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pBABEpuro GFP-LC3 Citations (90)

Originally described in: Induction of autophagy during extracellular matrix detachment promotes cell survival.
Fung C, Lock R, Gao S, Salas E, Debnath J Mol Biol Cell. 2008 Mar . 19(3):797-806.
PubMed Journal

Articles Citing pBABEpuro GFP-LC3

Viral mediated redirection of NEMO/IKKgamma to autophagosomes curtails the inflammatory cascade. Fliss PM, Jowers TP, Brinkmann MM, Holstermann B, Mack C, Dickinson P, Hohenberg H, Ghazal P, Brune W. PLoS Pathog. 2012 Feb;8(2):e1002517. doi: 10.1371/journal.ppat.1002517. Epub 2012 Feb 2. PubMed
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells. Galavotti S, Bartesaghi S, Faccenda D, Shaked-Rabi M, Sanzone S, McEvoy A, Dinsdale D, Condorelli F, Brandner S, Campanella M, Grose R, Jones C, Salomoni P. Oncogene. 2013 Feb 7;32(6):699-712. doi: 10.1038/onc.2012.111. Epub 2012 Apr 23. PubMed
IGFBP-3 binds GRP78, stimulates autophagy and promotes the survival of breast cancer cells exposed to adverse microenvironments. Grkovic S, O'Reilly VC, Han S, Hong M, Baxter RC, Firth SM. Oncogene. 2013 May 9;32(19):2412-20. doi: 10.1038/onc.2012.264. Epub 2012 Jul 2. PubMed
CD47 deficiency confers cell and tissue radioprotection by activation of autophagy. Soto-Pantoja DR, Miller TW, Pendrak ML, DeGraff WG, Sullivan C, Ridnour LA, Abu-Asab M, Wink DA, Tsokos M, Roberts DD. Autophagy. 2012 Nov;8(11):1628-42. doi: 10.4161/auto.21562. Epub 2012 Aug 9. PubMed
Autophagy inhibition due to thymidine analogues as novel mechanism leading to hepatocyte dysfunction and lipid accumulation. Stankov MV, Panayotova-Dimitrova D, Leverkus M, Vondran FW, Bauerfeind R, Binz A, Behrens GM. AIDS. 2012 Oct 23;26(16):1995-2006. doi: 10.1097/QAD.0b013e32835804f9. PubMed
Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes. Stankov MV, Panayotova-Dimitrova D, Leverkus M, Schmidt RE, Behrens GM. Antimicrob Agents Chemother. 2013 Jan;57(1):543-51. doi: 10.1128/AAC.01560-12. Epub 2012 Nov 12. PubMed
Host cell autophagy modulates early stages of adenovirus infections in airway epithelial cells. Zeng X, Carlin CR. J Virol. 2013 Feb;87(4):2307-19. doi: 10.1128/JVI.02014-12. Epub 2012 Dec 12. PubMed
Detection of the HIV-1 minus-strand-encoded antisense protein and its association with autophagy. Torresilla C, Larocque E, Landry S, Halin M, Coulombe Y, Masson JY, Mesnard JM, Barbeau B. J Virol. 2013 May;87(9):5089-105. doi: 10.1128/JVI.00225-13. Epub 2013 Feb 20. PubMed
Novel anti-glioblastoma agents and therapeutic combinations identified from a collection of FDA approved drugs. Jiang P, Mukthavaram R, Chao Y, Bharati IS, Fogal V, Pastorino S, Cong X, Nomura N, Gallagher M, Abbasi T, Vali S, Pingle SC, Makale M, Kesari S. J Transl Med. 2014 Jan 17;12:13. doi: 10.1186/1479-5876-12-13. PubMed
Mitophagy enhances oncolytic measles virus replication by mitigating DDX58/RIG-I-like receptor signaling. Xia M, Gonzalez P, Li C, Meng G, Jiang A, Wang H, Gao Q, Debatin KM, Beltinger C, Wei J. J Virol. 2014 May;88(9):5152-64. doi: 10.1128/JVI.03851-13. Epub 2014 Feb 26. PubMed
Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells. Klose J, Stankov MV, Kleine M, Ramackers W, Panayotova-Dimitrova D, Jager MD, Klempnauer J, Winkler M, Bektas H, Behrens GM, Vondran FW. PLoS One. 2014 May 9;9(5):e95970. doi: 10.1371/journal.pone.0095970. eCollection 2014. PubMed
Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. J Infect Dis. 2014 Dec 1;210(11):1844-54. doi: 10.1093/infdis/jiu290. Epub 2014 May 19. PubMed
The diabetes susceptibility gene Clec16a regulates mitophagy. Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA. Cell. 2014 Jun 19;157(7):1577-90. doi: 10.1016/j.cell.2014.05.016. PubMed
Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Xia M, Meng G, Jiang A, Chen A, Dahlhaus M, Gonzalez P, Beltinger C, Wei J. Oncotarget. 2014 Jun 15;5(11):3907-18. PubMed
Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells. Meng G, Xia M, Wang D, Chen A, Wang Y, Wang H, Yu D, Wei J. Oncotarget. 2014 Aug 15;5(15):6365-74. PubMed
Rab17-mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion. Haobam B, Nozawa T, Minowa-Nozawa A, Tanaka M, Oda S, Watanabe T, Aikawa C, Maruyama F, Nakagawa I. Cell Microbiol. 2014 Dec;16(12):1806-21. doi: 10.1111/cmi.12329. Epub 2014 Aug 30. PubMed
Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Nature. 2014 Oct 30;514(7524):628-32. doi: 10.1038/nature13611. Epub 2014 Aug 10. PubMed
Reorganization of the endosomal system in Salmonella-infected cells: the ultrastructure of Salmonella-induced tubular compartments. Krieger V, Liebl D, Zhang Y, Rajashekar R, Chlanda P, Giesker K, Chikkaballi D, Hensel M. PLoS Pathog. 2014 Sep 25;10(9):e1004374. doi: 10.1371/journal.ppat.1004374. eCollection 2014 Sep. PubMed
Autophagy-independent senescence and genome instability driven by targeted telomere dysfunction. Mar FA, Debnath J, Stohr BA. Autophagy. 2015;11(3):527-37. doi: 10.1080/15548627.2015.1017189. PubMed
Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. Sun T, Li X, Zhang P, Chen WD, Zhang HL, Li DD, Deng R, Qian XJ, Jiao L, Ji J, Li YT, Wu RY, Yu Y, Feng GK, Zhu XF. Nat Commun. 2015 May 26;6:7215. doi: 10.1038/ncomms8215. PubMed
Cocaine-mediated microglial activation involves the ER stress-autophagy axis. Guo ML, Liao K, Periyasamy P, Yang L, Cai Y, Callen SE, Buch S. Autophagy. 2015;11(7):995-1009. doi: 10.1080/15548627.2015.1052205. PubMed
Diabetes susceptibility genes Pdx1 and Clec16a function in a pathway regulating mitophagy in beta-cells. Soleimanpour SA, Ferrari AM, Raum JC, Groff DN, Yang J, Kaufman BA, Stoffers DA. Diabetes. 2015 Jun 17. pii: db150376. PubMed
KLF4-SQSTM1/p62-associated prosurvival autophagy contributes to carfilzomib resistance in multiple myeloma models. Riz I, Hawley TS, Hawley RG. Oncotarget. 2015 Jun 20;6(17):14814-31. PubMed
The crucial role of vitamin C and its transporter (SVCT2) in bone marrow stromal cell autophagy and apoptosis. Sangani R, Periyasamy-Thandavan S, Pathania R, Ahmad S, Kutiyanawalla A, Kolhe R, Bhattacharyya MH, Chutkan N, Hunter M, Hill WD, Hamrick M, Isales C, Fulzele S. Stem Cell Res. 2015 Jun 10;15(2):312-321. doi: 10.1016/j.scr.2015.06.002. PubMed
