Myc from two separate plasmids	Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science. 2008 Nov 7;322(5903):949-53.	Yamanaka
Replicating EBNA1 episome	Mouse	Non-integrating EBNA1-mediated polycistronic expression of mouse Oct4, Sox2, Klf4, c-Myc, and Lin28	Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 2011 Mar;21(3):518-29.	Cheng

You can also find gene-specific plasmids at the following links: NANOG, OCT4, SOX2, MYC, KLF4, LIN28.

Differentiation and Transdifferentiation Plasmids

Browse the table below for plasmids used for differentiation of iPSCs or transdifferentiation of a somatic cell to a new type of somatic cell. Sort the table by cell type, delivery system, species, or PI and then select the article link to find more information.

From → To	Delivery Method	Species	Article	PI
Fibroblasts → iPSCs, iTSCs, and iXENs	Lentiviral	Mouse	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun6.	Buganim
iPSC → Cardiomyocyte	Lentiviral	Human	Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci U S A. 2012 May 29.	Palecek
iPSC → Bipolar Neurons	Lentiviral	Human	Rapid neurogenesis through transcriptional activation in human stem cells. Mol Syst Biol. 2014 Nov 17;10(11):760.	Weiss
iPSC → Cortical or Lower Motor Neurons	CRISPR/TALEN	Human	Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Curr Protoc Cell Biol. 2018 Jun;79(1):e51. Next generation vectors for transcription factor mediated differentiation of iPSCs into cortical and motor neurons. Unpublished.	Ward
Fibroblast → Motor Neurons	Retroviral	Mouse/Human	Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell. 2011 Sep 2;9(3):205-18.	Eggan
Fibroblast → Neural Stem Cell	Retroviral	Mouse	Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell. 2012 Apr 6;10(4):465-72.	Scholer
Fibroblasts → Hepatocytes	Retroviral	Mouse	Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors. Nature. 2011 Jun 29;475(7356):390-3.	Suzuki
Fibroblast → Neurons	Lentiviral	Mouse	Direct conversion of fibroblasts to functional neurons by defined factors. Nature. 2010 Feb 25. 463(7284):1035-41	Wernig
Fibroblast → Neural Stem Cell	Lentiviral	Mouse	Direct Lineage Conversion of Adult Mouse Liver Cells and B Lymphocytes to Neural Stem Cells. Stem Cell Reports. 2014 Nov 6. pii: S2213-6711(14)00307-5.	Jaenisch
Fibroblast → Sensory Neurons	Lentiviral	Mouse	Selective conversion of fibroblasts into peripheral sensory neurons. Nat Neurosci. 2015 Jan;18(1):25-35.	Baldwin
Fibroblast → Astrocyte	Lentiviral	Mouse	Direct conversion of fibroblasts into functional astrocytes by defined transcription factors. Stem Cell Reports. 2015 Jan 13;4(1):25-36.	Broccoli
Fibroblast → Oligodendrocyte Progenitor	Lentiviral	Mouse	Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells. Nat Biotechnol. 2013 May;31(5):426-33.	Tesar
Fibroblast → Cardiomyocyte	Lentiviral	Mouse	Optimization of direct fibroblast reprogramming to cardiomyocytes using calcium activity as a functional measure of success. Mol Cell Cardiol. 2013 Apr 13;60C:97-106.	Gearhart
Fibroblast → Sertoli Cell	Lentiviral	Mouse	Direct Reprogramming of Fibroblasts into Embryonic Sertoli-like Cells by Defined Factors. Cell Stem Cell. 2012 Sep 7;11(3):373-86.	Jaenisch
Fibroblast → Hematopoietic Progenitor	Lentiviral	Mouse	Direct reprogramming of murine fibroblasts to hematopoietic progenitor cells. Cell Rep. 2014 Dec 11;9(5):1871-84.	Lacaud
Pancreatic Exocrine → Beta-cell	Adenoviral	Mouse	In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008 Aug 27.	Melton
Skin Fibroblast → Motor Neuron	Lentiviral	Human	Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients. Cell Rep. 2016 Jan 5;14(1):115-28.	Zhang
Adult Skin Fibroblast → Cholinergic Neuron	Lentiviral	Human	Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun. 2013;4:2183.	Zhang
Fetal Lung Fibroblast → Cholinergic Neuron	Lentiviral	Human	Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun. 2013;4:2183.	Zhang
Fibroblast → Dopaminergic Neuron	Lentiviral	Human	Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10343-8.	Parmar
Adult Dermal Fibroblast → Neuron	Lentiviral	Human	REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017 Aug;9(8):1117-1131.	Parmar
Astrocytes → Dopaminergic Neuron	Lentiviral	Human	Efficient conversion of astrocytes to functional midbrain dopaminergic neurons using a single polycistronic vector. PLoS One. 2011;6(12):e28719.	Gearhart

Stem Cell Research Plasmids

This table contains a general list of plasmids that have been used in Stem Cell research. You can search or sort this table based on plasmid name, species, gene name, and more.

Plasmid	Gene/Insert	Vector Type	PI	Publication
pWZL Blast myc	c-myc (Homo sapiens)	Mammalian Expression, Retroviral	Hahn	Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol. 2005 Aug . 25(15):6464-74.
RCAS-myc	c-myc (Homo sapiens)	Retroviral	Orsulic	Induction of ovarian cancer by defined multiple genetic changes in a mouse model system. Cancer Cell. 2002 Feb . 1(1):53-62.
pMXs-Nanog	Nanog homeobox (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-Oct3/4	POU domain, class 5, transcription factor 1 (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-Sox2	SRY-box containing gene 2 (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-Klf4	Kruppel-like factor 4 (gut) (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-c-Myc	myelocytomatosis oncogene (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pCAG-HA-Sox2-IP	Sox2 (Mus musculus)	Mammalian Expression	Yamanaka	Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 1. 280(26):24371-9.
pCAG-Myc-Oct3/4-IP	Oct3/4 (Mus musculus)	Mammalian Expression	Yamanaka	Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem. 2005 Jul 1. 280(26):24371-9.
pCAG-Oct3/4-IRES-Neo	Oct3/4 (Mus musculus)	Mammalian Expression	Yamanaka	Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr . 23(8):2699-708.
pCAG-Sox2-IRES-Neo	Sox2 (Mus musculus)	Mammalian Expression	Yamanaka	Fbx15 is a novel target of Oct3/4 but is dispensable for embryonic stem cell self-renewal and mouse development. Mol Cell Biol. 2003 Apr . 23(8):2699-708.
pTV-Nanog Hyg	IRES-Hyg-pA cassette flanked by Nanog homologous regions (Mus musculus)	Mammalian Expression ; Beta-gal	Yamanaka	The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30. 113(5):631-42.
pTV-Nanog Bgeo	IRES-Bgeo-pA cassette flanked by Nanog homologous regions (Mus musculus)	Mammalian Expression ; Beta-gal	Yamanaka	The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30. 113(5):631-42.
pPyCAG-Nanog-IP	Nanog (Mus musculus)	Mammalian Expression	Yamanaka	The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30. 113(5):631-42.
pDEST17-Nanog	Nanog (Mus musculus)	Bacterial Expression	Yamanaka	The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003 May 30. 113(5):631-42.
pBS human c-Myc	c-Myc (Homo sapiens)	Bacterial Expression	Massague	Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem. 2003 Sep 12. 278(37):35444-50.
pBS mouse c-Myc	c-Myc (Mus musculus)	Bacterial Expression	Massague	Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-beta-mediated epithelial cell growth suppression. J Biol Chem. 2003 Sep 12. 278(37):35444-50.
pMXs-Oct3/4-IP	POU domain, class 5, transcription factor 1 (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-Sox2-IP	SRY-box containing gene 2 (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-Klf4-IP	Kruppel-like factor 4 (gut) (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pMXs-c-Myc-IP	myelocytomatosis oncogene (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25. 126(4):663-76.
pLOVE-Klf4	Kruppel-like factor 4 (Mus musculus)	Mammalian Expression, Lentiviral	Ramalho-Santos	Generation of Induced Pluripotent Stem Cells in the Absence of Drug Selection. Cell Stem Cell. 2007 Sep 13. ():.
pLOVE-Nmyc	v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (Mus musculus)	Mammalian Expression, Lentiviral	Ramalho-Santos	Generation of Induced Pluripotent Stem Cells in the Absence of Drug Selection. Cell Stem Cell. 2007 Sep 13. ():.
pLOVE-Sox2	SRY (sex determining region Y)-box 2 (Mus musculus)	Mammalian Expression, Lentiviral	Ramalho-Santos	Generation of Induced Pluripotent Stem Cells in the Absence of Drug Selection. Cell Stem Cell. 2007 Sep 13. ():.
pcDNA3-cmyc	cmyc (Homo sapiens)	Mammalian Expression	El-Deiry	Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol. 2004 Oct . 24(19):8541-55.
