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mSin1 shRNA #1 Citations (4)

Originally described in: mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s.
Frias MA, Thoreen CC, Jaffe JD, Schroder W, Sculley T, Carr SA, Sabatini DM Curr Biol. 2006 Aug 15. ():.
PubMed Journal

Articles Citing mSin1 shRNA #1

TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Copp J, Manning G, Hunter T. Cancer Res. 2009 Mar 1. 69(5):1821-7. PubMed
Negative regulation of the FOXO3a transcription factor by mTORC2 induces a pro-survival response following exposure to ultraviolet-B irradiation. Feehan RP, Shantz LM. Cell Signal. 2016 Aug;28(8):798-809. doi: 10.1016/j.cellsig.2016.03.013. Epub 2016 Apr 4. PubMed
The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Carbonneau M, M Gagne L, Lalonde ME, Germain MA, Motorina A, Guiot MC, Secco B, Vincent EE, Tumber A, Hulea L, Bergeman J, Oppermann U, Jones RG, Laplante M, Topisirovic I, Petrecca K, Huot ME, Mallette FA. Nat Commun. 2016 Sep 14;7:12700. doi: 10.1038/ncomms12700. PubMed
Inhibition of mTORC2 enhances UVB-induced apoptosis in keratinocytes through a mechanism dependent on the FOXO3a transcriptional target NOXA but independent of TRAIL. Feehan RP, Nelson AM, Shantz LM. Cell Signal. 2018 Dec;52:35-47. doi: 10.1016/j.cellsig.2018.08.018. Epub 2018 Aug 30. PubMed

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