Licochalcone A induces autophagy through PI3K/Akt/mTOR inactivation and autophagy suppression enhances Licochalcone A-induced apoptosis of human cervical cancer cells. Tsai JP, Lee CH, Ying TH, Lin CL, Lin CL, Hsueh JT, Hsieh YH. Oncotarget. 2015 Oct 6;6(30):28851-66. doi: 10.18632/oncotarget.4767. PubMed
GSK-3beta controls autophagy by modulating LKB1-AMPK pathway in prostate cancer cells. Sun A, Li C, Chen R, Huang Y, Chen Q, Cui X, Liu H, Thrasher JB, Li B. Prostate. 2016 Feb;76(2):172-83. doi: 10.1002/pros.23106. Epub 2015 Oct 6. PubMed
Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells. Liu XY, He YJ, Yang QH, Huang W, Liu ZH, Ye GR, Tang SH, Shu JC. Am J Cancer Res. 2015 Aug 15;5(9):2569-89. eCollection 2015. PubMed
Dual inhibition of Type I and Type III PI3 kinases increases tumor cell apoptosis in HER2+ breast cancers. Young CD, Arteaga CL, Cook RS. Breast Cancer Res. 2015 Dec 4;17:148. doi: 10.1186/s13058-015-0656-2. PubMed
Lanatoside C suppressed colorectal cancer cell growth by inducing mitochondrial dysfunction and increased radiation sensitivity by impairing DNA damage repair. Kang MA, Kim MS, Kim W, Um JH, Shin YJ, Song JY, Jeong JH. Oncotarget. 2016 Feb 2;7(5):6074-87. doi: 10.18632/oncotarget.6832. PubMed
NBR1 enables autophagy-dependent focal adhesion turnover. Kenific CM, Stehbens SJ, Goldsmith J, Leidal AM, Faure N, Ye J, Wittmann T, Debnath J. J Cell Biol. 2016 Feb 29;212(5):577-590. Epub 2016 Feb 22. PubMed

Associated Plasmids

JNK1 INHIBITION ATTENUATES HYPOXIA-INDUCED AUTOPHAGY AND SENSITIZES TO CHEMOTHERAPY. Vasilevskaya IA, Selvakumaran M, Roberts D, O'Dwyer PJ. Mol Cancer Res. 2016 May 23. pii: molcanres.0035.2016. PubMed
Berberine induces autophagy in glioblastoma by targeting the AMPK/mTOR/ULK1-pathway. Wang J, Qi Q, Feng Z, Zhang X, Huang B, Chen A, Prestegarden L, Li X, Wang J. Oncotarget. 2016 Oct 11;7(41):66944-66958. doi: 10.18632/oncotarget.11396. PubMed
Autophagy mediates proteolysis of NPM1 and HEXIM1 and sensitivity to BET inhibition in AML cells. Huang M, Garcia JS, Thomas D, Zhu L, Nguyen LX, Chan SM, Majeti R, Medeiros BC, Mitchell BS. Oncotarget. 2016 Nov 15;7(46):74917-74930. doi: 10.18632/oncotarget.12493. PubMed
Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration. Yao J, Jia L, Feathers K, Lin C, Khan NW, Klionsky DJ, Ferguson TA, Zacks DN. Autophagy. 2016 Dec;12(12):2439-2450. Epub 2016 Oct 18. PubMed
Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Biochem Biophys Res Commun. 2017 Jan 22;482(4):1334-1340. doi: 10.1016/j.bbrc.2016.12.037. Epub 2016 Dec 7. PubMed
Endosomal sorting and c-Cbl targeting of paxillin to autophagosomes regulate cell-matrix adhesion turnover in human breast cancer cells. Chang CH, Bijian K, Qiu D, Su J, Saad A, Dahabieh MS, Miller WH Jr, Alaoui-Jamali MA. Oncotarget. 2017 May 9;8(19):31199-31214. doi: 10.18632/oncotarget.16105. PubMed