pGEM-LIN28	Homo sapiens lin-28 homolog (C. elegans) (Homo sapiens)	Bacterial Expression	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pGEM-Nanog	Homo sapiens Nanog homeobox (Homo sapiens)	Bacterial Expression	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pGEM-Oct4	Homo sapiens POU domain, class 5, transcription factor 1 (POU5F1) (Homo sapiens)	Bacterial Expression	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pGEM-Sox2	Homo sapiens SRY (sex determining region Y)-box 2 (SOX2) (Homo sapiens)	Bacterial Expression	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
deltaMyc-HA	c-MYC (Homo sapiens)	Mammalian Expression	Vogelstein	Identification of CDK4 as a target of c-MYC. Proc Natl Acad Sci U S A. 2000 Feb 29. 97(5):2229-34.
pSin-EF2-Sox2-Pur	Homo sapiens SRY (sex determining region Y)-box 2 (SOX2) (Homo sapiens)	Mammalian Expression, Lentiviral	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pSin-EF2-Nanog-Pur	Homo sapiens Nanog homeobox (Homo sapiens)	Mammalian Expression, Lentiviral	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pSin-EF2-Oct4-Pur	Homo sapiens POU domain, class 5, transcription factor 1 (POU5F1) (Homo sapiens)	Mammalian Expression, Lentiviral	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pSin-EF2-LIN28-Pur	Homo sapiens lin-28 homolog (C. elegans) (Homo sapiens)	Mammalian Expression, Lentiviral	Thomson	Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells. Science. 2007 Nov 20. ():.
pMXs-hOCT3/4	OCT3/4 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30. 131(5):861-72.
pMXs-hSOX2	SOX2 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30. 131(5):861-72.
pMXs-hKLF4	KLF4 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30. 131(5):861-72.
pMXs-hc-MYC	c-MYC (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30. 131(5):861-72.
pMIG-hOCT4	POU class 5 homeobox 1 (Homo sapiens)	Mammalian Expression, Retroviral	Daley	Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008 Jan 10. 451(7175):141-6.
pMIG-hSOX2	SRY (sex determining region Y)-box 2 (Homo sapiens)	Mammalian Expression, Retroviral	Daley	Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008 Jan 10. 451(7175):141-6.
pMIG-hKLF4	Kruppel-like factor 4 (gut) (Homo sapiens)	Mammalian Expression, Retroviral	Daley	Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008 Jan 10. 451(7175):141-6.
pBabe-c-myc-zeo	c-myc (Homo sapiens)	Mammalian Expression, Retroviral	Lindquist	Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell. 2007 Sep 21. 130(6):1005-18.
pMXs-hOCT4 (Plath)	POU domain, class 5, transcription factor 1 (Homo sapiens)	Mammalian Expression, Retroviral	Plath	Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26. 105(8):2883-8.
pMXs-hSOX2 (Plath)	SRY (sex determining region Y)-box 2 (Homo sapiens)	Mammalian Expression, Retroviral	Plath	Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26. 105(8):2883-8.
pMXs-hcMYC (Plath)	v-myc myelocytomatosis viral oncogene homolog (avian) (Homo sapiens)	Mammalian Expression, Retroviral	Plath	Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26. 105(8):2883-8.
pMXs-hKLF4 (Plath)	Kruppel-like factor 4 (gut) (Homo sapiens)	Mammalian Expression, Retroviral	Plath	Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26. 105(8):2883-8.
pMXs-hNANOG (Plath)	Nanog homeobox (Homo sapiens)	Mammalian Expression, Retroviral	Plath	Generation of human induced pluripotent stem cells from dermal fibroblasts. Proc Natl Acad Sci U S A. 2008 Feb 26. 105(8):2883-8.
MSCV h c-MYC IRES GFP	c-MYC (Homo sapiens)	Retroviral	Cleveland	Cleveland lab plasmids (unpublished)
tetO7_Ef1a_OCT4	OCT4 (Homo sapiens)	Mammalian Expression, Lentiviral, Cre/Lox	Cheng	Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug . 26(8):1998-2005.
tetO7_Ef1a_SOX2	SOX2 (Homo sapiens)	Mammalian Expression, Lentiviral, Cre/Lox	Cheng	Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug . 26(8):1998-2005.
Ef1a_NANOG_Ires_Puro	NANOG (Homo sapiens)	Mammalian Expression, Lentiviral, Cre/Lox	Cheng	Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug . 26(8):1998-2005.
Ef1a_LIN28_Ires_Puro	LIN28 (Homo sapiens)	Mammalian Expression, Lentiviral, Cre/Lox	Cheng	Improved efficiency and pace of generating induced pluripotent stem cells from human adult and fetal fibroblasts. Stem Cells. 2008 Aug . 26(8):1998-2005.
pBabepuro-myc-ER	c-myc (Homo sapiens)	Mammalian Expression, Retroviral	El-Deiry	Direct repression of FLIP expression by c-myc is a major determinant of TRAIL sensitivity. Mol Cell Biol. 2004 Oct . 24(19):8541-55.
pLV-tetO-myc T58A	c-myc (Homo sapiens)	Mammalian Expression, Lentiviral	Hochedlinger	Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 6. 2(3):230-40.
pLV-tetO-Klf4	Klf4 (Mus musculus)	Mammalian Expression, Lentiviral	Hochedlinger	Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 6. 2(3):230-40.
pLV-tetO-Sox2	Sox2 (Mus musculus)	Mammalian Expression, Lentiviral	Hochedlinger	Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 6. 2(3):230-40.
pLV-tetO-Oct4	Oct4 (Mus musculus)	Mammalian Expression, Lentiviral	Hochedlinger	Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 6. 2(3):230-40.
pAd-Sox2	Sox2 (Mus musculus)	Mammalian Expression, Adenoviral	Hochedlinger	Induced Pluripotent Stem Cells Generated Without Viral Integration. Science. 2008 Sep 25. ():.
pAd-Oct4	Oct4 (Mus musculus)	Mammalian Expression, Adenoviral	Hochedlinger	Induced Pluripotent Stem Cells Generated Without Viral Integration. Science. 2008 Sep 25. ():.
pAd-cMyc T58A	c-myc (Homo sapiens)	Mammalian Expression, Adenoviral	Hochedlinger	Induced Pluripotent Stem Cells Generated Without Viral Integration. Science. 2008 Sep 25. ():.
pAd-Klf4	Klf4 (Mus musculus)	Mammalian Expression, Adenoviral	Hochedlinger	Induced Pluripotent Stem Cells Generated Without Viral Integration. Science. 2008 Sep 25. ():.
pCX-OKS-2A	Oct3/4-2A-Klf4-2A-Sox2 (Mus musculus)	Mammalian Expression	Yamanaka	Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science. 2008 Oct 9. ():.
pCX-cMyc	c-Myc (Mus musculus)	Mammalian Expression	Yamanaka	Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors. Science. 2008 Oct 9. ():.
FU-tet-o-hc-myc	c-myc (Homo sapiens)	Mammalian Expression, Lentiviral	Hochedlinger	A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11. 3(3):340-5.
FU-tet-o-hKLF4	Klf4 (Homo sapiens)	Mammalian Expression, Lentiviral	Hochedlinger	A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11. 3(3):340-5.
FU-tet-o-hOct4	Oct4 (Homo sapiens)	Mammalian Expression, Lentiviral	Hochedlinger	A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11. 3(3):340-5.
FU-tet-o-hSox2	Sox2 (Homo sapiens)	Mammalian Expression, Lentiviral	Hochedlinger	A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 2008 Sep 11. 3(3):340-5.
pMSCV-Flag-cMyc T58A	cMyc (Homo sapiens)	Mammalian Expression, Retroviral	Belmonte	Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol. 2008 Nov . 26(11):1276-84.
pMSCVpuro-Flag-cMyc T58A	cMyc (Homo sapiens)	Mammalian Expression, Retroviral	Belmonte	Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes. Nat Biotechnol. 2008 Nov . 26(11):1276-84.
TetO-FUW-OSKM	Oct-4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
TetO-FUW-Klf4	Klf4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2008 Feb 7. 2(2):151-9.
TetO-FUW-oct4	oct4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2008 Feb 7. 2(2):151-9.
TetO-FUW-cMYC	cMYC (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2008 Feb 7. 2(2):151-9.
FUW-SOKM	Sox2-P2A-Oct4-T2A-Klf4-E2A-cMyc (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
TetO-FUW-sox2	sox2 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell. 2008 Feb 7. 2(2):151-9.
FUW-SOK	Sox2-F2A-Oct4-T2A-Klf4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-OSKM	Oct4-P2A-Sox2-T2A-Klf4-E2A-cMyc (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-SO	Sox2-F2A-Oct4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-SM	Sox2-F2A-cMyc (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-KO	Klf4-F2A-Oct4 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-KM	Klf4-F2A-cMyc (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Reprogramming of murine and human somatic cells using a single polycistronic vector. Proc Natl Acad Sci U S A. 2009 Jan 6. 106(1):157-62.
