pCMVHA hEZH2 Citations (29)

Originally described in: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K EMBO J. 2003 Oct 15. 22(20):5323-35. PubMed Journal

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Articles Citing pCMVHA hEZH2

Articles
The TRPM7 chanzyme is cleaved to release a chromatin-modifying kinase. Krapivinsky G, Krapivinsky L, Manasian Y, Clapham DE. Cell. 2014 May 22;157(5):1061-72. doi: 10.1016/j.cell.2014.03.046. PubMed
A long noncoding RNA Sox2ot regulates lung cancer cell proliferation and is a prognostic indicator of poor survival. Hou Z, Zhao W, Zhou J, Shen L, Zhan P, Xu C, Chang C, Bi H, Zou J, Yao X, Huang R, Yu L, Yan J. Int J Biochem Cell Biol. 2014 Aug;53:380-8. doi: 10.1016/j.biocel.2014.06.004. Epub 2014 Jun 10. PubMed
Regulation of p53 and Rb links the alternative NF-kappaB pathway to EZH2 expression and cell senescence. Iannetti A, Ledoux AC, Tudhope SJ, Sellier H, Zhao B, Mowla S, Moore A, Hummerich H, Gewurz BE, Cockell SJ, Jat PS, Willmore E, Perkins ND. PLoS Genet. 2014 Sep 25;10(9):e1004642. doi: 10.1371/journal.pgen.1004642. eCollection 2014 Sep. PubMed
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Koo JW, Mazei-Robison MS, LaPlant Q, Egervari G, Braunscheidel KM, Adank DN, Ferguson D, Feng J, Sun H, Scobie KN, Damez-Werno DM, Ribeiro E, Pena CJ, Walker D, Bagot RC, Cahill ME, Anderson SA, Labonte B, Hodes GE, Browne H, Chadwick B, Robison AJ, Vialou VF, Dias C, Lorsch Z, Mouzon E, Lobo MK, Dietz DM, Russo SJ, Neve RL, Hurd YL, Nestler EJ. Nat Neurosci. 2015 Mar;18(3):415-22. doi: 10.1038/nn.3932. Epub 2015 Feb 2. PubMed
SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells. Koumangoye RB, Andl T, Taubenslag KJ, Zilberman ST, Taylor CJ, Loomans HA, Andl CD. Mol Cancer. 2015 Feb 3;14:24. doi: 10.1186/s12943-014-0284-y. PubMed
Quantitative Histone Mass Spectrometry identifies elevated Histone H3 Lysine 27 Trimethylation in Melanoma. Sengupta D, Byrum SD, Avaritt NL, Davis L, Shields B, Mahmoud F, Reynolds M, Orr LM, Mackintosh SG, Shalin SC, Tackett AJ. Mol Cell Proteomics. 2015 Nov 30. pii: mcp.M115.053363. PubMed
EZH2-mediated Puma gene repression regulates non-small cell lung cancer cell proliferation and cisplatin-induced apoptosis. Liu H, Li W, Yu X, Gao F, Duan Z, Ma X, Tan S, Yuan Y, Liu L, Wang J, Zhou X, Yang Y. Oncotarget. 2016 Aug 30;7(35):56338-56354. doi: 10.18632/oncotarget.10841. PubMed
Non-Canonical EZH2 Transcriptionally Activates RelB in Triple Negative Breast Cancer. Lawrence CL, Baldwin AS. PLoS One. 2016 Oct 20;11(10):e0165005. doi: 10.1371/journal.pone.0165005. eCollection 2016. PubMed
SKP2 loss destabilizes EZH2 by promoting TRAF6-mediated ubiquitination to suppress prostate cancer. Lu W, Liu S, Li B, Xie Y, Izban MG, Ballard BR, Sathyanarayana SA, Adunyah SE, Matusik RJ, Chen Z. Oncogene. 2016 Nov 21. doi: 10.1038/onc.2016.300. PubMed
