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Flag p21 WT Citations (19)

Originally described in: Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells.
Zhou BP, Liao Y, Xia W, Spohn B, Lee MH, Hung MC Nat Cell Biol. 2001 Mar . 3(3):245-52.
PubMed Journal

Articles Citing Flag p21 WT

SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing. Chen Y, Zhang L, Jones KA. Genes Dev. 2011 Apr 1;25(7):701-16. doi: 10.1101/gad.2002611. PubMed
Hepatitis B virus core promoter mutations contribute to hepatocarcinogenesis by deregulating SKP2 and its target, p21. Huang Y, Tong S, Tai AW, Hussain M, Lok AS. Gastroenterology. 2011 Oct;141(4):1412-21, 1421.e1-5. doi: 10.1053/j.gastro.2011.06.048. Epub 2011 Jun 24. PubMed
IL-12-dependent innate immunity arrests endothelial cells in G0-G1 phase by a p21(Cip1/Waf1)-mediated mechanism. Napione L, Strasly M, Meda C, Mitola S, Alvaro M, Doronzo G, Marchio S, Giraudo E, Primo L, Arese M, Bussolino F. Angiogenesis. 2012 Dec;15(4):713-25. doi: 10.1007/s10456-012-9286-9. Epub 2012 Jul 15. PubMed
A novel function for p21Cip1 and acetyltransferase p/CAF as critical transcriptional regulators of TGFbeta-mediated breast cancer cell migration and invasion. Dai M, Al-Odaini AA, Arakelian A, Rabbani SA, Ali S, Lebrun JJ. Breast Cancer Res. 2012 Sep 20;14(5):R127. doi: 10.1186/bcr3322. PubMed
Cyclin D1 cooperates with p21 to regulate TGFbeta-mediated breast cancer cell migration and tumor local invasion. Dai M, Al-Odaini AA, Fils-Aime N, Villatoro MA, Guo J, Arakelian A, Rabbani SA, Ali S, Lebrun J. Breast Cancer Res. 2013 Jun 20;15(3):R49. doi: 10.1186/bcr3441. PubMed
The p90 ribosomal S6 kinase (RSK) inhibitor BI-D1870 prevents gamma irradiation-induced apoptosis and mediates senescence via RSK- and p53-independent accumulation of p21WAF1/CIP1. Neise D, Sohn D, Stefanski A, Goto H, Inagaki M, Wesselborg S, Budach W, Stuhler K, Janicke RU. Cell Death Dis. 2013 Oct 17;4:e859. doi: 10.1038/cddis.2013.386. PubMed
Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W. Mol Brain. 2015 Sep 18;8:54. doi: 10.1186/s13041-015-0145-7. PubMed
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers. Llanos S, Garcia-Pedrero JM, Morgado-Palacin L, Rodrigo JP, Serrano M. Nat Commun. 2016 Feb 2;7:10438. doi: 10.1038/ncomms10438. PubMed
Regulation of Neuronal Survival by Nucleophosmin 1 (NPM1) Is Dependent on Its Expression Level, Subcellular Localization, and Oligomerization Status. Pfister JA, D'Mello SR. J Biol Chem. 2016 Sep 23;291(39):20787-97. doi: 10.1074/jbc.M116.723015. Epub 2016 Aug 10. PubMed
The G1/S Specific Cyclin D2 Is a Regulator of HIV-1 Restriction in Non-proliferating Cells. Badia R, Pujantell M, Riveira-Munoz E, Puig T, Torres-Torronteras J, Marti R, Clotet B, Ampudia RM, Vives-Pi M, Este JA, Ballana E. PLoS Pathog. 2016 Aug 19;12(8):e1005829. doi: 10.1371/journal.ppat.1005829. eCollection 2016 Aug. PubMed
Identification of cellular senescence-specific genes by comparative transcriptomics. Nagano T, Nakano M, Nakashima A, Onishi K, Yamao S, Enari M, Kikkawa U, Kamada S. Sci Rep. 2016 Aug 22;6:31758. doi: 10.1038/srep31758. PubMed
Reduced Expression of Foxp1 as a Contributing Factor in Huntington's Disease. Louis Sam Titus ASC, Yusuff T, Cassar M, Thomas E, Kretzschmar D, D'Mello SR. J Neurosci. 2017 Jul 5;37(27):6575-6587. doi: 10.1523/JNEUROSCI.3612-16.2017. Epub 2017 May 26. PubMed
Correction to: Leucine-Rich Repeat Kinase 2 (LRRK2) phosphorylates p53 and induces p21(WAF1/CIP1) expression. Ho DH, Kim H, Kim J, Sim H, Ahn H, Kim J, Seo H, Chung KC, Park BJ, Son I, Seol W. Mol Brain. 2017 Oct 6;10(1):48. doi: 10.1186/s13041-017-0327-6. PubMed
Transcriptional Repression of High-Mobility Group Box 2 by p21 in Radiation-Induced Senescence. Kim HK, Kang MA, Kim MS, Shin YJ, Chi SG, Jeong JH. Mol Cells. 2018 Apr 30;41(4):362-372. doi: 10.14348/molcells.2018.2291. Epub 2018 Feb 28. PubMed
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes. Chen PJ, Hussmann JA, Yan J, Knipping F, Ravisankar P, Chen PF, Chen C, Nelson JW, Newby GA, Sahin M, Osborn MJ, Weissman JS, Adamson B, Liu DR. Cell. 2021 Oct 28;184(22):5635-5652.e29. doi: 10.1016/j.cell.2021.09.018. PubMed

Associated Plasmids

Dissecting the influence of cellular senescence on cell mechanics and extracellular matrix formation in vitro. Brauer E, Lange T, Keller D, Gorlitz S, Cho S, Keye J, Gossen M, Petersen A, Kornak U. Aging Cell. 2023 Mar;22(3):e13744. doi: 10.1111/acel.13744. Epub 2022 Dec 13. PubMed
Cell cycle arrest and p53 prevent ON-target megabase-scale rearrangements induced by CRISPR-Cas9. Cullot G, Boutin J, Fayet S, Prat F, Rosier J, Cappellen D, Lamrissi I, Pennamen P, Bouron J, Amintas S, Thibault C, Moranvillier I, Laharanne E, Merlio JP, Guyonnet-Duperat V, Blouin JM, Richard E, Dabernat S, Moreau-Gaudry F, Bedel A. Nat Commun. 2023 Jul 10;14(1):4072. doi: 10.1038/s41467-023-39632-w. PubMed
ATR inhibition augments the efficacy of lurbinectedin in small-cell lung cancer. Schultz CW, Zhang Y, Elmeskini R, Zimmermann A, Fu H, Murai Y, Wangsa D, Kumar S, Takahashi N, Atkinson D, Saha LK, Lee CF, Elenbaas B, Desai P, Sebastian R, Sharma AK, Abel M, Schroeder B, Krishnamurthy M, Kumar R, Roper N, Aladjem M, Zenke FT, Ohler ZW, Pommier Y, Thomas A. EMBO Mol Med. 2023 Aug 7;15(8):e17313. doi: 10.15252/emmm.202217313. Epub 2023 Jul 25. PubMed
Targeting PEG10 as a novel therapeutic approach to overcome CDK4/6 inhibitor resistance in breast cancer. Katuwal NB, Kang MS, Ghosh M, Hong SD, Jeong YG, Park SM, Kim SG, Sohn J, Kim TH, Moon YW. J Exp Clin Cancer Res. 2023 Nov 28;42(1):325. doi: 10.1186/s13046-023-02903-x. PubMed

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