FUW-tetO-hMYC	c-MYC (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 2008 Sep 11. 3(3):346-53.
FUW-tetO-hSOX2	SOX2 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 2008 Sep 11. 3(3):346-53.
FUW-tetO-hKLF4	KLF4 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 2008 Sep 11. 3(3):346-53.
FUW-tetO-hOCT4	OCT4 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. Cell Stem Cell. 2008 Sep 11. 3(3):346-53.
FUW-tetO-lox-hKLF4	KLF4 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors Cell, Volume 136, Issue 5, 964-977, 6 March 2009
FUW-tetO-lox-hOCT4	OCT4 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors Cell, Volume 136, Issue 5, 964-977, 6 March 2009
FUW-tetO-lox-hSOX2	SOX2 (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors Cell, Volume 136, Issue 5, 964-977, 6 March 2009
pCAGMKOSiE	myelocytomatosis oncogene-F2A-Kruppel-like factor 4-T2A-POU domain, class 5, transcription factor 1-E2A-SRY-box containing gene (Mus musculus)	Mammalian Expression	Kaji	Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 2009 Mar 1. ():.
pCAG2LMKOSimO	c-Myc-F2A-Klf4-T2A-Oct4-E2A-Sox2-ires-mOrange (Mus musculus)	Mammalian Expression	Kaji	Virus-free induction of pluripotency and subsequent excision of reprogramming factors. Nature. 2009 Mar 1. ():.
PB-TET-mcMyc	cMyc (Mus musculus)	Mammalian Expression ; piggyBac	Nagy	piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. ():.
PB-TET-mKLF4	KLF4 (Mus musculus)	Mammalian Expression ; piggyBac	Nagy	piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. ():.
PB-TET-mOct4	Oct4 (Mus musculus)	Mammalian Expression ; piggyBac	Nagy	piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. ():.
PB-TET-mSox2	Sox2 (Mus musculus)	Mammalian Expression ; piggyBac	Nagy	piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. ():.
pEP4 E02S EN2L	Oct4 and Sox2; Nanog and Lin28 (Homo sapiens)	Episomal/EBNA	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pEP4 E02S CK2M EN2L	Oct4 and Sox2; Nanog and Lin28; Klf4 and Myc (Homo sapiens)	Episomal/EBNA	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pEP4 E02S EN2K	Oct4 and Sox2; Nanog and Klf4 (Homo sapiens)	Episomal/EBNA	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pCEP4-M2L	MYC (Homo sapiens), LIN28 (Homo sapiens)	Episomal/EBNA	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pEP4 E02S ET2K	Oct4 and Sox2; SV40LT and Klf4 (Homo sapiens)	Episomal/EBNA	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
PB-TET-MKOS	cMyc, KLF4, Oct4, Sox2 (Mus musculus)	Mammalian Expression ; piggyBac	Nagy	piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells. Nature. 2009 Mar 1. ():.
pBABE-puro-mouse Oct4	Oct4 (Mus musculus)	Mammalian Expression, Retroviral	Tantin	A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev. 2009 Jan 15. 23(2):208-22.
pSIN4-EF2-O2S	Oct4, Sox2 (Homo sapiens)	Lentiviral ; reprogramming	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pSIN4-EF2-N2L	Nanog, Lin28 (Homo sapiens)	Mammalian Expression, Lentiviral ; reprogramming	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
pSIN4-CMV-K2M	Klf4, cMyc (Homo sapiens)	Mammalian Expression, Lentiviral ; reprogramming	Thomson	Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences Science. 2009 Mar 26.
Oct4-ires-EGFP(lox neo)	EGFP, Oct4 (Mus musculus)	Mouse Targeting	Jaenisch	Oct4 expression is not required for mouse somatic stem cell self-renewal Cell Stem Cell. 2007 Oct 11;1(4):403-15.
pLM-vexGFP-Oct4	vexGFP_2A_OCT4 (Homo sapiens)	Lentiviral	Sadelain	Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 2009 Aug 4. 106(31):12759-64.
pLM-mCitrine-Sox2	mCitrine_2A_SOX2 (Homo sapiens)	Lentiviral	Sadelain	Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 2009 Aug 4. 106(31):12759-64.
pLM-mCherry-Klf4	mCherry_2A_KLF4 (Homo sapiens)	Lentiviral	Sadelain	Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 2009 Aug 4. 106(31):12759-64.
pLM-mCerulean-cMyc	mCerulean-2A-MYC (Homo sapiens)	Lentiviral	Sadelain	Stoichiometric and temporal requirements of Oct4, Sox2, Klf4, and c-Myc expression for efficient human iPSC induction and differentiation. Proc Natl Acad Sci U S A. 2009 Aug 4. 106(31):12759-64.
OKSIM	Oct4 KLF4 Sox2 c-Myc (Homo sapiens)	Mammalian Expression, Lentiviral, Cre/Lox	Cibelli	Human Induced Pluripotent Stem Cells Produced Under Xeno-Free Conditions. Stem Cells Dev. 2009 Dec 23. ():.
HUW-TetO-hNanog	Nanog (Homo sapiens)	Mammalian Expression, Lentiviral	Jaenisch	Direct cell reprogramming is a stochastic process amenable to acceleration. Nature. 2009 Dec 3. 462(7273):595-601.
pMXs-Hu-L-Myc	L-Myc (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-Ms-L-Myc	L-Myc (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-Ms-c-Myc-W136E	c-Myc (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pBRPyCAG-fmKlf4-DsRed-Ip	Klf4 (Mus musculus)	Mammalian Expression, Cre/Lox	Jaenisch	Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc Natl Acad Sci U S A. 2010 May 18. 107(20):9222-7.
pWZL Sox2	Sox2 (Homo sapiens)	Mammalian Expression, Retroviral	Meyerson	SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov . 41(11):1238-42.
pWZL Sox2 R74P	Sox2 (Homo sapiens)	Mammalian Expression, Retroviral	Meyerson	SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas. Nat Genet. 2009 Nov . 41(11):1238-42.
pMSCV-mLin28A	lin-28 homolog A (Mus musculus)	Mammalian Expression, Retroviral	Daley	Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009 Jul . 41(7):843-8.
pBABE-hLin28B	lin-28 homolog B (Homo sapiens)	Mammalian Expression, Retroviral	Daley	Lin28 promotes transformation and is associated with advanced human malignancies. Nat Genet. 2009 Jul . 41(7):843-8.
pcDNA3.3_KLF4	5'UTR-KLF4-3'UTR (Homo sapiens)	Mammalian Expression	Rossi	Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Sep 29. ():.
pcDNA3.3_OCT4	5'UTR-OCT4-3'UTR (Homo sapiens)	Mammalian Expression	Rossi	Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Sep 29. ():.
pcDNA3.3_SOX2	5'UTR-SOX2-3'UTR (Homo sapiens)	Mammalian Expression	Rossi	Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Sep 29. ():.
pcDNA3.3_c-MYC	5'UTR-c-MYC-3'UTR (Homo sapiens)	Mammalian Expression	Rossi	Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA. Cell Stem Cell. 2010 Sep 29. ():.
pCXLE-hOCT3/4	OCT3/4 (Homo sapiens)	Mammalian Expression	Yamanaka	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 Apr 3. ():.
pCXLE-hOCT3/4-shp53-F	OCT3/4 (Homo sapiens)	Mammalian Expression	Yamanaka	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 Apr 3. ():.
pCXLE-hSK	SOX2, KLF4 (Homo sapiens)	Mammalian Expression	Yamanaka	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 Apr 3. ():.
pCXLE-hMLN	C-MYC, LIN28, NANOG (Homo sapiens)	Mammalian Expression	Yamanaka	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 Apr 3. ():.
pCXLE-hUL	L-MYC (Homo sapiens)	Mammalian Expression	Yamanaka	A more efficient method to generate integration-free human iPS cells. Nat Methods. 2011 Apr 3. ():.
pEB-C5	Oct4, Sox2, Klf4, c-Myc, Lin28 (Mus musculus)	Mammalian Expression	Cheng	Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 2011 Jan 18. ():.
pCDNA3.1-Nanog	Nanog (Homo sapiens)	Mammalian Expression	Cheng	Efficient human iPS cell derivation by a non-integrating plasmid from blood cells with unique epigenetic and gene expression signatures. Cell Res. 2011 Jan 18. ():.
pMXs-GLIS1	GLIS1 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature. 2011 . 474(7350):225-9.
OCT4-eGFP-PGK-Puro	OCT4 (Homo sapiens)	targeting donor	Jaenisch	Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol. 2011 Jul 7. doi: 10.1038/nbt.1927.
