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pcDNA3.1-p300 Citations (37)

Originally described in: Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB.
Chen LF, Mu Y, Greene WC EMBO J. 2002 Dec 2. 21(23):6539-48.
PubMed Journal

Articles Citing pcDNA3.1-p300

Aurora B interacts with NIR-p53, leading to p53 phosphorylation in its DNA-binding domain and subsequent functional suppression. Wu L, Ma CA, Zhao Y, Jain A. J Biol Chem. 2011 Jan 21;286(3):2236-44. doi: 10.1074/jbc.M110.174755. Epub 2010 Oct 19. PubMed
Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation. Fatoba ST, Tognetti S, Berto M, Leo E, Mulvey CM, Godovac-Zimmermann J, Pommier Y, Okorokov AL. Nucleic Acids Res. 2013 Apr;41(7):4065-79. doi: 10.1093/nar/gkt131. Epub 2013 Feb 28. PubMed
p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. Gao B, Xu W, Zhong L, Zhang Q, Su Y, Xiong S. Eur J Immunol. 2013 Aug;43(8):2174-84. doi: 10.1002/eji.201343308. Epub 2013 Jun 12. PubMed
Distinct roles for CBP and p300 on the RA-mediated expression of the meiosis commitment gene Stra8 in mouse embryonic stem cells. Chen W, Jia W, Wang K, Si X, Zhu S, Duan T, Kang J. PLoS One. 2013 Jun 13;8(6):e66076. doi: 10.1371/journal.pone.0066076. Print 2013. PubMed
ERK5 inhibition ameliorates pulmonary fibrosis via regulating Smad3 acetylation. Kim S, Lim JH, Woo CH. Am J Pathol. 2013 Dec;183(6):1758-68. doi: 10.1016/j.ajpath.2013.08.014. Epub 2013 Oct 1. PubMed
Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a single lysine on TIP60. Xiao Y, Nagai Y, Deng G, Ohtani T, Zhu Z, Zhou Z, Zhang H, Ji MQ, Lough JW, Samanta A, Hancock WW, Greene MI. Cell Rep. 2014 Jun 12;7(5):1471-80. doi: 10.1016/j.celrep.2014.04.021. Epub 2014 May 15. PubMed
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Hilton IB, D'Ippolito AM, Vockley CM, Thakore PI, Crawford GE, Reddy TE, Gersbach CA. Nat Biotechnol. 2015 May;33(5):510-7. doi: 10.1038/nbt.3199. Epub 2015 Apr 6. PubMed

