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pLKO.1 puro GFP siRNA Citations (22)

Originally described in: Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion.
Orimo A, Gupta PB, Sgroi DC, Arenzana-Seisdedos F, Delaunay T, Naeem R, Carey VJ, Richardson AL, Weinberg RA Cell. 2005 May 6. 121(3):335-48.
PubMed Journal

Articles Citing pLKO.1 puro GFP siRNA

Interaction between simian virus 40 large T antigen and insulin receptor substrate 1 is disrupted by the K1 mutation, resulting in the loss of large T antigen-mediated phosphorylation of Akt. Yu Y, Alwine JC. J Virol. 2008 May;82(9):4521-6. doi: 10.1128/JVI.02365-07. Epub 2008 Feb 27. PubMed
In vivo genetic manipulation of the rat trophoblast cell lineage using lentiviral vector delivery. Lee DS, Rumi MA, Konno T, Soares MJ. Genesis. 2009 Jul;47(7):433-9. doi: 10.1002/dvg.20518. PubMed
Raptor binds the SAIN (Shc and IRS-1 NPXY binding) domain of insulin receptor substrate-1 (IRS-1) and regulates the phosphorylation of IRS-1 at Ser-636/639 by mTOR. Tzatsos A. J Biol Chem. 2009 Aug 21;284(34):22525-34. doi: 10.1074/jbc.M109.027748. Epub 2009 Jun 26. PubMed
Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells. Hamid R, Brandt SJ. Mol Oncol. 2009 Dec;3(5-6):451-63. doi: 10.1016/j.molonc.2009.07.004. Epub 2009 Jul 29. PubMed
A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling. Prosser DC, Tran D, Schooley A, Wendland B, Ngsee JK. Traffic. 2010 Oct;11(10):1347-62. doi: 10.1111/j.1600-0854.2010.01100.x. PubMed
Protease-activated receptors mediate crosstalk between coagulation and fibrinolysis. McEachron TA, Pawlinski R, Richards KL, Church FC, Mackman N. Blood. 2010 Dec 2;116(23):5037-44. doi: 10.1182/blood-2010-06-293126. Epub 2010 Aug 24. PubMed
Silencing alpha1,3-fucosyltransferases in human leukocytes reveals a role for FUT9 enzyme during E-selectin-mediated cell adhesion. Buffone A Jr, Mondal N, Gupta R, McHugh KP, Lau JT, Neelamegham S. J Biol Chem. 2013 Jan 18;288(3):1620-33. doi: 10.1074/jbc.M112.400929. Epub 2012 Nov 28. PubMed
Mannose receptor 1 mediates cellular uptake and endosomal delivery of CpG-motif containing oligodeoxynucleotides. Moseman AP, Moseman EA, Schworer S, Smirnova I, Volkova T, von Andrian U, Poltorak A. J Immunol. 2013 Dec 1;191(11):5615-24. doi: 10.4049/jimmunol.1301438. Epub 2013 Nov 1. PubMed
A novel immunomodulatory function of PHLPP1: inhibition of iNOS via attenuation of STAT1 ser727 phosphorylation in mouse macrophages. Alamuru NP, Behera S, Butchar JP, Tridandapani S, Kaimal Suraj S, Babu PP, Hasnain SE, Ehtesham NZ, Parsa KV. J Leukoc Biol. 2014 Jan 17. PubMed
RIP1 maintains DNA integrity and cell proliferation by regulating PGC-1alpha-mediated mitochondrial oxidative phosphorylation and glycolysis. Chen W, Wang Q, Bai L, Chen W, Wang X, Tellez CS, Leng S, Padilla MT, Nyunoya T, Belinsky SA, Lin Y. Cell Death Differ. 2014 Jul;21(7):1061-70. doi: 10.1038/cdd.2014.25. Epub 2014 Feb 28. PubMed
A time- and matrix-dependent TGFBR3-JUND-KRT5 regulatory circuit in single breast epithelial cells and basal-like premalignancies. Wang CC, Bajikar SS, Jamal L, Atkins KA, Janes KA. Nat Cell Biol. 2014 Apr;16(4):345-56. doi: 10.1038/ncb2930. Epub 2014 Mar 23. PubMed

