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pDRGFP Citations (79)

Plasmid Article: XRCC3 promotes homology-directed repair of DNA damage in mammalian cells.
Pierce AJ, Johnson RD, Thompson LH, Jasin M Genes Dev. 1999 Oct 15. 13(20):2633-8.
PubMed Journal

Articles Citing pDRGFP

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair. Serrano MA, Li Z, Dangeti M, Musich PR, Patrick S, Roginskaya M, Cartwright B, Zou Y. Oncogene. 2013 May 9;32(19):2452-62. doi: 10.1038/onc.2012.257. Epub 2012 Jul 16. PubMed
Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors. Lin ZP, Ratner ES, Whicker ME, Lee Y, Sartorelli AC. Mol Cancer Res. 2014 Mar;12(3):381-93. doi: 10.1158/1541-7786.MCR-13-0480. Epub 2014 Jan 10. PubMed
Assaying break and nick-induced homologous recombination in mammalian cells using the DR-GFP reporter and Cas9 nucleases. Vriend LE, Jasin M, Krawczyk PM. Methods Enzymol. 2014;546:175-91. doi: 10.1016/B978-0-12-801185-0.00009-X. PubMed
Spindle Checkpoint Factors Bub1 and Bub2 Promote DNA Double-Strand Break Repair by Nonhomologous End Joining. Jessulat M, Malty RH, Nguyen-Tran DH, Deineko V, Aoki H, Vlasblom J, Omidi K, Jin K, Minic Z, Hooshyar M, Burnside D, Samanfar B, Phanse S, Freywald T, Prasad B, Zhang Z, Vizeacoumar F, Krogan NJ, Freywald A, Golshani A, Babu M. Mol Cell Biol. 2015 Jul 15;35(14):2448-63. doi: 10.1128/MCB.00007-15. Epub 2015 May 11. PubMed
RAD51 and BRCA2 Enhance Oncolytic Adenovirus Type 5 Activity in Ovarian Cancer. Tookman LA, Browne AK, Connell CM, Bridge G, Ingemarsdotter CK, Dowson S, Shibata A, Lockley M, Martin SA, McNeish IA. Mol Cancer Res. 2016 Jan;14(1):44-55. doi: 10.1158/1541-7786.MCR-15-0188-T. Epub 2015 Oct 9. PubMed
Combined Effects of Suberoylanilide Hydroxamic Acid and Cisplatin on Radiation Sensitivity and Cancer Cell Invasion in Non-Small Cell Lung Cancer. Feng J, Zhang S, Wu K, Wang B, Wong JY, Jiang H, Xu R, Ying L, Huang H, Zheng X, Chen X, Ma S. Mol Cancer Ther. 2016 May;15(5):842-53. doi: 10.1158/1535-7163.MCT-15-0445. Epub 2016 Feb 2. PubMed
The acetyltransferase Tip60 contributes to mammary tumorigenesis by modulating DNA repair. Bassi C, Li YT, Khu K, Mateo F, Baniasadi PS, Elia A, Mason J, Stambolic V, Pujana MA, Mak TW, Gorrini C. Cell Death Differ. 2016 Jul;23(7):1198-208. doi: 10.1038/cdd.2015.173. Epub 2016 Feb 26. PubMed
Enhanced Histone Deacetylase Activity in Malignant Melanoma Provokes RAD51 and FANCD2-Triggered Drug Resistance. Krumm A, Barckhausen C, Kucuk P, Tomaszowski KH, Loquai C, Fahrer J, Kramer OH, Kaina B, Roos WP. Cancer Res. 2016 May 15;76(10):3067-77. doi: 10.1158/0008-5472.CAN-15-2680. Epub 2016 Mar 15. PubMed
Cyclin A2 promotes DNA repair in the brain during both development and aging. Gygli PE, Chang JC, Gokozan HN, Catacutan FP, Schmidt TA, Kaya B, Goksel M, Baig FS, Chen S, Griveau A, Michowski W, Wong M, Palanichamy K, Sicinski P, Nelson RJ, Czeisler C, Otero JJ. Aging (Albany NY). 2016 Jul;8(7):1540-70. doi: 10.18632/aging.100990. PubMed
