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pCMV_AncBE4max Citations (39)

Originally described in: Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction.
Koblan LW, Doman JL, Wilson C, Levy JM, Tay T, Newby GA, Maianti JP, Raguram A, Liu DR Nat Biotechnol. 2018 May 29. pii: nbt.4172. doi: 10.1038/nbt.4172. PubMed Journal

Articles Citing pCMV_AncBE4max

Articles
Expanded targeting scope and enhanced base editing efficiency in rabbit using optimized xCas9(3.7). Liu Z, Chen M, Shan H, Chen S, Xu Y, Song Y, Zhang Q, Yuan H, Ouyang H, Li Z, Lai L. Cell Mol Life Sci. 2019 Apr 27. pii: 10.1007/s00018-019-03110-8. doi: 10.1007/s00018-019-03110-8. PubMed
Efficient base editing by RNA-guided cytidine base editors (CBEs) in pigs. Yuan H, Yu T, Wang L, Yang L, Zhang Y, Liu H, Li M, Tang X, Liu Z, Li Z, Lu C, Chen X, Pang D, Ouyang H. Cell Mol Life Sci. 2019 Jul 13. pii: 10.1007/s00018-019-03205-2. doi: 10.1007/s00018-019-03205-2. PubMed
BEAT: A Python Program to Quantify Base Editing from Sanger Sequencing. Xu L, Liu Y, Han R. CRISPR J. 2019 Aug;2:223-229. doi: 10.1089/crispr.2019.0017. Epub 2019 Jul 18. PubMed
A transient reporter for editing enrichment (TREE) in human cells. Standage-Beier K, Tekel SJ, Brookhouser N, Schwarz G, Nguyen T, Wang X, Brafman DA. Nucleic Acids Res. 2019 Aug 20. pii: 5552066. doi: 10.1093/nar/gkz713. PubMed

Associated Plasmids
Efficient Gene Disruption via Base Editing Induced Stop in Newt Pleurodeles waltl. Cai H, Peng Z, Ren R, Wang H. Genes (Basel). 2019 Oct 23;10(11). pii: genes10110837. doi: 10.3390/genes10110837. PubMed
BIG-TREE: Base-Edited Isogenic hPSC Line Generation Using a Transient Reporter for Editing Enrichment. Brookhouser N, Tekel SJ, Standage-Beier K, Nguyen T, Schwarz G, Wang X, Brafman DA. Stem Cell Reports. 2020 Feb 11;14(2):184-191. doi: 10.1016/j.stemcr.2019.12.013. Epub 2020 Jan 30. PubMed
A compact Cas9 ortholog from Staphylococcus Auricularis (SauriCas9) expands the DNA targeting scope. Hu Z, Wang S, Zhang C, Gao N, Li M, Wang D, Wang D, Liu D, Liu H, Ong SG, Wang H, Wang Y. PLoS Biol. 2020 Mar 30;18(3):e3000686. doi: 10.1371/journal.pbio.3000686. eCollection 2020 Mar. PubMed

Associated Plasmids
Enabling large-scale genome editing at repetitive elements by reducing DNA nicking. Smith CJ, Castanon O, Said K, Volf V, Khoshakhlagh P, Hornick A, Ferreira R, Wu CT, Guell M, Garg S, Ng AHM, Myllykallio H, Church GM. Nucleic Acids Res. 2020 May 21;48(9):5183-5195. doi: 10.1093/nar/gkaa239. PubMed

Associated Plasmids
Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response. Wang X, Ding C, Yu W, Wang Y, He S, Yang B, Xiong YC, Wei J, Li J, Liang J, Lu Z, Zhu W, Wu J, Zhou Z, Huang X, Liu Z, Yang L, Chen J. Cell Rep. 2020 Jun 2;31(9):107723. doi: 10.1016/j.celrep.2020.107723. PubMed

Associated Plasmids
BE4max and AncBE4max Are Efficient in Germline Conversion of C:G to T:A Base Pairs in Zebrafish. Carrington B, Weinstein RN, Sood R. Cells. 2020 Jul 14;9(7). pii: cells9071690. doi: 10.3390/cells9071690. PubMed
AcrIIA5 Suppresses Base Editors and Reduces Their Off-Target Effects. Liang M, Sui T, Liu Z, Chen M, Liu H, Shan H, Lai L, Li Z. Cells. 2020 Jul 27;9(8). pii: cells9081786. doi: 10.3390/cells9081786. PubMed
Base Editing Mediated Generation of Point Mutations Into Human Pluripotent Stem Cells for Modeling Disease. Qi T, Wu F, Xie Y, Gao S, Li M, Pu J, Li D, Lan F, Wang Y. Front Cell Dev Biol. 2020 Sep 25;8:590581. doi: 10.3389/fcell.2020.590581. eCollection 2020. PubMed