Autophagy plays a role in FSTL1-induced epithelial mesenchymal transition and airway remodeling in asthma. Liu T, Liu Y, Miller M, Cao L, Zhao J, Wu J, Wang J, Liu L, Li S, Zou M, Xu J, Broide DH, Dong L. Am J Physiol Lung Cell Mol Physiol. 2017 Jul 1;313(1):L27-L40. doi: 10.1152/ajplung.00510.2016. Epub 2017 May 4. PubMed
SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, Shi L, Zhang S, Li Z, Yang C, Zhang J, Xie C. Oncol Rep. 2017 Jun;37(6):3449-3458. doi: 10.3892/or.2017.5635. Epub 2017 May 10. PubMed
Rab35 GTPase recruits NDP52 to autophagy targets. Minowa-Nozawa A, Nozawa T, Okamoto-Furuta K, Kohda H, Nakagawa I. EMBO J. 2017 Sep 15;36(18):2790-2807. doi: 10.15252/embj.201796463. Epub 2017 Aug 28. PubMed
NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, Lin B, Wang G, Wang Z, Sun W, Sun M, Chang S, Cai Z, Hua Y. Cell Death Dis. 2017 Sep 14;8(9):e3048. doi: 10.1038/cddis.2017.438. PubMed
Beclin 1 acetylation impairs the anticancer effect of aspirin in colorectal cancer cells. Sun T, Ming L, Yan Y, Zhang Y, Xue H. Oncotarget. 2017 Aug 19;8(43):74781-74790. doi: 10.18632/oncotarget.20367. eCollection 2017 Sep 26. PubMed
TGF-beta2 initiates autophagy via Smad and non-Smad pathway to promote glioma cells' invasion. Zhang C, Zhang X, Xu R, Huang B, Chen AJ, Li C, Wang J, Li XG. J Exp Clin Cancer Res. 2017 Nov 16;36(1):162. doi: 10.1186/s13046-017-0628-8. PubMed
Clec16a, Nrdp1, and USP8 Form a Ubiquitin-Dependent Tripartite Complex That Regulates beta-Cell Mitophagy. Pearson G, Chai B, Vozheiko T, Liu X, Kandarpa M, Piper RC, Soleimanpour SA. Diabetes. 2018 Feb;67(2):265-277. doi: 10.2337/db17-0321. Epub 2017 Nov 27. PubMed
Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. Li M, Li J, Zeng R, Yang J, Liu J, Zhang Z, Song X, Yao Z, Ma C, Li W, Wang K, Wei L. J Virol. 2018 Mar 28;92(8). pii: JVI.02193-17. doi: 10.1128/JVI.02193-17. Print 2018 Apr 15. PubMed
Lipin-1 determines lung cancer cell survival and chemotherapy sensitivity by regulation of endoplasmic reticulum homeostasis and autophagy. Fan X, Weng Y, Bai Y, Wang Z, Wang S, Zhu J, Zhang F. Cancer Med. 2018 Jun;7(6):2541-2554. doi: 10.1002/cam4.1483. Epub 2018 Apr 16. PubMed
Combining high-pressure freezing with pre-embedding immunogold electron microscopy and tomography. Hess MW, Vogel GF, Yordanov TE, Witting B, Gutleben K, Ebner HL, de Araujo MEG, Filipek PA, Huber LA. Traffic. 2018 Aug;19(8):639-649. doi: 10.1111/tra.12575. Epub 2018 May 21. PubMed
Transcriptional and epigenetic modulation of autophagy promotes EBV oncoprotein EBNA3C induced B-cell survival. Bhattacharjee S, Bose P, Patel K, Roy SG, Gain C, Gowda H, Robertson ES, Saha A. Cell Death Dis. 2018 May 22;9(6):605. doi: 10.1038/s41419-018-0668-9. PubMed
Autophagy promotes the survival of dormant breast cancer cells and metastatic tumour recurrence. Vera-Ramirez L, Vodnala SK, Nini R, Hunter KW, Green JE. Nat Commun. 2018 May 22;9(1):1944. doi: 10.1038/s41467-018-04070-6. PubMed
