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HA PKB T308D S473D pcDNA3 Citations (22)

Originally described in: Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.
Scheid MP, Marignani PA, Woodgett JR Mol Cell Biol. 2002 Sep . 22(17):6247-60.
PubMed Journal

Articles Citing HA PKB T308D S473D pcDNA3

Tangeretin sensitizes cisplatin-resistant human ovarian cancer cells through downregulation of phosphoinositide 3-kinase/Akt signaling pathway. Arafa el-SA, Zhu Q, Barakat BM, Wani G, Zhao Q, El-Mahdy MA, Wani AA. Cancer Res. 2009 Dec 1;69(23):8910-7. doi: 10.1158/0008-5472.CAN-09-1543. Epub 2009 Nov 10. PubMed
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores. Martin VA, Wang WH, Lipchik AM, Parker LL, He Y, Zhang S, Zhang ZY, Geahlen RL. Cell Signal. 2012 May;24(5):1064-73. doi: 10.1016/j.cellsig.2012.01.001. Epub 2012 Jan 11. PubMed
3-phosphoinositide-dependent kinase 1 controls breast tumor growth in a kinase-dependent but Akt-independent manner. Gagliardi PA, di Blasio L, Orso F, Seano G, Sessa R, Taverna D, Bussolino F, Primo L. Neoplasia. 2012 Aug;14(8):719-31. PubMed
CXCL12/CXCR4 protein signaling axis induces sonic hedgehog expression in pancreatic cancer cells via extracellular regulated kinase- and Akt kinase-mediated activation of nuclear factor kappaB: implications for bidirectional tumor-stromal interactions. Singh AP, Arora S, Bhardwaj A, Srivastava SK, Kadakia MP, Wang B, Grizzle WE, Owen LB, Singh S. J Biol Chem. 2012 Nov 9;287(46):39115-24. doi: 10.1074/jbc.M112.409581. Epub 2012 Sep 20. PubMed
Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization. Imam JS, Plyler JR, Bansal H, Prajapati S, Bansal S, Rebeles J, Chen HI, Chang YF, Panneerdoss S, Zoghi B, Buddavarapu KC, Broaddus R, Hornsby P, Tomlinson G, Dome J, Vadlamudi RK, Pertsemlidis A, Chen Y, Rao MK. PLoS One. 2012;7(12):e52397. doi: 10.1371/journal.pone.0052397. Epub 2012 Dec 21. PubMed
Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. Hung SY, Shih YP, Chen M, Lo SH. Mol Carcinog. 2014 Oct;53(10):787-92. doi: 10.1002/mc.22034. Epub 2013 Apr 26. PubMed
Optimization of a genetically encoded biosensor for cyclin B1-cyclin dependent kinase 1. Belal AS, Sell BR, Hoi H, Davidson MW, Campbell RE. Mol Biosyst. 2014 Feb;10(2):191-5. doi: 10.1039/c3mb70402e. PubMed
Piperlongumine promotes autophagy via inhibition of Akt/mTOR signalling and mediates cancer cell death. Makhov P, Golovine K, Teper E, Kutikov A, Mehrazin R, Corcoran A, Tulin A, Uzzo RG, Kolenko VM. Br J Cancer. 2014 Feb 18;110(4):899-907. doi: 10.1038/bjc.2013.810. Epub 2014 Jan 16. PubMed
Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model. Bhardwaj A, Singh S, Srivastava SK, Arora S, Hyde SJ, Andrews J, Grizzle WE, Singh AP. Br J Cancer. 2014 Apr 15;110(8):2000-10. doi: 10.1038/bjc.2014.141. Epub 2014 Mar 18. PubMed
PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells. Cai XP, Chen LD, Song HB, Zhang CX, Yuan ZW, Xiang ZX. Am J Transl Res. 2016 Oct 15;8(10):4172-4183. eCollection 2016. PubMed
Glucose Metabolism Reprogrammed by Overexpression of IKKepsilon Promotes Pancreatic Tumor Growth. Zubair H, Azim S, Srivastava SK, Ahmad A, Bhardwaj A, Khan MA, Patel GK, Arora S, Carter JE, Singh S, Singh AP. Cancer Res. 2016 Dec 15;76(24):7254-7264. doi: 10.1158/0008-5472.CAN-16-1666. Epub 2016 Oct 20. PubMed
