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pBABE-puro-hTERT Citations (26)

Originally described in: Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization.
Counter CM, Hahn WC, Wei W, Caddle SD, Beijersbergen RL, Lansdorp PM, Sedivy JM, Weinberg RA Proc Natl Acad Sci U S A 1998 Dec 8;95(25):14723-8.
PubMed Journal

Articles Citing pBABE-puro-hTERT

Genes involved in differentiation, stem cell renewal, and tumorigenesis are modulated in telomerase-immortalized human urothelial cells. Chapman EJ, Kelly G, Knowles MA. Mol Cancer Res. 2008 Jul;6(7):1154-68. doi: 10.1158/1541-7786.MCR-07-2168. PubMed
Overexpression of smoothened activates the sonic hedgehog signaling pathway in pancreatic cancer-associated fibroblasts. Walter K, Omura N, Hong SM, Griffith M, Vincent A, Borges M, Goggins M. Clin Cancer Res. 2010 Mar 15;16(6):1781-9. doi: 10.1158/1078-0432.CCR-09-1913. Epub 2010 Mar 9. PubMed
Culture, immortalization, and characterization of human meibomian gland epithelial cells. Liu S, Hatton MP, Khandelwal P, Sullivan DA. Invest Ophthalmol Vis Sci. 2010 Aug;51(8):3993-4005. doi: 10.1167/iovs.09-5108. Epub 2010 Mar 24. PubMed
Acycloguanosyl 5'-thymidyltriphosphate, a thymidine analogue prodrug activated by telomerase, reduces pancreatic tumor growth in mice. Polvani S, Calamante M, Foresta V, Ceni E, Mordini A, Quattrone A, D'Amico M, Luchinat C, Bertini I, Galli A. Gastroenterology. 2011 Feb;140(2):709-720.e9. doi: 10.1053/j.gastro.2010.10.050. Epub 2010 Oct 30. PubMed
Telomerase efficiently elongates highly transcribing telomeres in human cancer cells. Farnung BO, Brun CM, Arora R, Lorenzi LE, Azzalin CM. PLoS One. 2012;7(4):e35714. doi: 10.1371/journal.pone.0035714. Epub 2012 Apr 27. PubMed
Telomerase immortalization of human corneal endothelial cells yields functional hexagonal monolayers. Schmedt T, Chen Y, Nguyen TT, Li S, Bonanno JA, Jurkunas UV. PLoS One. 2012;7(12):e51427. doi: 10.1371/journal.pone.0051427. Epub 2012 Dec 21. PubMed
Constitutive expression of human telomerase enhances the proliferation potential of human mesenchymal stem cells. Bischoff DS, Makhijani NS, Yamaguchi DT. Biores Open Access. 2012 Dec;1(6):273-9. doi: 10.1089/biores.2012.0252. PubMed
Induction of STEAP4 correlates with 1,25-dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue. Narvaez CJ, Simmons KM, Brunton J, Salinero A, Chittur SV, Welsh JE. J Cell Physiol. 2013 Oct;228(10):2024-36. doi: 10.1002/jcp.24371. PubMed
Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, Li B, Houghton JA. PLoS One. 2013 Sep 25;8(9):e75253. doi: 10.1371/journal.pone.0075253. eCollection 2013. PubMed
Generation and characterization of an immortalized human mesenchymal stromal cell line. Skarn M, Noordhuis P, Wang MY, Veuger M, Kresse SH, Egeland EV, Micci F, Namlos HM, Hakelien AM, Olafsrud SM, Lorenz S, Haraldsen G, Kvalheim G, Meza-Zepeda LA, Myklebost O. Stem Cells Dev. 2014 Oct 1;23(19):2377-89. doi: 10.1089/scd.2013.0599. Epub 2014 Jun 30. PubMed
The use of transformed IMR90 cell model to identify the potential extra-telomeric effects of hTERT in cell migration and DNA damage response. Cao X, Kong CM, Mathi KM, Lim YP, Cacheux-Rataboul V, Wang X. BMC Biochem. 2014 Aug 7;15:17. doi: 10.1186/1471-2091-15-17. PubMed
hTERT-immortalized ovine microglia propagate natural scrapie isolates. Munoz-Gutierrez JF, Schneider DA, Baszler TV, Greenlee JJ, Nicholson EM, Stanton JB. Virus Res. 2015 Feb 16;198:35-43. doi: 10.1016/j.virusres.2014.10.028. Epub 2015 Jan 12. PubMed
Transcriptome Profiling of the Virus-Induced Innate Immune Response in Pteropus vampyrus and Its Attenuation by Nipah Virus Interferon Antagonist Functions. Glennon NB, Jabado O, Lo MK, Shaw ML. J Virol. 2015 Aug 1;89(15):7550-66. doi: 10.1128/JVI.00302-15. Epub 2015 May 13. PubMed
Humanization of the mouse mammary gland. Wronski A, Arendt LM, Kuperwasser C. Methods Mol Biol. 2015;1293:173-86. doi: 10.1007/978-1-4939-2519-3_10. PubMed