The proton pump inhibitor pantoprazole disrupts protein degradation systems and sensitizes cancer cells to death under various stresses. Cao Y, Chen M, Tang D, Yan H, Ding X, Zhou F, Zhang M, Xu G, Zhang W, Zhang S, Zhuge Y, Wang L, Zou X. Cell Death Dis. 2018 May 22;9(6):604. doi: 10.1038/s41419-018-0642-6. PubMed
Monitoring and Measuring Mammalian Autophagy. Bhutia SK, Praharaj PP, Bhol CS, Panigrahi DP, Mahapatra KK, Patra S, Saha S, Das DN, Mukhopadhyay S, Sinha N, Panda PK, Naik PP. Methods Mol Biol. 2019;1854:209-222. doi: 10.1007/7651_2018_159. PubMed
Loss of the ubiquitin conjugating enzyme UBE2E3 induces cellular senescence. Plafker KS, Zyla K, Berry W, Plafker SM. Redox Biol. 2018 Jul;17:411-422. doi: 10.1016/j.redox.2018.05.008. Epub 2018 May 21. PubMed
Adenosine 5'-monophosphate-activated protein kinase-dependent mTOR pathway is involved in flavokawain B-induced autophagy in thyroid cancer cells. He Q, Liu W, Sha S, Fan S, Yu Y, Chen L, Dong M. Cancer Sci. 2018 Aug;109(8):2576-2589. doi: 10.1111/cas.13699. Epub 2018 Jul 20. PubMed
Heterogeneity in pneumolysin expression governs the fate of Streptococcus pneumoniae during blood-brain barrier trafficking. Surve MV, Bhutda S, Datey A, Anil A, Rawat S, Pushpakaran A, Singh D, Kim KS, Chakravortty D, Banerjee A. PLoS Pathog. 2018 Jul 16;14(7):e1007168. doi: 10.1371/journal.ppat.1007168. eCollection 2018 Jul. PubMed
Zidovudine-Mediated Autophagy Inhibition Enhances Mitochondrial Toxicity in Muscle Cells. Lin H, Stankov MV, Hegermann J, Budida R, Panayotova-Dimitrova D, Schmidt RE, Behrens GMN. Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: AAC.01443-18. doi: 10.1128/AAC.01443-18. Print 2019 Jan. PubMed
p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. Cancer Cell. 2019 Feb 11;35(2):204-220.e9. doi: 10.1016/j.ccell.2019.01.006. PubMed
Iron-Induced Apoptotic Cell Death and Autophagy Dysfunction in Human Neuroblastoma Cell Line SH-SY5Y. Rakshit J, Mallick A, Roy S, Sarbajna A, Dutta M, Bandyopadhyay J. Biol Trace Elem Res. 2019 Mar 5. pii: 10.1007/s12011-019-01679-6. doi: 10.1007/s12011-019-01679-6. PubMed
IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration. Guha P, Tyagi R, Chowdhury S, Reilly L, Fu C, Xu R, Resnick AC, Snyder SH. Cell Rep. 2019 Mar 5;26(10):2692-2703.e7. doi: 10.1016/j.celrep.2019.02.013. PubMed
Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog. Yao N, Wang C, Hu N, Li Y, Liu M, Lei Y, Chen M, Chen L, Chen C, Lan P, Chen W, Chen Z, Fu D, Ye W, Zhang D. Cell Death Dis. 2019 Mar 8;10(3):232. doi: 10.1038/s41419-019-1470-z. PubMed
Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits Ca(2+) influx in mitosis. Yu F, Hubrack SZ, Chakraborty S, Sun L, Alcantara-Adap E, Kulkarni R, Billing AM, Graumann J, Taylor CW, Machaca K. Proc Natl Acad Sci U S A. 2019 May 21;116(21):10392-10401. doi: 10.1073/pnas.1821399116. Epub 2019 May 7. PubMed
Beclin1 Modulates Bone Homeostasis by Regulating Osteoclast and Chondrocyte Differentiation. Arai A, Kim S, Goldshteyn V, Kim T, Park NH, Wang CY, Kim RH. J Bone Miner Res. 2019 May 10. doi: 10.1002/jbmr.3756. PubMed
