LRRK2-WT Citations (7)

Originally described in: Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity.
West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16842-7. Epub 2005 Nov 3. PubMed Journal

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Articles Citing LRRK2-WT

Articles
LRRK2 knockdown in zebrafish causes developmental defects, neuronal loss, and synuclein aggregation. Prabhudesai S, Bensabeur FZ, Abdullah R, Basak I, Baez S, Alves G, Holtzman NG, Larsen JP, Moller SG. J Neurosci Res. 2016 Aug;94(8):717-35. doi: 10.1002/jnr.23754. Epub 2016 Jun 5. PubMed
LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP. Nat Commun. 2016 Jul 19;7:12188. doi: 10.1038/ncomms12188. PubMed
LRRK2 mediated Rab8a phosphorylation promotes lipid storage. Yu M, Arshad M, Wang W, Zhao D, Xu L, Zhou L. Lipids Health Dis. 2018 Feb 27;17(1):34. doi: 10.1186/s12944-018-0684-x. PubMed
Isoprenylcysteine carboxylmethyltransferase is associated with nasopharyngeal carcinoma chemoresistance and Ras activation. Zhu Y, Hu Q, Li H. Biochem Biophys Res Commun. 2019 Aug 27;516(3):784-789. doi: 10.1016/j.bbrc.2019.06.074. Epub 2019 Jun 26. PubMed
Dysregulation of the AP2M1 phosphorylation cycle by LRRK2 impairs endocytosis and leads to dopaminergic neurodegeneration. Liu Q, Bautista-Gomez J, Higgins DA, Yu J, Xiong Y. Sci Signal. 2021 Jul 27;14(693):eabg3555. doi: 10.1126/scisignal.abg3555. PubMed
Regulation of LRRK2 mRNA stability by ATIC and its substrate AICAR through ARE-mediated mRNA decay in Parkinson's disease. Liu Q, Zhu D, Li N, Chen S, Hu L, Yu J, Xiong Y. EMBO J. 2023 Aug 1;42(15):e113410. doi: 10.15252/embj.2022113410. Epub 2023 Jun 27. PubMed
CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration. Liu Q, Huang B, Guiberson NGL, Chen S, Zhu D, Ma G, Ma XM, Crittenden JR, Yu J, Graybiel AM, Dawson TM, Dawson VL, Xiong Y. Sci Adv. 2024 Nov 22;10(47):eadn5417. doi: 10.1126/sciadv.adn5417. Epub 2024 Nov 22. PubMed

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