Panobinostat sensitizes cyclin E high, homologous recombination-proficient ovarian cancer to olaparib. Wilson AJ, Sarfo-Kantanka K, Barrack T, Steck A, Saskowski J, Crispens MA, Khabele D. Gynecol Oncol. 2016 Oct;143(1):143-51. doi: 10.1016/j.ygyno.2016.07.088. Epub 2016 Jul 19. PubMed
Epigenetic therapy potential of suberoylanilide hydroxamic acid on invasive human non-small cell lung cancer cells. Zhang S, Wu K, Feng J, Wu Z, Deng Q, Guo C, Xia B, Zhang J, Huang H, Zhu L, Zhang K, Shen B, Chen X, Ma S. Oncotarget. 2016 Oct 18;7(42):68768-68780. doi: 10.18632/oncotarget.11967. PubMed
CHK1 and RAD51 activation after DNA damage is regulated via urokinase receptor/TLR4 signaling. Narayanaswamy PB, Tkachuk S, Haller H, Dumler I, Kiyan Y. Cell Death Dis. 2016 Sep 29;7(9):e2383. doi: 10.1038/cddis.2016.291. PubMed
Assessing the Effect of Class I Histone Deacetylase Activity on DNA Double-Strand Break Repair by Homologous Recombination. Krumm A, Roos WP. Methods Mol Biol. 2017;1510:115-123. PubMed
FLT3 and JAK2 Mutations in Acute Myeloid Leukemia Promote Interchromosomal Homologous Recombination and the Potential for Copy Neutral Loss of Heterozygosity. Gaymes TJ, Mohamedali A, Eiliazadeh AL, Darling D, Mufti GJ. Cancer Res. 2017 Apr 1;77(7):1697-1708. doi: 10.1158/0008-5472.CAN-16-1678. Epub 2017 Jan 20. PubMed
TOPBP1(Dpb11) plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1(Rad9). Liu Y, Cussiol JR, Dibitetto D, Sims JR, Twayana S, Weiss RS, Freire R, Marini F, Pellicioli A, Smolka MB. J Cell Biol. 2017 Mar 6;216(3):623-639. doi: 10.1083/jcb.201607031. Epub 2017 Feb 22. PubMed
Dual-utility NLS drives RNF169-dependent DNA damage responses. An L, Jiang Y, Ng HH, Man EP, Chen J, Khoo US, Gong Q, Huen MS. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2872-E2881. doi: 10.1073/pnas.1616602114. Epub 2017 Mar 21. PubMed

Associated Plasmids

Localisation of Nup153 and SENP1 to nuclear pore complexes is required for 53BP1-mediated DNA double-strand break repair. Duheron V, Nilles N, Pecenko S, Martinelli V, Fahrenkrog B. J Cell Sci. 2017 Jul 15;130(14):2306-2316. doi: 10.1242/jcs.198390. Epub 2017 Jun 2. PubMed
Suppression of Sirt1 sensitizes lung cancer cells to WEE1 inhibitor MK-1775-induced DNA damage and apoptosis. Chen G, Zhang B, Xu H, Sun Y, Shi Y, Luo Y, Jia H, Wang F. Oncogene. 2017 Dec 14;36(50):6863-6872. doi: 10.1038/onc.2017.297. Epub 2017 Sep 4. PubMed
The role of Rak in the regulation of stability and function of BRCA1. Kim JL, Ha GH, Campo L, Denning MF, Patel TB, Osipo C, Lin SY, Breuer EK. Oncotarget. 2015 Oct 14;8(49):86799-86815. doi: 10.18632/oncotarget.5717. eCollection 2017 Oct 17. PubMed