Emodin-induced autophagy against cell apoptosis through the PI3K/AKT/mTOR pathway in human hepatocytes. Zheng XY, Yang SM, Zhang R, Wang SM, Li GB, Zhou SW. Drug Des Devel Ther. 2019 Sep 3;13:3171-3180. doi: 10.2147/DDDT.S204958. eCollection 2019. PubMed
The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles. Leidal AM, Huang HH, Marsh T, Solvik T, Zhang D, Ye J, Kai F, Goldsmith J, Liu JY, Huang YH, Monkkonen T, Vlahakis A, Huang EJ, Goodarzi H, Yu L, Wiita AP, Debnath J. Nat Cell Biol. 2020 Feb;22(2):187-199. doi: 10.1038/s41556-019-0450-y. Epub 2020 Jan 13. PubMed
Proteasomal inhibition triggers viral oncoprotein degradation via autophagy-lysosomal pathway. Gain C, Malik S, Bhattacharjee S, Ghosh A, Robertson ES, Das BB, Saha A. PLoS Pathog. 2020 Feb 24;16(2):e1008105. doi: 10.1371/journal.ppat.1008105. eCollection 2020 Feb. PubMed
Studies of Non-Protective Autophagy Provide Evidence that Recovery from Therapy-Induced Senescence is Independent of Early Autophagy. Saleh T, Tyutyunyk-Massey L, Patel NH, Cudjoe EK Jr, Alotaibi M, Gewirtz DA. Int J Mol Sci. 2020 Feb 20;21(4). pii: ijms21041427. doi: 10.3390/ijms21041427. PubMed
Microtubule disrupting agent-mediated inhibition of cancer cell growth is associated with blockade of autophagic flux and simultaneous induction of apoptosis. Hasanain M, Sahai R, Pandey P, Maheshwari M, Choyal K, Gandhi D, Singh A, Singh K, Mitra K, Datta D, Sarkar J. Cell Prolif. 2020 Apr;53(4):e12749. doi: 10.1111/cpr.12749. Epub 2020 Mar 13. PubMed
BRCA1 Deficiency Impairs Mitophagy and Promotes Inflammasome Activation and Mammary Tumor Metastasis. Chen Q, Lei JH, Bao J, Wang H, Hao W, Li L, Peng C, Masuda T, Miao K, Xu J, Xu X, Deng CX. Adv Sci (Weinh). 2020 Feb 14;7(6):1903616. doi: 10.1002/advs.201903616. eCollection 2020 Mar. PubMed
Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Nat Cell Biol. 2020 Apr;22(4):412-424. doi: 10.1038/s41556-020-0481-4. Epub 2020 Mar 16. PubMed
PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. Park JH, Park SA, Lee YJ, Park HW, Oh SM. FEBS Open Bio. 2020 May;10(5):937-950. doi: 10.1002/2211-5463.12855. Epub 2020 Apr 14. PubMed
Trichoplein binds PCM1 and controls endothelial cell function by regulating autophagy. Martello A, Lauriola A, Mellis D, Parish E, Dawson JC, Imrie L, Vidmar M, Gammoh N, Mitic T, Brittan M, Mills NL, Carragher NO, D'Arca D, Caporali A. EMBO Rep. 2020 Jul 3;21(7):e48192. doi: 10.15252/embr.201948192. Epub 2020 Apr 26. PubMed
Mesenchymal stem cell-derived exosomes exert ameliorative effects in type 2 diabetes by improving hepatic glucose and lipid metabolism via enhancing autophagy. He Q, Wang L, Zhao R, Yan F, Sha S, Cui C, Song J, Hu H, Guo X, Yang M, Cui Y, Sun Y, Sun Z, Liu F, Dong M, Hou X, Chen L. Stem Cell Res Ther. 2020 Jun 8;11(1):223. doi: 10.1186/s13287-020-01731-6. PubMed
Androgen receptor-induced integrin alpha6beta1 and Bnip3 promote survival and resistance to PI3K inhibitors in castration-resistant prostate cancer. Nollet EA, Cardo-Vila M, Ganguly SS, Tran JD, Schulz VV, Cress A, Corey E, Miranti CK. Oncogene. 2020 Jul;39(31):5390-5404. doi: 10.1038/s41388-020-1370-9. Epub 2020 Jun 21. PubMed