OCT4-2A-eGFP-PGK-Puro	OCT4 (Homo sapiens)	targeting donor	Jaenisch	Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol. 2011 Jul 7. doi: 10.1038/nbt.1927.
OCT4-eGFP-2A-Puro	OCT4 (Homo sapiens), eGFP	targeting donor	Jaenisch	Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol. 2011 Jul 7. doi: 10.1038/nbt.1927.
pMXs-mGLIS1	GLIS1, Gateway casette A (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature. 2011 . 474(7350):225-9.
pMXs-GLIS1 (FLJ33315SAAN)	GLIS1, Gateway casette A (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1. Nature. 2011 . 474(7350):225-9.
pBpuro - HA KLF4 FL	KLF4 (Homo sapiens)	Mammalian Expression, Retroviral	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pBpuro - HA KLF4 FL delta K5S	KLF4 (Homo sapiens)	Mammalian Expression, Retroviral	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pcDNA3.1 - HA-KLF4 FL	KLF4 (Homo sapiens)	Mammalian Expression	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pcDNA3.1 - HA-KLF4 FL delta K5S	KLF4 (Homo sapiens)	Mammalian Expression	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pLJD-KLF4-ER	KLF4 (Homo sapiens)	Mammalian Expression, Retroviral	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pMIR-Report-Luc-KLF4-FL	KLF4 (Homo sapiens)	Mammalian Expression, Luciferase	Ruppert	A KLF4-miRNA-206 autoregulatory feedback loop can promote or inhibit protein translation depending upon cell context. Mol Cell Biol. 2011 Jun;31(12):2513-27. Epub 2011 Apr 25.
pBpuro_KLF4_ER	KLF4 (Homo sapiens)	Mammalian Expression, Retroviral	Ruppert	Induction of KLF4 in basal keratinocytes blocks the proliferation-differentiation switch and initiates squamous epithelial dysplasia. Oncogene. 2005 Feb 24;24(9):1491-500.
pLenti-EF1a-SOX2	TALE-Sox2 (Synthetic)	Mammalian Expression, Lentiviral	Zhang	Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011 Jan 19. ():.
pLenti-EF1a-KLF4	TALE-Klf4 (Synthetic)	Mammalian Expression, Lentiviral	Zhang	Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011 Jan 19. ():.
pLenti-EF1a-OCT4	TALE-Oct4 (Synthetic)	Mammalian Expression, Lentiviral	Zhang	Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol. 2011 Jan 19. ():.
pCX4-Oct4	Oct4 (Homo sapiens)	Retroviral	Dowdy	Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.
pCX4-Sox2	Sox2 (Homo sapiens)	Retroviral	Dowdy	Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.
pCX4-KLF4	kruppel-like factor 4 (Homo sapiens)	Retroviral	Dowdy	Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.
pCX4-cMyc	cMyc (Homo sapiens)	Retroviral	Dowdy	Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells. Nature. 2012 Jan 25;482(7384):216-20. doi: 10.1038/nature10821.
pWPXL-c-Myc	c-Myc (Mus musculus)	Mammalian Expression, Lentiviral	Weinberg	Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012 Mar 2;148(5):1015-28.
pWPXL-Klf4	Klf4 (Mus musculus)	Mammalian Expression, Lentiviral	Weinberg	Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012 Mar 2;148(5):1015-28.
pCXLE-hGLIS1	human GLIS1 (Homo sapiens)	Mammalian Expression	Yamanaka	An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells. 2012 Nov 29. doi: 10.1002/stem.1293.
pCEP4_WT_OCT4	POU5F1 (Homo sapiens)	Mammalian Expression	Thomson	Phosphorylation regulates human OCT4. Proc Natl Acad Sci U S A. 2012 May 8;109(19):7162-8. Epub 2012 Apr 2.
FUW-TetO-Nanog	Nanog (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase. Cell. 2012 Sep 14;150(6):1209-22. doi: 10.1016/j.cell.2012.08.023.
pCE-hSK	SOX2, KLF4 (Homo sapiens)	Mammalian Expression	Yamanaka	An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells. 2012 Nov 29. doi: 10.1002/stem.1293.
pCE-hUL	L-MYC, LIN28 (Homo sapiens)	Mammalian Expression	Yamanaka	An Efficient Non-viral Method to Generate Integration-Free Human iPS Cells from Cord Blood and Peripheral Blood Cells. Stem Cells. 2012 Nov 29. doi: 10.1002/stem.1293.
pMYC-GFP	c-Myc (Homo sapiens)	Mammalian Expression, Bacterial Expression	Olopade	c-Myc activates BRCA1 gene expression through distal promoter elements in breast cancer cells. BMC Cancer. 2011 Jun 13;11:246. doi: 10.1186/1471-2407-11-246.
pD40-His/V5-c-Myc	c-Myc (Mus musculus)	Mammalian Expression	Sears	A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. Nat Cell Biol. 2004 Apr;6(4):308-18. Epub 2004 Mar 14.
pMXs-mM₃O-IP	mM₃O (Mus musculus)	Mammalian Expression, Retroviral	Kikyo	Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells. 2011 Sep;29(9):1349-61. doi: 10.1002/stem.684.
pMXs-hM₃O-IP	hM₃O (Homo sapiens)	Mammalian Expression, Retroviral	Kikyo	Radical acceleration of nuclear reprogramming by chromatin remodeling with the transactivation domain of MyoD. Stem Cells. 2011 Sep;29(9):1349-61. doi: 10.1002/stem.684.
pCDH-puro-cMyc	MYC (Homo sapiens)	Mammalian Expression, Lentiviral	Wang	Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res. 2013 Apr 1;19(7):1748-59. doi: 10.1158/1078-0432.CCR-12-3066. Epub 2013 Feb 12.
Tet-pLKO-puro-SOX2	SOX2 shRNA (Synthetic)	Mammalian Expression, Lentiviral, RNAi	Rudin	Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer. Nat Genet. 2012 Oct;44(10):1111-6. doi: 10.1038/ng.2405. Epub 2012 Sep 2.
Nanog-2A-mCherry	Nanog (Mus musculus)	CRISPR	Jaenisch	One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering. Cell. 2013 Aug 27. pii: S0092-8674(13)01016-7. doi: 10.1016/j.cell.2013.08.022.
Oct4-IRES-eGFP-PGK-Neo	Oct4 (Mus musculus)	CRISPR	Jaenisch	One-Step Generation of Mice Carrying Reporter and Conditional Alleles by CRISPR/Cas-Mediated Genome Engineering. Cell. 2013 Aug 27. pii: S0092-8674(13)01016-7. doi: 10.1016/j.cell.2013.08.022.
pDNR-hSox2	Sox2 (Homo sapiens)	Cre/Lox ; donor vector	McKinnon	McKinnon Lab plasmids (unpublished)
pLPS-hSox2-gfp	Sox2 (Homo sapiens)	Mammalian Expression, Cre/Lox ; acceptor vector	McKinnon	McKinnon Lab plasmids (unpublished)
pLP-hSox2-ires-gfp	Sox2 (Homo sapiens)	Mammalian Expression, Cre/Lox ; acceptor vector	McKinnon	McKinnon Lab plasmids (unpublished)
pLP-TRE2-hSox2	Sox2 (Homo sapiens)	Mammalian Expression, Cre/Lox ; donor vector	McKinnon	McKinnon Lab plasmids (unpublished)
pMXs-hu-N-Myc	N-myc (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-hu-c-Myc-dN1	c-Myc -dN1 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-hu-c-Myc-dN2	c-Myc -dN2 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-ms-c-Myc-V394D	c-Myc V394D (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-ms-c-Myc-L420P	c-Myc L420P (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pMXs-ms-L-Myc-L351P	L-Myc-L351P (Mus musculus)	Mammalian Expression, Retroviral	Yamanaka	Promotion of direct reprogramming by transformation-deficient Myc. Proc Natl Acad Sci U S A. 2010 Jul 26. ():.
pcDNA3-FLAG-Lin28A	Lin28A (Homo sapiens)	Mammalian Expression	Kim	Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008 Oct 24;32(2):276-84. doi: 10.1016/j.molcel.2008.09.014.
pcDNA3-FLAG-Lin28A-mCCHC	Lin28A (Homo sapiens)	Mammalian Expression	Kim	Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell. 2008 Oct 24;32(2):276-84. doi: 10.1016/j.molcel.2008.09.014.
pcDNA3-V5-Lin28A	Lin28A (Homo sapiens)	Mammalian Expression	Kim	TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell. 2009 Aug 21;138(4):696-708. doi: 10.1016/j.cell.2009.08.002.
FUW-tetO-hOKMS	hOKMS (Homo sapiens)	Mammalian Expression, Lentiviral	Mikkelsen	Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency. Cell. 2015 Jul 16;162(2):412-24. doi: 10.1016/j.cell.2015.06.016.
