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SIRT2 Flag Citations (26)

Originally described in: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E Mol Cell. 2003 Feb . 11(2):437-44.
PubMed Journal

Articles Citing SIRT2 Flag

Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. Pickard A, Wong PP, McCance DJ. J Cell Sci. 2010 Nov 1;123(Pt 21):3718-26. doi: 10.1242/jcs.068924. Epub 2010 Oct 12. PubMed
Sirtuin 2 (SIRT2) enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via deacetylating forkhead box O3a (Foxo3a) and activating Bim protein. Liu L, Arun A, Ellis L, Peritore C, Donmez G. J Biol Chem. 2012 Sep 21;287(39):32307-11. Epub 2012 Aug 16. PubMed
Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation. Snider NT, Leonard JM, Kwan R, Griggs NW, Rui L, Omary MB. J Cell Biol. 2013 Feb 4;200(3):241-7. doi: 10.1083/jcb.201209028. Epub 2013 Jan 28. PubMed
Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J, Pommier Y, Okorokov AL. Nucleic Acids Res. 2013 Apr;41(7):4065-79. doi: 10.1093/nar/gkt131. Epub 2013 Feb 28. PubMed
Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells. Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew EL, Edahiro Y, Tsutsui M, Ohsaka A, Komatsu N. PLoS One. 2013;8(2):e57633. doi: 10.1371/journal.pone.0057633. Epub 2013 Feb 27. PubMed
Regulation of SIRT2 levels for human non-small cell lung cancer therapy. Li Z, Xie QR, Chen Z, Lu S, Xia W. Lung Cancer. 2013 Oct;82(1):9-15. doi: 10.1016/j.lungcan.2013.05.013. Epub 2013 Jul 31. PubMed
The ubiquitin ligase CHIP prevents SirT6 degradation through noncanonical ubiquitination. Ronnebaum SM, Wu Y, McDonough H, Patterson C. Mol Cell Biol. 2013 Nov;33(22):4461-72. doi: 10.1128/MCB.00480-13. Epub 2013 Sep 16. PubMed
SIRT2 enhances 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal damage via apoptotic pathway. Liu L, Arun A, Ellis L, Peritore C, Donmez G. Front Aging Neurosci. 2014 Aug 11;6:184. doi: 10.3389/fnagi.2014.00184. eCollection 2014. PubMed
Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment. Belman JP, Bian RR, Habtemichael EN, Li DT, Jurczak MJ, Alcazar-Roman A, McNally LJ, Shulman GI, Bogan JS. J Biol Chem. 2015 Feb 13;290(7):4447-63. doi: 10.1074/jbc.M114.603977. Epub 2015 Jan 5. PubMed
Cell and Context-Dependent Effects of the Heat Shock Protein DNAJB6 on Neuronal Survival. Smith C, D'Mello SR. Mol Neurobiol. 2015 Oct 17. PubMed
Regulation of Retinoic Acid Inducible Gene-I (RIG-I) Activation by the Histone Deacetylase 6. Liu HM, Jiang F, Loo YM, Hsu S, Hsiang TY, Marcotrigiano J, Gale M Jr. EBioMedicine. 2016 Jul;9:195-206. doi: 10.1016/j.ebiom.2016.06.015. Epub 2016 Jun 11. PubMed
Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice. Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V. PLoS One. 2016 Aug 8;11(8):e0160431. doi: 10.1371/journal.pone.0160431. eCollection 2016. PubMed
Sirtuin 2 mutations in human cancers impair its function in genome maintenance. Head PE, Zhang H, Bastien AJ, Koyen AE, Withers AE, Daddacha WB, Cheng X, Yu DS. J Biol Chem. 2017 Jun 16;292(24):9919-9931. doi: 10.1074/jbc.M116.772566. Epub 2017 May 1. PubMed