Associated Plasmids

G Protein-Coupled Receptor 40 (GPR40) and Peroxisome Proliferator-Activated Receptor gamma (PPARgamma): An Integrated Two-Receptor Signaling Pathway. Wang S, Awad KS, Elinoff JM, Dougherty EJ, Ferreyra GA, Wang JY, Cai R, Sun J, Ptasinska A, Danner RL. J Biol Chem. 2015 Jun 23. pii: jbc.M115.638924. PubMed
Targeting p300 Addiction in CBP-Deficient Cancers Causes Synthetic Lethality by Apoptotic Cell Death due to Abrogation of MYC Expression. Ogiwara H, Sasaki M, Mitachi T, Oike T, Higuchi S, Tominaga Y, Kohno T. Cancer Discov. 2016 Apr;6(4):430-45. doi: 10.1158/2159-8290.CD-15-0754. Epub 2015 Nov 24. PubMed
Acetylation of glucokinase regulatory protein decreases glucose metabolism by suppressing glucokinase activity. Park JM, Kim TH, Jo SH, Kim MY, Ahn YH. Sci Rep. 2015 Dec 1;5:17395. doi: 10.1038/srep17395. PubMed
Acetylation of lysine 109 modulates pregnane X receptor DNA binding and transcriptional activity. Pasquel D, Doricakova A, Li H, Kortagere S, Krasowski MD, Biswas A, Walton WG, Redinbo MR, Dvorak Z, Mani S. Biochim Biophys Acta. 2016 Sep;1859(9):1155-69. doi: 10.1016/j.bbagrm.2016.01.006. Epub 2016 Feb 23. PubMed
Acetylation regulates DNA repair mechanisms in human cells. Piekna-Przybylska D, Bambara RA, Balakrishnan L. Cell Cycle. 2016 Jun 2;15(11):1506-17. doi: 10.1080/15384101.2016.1176815. Epub 2016 Apr 22. PubMed
Wnt/beta-catenin-dependent acetylation of Pygo2 by CBP/p300 histone acetyltransferase family members. Andrews PG, Kao KR. Biochem J. 2016 Nov 15;473(22):4193-4203. Epub 2016 Sep 19. PubMed
The roles of p300 and CREB in high glucose induced HIF-1alpha inactivation under hypoxia condition. Ding L, Yang M, Zhao T, Lv G. J Diabetes Investig. 2016 Nov 3. doi: 10.1111/jdi.12592. PubMed
Tumour suppressor EP300, a modulator of paclitaxel resistance and stemness, is downregulated in metaplastic breast cancer. Asaduzzaman M, Constantinou S, Min H, Gallon J, Lin ML, Singh P, Raguz S, Ali S, Shousha S, Coombes RC, Lam EW, Hu Y, Yague E. Breast Cancer Res Treat. 2017 Jun;163(3):461-474. doi: 10.1007/s10549-017-4202-z. Epub 2017 Mar 24. PubMed
Hypoxia reduces HNF4alpha/MODY1 protein expression in pancreatic beta-cells by activating AMP-activated protein kinase. Sato Y, Tsuyama T, Sato C, Karim MF, Yoshizawa T, Inoue M, Yamagata K. J Biol Chem. 2017 May 26;292(21):8716-8728. doi: 10.1074/jbc.M116.767574. Epub 2017 Mar 31. PubMed
Hyper-O-GlcNAcylation activates nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) signaling through interplay with phosphorylation and acetylation. Ma Z, Chalkley RJ, Vosseller K. J Biol Chem. 2017 Jun 2;292(22):9150-9163. doi: 10.1074/jbc.M116.766568. Epub 2017 Apr 17. PubMed
Alterations of Histone Modifications Contribute to Pregnane X Receptor-Mediated Induction of CYP3A4 by Rifampicin. Yan L, Wang Y, Liu J, Nie Y, Zhong XB, Kan Q, Zhang L. Mol Pharmacol. 2017 Aug;92(2):113-123. doi: 10.1124/mol.117.108225. Epub 2017 May 25. PubMed
Histone modifications affect differential regulation of TGFbeta- induced NADPH oxidase 4 (NOX4) by wild-type and mutant p53. Boudreau HE, Ma WF, Korzeniowska A, Park JJ, Bhagwat MA, Leto TL. Oncotarget. 2017 Jul 4;8(27):44379-44397. doi: 10.18632/oncotarget.17892. PubMed
Inhibiting p53 acetylation reduces cancer chemotoxicity. Zheng S, Koh XY, Goh HC, Rahmat SAB, Hwang LA, Lane DP. Cancer Res. 2017 Jun 27. pii: canres.0424.2017. doi: 10.1158/0008-5472.CAN-17-0424. PubMed
Functional Impact of Chromatin Remodeling Gene Mutations and Predictive Signature for Therapeutic Response in Bladder Cancer. Duex JE, Swain KE, Dancik GM, Paucek RD, Owens C, Churchill MEA, Theodorescu D. Mol Cancer Res. 2018 Jan;16(1):69-77. doi: 10.1158/1541-7786.MCR-17-0260. Epub 2017 Oct 2. PubMed
Gene-specific mechanisms direct glucocorticoid-receptor-driven repression of inflammatory response genes in macrophages. Sacta MA, Tharmalingam B, Coppo M, Rollins DA, Deochand DK, Benjamin B, Yu L, Zhang B, Hu X, Li R, Chinenov Y, Rogatsky I. Elife. 2018 Feb 9;7. pii: 34864. doi: 10.7554/eLife.34864. PubMed
Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A. Son SM, Park SJ, Lee H, Siddiqi F, Lee JE, Menzies FM, Rubinsztein DC. Cell Metab. 2019 Jan 8;29(1):192-201.e7. doi: 10.1016/j.cmet.2018.08.013. Epub 2018 Sep 6. PubMed