OCT4-GFP-2A-PURO transgenic reporter	GFP-2A-puro (Synthetic), OCT4 (Homo sapiens)	Mammalian Expression	Hanna	Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
delta PE OCT4-GFP-2A-PURO transgenic reporter	GFP-2A-puro (Synthetic), OCT4 (Homo sapiens)	Mammalian Expression	Hanna	Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
delta DE OCT4-GFP-2A-PURO transgenic reporter	GFP-2A-puro (Synthetic), OCT4 (Homo sapiens)	Mammalian Expression	Hanna	Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
mouse deltaPE Oct4-GFP transgenic reporter	GFP pA (Synthetic), Oct4 (Mus musculus), PGK-gb2-Neo (Synthetic)	Mammalian Expression	Hanna	Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
pGL3-human OCT4 DE-SV40-Luc	Distal element of human OCT4 promoter (Homo sapiens)	Mammalian Expression, Luciferase	Hanna	Derivation of novel human ground state naive pluripotent stem cells. Nature. 2013 Dec 12;504(7479):282-6. doi: 10.1038/nature12745. Epub 2013 Oct 30.
pBABEpuro-CMYC T58A	CMYC (Mus musculus)	Mammalian Expression, Retroviral	Counter	Copper is required for oncogenic BRAF signalling and tumorigenesis. Nature. 2014 Apr 9. doi: 10.1038/nature13180.
pMaster1	neo (Other), tk (Other), oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2, myc (Homo sapiens), EBNA-1, Amp (Other), Lin28 (Homo sapiens), Nanog (Homo sapiens), IRES		Capecchi	Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83. doi: 10.1073/pnas.1409933111. Epub 2014 Jul 7.
pMaster3	neo (Other), tk (Other), oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2, myc (Homo sapiens), EBNA-1, Amp (Other), Lin28 (Homo sapiens), Nanog (Homo sapiens), IRES, NR5A2 (Homo sapiens)		Capecchi	Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83. doi: 10.1073/pnas.1409933111. Epub 2014 Jul 7.
pMaster12	neo (Other), tk (Other), oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2 (Homo sapiens), Myc (Homo sapiens), EBNA-1, Amp (Other), Lin28 (Homo sapiens), NANOG (Homo sapiens), IRES, NR5A2 (Homo sapiens), miR302/367 (Homo sapiens)	Mammalian Expression	Capecchi	Efficient germ-line transmission obtained with transgene-free induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):10678-83. doi: 10.1073/pnas.1409933111. Epub 2014 Jul 7.
T7-VEE-OKS-iM	Oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2 (Homo sapiens), cMyc (Homo sapiens)	Mammalian Expression ; Venezuelan equine encephalitis (VEE) virus RNA replicon	Dowdy	Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1;13(2):246-54. doi: 10.1016/j.stem.2013.06.001.
SP6-VEE-OKS-iM	Oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2 (Homo sapiens), cMyc (Homo sapiens)	Mammalian Expression ; Venezuelan equine encephalitis (VEE) virus RNA replicon	Dowdy	Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1;13(2):246-54. doi: 10.1016/j.stem.2013.06.001.
T7-VEE-OKS-iG	Oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2 (Homo sapiens), GLIS (Homo sapiens)	Mammalian Expression ; Venezuelan equine encephalitis (VEE) virus RNA replicon	Dowdy	Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1;13(2):246-54. doi: 10.1016/j.stem.2013.06.001.
SP6-VEE-OKS-iG	Oct4 (Homo sapiens), Klf4 (Homo sapiens), Sox2 (Homo sapiens), GLIS (Homo sapiens)	Mammalian Expression ; Venezuelan equine encephalitis (VEE) virus RNA replicon	Dowdy	Efficient generation of human iPSCs by a synthetic self-replicative RNA. Cell Stem Cell. 2013 Aug 1;13(2):246-54. doi: 10.1016/j.stem.2013.06.001.
pMXs-hGLIS1GR	GLIS1 (Homo sapiens)	Mammalian Expression, Retroviral	Yamanaka	Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm. Nat Commun. 2014 Apr 24;5:3678. doi: 10.1038/ncomms4678.
Nanog-2A-GFP	Nanog (Mus musculus)	Mouse Targeting	Jaenisch	Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell. 2013 Jul 3;13(1):23-9. doi: 10.1016/j.stem.2013.04.019.
Nanog-2A-mCherry	Nanog (Mus musculus)	Mouse Targeting	Jaenisch	Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell. 2013 Jul 3;13(1):23-9. doi: 10.1016/j.stem.2013.04.019.
Mouse Nanog locus 3' probe	Nanog (Mus musculus)	Unspecified ; cloning	Hanna	Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors. Nat Biotechnol. 2015 Jun 22. doi: 10.1038/nbt.3270.
FUW-TetO-Lin28	Lin28 (Mus musculus)	Mammalian Expression, Lentiviral	Jaenisch	Single-Cell Expression Analyses during Cellular Reprogramming Reveal an Early Stochastic and a Late Hierarchic Phase. Cell. 2012 Sep 14;150(6):1209-22. doi: 10.1016/j.cell.2012.08.023.
pPB-hCMV1-hNANOG-IV	NANOG (Homo sapiens)	Mammalian Expression	Smith	Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell. 2014 Sep 11;158(6):1254-69. doi: 10.1016/j.cell.2014.08.029.
pPB-PGK-hKLF4	KLF4 (Homo sapiens)	Mammalian Expression	Smith	Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell. 2014 Sep 11;158(6):1254-69. doi: 10.1016/j.cell.2014.08.029.
PpyCAG-NANOG-IB	NANOG (Homo sapiens)	Mammalian Expression	Smith	Resetting Transcription Factor Control Circuitry toward Ground-State Pluripotency in Human. Cell. 2014 Sep 11;158(6):1254-69. doi: 10.1016/j.cell.2014.08.029.
pPyCAG-Nanog(T100A)-IP	Mouse Nanog T100A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(F102A)-IP	Mouse Nanog F102A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(Y119A)-IP	Mouse Nanog Y119A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(L122A)-IP	Mouse Nanog L122A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(Q124A)-IP	Mouse Nanog Q124A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(M125A)-IP	Mouse Nanog M125A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(Y136A)-IP	Mouse Nanog Y136A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(K137A)-IP	Mouse Nanog K137A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(Q138A)-IP	Mouse Nanog Q138A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(K140A)-IP	Mouse Nanog K140A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(T141A)-IP	Mouse Nanog T141A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(Q144A)-IP	Mouse Nanog Q144A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(N145A)-IP	Mouse Nanog N145A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(R147A)-IP	Mouse Nanog R147A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pPyCAG-Nanog(K151A)-IP	Mouse Nanog K151A Mutant (Mus musculus)	Mammalian Expression	Yamanaka	Plasmids of NANOG HD Mutants (unpublished)
pP2A_NLS_sfGFP	Nanog homologous arm, p2A, NLS, sfGFP, Nanog homologous arm (Mus musculus)	Just a donor DNA with Nanog homologous arm for knock-in sfGFP	Qi	Small Molecules Enhance CRISPR Genome Editing in Pluripotent Stem Cells. Cell Stem Cell. 2015 Feb 5;16(2):142-7. doi: 10.1016/j.stem.2015.01.003.
MIP 247 CoMiP 4in1 with shRNA p53	Mini-intronic-plasmid intron (Homo sapiens)	Mammalian Expression	Kay	Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep. 2015 Jan 28;5:8081. doi: 10.1038/srep08081.
MIP 227 CoMiP 4in1 wo shRNA p53	Mini-intronic-plasmid intron (Homo sapiens)	Mammalian Expression	Kay	Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep. 2015 Jan 28;5:8081. doi: 10.1038/srep08081.
MIP 339 CoMiP coLin28 2A Nanog IRES eGFP	Lin28 (Homo sapiens), Nanog (Homo sapiens)	Mammalian Expression	Kay	Novel codon-optimized mini-intronic plasmid for efficient, inexpensive, and xeno-free induction of pluripotency. Sci Rep. 2015 Jan 28;5:8081. doi: 10.1038/srep08081.
Luc-Nanog-3'UTR	Nanog homeobox (Mus musculus)	Mammalian Expression	He	miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011 Oct 23;13(11):1353-60. doi: 10.1038/ncb2366.
Luc-Nanog-3'UTRmut	Nanog homeobox (Mus musculus)	Mammalian Expression	He	miR-34 miRNAs provide a barrier for somatic cell reprogramming. Nat Cell Biol. 2011 Oct 23;13(11):1353-60. doi: 10.1038/ncb2366.
MOS	OCT4-2A-SOX2 (Homo sapiens)	Mammalian Expression	Cheng	A Facile Method to Establish Human Induced Pluripotent Stem Cells From Adult Blood Cells Under Feeder-Free and Xeno-Free Culture Conditions: A Clinically Compliant Approach. Stem Cells Transl Med. 2015 Mar 5. pii: sctm.2014-0214.