Hederagenin potentiated cisplatin- and paclitaxel-mediated cytotoxicity by impairing autophagy in lung cancer cells. Wang K, Liu X, Liu Q, Ho IH, Wei X, Yin T, Zhan Y, Zhang W, Zhang W, Chen B, Gu J, Tan Y, Zhang L, Chan MT, Wu WK, Du B, Xiao J. Cell Death Dis. 2020 Aug 13;11(8):611. doi: 10.1038/s41419-020-02880-5. PubMed
LY6D-induced macropinocytosis as a survival mechanism of senescent cells. Nagano T, Iwasaki T, Onishi K, Awai Y, Terachi A, Kuwaba S, Asano S, Katasho R, Nagai K, Nakashima A, Kikkawa U, Kamada S. J Biol Chem. 2021 Jan-Jun;296:100049. doi: 10.1074/jbc.RA120.013500. Epub 2020 Nov 24. PubMed
Homoharringtonine Exerts an Antimyeloma Effect by Promoting Excess Parkin-Dependent Mitophagy. Zhang Y, Huang N, Xu J, Zheng W, Cui X. Drug Des Devel Ther. 2020 Nov 5;14:4749-4763. doi: 10.2147/DDDT.S279054. eCollection 2020. PubMed
BIX-01294, a G9a inhibitor, suppresses cell proliferation by inhibiting autophagic flux in nasopharyngeal carcinoma cells. Li Q, Wang L, Ji D, Bao X, Tan G, Liang X, Deng P, Pi H, Lu Y, Chen C, He M, Zhang L, Zhou Z, Yu Z, Deng A. Invest New Drugs. 2021 Jun;39(3):686-696. doi: 10.1007/s10637-020-01053-7. Epub 2021 Jan 2. PubMed
Role and dynamics of vacuolar pH during cell-in-cell mediated death. Su Y, Ren H, Tang M, Zheng Y, Zhang B, Wang C, Hou X, Niu Z, Wang Z, Gao X, Gao L, Jiang H, Chen Z, Luo T, Sun Q. Cell Death Dis. 2021 Jan 22;12(1):119. doi: 10.1038/s41419-021-03396-2. PubMed
BNIP3 promotes HIF-1alpha-driven melanoma growth by curbing intracellular iron homeostasis. Vara-Perez M, Rossi M, Van den Haute C, Maes H, Sassano ML, Venkataramani V, Michalke B, Romano E, Rillaerts K, Garg AD, Schepkens C, Bosisio FM, Wouters J, Oliveira AI, Vangheluwe P, Annaert W, Swinnen JV, Colet JM, van den Oord JJ, Fendt SM, Mazzone M, Agostinis P. EMBO J. 2021 May 17;40(10):e106214. doi: 10.15252/embj.2020106214. Epub 2021 May 1. PubMed
The autophagy protein Becn1 improves insulin sensitivity by promoting adiponectin secretion via exocyst binding. Kuramoto K, Kim YJ, Hong JH, He C. Cell Rep. 2021 May 25;35(8):109184. doi: 10.1016/j.celrep.2021.109184. PubMed
Mitochondrial Ca(2+) oscillation induces mitophagy initiation through the PINK1-Parkin pathway. Yu Z, Wang H, Tang W, Wang S, Tian X, Zhu Y, He H. Cell Death Dis. 2021 Jun 19;12(7):632. doi: 10.1038/s41419-021-03913-3. PubMed
Axotomy Induces Drp1-Dependent Fragmentation of Axonal Mitochondria. Kedra J, Lin S, Pacheco A, Gallo G, Smith GM. Front Mol Neurosci. 2021 Jun 3;14:668670. doi: 10.3389/fnmol.2021.668670. eCollection 2021. PubMed
GRASP55 restricts early-stage autophagy and regulates spatial organization of the early secretory network. Liu JY, Lin YT, Leidal AM, Huang HH, Ye J, Wiita AP, Debnath J. Biol Open. 2021 Oct 15;10(10). pii: 272216. doi: 10.1242/bio.058736. Epub 2021 Oct 12. PubMed
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