Associated Plasmids

Brd4's Bromodomains Mediate Histone H3 Acetylation and Chromatin Remodeling in Pluripotent Cells through P300 and Brg1. Wu T, Kamikawa YF, Donohoe ME. Cell Rep. 2018 Nov 13;25(7):1756-1771. doi: 10.1016/j.celrep.2018.10.003. PubMed
LAP2 Proteins Chaperone GLI1 Movement between the Lamina and Chromatin to Regulate Transcription. Mirza AN, McKellar SA, Urman NM, Brown AS, Hollmig T, Aasi SZ, Oro AE. Cell. 2019 Jan 10;176(1-2):198-212.e15. doi: 10.1016/j.cell.2018.10.054. Epub 2018 Nov 29. PubMed
Muscle A-kinase-anchoring protein-beta-bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D. Li J, Aponte Paris S, Thakur H, Kapiloff MS, Dodge-Kafka KL. J Biol Chem. 2019 Feb 15;294(7):2543-2554. doi: 10.1074/jbc.RA118.005465. Epub 2018 Dec 6. PubMed
Oncogenic EP300 can be targeted with inhibitors of aldo-keto reductases. Mahmud Z, Asaduzzaman M, Kumar U, Masrour N, Jugov R, Coombes RC, Shousha S, Hu Y, Lam EW, Yague E. Biochem Pharmacol. 2019 May;163:391-403. doi: 10.1016/j.bcp.2019.03.009. Epub 2019 Mar 9. PubMed
EP300 and SIRT1/6 Co-Regulate Lapatinib Sensitivity Via Modulating FOXO3-Acetylation and Activity in Breast Cancer. Mahmud Z, Gomes AR, Lee HJ, Aimjongjun S, Jiramongkol Y, Yao S, Zona S, Alasiri G, Gong G, Yague E, Lam EW. Cancers (Basel). 2019 Jul 28;11(8). pii: cancers11081067. doi: 10.3390/cancers11081067. PubMed
p300 mediates the histone acetylation of ORMDL3 to affect airway inflammation and remodeling in asthma. Cheng Q, Shang Y, Huang W, Zhang Q, Li X, Zhou Q. Int Immunopharmacol. 2019 Nov;76:105885. doi: 10.1016/j.intimp.2019.105885. Epub 2019 Sep 16. PubMed
Leucine regulates autophagy via acetylation of the mTORC1 component raptor. Son SM, Park SJ, Stamatakou E, Vicinanza M, Menzies FM, Rubinsztein DC. Nat Commun. 2020 Jun 19;11(1):3148. doi: 10.1038/s41467-020-16886-2. PubMed
Olfactory bulb-targeted quantum dot (QD) bioconjugate and Kv1.3 blocking peptide improve metabolic health in obese male mice. Schwartz AB, Kapur A, Huang Z, Anangi R, Spear JM, Stagg S, Fardone E, Dekan Z, Rosenberg JT, Grant SC, King GF, Mattoussi H, Fadool DA. J Neurochem. 2021 Jun;157(6):1876-1896. doi: 10.1111/jnc.15200. Epub 2020 Oct 20. PubMed
Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells. Chang CC, Liu YC, Lin CH, Liao YC. Biochem Biophys Res Commun. 2021 Jan 1;534:53-58. doi: 10.1016/j.bbrc.2020.12.009. Epub 2020 Dec 10. PubMed
The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization. Li W, Wang Y, Zhu L, Du S, Mao J, Wang Y, Wang S, Bo Q, Tu Y, Yi Q. J Cell Mol Med. 2021 Jul;25(14):6709-6720. doi: 10.1111/jcmm.16673. Epub 2021 May 31. PubMed
Modulating the Excitability of Olfactory Output Neurons Affects Whole-Body Metabolism. Kolling LJ, Tatti R, Lowry T, Loeven AM, Fadool JM, Fadool DA. J Neurosci. 2022 Jul 27;42(30):5966-5990. doi: 10.1523/JNEUROSCI.0190-22.2022. Epub 2022 Jun 16. PubMed
Ep300 sequestration to functionally distinct glucocorticoid receptor binding loci underlie rapid gene activation and repression. Portuguez AS, Grbesa I, Tal M, Deitch R, Raz D, Kliker L, Weismann R, Schwartz M, Loza O, Cohen L, Marchenkov-Flam L, Sung MH, Kaplan T, Hakim O. Nucleic Acids Res. 2022 Jun 17. pii: 6609818. doi: 10.1093/nar/gkac488. PubMed
Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma. Yu D, Liang Y, Kim C, Jaganathan A, Ji D, Han X, Yang X, Jia Y, Gu R, Wang C, Zhang Q, Cheung KL, Zhou MM, Zeng L. Nat Commun. 2023 Jan 24;14(1):378. doi: 10.1038/s41467-023-36063-5. PubMed
Oncogenic KRAS mutation confers chemoresistance by upregulating SIRT1 in non-small cell lung cancer. Shin DH, Jo JY, Choi M, Kim KH, Bae YK, Kim SS. Exp Mol Med. 2023 Oct;55(10):2220-2237. doi: 10.1038/s12276-023-01091-0. Epub 2023 Oct 2. PubMed

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