The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins. Wang AH, Juan AH, Ko KD, Tsai PF, Zare H, Dell'Orso S, Sartorelli V. Mol Cell. 2017 Oct 19;68(2):398-413.e6. doi: 10.1016/j.molcel.2017.09.016. Epub 2017 Oct 12. PubMed
Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W. Mol Cell. 2018 Jan 18;69(2):279-291.e5. doi: 10.1016/j.molcel.2017.12.024. PubMed
Regulatory characterisation of the schizophrenia-associated CACNA1C proximal promoter and the potential role for the transcription factor EZH2 in schizophrenia aetiology. Billingsley KJ, Manca M, Gianfrancesco O, Collier DA, Sharp H, Bubb VJ, Quinn JP. Schizophr Res. 2018 Sep;199:168-175. doi: 10.1016/j.schres.2018.02.036. Epub 2018 Feb 28. PubMed
Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage. Caruso LB, Martin KA, Lauretti E, Hulse M, Siciliano M, Lupey-Green LN, Abraham A, Skorski T, Tempera I. Oncotarget. 2018 Jan 24;9(12):10585-10605. doi: 10.18632/oncotarget.24291. eCollection 2018 Feb 13. PubMed
Estrogen-related receptors alpha, beta and gamma expression and function is associated with transcriptional repressor EZH2 in breast carcinoma. Kumari K, Adhya AK, Rath AK, Reddy PB, Mishra SK. BMC Cancer. 2018 Jun 26;18(1):690. doi: 10.1186/s12885-018-4586-0. PubMed
The WNT10B Network Is Associated with Survival and Metastases in Chemoresistant Triple-Negative Breast Cancer. El Ayachi I, Fatima I, Wend P, Alva-Ornelas JA, Runke S, Kuenzinger WL, Silva J, Silva W, Gray JK, Lehr S, Barch HC, Krutilina RI, White AC, Cardiff R, Yee LD, Yang L, O'Regan RM, Lowry WE, Seagroves TN, Seewaldt V, Krum SA, Miranda-Carboni GA. Cancer Res. 2019 Mar 1;79(5):982-993. doi: 10.1158/0008-5472.CAN-18-1069. Epub 2018 Dec 18. PubMed
Ezh2 programs TFH differentiation by integrating phosphorylation-dependent activation of Bcl6 and polycomb-dependent repression of p19Arf. Li F, Zeng Z, Xing S, Gullicksrud JA, Shan Q, Choi J, Badovinac VP, Crotty S, Peng W, Xue HH. Nat Commun. 2018 Dec 21;9(1):5452. doi: 10.1038/s41467-018-07853-z. PubMed
The TGFB2-AS1 lncRNA Regulates TGF-beta Signaling by Modulating Corepressor Activity. Papoutsoglou P, Tsubakihara Y, Caja L, Moren A, Pallis P, Ameur A, Heldin CH, Moustakas A. Cell Rep. 2019 Sep 17;28(12):3182-3198.e11. doi: 10.1016/j.celrep.2019.08.028. PubMed
A lactate-induced Snail/STAT3 pathway drives GPR81 expression in lung cancer cells. Xie Q, Zhu Z, He Y, Zhang Z, Zhang Y, Wang Y, Luo J, Peng T, Cheng F, Gao J, Cao Y, Wei H, Wu Z. Biochim Biophys Acta Mol Basis Dis. 2020 Jan 1;1866(1):165576. doi: 10.1016/j.bbadis.2019.165576. Epub 2019 Oct 28. PubMed
Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader. Potjewyd F, Turner AW, Beri J, Rectenwald JM, Norris-Drouin JL, Cholensky SH, Margolis DM, Pearce KH, Herring LE, James LI. Cell Chem Biol. 2020 Jan 16;27(1):47-56.e15. doi: 10.1016/j.chembiol.2019.11.006. Epub 2019 Dec 9. PubMed