Sirtuin-2 Protects Neural Cells from Oxidative Stress and Is Elevated in Neurodegeneration. Singh P, Hanson PS, Morris CM. Parkinsons Dis. 2017;2017:2643587. doi: 10.1155/2017/2643587. Epub 2017 May 28. PubMed
Membrane localization of acetylated CNK1 mediates a positive feedback on RAF/ERK signaling. Fischer A, Muhlhauser WWD, Warscheid B, Radziwill G. Sci Adv. 2017 Aug 11;3(8):e1700475. doi: 10.1126/sciadv.1700475. eCollection 2017 Aug. PubMed
Development of Activity-Based Chemical Probes for Human Sirtuins. Graham E, Rymarchyk S, Wood M, Cen Y. ACS Chem Biol. 2018 Mar 16;13(3):782-792. doi: 10.1021/acschembio.7b00754. Epub 2018 Feb 8. PubMed
SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation. Sarikhani M, Mishra S, Maity S, Kotyada C, Wolfgeher D, Gupta MP, Singh M, Sundaresan NR. Elife. 2018 Mar 5;7. pii: 32952. doi: 10.7554/eLife.32952. PubMed
Cysteine thiol oxidation on SIRT2 regulates inflammation in obese mice with sepsis. Wang X, Buechler NL, Long DL, Furdui CM, Yoza BK, McCall CE, Vachharajani V. Inflammation. 2019 Feb;42(1):156-169. doi: 10.1007/s10753-018-0881-9. PubMed
Methods for studying human sirtuins with activity-based chemical probes. Zheng S, Wohlfahrt J, Cohen I, Cen Y. Methods Enzymol. 2020;633:251-269. doi: 10.1016/bs.mie.2019.11.004. Epub 2019 Nov 23. PubMed
SIRT1 decelerates morphological processing of oligodendrocyte cell lines and regulates the expression of cytoskeleton-related oligodendrocyte proteins. Hisahara S, Iwahara N, Matsushita T, Suzuki S, Matsumura A, Fujikura M, Yokokawa K, Saito T, Manabe T, Kawamata J, Horio Y, Shimohama S. Biochem Biophys Res Commun. 2021 Mar 26;546:7-14. doi: 10.1016/j.bbrc.2021.01.095. Epub 2021 Feb 5. PubMed
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. Minten EV, Kapoor-Vazirani P, Li C, Zhang H, Balakrishnan K, Yu DS. Cell Rep. 2021 Mar 30;34(13):108921. doi: 10.1016/j.celrep.2021.108921. PubMed
Profiling sirtuin activity using Copper-free click chemistry. Curry AM, Cohen I, Zheng S, Wohlfahrt J, White DS, Donu D, Cen Y. Bioorg Chem. 2021 Dec;117:105413. doi: 10.1016/j.bioorg.2021.105413. Epub 2021 Oct 8. PubMed
Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Shimizu K, Gi M, Suzuki S, North BJ, Watahiki A, Fukumoto S, Asara JM, Tokunaga F, Wei W, Inuzuka H. Cell Rep. 2021 Nov 9;37(6):109988. doi: 10.1016/j.celrep.2021.109988. PubMed
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43. Garcia Morato J, Hans F, von Zweydorf F, Feederle R, Elsasser SJ, Skodras AA, Gloeckner CJ, Buratti E, Neumann M, Kahle PJ. Nat Commun. 2022 Mar 9;13(1):1223. doi: 10.1038/s41467-022-28822-7. PubMed
RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice. Thomas G, Villar-Pazos S, Thomas L, Yang Y, Chen K, Lyles J, Deitch B, Ochaba J, Ling K, Powers B, Gingras S, Kordasiewicz H, Grubisha M, Huang Y. Res Sq. 2023 Jan doi: 10.21203/ Preprint. PubMed
Neural deficits in a mouse model of PACS1 syndrome are corrected with PACS1- or HDAC6-targeting therapy. Villar-Pazos S, Thomas L, Yang Y, Chen K, Lyles JB, Deitch BJ, Ochaba J, Ling K, Powers B, Gingras S, Kordasiewicz HB, Grubisha MJ, Huang YH, Thomas G. Nat Commun. 2023 Oct 17;14(1):6547. doi: 10.1038/s41467-023-42176-8. PubMed

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