MMK	MYC-2A-KLF4 (Homo sapiens)	Mammalian Expression	Cheng	A Facile Method to Establish Human Induced Pluripotent Stem Cells From Adult Blood Cells Under Feeder-Free and Xeno-Free Culture Conditions: A Clinically Compliant Approach. Stem Cells Transl Med. 2015 Mar 5. pii: sctm.2014-0214.
sgRNA1_NANOG	sgRNA1_NANOG (Homo sapiens)	Mammalian Expression, Lentiviral, CRISPR	Sato	CRISPR-Cas9-based Photoactivatable Transcription System. Chem Biol. 2015 Feb 19;22(2):169-74. doi: 10.1016/j.chembiol.2014.12.011. Epub 2015 Jan 22.
sgRNA2_NANOG	sgRNA2_NANOG (Homo sapiens)	Mammalian Expression, Lentiviral, CRISPR	Sato	CRISPR-Cas9-based Photoactivatable Transcription System. Chem Biol. 2015 Feb 19;22(2):169-74. doi: 10.1016/j.chembiol.2014.12.011. Epub 2015 Jan 22.
sgRNA3_NANOG	sgRNA3_NANOG (Homo sapiens)	Mammalian Expression, Lentiviral, CRISPR	Sato	CRISPR-Cas9-based Photoactivatable Transcription System. Chem Biol. 2015 Feb 19;22(2):169-74. doi: 10.1016/j.chembiol.2014.12.011. Epub 2015 Jan 22.
sgRNA4_NANOG	sgRNA4_NANOG (Homo sapiens)	Mammalian Expression, Lentiviral, CRISPR	Sato	CRISPR-Cas9-based Photoactivatable Transcription System. Chem Biol. 2015 Feb 19;22(2):169-74. doi: 10.1016/j.chembiol.2014.12.011. Epub 2015 Jan 22.
pRZ-mNanog-YNL	murine Nanog promoter and YNL (Mus musculus)	Lentiviral, Luciferase	Okada	Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23.
pRZ-mOct4-CNL	murine Oct4 promoter and CNL (Mus musculus)	Lentiviral, Luciferase	Okada	Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23.
pGF-mSox2-ONL	murine Sox2 promoter and ONL (Mus musculus)	Lentiviral, Luciferase	Okada	Expanded palette of Nano-lanterns for real-time multicolor luminescence imaging. Proc Natl Acad Sci U S A. 2015 Apr 7;112(14):4352-6. doi: 10.1073/pnas.1418468112. Epub 2015 Mar 23.
pCX-Klf4	Klf4 (Mus musculus)	Mammalian Expression	Cohen	Pluripotent TFs CRE-seq (unpublished)
Oct4-Cr1	gRNA for Crispr targeting the OCT4 stop codon (Homo sapiens)	Mammalian Expression	Huangfu	A CRISPR/Cas-Mediated Selection-free Knockin Strategy in Human Embryonic Stem Cells. Stem Cell Reports. 2015 May 28. pii: S2213-6711(15)00128-9. doi: 10.1016/j.stemcr.2015.04.016.
6xO/S luc	minimal fgf4 promoter and 6XOS tandem repeat of composite OCT4/Sox2 binding site from FGF4 enhancer (Mus musculus)	Mammalian Expression, Luciferase	Dailey	luciferase reporter plasmid containing 6 tandem copies of the composite Oct4/Sox2 binding site of the FGF4 enhancer. Used for detection of active Oct4/Sox2 complexes (unpublished)
GG-EBNA-OCT4	5 concatenated gRNA transcriptional cassettes targeting OCT4	CRISPR	Otonkoski	Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation. Stem Cell Reports. 2015 Sep 8;5(3):448-59. doi: 10.1016/j.stemcr.2015.08.001.
pPB-CAG-Klf4-pA-pgk-hph	Klf4 (Mus musculus)	Mammalian Expression	Silva	MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner. Cell Stem Cell. 2014 Jul 3;15(1):102-10. doi: 10.1016/j.stem.2014.04.019. Epub 2014 May 15.
pPB-CAG-cNanog-pgk-hph	Nanog (Gallus gallus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-mNanogHD-pgk-hph	Nanog (Mus musculus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-zNanogHD-pgk-hph	Nanog (Danio rerio)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-Flag3-pG-mNanog-pgk-hph	Nanog (Mus musculus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-Flag3-pG-cNanog-pgk-hph	Nanog (Gallus gallus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-mNanog-mut-pgk-hph	Nanog (Mus musculus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-Nanog-pA-pgk-hph	Nanog (Mus musculus)	Mammalian Expression	Silva	Nanog overcomes reprogramming barriers and induces pluripotency in minimal conditions. Curr Biol. 2011 Jan 11;21(1):65-71. doi: 10.1016/j.cub.2010.11.074. Epub 2010 Dec 30.
pPB-CAG-rNanog-pgk-hph	Nanog (Rattus norvegicus)	Mammalian Expression	Silva	Reprogramming capacity of Nanog is functionally conserved in vertebrates and resides in a unique homeodomain. Development. 2011 Nov;138(22):4853-65. doi: 10.1242/dev.068775.
pPB-CAG-Klf2.2A.Nanog-Cherry-pA-pgk-zeo	Klf2 (Mus musculus), Nanog (Mus musculus)	Mammalian Expression	Silva	MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner. Cell Stem Cell. 2014 Jul 3;15(1):102-10. doi: 10.1016/j.stem.2014.04.019. Epub 2014 May 15.
PCXLE-hUL + mTAGBFP2	LMyc/Lin28 (Homo sapiens)	Mammalian Expression	Zovein	Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 5;8(1):132. doi: 10.1186/s13287-017-0581-7.
pCXLE-hS + eGFP	Sox2 (Homo sapiens)	Mammalian Expression	Zovein	Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 5;8(1):132. doi: 10.1186/s13287-017-0581-7.
pCXLE-hK + E2-Crimson	Klf4 (Homo sapiens)	Mammalian Expression	Zovein	Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 5;8(1):132. doi: 10.1186/s13287-017-0581-7.
pCXLE-hOCT3/4-shp53-F + mCherry-2A-puro	Oct3/4 (Homo sapiens)	Mammalian Expression	Zovein	Fluorescent tagged episomals for stoichiometric induced pluripotent stem cell reprogramming. Stem Cell Res Ther. 2017 Jun 5;8(1):132. doi: 10.1186/s13287-017-0581-7.
pCAG-SpCas9-GFP-U6-gRNA	SpCas9	Mammalian Expression, CRISPR	Zou	pCAG-SpCas9-U6-gRNA (unpublished)
FUGW-d2GFP-200	d2GFP + miR-200 family targets	Lentiviral	Rosen	The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biol. 2016 Jun 17;14(1):47. doi: 10.1186/s12915-016-0269-y.
PB-TA-ERN		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TAC-ERN		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TAG-ERN		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TA-ERP2		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TAC-ERP2		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TAG-ERP2		Mammalian Expression ; piggyBac transposon	Woltjen	Inducible Transgene Expression in Human iPS Cells Using Versatile All-in-One piggyBac Transposons. Methods Mol Biol. 2016;1357:111-31. doi: 10.1007/7651_2015_251.
PB-TAC-OKMS	OKMS (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
PB-TAC-OSKM	OSKM (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
PB-TAC-OK+9MS	OK+9MS (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
PB-TAC-MKOS	MKOS (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
PB-TAC-EB-C5	lin-28 homolog A (C. elegans) (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
PB-TAC-WTSI	WTSI (Mus musculus)	Mammalian Expression ; piggyBac transposon	Woltjen	KLF4 N-terminal variance modulates induced reprogramming to pluripotency. Stem Cell Reports. 2015 Apr 14;4(4):727-43. doi: 10.1016/j.stemcr.2015.02.004. Epub 2015 Mar 12.
pDONR223_NANOG_WT	NANOG (Homo sapiens)	Gateway Entry vector	Boehm	Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. Cancer Discov. 2016 Jul;6(7):714-26. doi: 10.1158/2159-8290.CD-16-0160. Epub 2016 May 4.
pDONR223_SOX2_WT	SOX2 (Homo sapiens)	Gateway Entry vector	Boehm	Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles. Cancer Discov. 2016 Jul;6(7):714-26. doi: 10.1158/2159-8290.CD-16-0160. Epub 2016 May 4.
pLVX-TREtight-Ngn2:2A:Ascl1-PGK-Puro (XTP-N2A)	Ngn2 and Mash1 with a T2A	Lentiviral	Gage	Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell. 2015 Oct 6. pii: S1934-5909(15)00408-7. doi: 10.1016/j.stem.2015.09.001.