Binding of the sphingolipid S1P to hTERT stabilizes telomerase at the nuclear periphery by allosterically mimicking protein phosphorylation. Panneer Selvam S, De Palma RM, Oaks JJ, Oleinik N, Peterson YK, Stahelin RV, Skordalakes E, Ponnusamy S, Garrett-Mayer E, Smith CD, Ogretmen B. Sci Signal. 2015 Jun 16;8(381):ra58. doi: 10.1126/scisignal.aaa4998. PubMed
In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells. Yamamoto Y, Ning G, Howitt BE, Mehra K, Wu L, Wang X, Hong Y, Kern F, Wei TS, Zhang T, Nagarajan N, Basuli D, Torti S, Brewer M, Choolani M, McKeon F, Crum CP, Xian W. J Pathol. 2016 Mar;238(4):519-30. doi: 10.1002/path.4649. Epub 2016 Jan 9. PubMed
Derepression of hTERT gene expression promotes escape from oncogene-induced cellular senescence. Patel PL, Suram A, Mirani N, Bischof O, Herbig U. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E5024-33. doi: 10.1073/pnas.1602379113. Epub 2016 Aug 8. PubMed
Potent EMT and CSC Phenotypes are Induced by Oncostatin-M in Pancreatic Cancer. Smigiel JM, Parameswaran N, Jackson MW. Mol Cancer Res. 2017 Jan 4. pii: molcanres.0337.2016. doi: 10.1158/1541-7786.MCR-16-0337. PubMed
Mutations in DONSON disrupt replication fork stability and cause microcephalic dwarfism. Reynolds JJ, Bicknell LS, Carroll P, Higgs MR, Shaheen R, Murray JE, Papadopoulos DK, Leitch A, Murina O, Tarnauskaite Z, Wessel SR, Zlatanou A, Vernet A, von Kriegsheim A, Mottram RM, Logan CV, Bye H, Li Y, Brean A, Maddirevula S, Challis RC, Skouloudaki K, Almoisheer A, Alsaif HS, Amar A, Prescott NJ, Bober MB, Duker A, Faqeih E, Seidahmed MZ, Al Tala S, Alswaid A, Ahmed S, Al-Aama JY, Altmuller J, Al Balwi M, Brady AF, Chessa L, Cox H, Fischetto R, Heller R, Henderson BD, Hobson E, Nurnberg P, Percin EF, Peron A, Spaccini L, Quigley AJ, Thakur S, Wise CA, Yoon G, Alnemer M, Tomancak P, Yigit G, Taylor AM, Reijns MA, Simpson MA, Cortez D, Alkuraya FS, Mathew CG, Jackson AP, Stewart GS. Nat Genet. 2017 Apr;49(4):537-549. doi: 10.1038/ng.3790. Epub 2017 Feb 13. PubMed
Hypoxia-inducible factor-1alpha plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter. Kraus RJ, Yu X, Cordes BA, Sathiamoorthi S, Iempridee T, Nawandar DM, Ma S, Romero-Masters JC, McChesney KG, Lin Z, Makielski KR, Lee DL, Lambert PF, Johannsen EC, Kenney SC, Mertz JE. PLoS Pathog. 2017 Jun 15;13(6):e1006404. doi: 10.1371/journal.ppat.1006404. eCollection 2017 Jun. PubMed
Extensive Proliferation of Human Cancer Cells with Ever-Shorter Telomeres. Dagg RA, Pickett HA, Neumann AA, Napier CE, Henson JD, Teber ET, Arthur JW, Reynolds CP, Murray J, Haber M, Sobinoff AP, Lau LMS, Reddel RR. Cell Rep. 2017 Jun 20;19(12):2544-2556. doi: 10.1016/j.celrep.2017.05.087. PubMed
Telomerase reverse transcriptase promotes chemoresistance by suppressing cisplatin-dependent apoptosis in osteosarcoma cells. Zhang Z, Yu L, Dai G, Xia K, Liu G, Song Q, Tao C, Gao T, Guo W. Sci Rep. 2017 Aug 1;7(1):7070. doi: 10.1038/s41598-017-07204-w. PubMed
Transformation of mouse T cells requires MYC and AKT activity in conjunction with inhibition of intrinsic apoptosis. Hogstrand K, Darmanin S, Forshell TP, Grandien A. Oncotarget. 2018 Apr 20;9(30):21396-21410. doi: 10.18632/oncotarget.25113. eCollection 2018 Apr 20. PubMed
Telomerase reverse transcriptase coordinates with the epithelial-to-mesenchymal transition through a feedback loop to define properties of breast cancer stem cells. El-Badawy A, Ghoneim NI, Nasr MA, Elkhenany H, Ahmed TA, Ahmed SM, El-Badri N. Biol Open. 2018 Jul 25;7(7). pii: bio.034181. doi: 10.1242/bio.034181. PubMed
MYC-driven malignant transformation of mature murine B cells requires inhibition of both intrinsic apoptosis and p53 activity. Hogstrand K, Grandien A. Eur J Immunol. 2019 Mar;49(3):375-385. doi: 10.1002/eji.201847585. Epub 2018 Oct 12. PubMed
Telomerase reverse transcriptase activates transcription of miR500A to inhibit Hedgehog signalling and promote cell invasiveness. Bernabe-Garcia M, Martinez-Balsalobre E, Garcia-Moreno D, Garcia-Castillo J, Revilla-Nuin B, Blanco-Alcaina E, Mulero V, Alcaraz-Perez F, Cayuela ML. Mol Oncol. 2021 Jul;15(7):1818-1834. doi: 10.1002/1878-0261.12943. Epub 2021 May 2. PubMed

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