Associated Plasmids
A Cas-embedding strategy for minimizing off-target effects of DNA base editors. Liu Y, Zhou C, Huang S, Dang L, Wei Y, He J, Zhou Y, Mao S, Tao W, Zhang Y, Yang H, Huang X, Chi T. Nat Commun. 2020 Nov 27;11(1):6073. doi: 10.1038/s41467-020-19690-0. PubMed
An optimized base editor with efficient C-to-T base editing in zebrafish. Zhao Y, Shang D, Ying R, Cheng H, Zhou R. BMC Biol. 2020 Dec 3;18(1):190. doi: 10.1186/s12915-020-00923-z. PubMed
Precise base editing for the in vivo study of developmental signaling and human pathologies in zebrafish. Rosello M, Vougny J, Czarny F, Mione MC, Concordet JP, Albadri S, Del Bene F. Elife. 2021 Feb 12;10. pii: 65552. doi: 10.7554/eLife.65552. PubMed
Identification of pathogenic variants in cancer genes using base editing screens with editing efficiency correction. Huang C, Li G, Wu J, Liang J, Wang X. Genome Biol. 2021 Mar 10;22(1):80. doi: 10.1186/s13059-021-02305-2. PubMed
Discovery and engineering of small SlugCas9 with broad targeting range and high specificity and activity. Hu Z, Zhang C, Wang S, Gao S, Wei J, Li M, Hou L, Mao H, Wei Y, Qi T, Liu H, Liu D, Lan F, Lu D, Wang H, Li J, Wang Y. Nucleic Acids Res. 2021 Mar 15. pii: 6171296. doi: 10.1093/nar/gkab148. PubMed

Associated Plasmids
Correction of the pathogenic mutation in TGM1 gene by adenine base editing in mutant embryos. Dang L, Zhou X, Zhong X, Yu W, Huang S, Liu H, Chen Y, Zhang W, Yuan L, Li L, Huang X, Li G, Liu J, Tong G. Mol Ther. 2021 May 8. pii: S1525-0016(21)00259-8. doi: 10.1016/j.ymthe.2021.05.007. PubMed
In vivo genome editing in single mammalian brain neurons through CRISPR-Cas9 and cytosine base editors. Song B, Kang CY, Han JH, Kano M, Konnerth A, Bae S. Comput Struct Biotechnol J. 2021 Apr 25;19:2477-2485. doi: 10.1016/j.csbj.2021.04.051. eCollection 2021. PubMed
Adenine base editor engineering reduces editing of bystander cytosines. Jeong YK, Lee S, Hwang GH, Hong SA, Park SE, Kim JS, Woo JS, Bae S. Nat Biotechnol. 2021 Nov;39(11):1426-1433. doi: 10.1038/s41587-021-00943-2. Epub 2021 Jul 1. PubMed
High-purity production and precise editing of DNA base editing ribonucleoproteins. Jang HK, Jo DH, Lee SN, Cho CS, Jeong YK, Jung Y, Yu J, Kim JH, Woo JS, Bae S. Sci Adv. 2021 Aug 27;7(35). pii: 7/35/eabg2661. doi: 10.1126/sciadv.abg2661. Print 2021 Aug. PubMed
BVES is a novel interactor of ANO5 and regulates myoblast differentiation. Li H, Xu L, Gao Y, Zuo Y, Yang Z, Zhao L, Chen Z, Guo S, Han R. Cell Biosci. 2021 Dec 28;11(1):222. doi: 10.1186/s13578-021-00735-w. PubMed
Comprehensive analysis of prime editing outcomes in human embryonic stem cells. Habib O, Habib G, Hwang GH, Bae S. Nucleic Acids Res. 2022 Jan 25;50(2):1187-1197. doi: 10.1093/nar/gkab1295. PubMed
Precise in vivo functional analysis of DNA variants with base editing using ACEofBASEs target prediction. Cornean A, Gierten J, Welz B, Mateo JL, Thumberger T, Wittbrodt J. Elife. 2022 Apr 4;11:e72124. doi: 10.7554/eLife.72124. PubMed
PPARgamma phase separates with RXRalpha at PPREs to regulate target gene expression. Li Z, Luo L, Yu W, Li P, Ou D, Liu J, Ma H, Sun Q, Liang A, Huang C, Chi T, Huang X, Zhang Y. Cell Discov. 2022 Apr 26;8(1):37. doi: 10.1038/s41421-022-00388-0. PubMed
Disease modeling by efficient genome editing using a near PAM-less base editor in vivo. Rosello M, Serafini M, Mignani L, Finazzi D, Giovannangeli C, Mione MC, Concordet JP, Del Bene F. Nat Commun. 2022 Jun 15;13(1):3435. doi: 10.1038/s41467-022-31172-z. PubMed
PAM-flexible dual base editor-mediated random mutagenesis and self-activation strategies to improve CRISPRa potency. Lau CH, Huang S, Lam RHW, Tin C. Mol Ther Methods Clin Dev. 2022 May 29;26:26-37. doi: 10.1016/j.omtm.2022.05.005. eCollection 2022 Sep 8. PubMed
Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites. Tao J, Wang Q, Mendez-Dorantes C, Burns KH, Chiarle R. Nat Commun. 2022 Jun 27;13(1):3685. doi: 10.1038/s41467-022-31322-3. PubMed
Translational enhancement by base editing of the Kozak sequence rescues haploinsufficiency. Ambrosini C, Destefanis E, Kheir E, Broso F, Alessandrini F, Longhi S, Battisti N, Pesce I, Dassi E, Petris G, Cereseto A, Quattrone A. Nucleic Acids Res. 2022 Oct 14;50(18):10756-10771. doi: 10.1093/nar/gkac799. PubMed