Genistein Represses HOTAIR/Chromatin Remodeling Pathways to Suppress Kidney Cancer. Imai-Sumida M, Dasgupta P, Kulkarni P, Shiina M, Hashimoto Y, Shahryari V, Majid S, Tanaka Y, Dahiya R, Yamamura S. Cell Physiol Biochem. 2020 Jan 22;54(1):53-70. doi: 10.33594/000000205. PubMed
Unraveling the role of H3K4 trimethylation and lncRNA HOTAIR in SATB1 and DUSP4-dependent survival of virulent Mycobacterium tuberculosis in macrophages. Subuddhi A, Kumar M, Majumder D, Sarkar A, Ghosh Z, Vasudevan M, Kundu M, Basu J. Tuberculosis (Edinb). 2020 Jan;120:101897. doi: 10.1016/j.tube.2019.101897. Epub 2019 Dec 24. PubMed
Mdm4 supports DNA replication in a p53-independent fashion. Wohlberedt K, Klusmann I, Derevyanko PK, Henningsen K, Choo JAMY, Manzini V, Magerhans A, Giansanti C, Eischen CM, Jochemsen AG, Dobbelstein M. Oncogene. 2020 Jun;39(25):4828-4843. doi: 10.1038/s41388-020-1325-1. Epub 2020 May 19. PubMed
Cancer Stem Cell-Inducing Media Activates Senescence Reprogramming in Fibroblasts. Perrigue PM, Rakoczy M, Pawlicka KP, Belter A, Giel-Pietraszuk M, Naskret-Barciszewska M, Barciszewski J, Figlerowicz M. Cancers (Basel). 2020 Jun 30;12(7). pii: cancers12071745. doi: 10.3390/cancers12071745. PubMed
Salinomycin inhibits epigenetic modulator EZH2 to enhance death receptors in colon cancer stem cells. Singh AK, Verma A, Singh A, Arya RK, Maheshwari S, Chaturvedi P, Nengroo MA, Saini KK, Vishwakarma AL, Singh K, Sarkar J, Datta D. Epigenetics. 2020 Jul 8:1-18. doi: 10.1080/15592294.2020.1789270. PubMed
The CDK4/6-EZH2 pathway is a potential therapeutic target for psoriasis. Muller A, Dickmanns A, Resch C, Schakel K, Hailfinger S, Dobbelstein M, Schulze-Osthoff K, Kramer D. J Clin Invest. 2020 Jul 23. pii: 134217. doi: 10.1172/JCI134217. PubMed
SUMOylation of E2F1 Regulates Expression of EZH2. Du L, Fakih MG, Rosen ST, Chen Y. Cancer Res. 2020 Oct 1;80(19):4212-4223. doi: 10.1158/0008-5472.CAN-20-1259. Epub 2020 Aug 14. PubMed
EZH2 inhibition reduces cartilage loss and functional impairment related to osteoarthritis. Allas L, Brochard S, Rochoux Q, Ribet J, Dujarrier C, Veyssiere A, Aury-Landas J, Grard O, Leclercq S, Vivien D, Ea HK, Maubert E, Cohen-Solal M, Boumediene K, Agin V, Bauge C. Sci Rep. 2020 Nov 11;10(1):19577. doi: 10.1038/s41598-020-76724-9. PubMed
RP58 Represses Transcriptional Programs Linked to Nonneuronal Cell Identity and Glioblastoma Subtypes in Developing Neurons. Xiang C, Frietze KK, Bi Y, Li Y, Dal Pozzo V, Pal S, Alexander N, Baubet V, D'Acunto V, Mason CE, Davuluri RV, Dahmane N. Mol Cell Biol. 2021 Jun 23;41(7):e0052620. doi: 10.1128/MCB.00526-20. Epub 2021 Jun 23. PubMed
Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal. Yeh DW, Liu C, Hernandez JC, Tahara SM, Tsukamoto H, Machida K. iScience. 2023 Jun 7;26(7):107035. doi: 10.1016/j.isci.2023.107035. eCollection 2023 Jul 21. PubMed

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