pREPROII-attB	Oct4 (Mus musculus), cMyc (Mus musculus), Sox2 (Mus musculus), Kruppel-like factor 4 (Mus musculus)	Mammalian Expression, Cre/Lox	Kuehn	Efficient generation of rat induced pluripotent stem cells using a non-viral inducible vector. PLoS One. 2013;8(1):e55170. doi: 10.1371/journal.pone.0055170. Epub 2013 Jan 31.
pUC19-SOX2-T2A-2xNLS-tdTomato-F2A-Puro	SOX2-T2A-2xNLS-TdTomato-F2A-Puro (Homo sapiens)	CRISPR	Otonkoski	Generation of a SOX2 reporter human induced pluripotent stem cell line using CRISPR/SaCas9. Stem Cell Res. 2017 Jul;22:16-19. doi: 10.1016/j.scr.2017.05.005. Epub 2017 May 17.
pUC19-OCT4-T2A-NLS-EmGFP-P2A-Puro	OCT4-T2A-NLS-EmGFP-P2A-Puro (Homo sapiens)	CRISPR	Otonkoski	Generation of an OCT4 reporter human induced pluripotent stem cell line using CRISPR/SpCas9. Stem Cell Res. 2017 Aug;23:105-108. doi: 10.1016/j.scr.2017.07.006. Epub 2017 Jul 11.
pLenti_CamKIIa_GFP	Green fluorescent protein	Lentiviral	Dolmetsch	SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature. 2013 Nov 14;503(7475):267-71. doi: 10.1038/nature12618. Epub 2013 Oct 16.
pLenti_CamKIIa_mKate2	far-red fluorescent protein	Lentiviral	Dolmetsch	SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature. 2013 Nov 14;503(7475):267-71. doi: 10.1038/nature12618. Epub 2013 Oct 16.
pSimple-miR302/367	miR302/367 (miRNA cluster) (Homo sapiens)	Mammalian Expression	Thomson	Simultaneous Reprogramming and Gene Correction of Patient Fibroblasts. Stem Cell Reports. 2015 Dec 8;5(6):1109-18. doi: 10.1016/j.stemcr.2015.10.009. Epub 2015 Nov 12.
pSN16	vexGFP-P2A-OCT4 fused to a 'strong' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN17	vexGFP-P2A-OCT4 fused to full length HP1 alpha (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN20	vexGFP-P2A-OCT4 fused to a 'medium' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN21	vexGFP-P2A-OCT4 fused to a 'weak' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN22	mCitrine-P2A-SOX2 fused to a 'strong' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN23	mCitrine-P2A-SOX2 fused to a 'medium' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN24	mCitrine-P2A-SOX2 fused to a 'weak' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN25	mCitrine-P2A-SOX2 fused to full length HP1 alpha (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN26	mCerulean-P2A-cMYC fused to a 'strong' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN27	mCerulean-P2A-cMYC fused to a 'medium' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN28	mCerulean-P2A-cMYC fused to a 'weak' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN29	mCerulean-P2A-cMYC fused to full length HP1 alpha (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN30	mCherry-P2A-KLF4 fused to a 'strong' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN31	mCherry-P2A-KLF4 fused to a 'medium' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN32	mCherry-P2A-KLF4 fused to a 'weak' VP16 domain (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN33	mCherry-P2A-KLF4 fused to full length HP1 alpha (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN34	vexGFP-P2A-OCT4 fused to 2 VP16 domains (413-460) separated by linkers (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN35	vexGFP-P2A-OCT4 fused to an Engrailed domain (168-281) separated by a linker (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN36	vexGFP-P2A-OCT4 fused to 1 VP16 domain (413-460) separated by a linker (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN61	vexGFP-P2A-putative OCT4 DBD (138-289) with a T7 tag (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN65	mCitrine-P2A-putative SOX2 DBD (41-109) with a V5 tag (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN67	mCherry-P2A-putative KLF4 DBD with a 6xHis tag (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
pSN69	mCerulean-P2A-putative cMYC DBD with a HA tag (Homo sapiens)	Mammalian Expression, Lentiviral	Ptashne	OCT4 and SOX2 Work as Transcriptional Activators in Reprogramming Human Fibroblasts. Cell Rep. 2017 Aug 15;20(7):1585-1596. doi: 10.1016/j.celrep.2017.07.071.
U6REST1_U6REST2.hPGK.BRN2.hPGK.Ascl1WPRE	Ascl1, Brn2 (Mus musculus)	Lentiviral	Parmar	REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017 Aug;9(8):1117-1131. doi: 10.15252/emmm.201607471.
PB-GG-OCT4-1-5-PGK-Puro	OCT4-gRNAs-1-5-PGK-puro (Other)	Mammalian Expression, CRISPR	Otonkoski	Human pluripotent reprogramming with CRISPR activators. Nat Commun. 2018 Jul 6;9(1):2643. doi: 10.1038/s41467-018-05067-x.
pUCM-AAVS1-TO-hNGN2	Neurogenin 2 (Homo sapiens), mCherry (Synthetic), rtTA3G (Other)	CRISPR, TALEN	Ward	Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.
pUCM-CLYBL-hNIL	Neurogenin 2 (Homo sapiens), ISL LIM Homeobox 1 (Homo sapiens), LIM Homeobox 3 (Homo sapiens), mCherry (Synthetic), rtTA3G (Other)	CRISPR, TALEN	Ward	Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons. Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.
pX-APRT-sg2	APRT sgRNA-2	Mammalian Expression, CRISPR	Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
p3-HPRT1-S104R-PdTK-mCh	HPRT genomic DNA (Homo sapiens), puro-deltaTK; CAG::mCherry		Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
p3-HPRT1-S104Rf-PdTK-mCh	HPRT genomic DNA (Homo sapiens), puro-deltaTK; CAG::mCherry		Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
pbG-APRT-J-u32uni-PdTKmCh	APRT (Homo sapiens), puro-deltaTK; CAG::mCherry		Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
pAAVS1-PdTK-CAG-mCh-[uBglII]	AAVS1 puro-deltaTK; CAG-mCherry		Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
pCAG-eGFP-pA	GFP	Mammalian Expression	Woltjen	Microhomology-assisted scarless genome editing in human iPSCs. Nat Commun. 2018 Mar 5;9(1):939. doi: 10.1038/s41467-018-03044-y.
H52-pUCM-hNGN2-inv	Neurogenin 2 (Homo sapiens), mcherry (Other), rtTA3G	Mammalian Expression, Cre/Lox, CRISPR, TALEN	Ward	A comprehensive guide for transcription-factor mediated differentiation of human iPSC into neurons (unpublished)
pMx-puro-MGT	Mef2c, Tbx5 and Gata4 (Mus musculus)	Mammalian Expression, Retroviral	Qian	Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. Circ Res. 2015 Jan 16;116(2):237-44. doi: 10.1161/CIRCRESAHA.116.305547. Epub 2014 Nov 21.
pMx-MGT	Mef2c, Tbx5 and Gata4 (Mus musculus)	Mammalian Expression, Retroviral	Qian	Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming. Circ Res. 2015 Jan 16;116(2):237-44. doi: 10.1161/CIRCRESAHA.116.305547. Epub 2014 Nov 21.
pAAVS1-TRE-MA4-GFP	MLL-AF4 fusion gene (Homo sapiens)	Mammalian Expression	Kan	Respecifying human iPSC-derived blood cells into highly engraftable hematopoietic stem and progenitor cells with a single factor. Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2180-2185. doi: 10.1073/pnas.1718446115. Epub 2018 Jan 31.
pLV-PGK-SNAP-MD-SOX2	SNAP-MD-SOX2 (Synthetic)	Lentiviral	Suter	A role for mitotic bookmarking of SOX2 in pluripotency and differentiation. Genes Dev. 2016 Nov 15;30(22):2538-2550. doi: 10.1101/gad.289256.116. Epub 2016 Dec 5.
pLV-PGK-SNAP-MDMUT-SOX2	SNAP-MDMUT-SOX2 (Synthetic)	Lentiviral	Suter	A role for mitotic bookmarking of SOX2 in pluripotency and differentiation. Genes Dev. 2016 Nov 15;30(22):2538-2550. doi: 10.1101/gad.289256.116. Epub 2016 Dec 5.
pKIOct4-Halo-IRES-Bsd	OCT4-Halo-IRES-Bsd (Synthetic)	Mammalian Expression	Suter	Endogenous fluctuations of OCT4 and SOX2 bias pluripotent cell fate decisions bioRxiv 299073
tetO.Sox9.Puro	Sox9 (Mus musculus)	Mammalian Expression, Lentiviral	Ahlenius	Rapid and efficient induction of functional astrocytes from human pluripotent stem cells. Nat Methods. 2018 Sep;15(9):693-696. doi: 10.1038/s41592-018-0103-2. Epub 2018 Aug 20.