Associated Plasmids
MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis. Zou X, Ouyang H, Lin F, Zhang H, Yang Y, Pang D, Han R, Tang X. Cell Death Dis. 2022 Nov 10;13(11):948. doi: 10.1038/s41419-022-05403-6. PubMed
De novo PAM generation to reach initially inaccessible target sites for base editing. Pakari K, Wittbrodt J, Thumberger T. Development. 2023 Jan 15;150(2):dev201115. doi: 10.1242/dev.201115. Epub 2023 Jan 23. PubMed
Transition Substitution of Desired Bases in Human Pluripotent Stem Cells with Base Editors: A Step-by-Step Guide. Park JC, Kim KT, Jang HK, Cha HJ. Int J Stem Cells. 2023 May 30;16(2):234-243. doi: 10.15283/ijsc22171. Epub 2023 Feb 28. PubMed
PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez TS, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. Res Sq. 2023 Mar 7:rs.3.rs-2625838. doi: 10.21203/rs.3.rs-2625838/v1. Preprint. PubMed

Associated Plasmids
Defective BVES-mediated feedback control of cAMP in muscular dystrophy. Li H, Wang P, Zhang C, Zuo Y, Zhou Y, Han R. Nat Commun. 2023 Mar 30;14(1):1785. doi: 10.1038/s41467-023-37496-8. PubMed
Generation of a human embryonic stem cell line WAe009-A-79 carrying a long QT syndrome mutation in KCNQ1. Wang H, Guo T, Lan F. Stem Cell Res. 2023 Aug;70:103119. doi: 10.1016/j.scr.2023.103119. Epub 2023 May 10. PubMed
Liver-specific in vivo base editing of Angptl3 via AAV delivery efficiently lowers blood lipid levels in mice. Zuo Y, Zhang C, Zhou Y, Li H, Xiao W, Herzog RW, Xu J, Zhang J, Chen YE, Han R. Cell Biosci. 2023 Jun 15;13(1):109. doi: 10.1186/s13578-023-01036-0. PubMed
HOXDeRNA activates a cancerous transcription program and super-enhancers genome-wide. Deforzh E, Kharel P, Karelin A, Ivanov P, Krichevsky AM. bioRxiv. 2023 Jun 30:2023.06.30.547275. doi: 10.1101/2023.06.30.547275. Preprint. PubMed
PAM-flexible genome editing with an engineered chimeric Cas9. Zhao L, Koseki SRT, Silverstein RA, Amrani N, Peng C, Kramme C, Savic N, Pacesa M, Rodriguez TC, Stan T, Tysinger E, Hong L, Yudistyra V, Ponnapati MR, Jacobson JM, Church GM, Jakimo N, Truant R, Jinek M, Kleinstiver BP, Sontheimer EJ, Chatterjee P. Nat Commun. 2023 Oct 4;14(1):6175. doi: 10.1038/s41467-023-41829-y. PubMed

Associated Plasmids
Decreasing predictable DNA off-target effects and narrowing editing windows of adenine base editors by fusing human Rad18 protein variant. Wang Z, Yuan H, Yang L, Ma L, Zhang Y, Deng J, Li X, Xiao W, Li Z, Qiu J, Ouyang H, Pang D. Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127418. doi: 10.1016/j.ijbiomac.2023.127418. Epub 2023 Oct 16. PubMed

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