Negative regulation of BRCA1 by transforming acidic coiled-coil protein 3 (TACC3). Kim JL, Ha GH, Campo L, Breuer EK. Biochem Biophys Res Commun. 2018 Feb 5;496(2):633-640. doi: 10.1016/j.bbrc.2018.01.101. Epub 2018 Jan 19. PubMed
Impact of RAD51C-mediated Homologous Recombination on Genomic Integrity in Barrett's Adenocarcinoma Cells. Pal J, Nanjappa P, Kumar S, Shi J, Buon L, Munshi NC, Shammas MA. J Gastroenterol Hepatol Res. 2017;6(1):2286-2295. doi: 10.17554/j.issn.2224-3992.2017.06.687. Epub 2017 Feb 21. PubMed
The BET inhibitor INCB054329 reduces homologous recombination efficiency and augments PARP inhibitor activity in ovarian cancer. Wilson AJ, Stubbs M, Liu P, Ruggeri B, Khabele D. Gynecol Oncol. 2018 Jun;149(3):575-584. doi: 10.1016/j.ygyno.2018.03.049. Epub 2018 Mar 20. PubMed
Targeting the MALAT1/PARP1/LIG3 complex induces DNA damage and apoptosis in multiple myeloma. Hu Y, Lin J, Fang H, Fang J, Li C, Chen W, Liu S, Ondrejka S, Gong Z, Reu F, Maciejewski J, Yi Q, Zhao JJ. Leukemia. 2018 Mar 22. pii: 10.1038/s41375-018-0104-2. doi: 10.1038/s41375-018-0104-2. PubMed

Associated Plasmids

Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair. Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH. Cell Death Dis. 2018 May 1;9(5):543. doi: 10.1038/s41419-018-0575-0. PubMed
ATR-mediated proteome remodeling is a major determinant of homologous recombination capacity in cancer cells. Kim D, Liu Y, Oberly S, Freire R, Smolka MB. Nucleic Acids Res. 2018 Sep 19;46(16):8311-8325. doi: 10.1093/nar/gky625. PubMed
Melatonin Sensitizes Hepatocellular Carcinoma Cells to Chemotherapy Through Long Non-Coding RNA RAD51-AS1-Mediated Suppression of DNA Repair. Chen CC, Chen CY, Wang SH, Yeh CT, Su SC, Ueng SH, Chuang WY, Hsueh C, Wang TH. Cancers (Basel). 2018 Sep 10;10(9). pii: cancers10090320. doi: 10.3390/cancers10090320. PubMed
AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice. Kim D, Kim S, Oh Y, Park S, Jeon Y, Kim H, Lee H, Kim S. Sci Rep. 2018 Oct 9;8(1):15025. doi: 10.1038/s41598-018-33303-3. PubMed
PARP Inhibition Induces Enrichment of DNA Repair-Proficient CD133 and CD117 Positive Ovarian Cancer Stem Cells. Bellio C, DiGloria C, Foster R, James K, Konstantinopoulos PA, Growdon WB, Rueda BR. Mol Cancer Res. 2019 Feb;17(2):431-445. doi: 10.1158/1541-7786.MCR-18-0594. Epub 2018 Nov 6. PubMed
Preclinical study using androgen receptor (AR) degradation enhancer to increase radiotherapy efficacy via targeting radiation-increased AR to better suppress prostate cancer progression. Chou FJ, Chen Y, Chen D, Niu Y, Li G, Keng P, Yeh S, Chang C. EBioMedicine. 2019 Feb;40:504-516. doi: 10.1016/j.ebiom.2018.12.050. Epub 2019 Jan 26. PubMed
E3 Ubiquitin Ligases RNF20 and RNF40 Are Required for Double-Stranded Break (DSB) Repair: Evidence for Monoubiquitination of Histone H2B Lysine 120 as a Novel Axis of DSB Signaling and Repair. So CC, Ramachandran S, Martin A. Mol Cell Biol. 2019 Apr 2;39(8). pii: MCB.00488-18. doi: 10.1128/MCB.00488-18. Print 2019 Apr 15. PubMed
DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169. Menon VR, Ananthapadmanabhan V, Swanson S, Saini S, Sesay F, Yakovlev V, Florens L, DeCaprio JA, Washburn MP, Dozmorov M, Litovchick L. Cell Cycle. 2019 Mar;18(5):531-551. doi: 10.1080/15384101.2019.1577525. Epub 2019 Feb 17. PubMed
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair. Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M. Cell Rep. 2019 Feb 19;26(8):2028-2036.e6. doi: 10.1016/j.celrep.2019.01.083. PubMed
Depletion of the RNA binding protein HNRNPD impairs homologous recombination by inhibiting DNA-end resection and inducing R-loop accumulation. Alfano L, Caporaso A, Altieri A, Dell'Aquila M, Landi C, Bini L, Pentimalli F, Giordano A. Nucleic Acids Res. 2019 May 7;47(8):4068-4085. doi: 10.1093/nar/gkz076. PubMed
Discovery of Isaindigotone Derivatives as Novel Bloom's Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair. Yin QK, Wang CX, Wang YQ, Guo QL, Zhang ZL, Ou TM, Huang SL, Li D, Wang HG, Tan JH, Chen SB, Huang ZS. J Med Chem. 2019 Mar 28;62(6):3147-3162. doi: 10.1021/acs.jmedchem.9b00083. Epub 2019 Mar 14. PubMed
RB1 Deletion in Retinoblastoma Protein Pathway-Disrupted Cells Results in DNA Damage and Cancer Progression. Marshall AE, Roes MV, Passos DT, DeWeerd MC, Chaikovsky AC, Sage J, Howlett CJ, Dick FA. Mol Cell Biol. 2019 Jul 29;39(16). pii: MCB.00105-19. doi: 10.1128/MCB.00105-19. Print 2019 Aug 15. PubMed
MiR-7-5p-mediated downregulation of PARP1 impacts DNA homologous recombination repair and resistance to doxorubicin in small cell lung cancer. Lai J, Yang H, Zhu Y, Ruan M, Huang Y, Zhang Q. BMC Cancer. 2019 Jun 18;19(1):602. doi: 10.1186/s12885-019-5798-7. PubMed
Activation of Wnt signaling promotes olaparib resistant ovarian cancer. Yamamoto TM, McMellen A, Watson ZL, Aguilera J, Ferguson R, Nurmemmedov E, Thakar T, Moldovan GL, Kim H, Cittelly DM, Joglar AM, Brennecke EP, Wilson H, Behbakht K, Sikora MJ, Bitler BG. Mol Carcinog. 2019 Jun 10. doi: 10.1002/mc.23064. PubMed
RIF1 promotes replication fork protection and efficient restart to maintain genome stability. Mukherjee C, Tripathi V, Manolika EM, Heijink AM, Ricci G, Merzouk S, de Boer HR, Demmers J, van Vugt MATM, Ray Chaudhuri A. Nat Commun. 2019 Jul 23;10(1):3287. doi: 10.1038/s41467-019-11246-1. PubMed
LMO2 Confers Synthetic Lethality to PARP Inhibition in DLBCL. Parvin S, Ramirez-Labrada A, Aumann S, Lu X, Weich N, Santiago G, Cortizas EM, Sharabi E, Zhang Y, Sanchez-Garcia I, Gentles AJ, Roberts E, Bilbao-Cortes D, Vega F, Chapman JR, Verdun RE, Lossos IS. Cancer Cell. 2019 Sep 16;36(3):237-249.e6. doi: 10.1016/j.ccell.2019.07.007. Epub 2019 Aug 22. PubMed
PINK1/Parkin Influences Cell Cycle by Sequestering TBK1 at Damaged Mitochondria, Inhibiting Mitosis. Sarraf SA, Sideris DP, Giagtzoglou N, Ni L, Kankel MW, Sen A, Bochicchio LE, Huang CH, Nussenzweig SC, Worley SH, Morton PD, Artavanis-Tsakonas S, Youle RJ, Pickrell AM. Cell Rep. 2019 Oct 1;29(1):225-235.e5. doi: 10.1016/j.celrep.2019.08.085. PubMed
