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Mfn2-Myc Citations (18)

Originally described in: Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development.
Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC J Cell Biol. 2003 Jan 20. 160(2):189-200.
PubMed Journal

Articles Citing Mfn2-Myc

Articles
Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. Martorell-Riera A, Segarra-Mondejar M, Munoz JP, Ginet V, Olloquequi J, Perez-Clausell J, Palacin M, Reina M, Puyal J, Zorzano A, Soriano FX. EMBO J. 2014 Oct 16;33(20):2388-407. doi: 10.15252/embj.201488327. Epub 2014 Aug 21. PubMed
Sirtuin 1 suppresses mitochondrial dysfunction of ischemic mouse livers in a mitofusin 2-dependent manner. Biel TG, Lee S, Flores-Toro JA, Dean JW, Go KL, Lee MH, Law BK, Law ME, Dunn WA Jr, Zendejas I, Behrns KE, Kim JS. Cell Death Differ. 2016 Feb;23(2):279-90. doi: 10.1038/cdd.2015.96. Epub 2015 Jul 17. PubMed
p38 MAP kinase-dependent phosphorylation of the Gp78 E3 ubiquitin ligase controls ER-mitochondria association and mitochondria motility. Li L, Gao G, Shankar J, Joshi B, Foster LJ, Nabi IR. Mol Biol Cell. 2015 Nov 1;26(21):3828-40. doi: 10.1091/mbc.E15-02-0120. Epub 2015 Sep 2. PubMed
DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites. Norkett R, Modi S, Birsa N, Atkin TA, Ivankovic D, Pathania M, Trossbach SV, Korth C, Hirst WD, Kittler JT. J Biol Chem. 2016 Jan 8;291(2):613-29. doi: 10.1074/jbc.M115.699447. Epub 2015 Nov 9. PubMed
A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. Mattie S, Riemer J, Wideman JG, McBride HM. J Cell Biol. 2018 Feb 5;217(2):507-515. doi: 10.1083/jcb.201611194. Epub 2017 Dec 6. PubMed
Mitochondria Restrict Growth of the Intracellular Parasite Toxoplasma gondii by Limiting Its Uptake of Fatty Acids. Pernas L, Bean C, Boothroyd JC, Scorrano L. Cell Metab. 2018 Apr 3;27(4):886-897.e4. doi: 10.1016/j.cmet.2018.02.018. PubMed
Loss of sirtuin 1 and mitofusin 2 contributes to enhanced ischemia/reperfusion injury in aged livers. Chun SK, Lee S, Flores-Toro J, U RY, Yang MJ, Go KL, Biel TG, Miney CE, Pierre Louis S, Law BK, Law ME, Thomas EM, Behrns KE, Leeuwenburgh C, Kim JS. Aging Cell. 2018 May 17:e12761. doi: 10.1111/acel.12761. PubMed
Inhibition of ERK-Drp1 signaling and mitochondria fragmentation alleviates IGF-IIR-induced mitochondria dysfunction during heart failure. Huang CY, Lai CH, Kuo CH, Chiang SF, Pai PY, Lin JY, Chang CF, Viswanadha VP, Kuo WW, Huang CY. J Mol Cell Cardiol. 2018 Sep;122:58-68. doi: 10.1016/j.yjmcc.2018.08.006. Epub 2018 Aug 9. PubMed
Amyloid beta Peptide Compromises Neural Stem Cell Fate by Irreversibly Disturbing Mitochondrial Oxidative State and Blocking Mitochondrial Biogenesis and Dynamics. Ribeiro MF, Genebra T, Rego AC, Rodrigues CMP, Sola S. Mol Neurobiol. 2018 Sep 18. pii: 10.1007/s12035-018-1342-z. doi: 10.1007/s12035-018-1342-z. PubMed
MTCH2-mediated mitochondrial fusion drives exit from naive pluripotency in embryonic stem cells. Bahat A, Goldman A, Zaltsman Y, Khan DH, Halperin C, Amzallag E, Krupalnik V, Mullokandov M, Silberman A, Erez A, Schimmer AD, Hanna JH, Gross A. Nat Commun. 2018 Dec 3;9(1):5132. doi: 10.1038/s41467-018-07519-w. PubMed
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice. Shen M, Wang F, Li M, Sah N, Stockton ME, Tidei JJ, Gao Y, Korabelnikov T, Kannan S, Vevea JD, Chapman ER, Bhattacharyya A, van Praag H, Zhao X. Nat Neurosci. 2019 Mar;22(3):386-400. doi: 10.1038/s41593-019-0338-y. Epub 2019 Feb 11. PubMed

Associated Plasmids

Morphological control of mitochondria as the novel mechanism of Gastrodia elata in attenuating mutant huntingtin-induced protein aggregations. Huang NK, Lin CC, Lin YL, Huang CL, Chiou CT, Lee YC, Lee SY, Huang HT, Yang YC. Phytomedicine. 2019 Jun;59:152756. doi: 10.1016/j.phymed.2018.11.016. Epub 2018 Nov 14. PubMed
Lysosomal Regulation of Inter-mitochondrial Contact Fate and Motility in Charcot-Marie-Tooth Type 2. Wong YC, Peng W, Krainc D. Dev Cell. 2019 Aug 5;50(3):339-354.e4. doi: 10.1016/j.devcel.2019.05.033. Epub 2019 Jun 20. PubMed
MIGA2 Links Mitochondria, the ER, and Lipid Droplets and Promotes De Novo Lipogenesis in Adipocytes. Freyre CAC, Rauher PC, Ejsing CS, Klemm RW. Mol Cell. 2019 Dec 5;76(5):811-825.e14. doi: 10.1016/j.molcel.2019.09.011. Epub 2019 Oct 15. PubMed
The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca(2+)-NFATc1 axis. Ballard A, Zeng R, Zarei A, Shao C, Cox L, Yan H, Franco A, Dorn GW 2nd, Faccio R, Veis DJ. J Biol Chem. 2020 May 8;295(19):6629-6640. doi: 10.1074/jbc.RA119.012023. Epub 2020 Mar 12. PubMed
Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological alpha-synuclein. Chung E, Choi Y, Park J, Nah W, Park J, Jung Y, Lee J, Lee H, Park S, Hwang S, Kim S, Lee J, Min D, Jo J, Kang S, Jung M, Lee PH, Ruley HE, Jo D. Sci Adv. 2020 Apr 29;6(18):eaba1193. doi: 10.1126/sciadv.aba1193. eCollection 2020 May. PubMed
Neuronal metabolic rewiring promotes resilience to neurodegeneration caused by mitochondrial dysfunction. Motori E, Atanassov I, Kochan SMV, Folz-Donahue K, Sakthivelu V, Giavalisco P, Toni N, Puyal J, Larsson NG. Sci Adv. 2020 Aug 28;6(35):eaba8271. doi: 10.1126/sciadv.aba8271. eCollection 2020 Aug. PubMed
Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells. Wang Y, Troughton LD, Xu F, Chatterjee A, Ding C, Zhao H, Cifuentes LP, Wagner RB, Wang T, Tan S, Chen J, Li L, Umulis D, Kuang S, Suter DM, Yuan C, Chan D, Huang F, Oakes PW, Deng Q. Elife. 2023 Sep 19;12:e88828. doi: 10.7554/eLife.88828. PubMed

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