Associated Plasmids

Toll-like receptor-mediated down-regulation of the deubiquitinase cylindromatosis (CYLD) protects macrophages from necroptosis in wild-derived mice. Schworer SA, Smirnova II, Kurbatova I, Bagina U, Churova M, Fowler T, Roy AL, Degterev A, Poltorak A. J Biol Chem. 2014 May 16;289(20):14422-33. doi: 10.1074/jbc.M114.547547. Epub 2014 Apr 4. PubMed
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, Zhang H, Marquez VE, Hammerman PS, Wong KK, Kim CF. Nature. 2015 Apr 9;520(7546):239-42. doi: 10.1038/nature14122. Epub 2015 Jan 28. PubMed
The protein kinase C super-family member PKN is regulated by mTOR and influences differentiation during prostate cancer progression. Yang CS, Melhuish TA, Spencer A, Ni L, Hao Y, Jividen K, Harris TE, Snow C, Frierson HF Jr, Wotton D, Paschal BM. Prostate. 2017 Nov;77(15):1452-1467. doi: 10.1002/pros.23400. Epub 2017 Sep 6. PubMed
FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway. Okada K, Nogami A, Ishida S, Akiyama H, Chen C, Umezawa Y, Miura O. Oncotarget. 2017 Dec 4;9(10):8870-8886. doi: 10.18632/oncotarget.22926. eCollection 2018 Feb 6. PubMed
Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation. Wakae K, Nishiyama T, Kondo S, Izuka T, Que L, Chen C, Kase K, Kitamura K, Mohiuddin M, Wang Z, Ahasan MM, Nakamura M, Fujiwara H, Yoshizaki T, Hosomochi K, Tajima A, Nakahara T, Kiyono T, Muramatsu M. Sci Rep. 2018 Jun 27;8(1):9745. doi: 10.1038/s41598-018-27930-z. PubMed
H3K9 methyltransferases and demethylases control lung tumor-propagating cells and lung cancer progression. Rowbotham SP, Li F, Dost AFM, Louie SM, Marsh BP, Pessina P, Anbarasu CR, Brainson CF, Tuminello SJ, Lieberman A, Ryeom S, Schlaeger TM, Aronow BJ, Watanabe H, Wong KK, Kim CF. Nat Commun. 2018 Nov 19;9(1):4559. doi: 10.1038/s41467-018-07077-1. PubMed
Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Nakanishi M, Mitchell RR, Benoit YD, Orlando L, Reid JC, Shimada K, Davidson KC, Shapovalova Z, Collins TJ, Nagy A, Bhatia M. Cell. 2019 May 2;177(4):910-924.e22. doi: 10.1016/j.cell.2019.03.013. Epub 2019 Apr 11. PubMed
Syndecan-4 regulates extravillous trophoblast migration by coordinating protein kinase C activation. Jeyarajah MJ, Jaju Bhattad G, Kops BF, Renaud SJ. Sci Rep. 2019 Jul 15;9(1):10175. doi: 10.1038/s41598-019-46599-6. PubMed
FLT3-ITD Activates RSK1 to Enhance Proliferation and Survival of AML Cells by Activating mTORC1 and eIF4B Cooperatively with PIM or PI3K and by Inhibiting Bad and BIM. Watanabe D, Nogami A, Okada K, Akiyama H, Umezawa Y, Miura O. Cancers (Basel). 2019 Nov 20;11(12). pii: cancers11121827. doi: 10.3390/cancers11121827. PubMed
Estrogen Receptor-Alpha and p53 Status as Regulators of AMPK and mTOR in Luminal Breast Cancer. Gandhi N, Oturkar CC, Das GM. Cancers (Basel). 2021 Jul 19;13(14). pii: cancers13143612. doi: 10.3390/cancers13143612. PubMed
Polycomb deficiency drives a FOXP2-high aggressive state targetable by epigenetic inhibitors. Chen F, Byrd AL, Liu J, Flight RM, DuCote TJ, Naughton KJ, Song X, Edgin AR, Lukyanchuk A, Dixon DT, Gosser CM, Esoe DP, Jayswal RD, Orkin SH, Moseley HNB, Wang C, Brainson CF. Nat Commun. 2023 Jan 20;14(1):336. doi: 10.1038/s41467-023-35784-x. PubMed

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