The Par3 polarity protein is an exocyst receptor essential for mammary cell survival. Ahmed SM, Macara IG. Nat Commun. 2017 Mar 30;8:14867. doi: 10.1038/ncomms14867. PubMed
Over-activated PD-1/PD-L1 axis facilitates the chemoresistance of diffuse large B-cell lymphoma cells to the CHOP regimen. Liu J, Quan L, Zhang C, Liu A, Tong D, Wang J. Oncol Lett. 2018 Mar;15(3):3321-3328. doi: 10.3892/ol.2017.7682. Epub 2017 Dec 21. PubMed
The Dietary Supplement Chondroitin-4-Sulfate Exhibits Oncogene-Specific Pro-tumor Effects on BRAF V600E Melanoma Cells. Lin R, Xia S, Shan C, Chen D, Liu Y, Gao X, Wang M, Kang HB, Pan Y, Liu S, Chung YR, Abdel-Wahab O, Merghoub T, Rossi M, Kudchadkar RR, Lawson DH, Khuri FR, Lonial S, Chen J. Mol Cell. 2018 Mar 15;69(6):923-937.e8. doi: 10.1016/j.molcel.2018.02.010. PubMed
Cytoplasmic p21 Mediates 5-Fluorouracil Resistance by Inhibiting Pro-Apoptotic Chk2. Maiuthed A, Ninsontia C, Erlenbach-Wuensch K, Ndreshkjana B, Muenzner JK, Caliskan A, Husayn AP, Chaotham C, Hartmann A, Vial Roehe A, Mahadevan V, Chanvorachote P, Schneider-Stock R. Cancers (Basel). 2018 Oct 9;10(10). pii: cancers10100373. doi: 10.3390/cancers10100373. PubMed
Apoptosis of cancer cells is triggered by selective crosslinking and inhibition of receptor tyrosine kinases. Wang K, Wang X, Hou Y, Zhou H, Mai K, He G. Commun Biol. 2019 Jun 21;2:231. doi: 10.1038/s42003-019-0484-5. eCollection 2019. PubMed
Sulfated polysaccharide of Sepiella maindroni ink targets Akt and overcomes resistance to the FGFR inhibitor AZD4547 in bladder cancer. Shan L, Liu W, Zhan Y. Aging (Albany NY). 2019 Sep 23;11(18):7780-7795. doi: 10.18632/aging.102286. Epub 2019 Sep 23. PubMed
Involvement of Phosphatase and Tensin Homolog in Cyclin-Dependent Kinase 4/6 Inhibitor-Induced Blockade of Glioblastoma. Liu S, Yuan D, Li Y, Qi Q, Guo B, Yang S, Zhou J, Xu L, Chen T, Yang C, Liu J, Li B, Yao L, Jiang W. Front Pharmacol. 2019 Nov 7;10:1316. doi: 10.3389/fphar.2019.01316. eCollection 2019. PubMed
Hemistepsin A alleviates liver fibrosis by inducing apoptosis of activated hepatic stellate cells via inhibition of nuclear factor-kappaB and Akt. Kim JK, Han NR, Park SM, Jegal KH, Jung JY, Jung EH, Kim EO, Kim D, Jung DH, Lee JR, Park CA, Ku SK, Cho IJ, Kim SC. Food Chem Toxicol. 2020 Jan;135:111044. doi: 10.1016/j.fct.2019.111044. Epub 2019 Dec 9. PubMed
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer. Tian S, Lou L, Tian M, Lu G, Tian J, Chen X. J Exp Clin Cancer Res. 2020 Jul 25;39(1):143. doi: 10.1186/s13046-020-01644-5. PubMed
Dihydroartemisinin inhibits the migration of esophageal cancer cells by inducing autophagy. Chen X, He LY, Lai S, He Y. Oncol Lett. 2020 Oct;20(4):94. doi: 10.3892/ol.2020.11955. Epub 2020 Aug 6. PubMed
IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms. Wu Q, Tian AL, Li B, Leduc M, Forveille S, Hamley P, Galloway W, Xie W, Liu P, Zhao L, Zhang S, Hui P, Madeo F, Tu Y, Kepp O, Kroemer G. J Immunother Cancer. 2021 Jun;9(6). pii: jitc-2021-002722. doi: 10.1136/jitc-2021-002722. PubMed

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