tetO.Nfia.Blast	Nfia (Mus musculus)	Mammalian Expression, Lentiviral	Ahlenius	Rapid and efficient induction of functional astrocytes from human pluripotent stem cells. Nat Methods. 2018 Sep;15(9):693-696. doi: 10.1038/s41592-018-0103-2. Epub 2018 Aug 20.
tetO.Nfib.Hygro	Nfib (Mus musculus)	Mammalian Expression, Lentiviral	Ahlenius	Rapid and efficient induction of functional astrocytes from human pluripotent stem cells. Nat Methods. 2018 Sep;15(9):693-696. doi: 10.1038/s41592-018-0103-2. Epub 2018 Aug 20.
pMX-eSOX2NRR	eSOX2NRR (Mus musculus)	Mammalian Expression, Retroviral	Jauch	Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports. 2018 Aug 14;11(2):593-606. doi: 10.1016/j.stemcr.2018.07.002. Epub 2018 Aug 2.
pMX-eSOX2AHK	eSox2AHK (Mus musculus)	Mammalian Expression, Retroviral	Jauch	Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports. 2018 Aug 14;11(2):593-606. doi: 10.1016/j.stemcr.2018.07.002. Epub 2018 Aug 2.
pMX-eSOX17FNV	eSOX17FNV (Mus musculus)	Mammalian Expression, Retroviral	Jauch	Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports. 2018 Aug 14;11(2):593-606. doi: 10.1016/j.stemcr.2018.07.002. Epub 2018 Aug 2.
pMX-eSOX17WHC	eSOX17WHC (Mus musculus)	Mammalian Expression, Retroviral	Jauch	Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports. 2018 Aug 14;11(2):593-606. doi: 10.1016/j.stemcr.2018.07.002. Epub 2018 Aug 2.
EF1a_ETV2_P2A_Hygro_Barcode	ETV2 (Homo sapiens)	Lentiviral	Mali	Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
EF1a_KLF4_P2A_Hygro_Barcode	KLF4 (Homo sapiens)	Lentiviral	Mali	Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
EF1a_SOX2_P2A_Hygro_Barcode	SOX2 (Homo sapiens)	Lentiviral	Mali	Mapping Cellular Reprogramming via Pooled Overexpression Screens with Paired Fitness and Single-Cell RNA-Sequencing Readout. Cell Syst. 2018 Nov 12. pii: S2405-4712(18)30433-2. doi: 10.1016/j.cels.2018.10.008.
CLYBL-TO-hNGN2-BSD-mApple	NGN2 (Homo sapiens)	Mammalian Expression	Ward	Next generation vectors for transcription factor mediated differentiation of iPSCs into cortical and motor neurons (unpublished)
CLYBL-TO-hNIL-BSD-mApple	NGN2, ISL1, LHX3 (Homo sapiens)	Mammalian Expression	Ward	Next generation vectors for transcription factor mediated differentiation of iPSCs into cortical and motor neurons (unpublished)
AICSDP-60: SOX2-mEGFP	SOX2 Homology Arms with linker-mEGFP (Homo sapiens)	Mammalian Expression, CRISPR ; Donor Template	Allen Institute for Cell Science	Allen Institute for Cell Science Plasmids (unpublished)
pLVX-UbC-rtTA-Ngn2:2A:EGFP	Ngn2:2A:Ascl1 (Homo sapiens)	Mammalian Expression, Lentiviral	Gage	Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. Nat Neurosci. 2019 Feb;22(2):243-255. doi: 10.1038/s41593-018-0295-x. Epub 2019 Jan 7.
pLVX-UbC-rtTA-Ngn2:2A:Ascl1	Ngn2:2A:Ascl1 (Homo sapiens), Ngn2:2A:Ascl1 (Homo sapiens)	Mammalian Expression, Lentiviral	Gage	Chemical modulation of transcriptionally enriched signaling pathways to optimize conversion of fibroblasts into neurons (unpublished)
Sox2-t2A-GFP	SOX2 (Homo sapiens)	Mammalian Expression	Mitchell	KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control. Genes Dev. 2019 Jun 20. pii: gad.324319.119. doi: 10.1101/gad.324319.119.
Sox2-t2A-mCherry	SOX2 (Homo sapiens)	Mammalian Expression	Mitchell	KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control. Genes Dev. 2019 Jun 20. pii: gad.324319.119. doi: 10.1101/gad.324319.119.
Nanog-t2A-mCherry	Nanog (Mus musculus)	Mammalian Expression	Mitchell	KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control. Genes Dev. 2019 Jun 20. pii: gad.324319.119. doi: 10.1101/gad.324319.119.
pLKO.1-REST_sh_seq1_WPRE	shRNA for knock down of REST (Homo sapiens)	Lentiviral	Parmar	REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017 Aug;9(8):1117-1131. doi: 10.15252/emmm.201607471.
pLKO.1REST_sh_seq2_WPRE	shRNA for knock down of REST (Homo sapiens)	Lentiviral	Parmar	REST suppression mediates neural conversion of adult human fibroblasts via microRNA-dependent and -independent pathways. EMBO Mol Med. 2017 Aug;9(8):1117-1131. doi: 10.15252/emmm.201607471.
FUW-TetO-Gata3	Gata3 (Mus musculus)	Lentiviral	Buganim	Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Cell Stem Cell. 2015 Nov 5;17(5):543-56. doi: 10.1016/j.stem.2015.08.006. Epub 2015 Sep 24.
FUW-TetO-Tfap2c	Tfap2c (Mus musculus)	Lentiviral	Buganim	Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Cell Stem Cell. 2015 Nov 5;17(5):543-56. doi: 10.1016/j.stem.2015.08.006. Epub 2015 Sep 24.
FUW-TetO-Gata6	Gata6 (Mus musculus)	Lentiviral	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
FUW-TetO-Sox17	Sox17 (Mus musculus)	Lentiviral	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
FUW-TetO-Cdx2	Cdx2 (Mus musculus)	Lentiviral	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
FUW-TetO-Klf5	Klf5 (Mus musculus)	Lentiviral	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
FUW-TetO-Sox15	Sox15 (Mus musculus)	Lentiviral	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
FUW-TetO-Tead4	Tead4 (Mus musculus)	Lentiviral	Buganim	Extensive Nuclear Reprogramming Underlies Lineage Conversion into Functional Trophoblast Stem-like Cells. Cell Stem Cell. 2015 Nov 5;17(5):543-56. doi: 10.1016/j.stem.2015.08.006. Epub 2015 Sep 24.
pNTKV- Elf5-KI-3'UTR-2A-EYFP-NLS	Nuclear EYFP into Elf5 locus (Mus musculus)	Mouse Targeting	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
pNTKV- Utf1-KI-3'UTR-2A-tdTomato-RBGpA	tdTomato into Utf1 locus (Mus musculus)	Mouse Targeting	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
pNTKV- Esrrb-KI-3'UTR-2A-TagBFP-RBGpA	tagBFP into Esrrb locus (Mus musculus)	Mouse Targeting	Buganim	Direct Induction of the Three Pre-implantation Blastocyst Cell Types from Fibroblasts. Cell Stem Cell. 2019 Jun 6;24(6):983-994.e7. doi: 10.1016/j.stem.2019.03.018. Epub 2019 Apr 25.
pLVH-EF1a-GFP-P2A-OCT4	human OCT4 (Homo sapiens)	Lentiviral	Hu	The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun. 2016 Mar 7;7:10869. doi: 10.1038/ncomms10869.
pLVH-EF1a-GFP-P2A-SOX2	human SOX2 (Homo sapiens)	Lentiviral	Hu	The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun. 2016 Mar 7;7:10869. doi: 10.1038/ncomms10869.
pLVH-EF1a-GFP-P2A-KLF4	human KLF4 (Homo sapiens)	Lentiviral	Hu	The acetyllysine reader BRD3R promotes human nuclear reprogramming and regulates mitosis. Nat Commun. 2016 Mar 7;7:10869. doi: 10.1038/ncomms10869.
pCW57-GFP-miR-302cluster	human miR-302 cluster: MIR302B, MIR302C, MIR302A, MIR302D, MIR367 (Homo sapiens)	Mammalian Expression, Lentiviral ; Doxycycline inducible, microRNA expression	Bárta	Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts. Sci Rep. 2019 Oct 31;9(1):15759. doi: 10.1038/s41598-019-52294-3.
Sox2-SE-RGM-eGFP targeting vector	Sox2-SE-5arm-RGM-Sox2-SE-3arm (Mus musculus)	Mouse Targeting	Jaenisch	Dynamic Enhancer DNA Methylation as Basis for Transcriptional and Cellular Heterogeneity of ESCs. Mol Cell. 2019 Aug 15. pii: S1097-2765(19)30502-7. doi: 10.1016/j.molcel.2019.06.045.

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