Synergism between ATM and PARP1 Inhibition Involves DNA Damage and Abrogating the G2 DNA Damage Checkpoint. Mak JPY, Ma HT, Poon RYC. Mol Cancer Ther. 2020 Jan;19(1):123-134. doi: 10.1158/1535-7163.MCT-19-0474. Epub 2019 Oct 9. PubMed
PML isoform expression and DNA break location relative to PML nuclear bodies impacts the efficiency of homologous recombination. Attwood KM, Salsman J, Chung D, Mathavarajah S, Van Iderstine C, Dellaire G. Biochem Cell Biol. 2019 Oct 31. doi: 10.1139/bcb-2019-0115. PubMed
Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma. Watson ZL, Yamamoto TM, McMellen A, Kim H, Hughes CJ, Wheeler LJ, Post MD, Behbakht K, Bitler BG. Clin Epigenetics. 2019 Nov 27;11(1):165. doi: 10.1186/s13148-019-0758-2. PubMed
Prevention of DNA Replication Stress by CHK1 Leads to Chemoresistance Despite a DNA Repair Defect in Homologous Recombination in Breast Cancer. Meyer F, Becker S, Classen S, Parplys AC, Mansour WY, Riepen B, Timm S, Ruebe C, Jasin M, Wikman H, Petersen C, Rothkamm K, Borgmann K. Cells. 2020 Jan 17;9(1). pii: cells9010238. doi: 10.3390/cells9010238. PubMed
Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Wang H, Zhang S, Song L, Qu M, Zou Z. Oncogene. 2020 Apr;39(14):2905-2920. doi: 10.1038/s41388-020-1191-x. Epub 2020 Feb 6. PubMed
Olaparib and enzalutamide synergistically suppress HCC progression via the AR-mediated miR-146a-5p/BRCA1 signaling. Zhao J, Sun Y, Lin H, Chou F, Xiao Y, Jin R, Cai X, Chang C. FASEB J. 2020 Apr;34(4):5877-5891. doi: 10.1096/fj.201903045RR. Epub 2020 Mar 5. PubMed
Histone demethylase JMJD1A promotes expression of DNA repair factors and radio-resistance of prostate cancer cells. Fan L, Xu S, Zhang F, Cui X, Fazli L, Gleave M, Clark DJ, Yang A, Hussain A, Rassool F, Qi J. Cell Death Dis. 2020 Apr 1;11(4):214. doi: 10.1038/s41419-020-2405-4. PubMed
Protein expression profiling identifies differential modulation of homologous recombination by platinum-based antitumor agents. He G, Xie X, Siddik ZH. Cancer Chemother Pharmacol. 2020 Jun;85(6):1129-1140. doi: 10.1007/s00280-020-04085-1. Epub 2020 May 28. PubMed
BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice. Perkail S, Andricovich J, Kai Y, Tzatsos A. Nat Commun. 2020 Jun 15;11(1):3018. doi: 10.1038/s41467-020-16589-8. PubMed
Computational inference of cancer-specific vulnerabilities in clinical samples. Jang K, Park MJ, Park JS, Hwangbo H, Sung MK, Kim S, Jung J, Lee JW, Ahn SH, Chang S, Choi JK. Genome Biol. 2020 Jun 29;21(1):155. doi: 10.1186/s13059-020-02077-1. PubMed
Characterisation of Ovarian Cancer Cell Line NIH-OVCAR3 and Implications of Genomic, Transcriptomic, Proteomic and Functional DNA Damage Response Biomarkers for Therapeutic Targeting. Bradbury A, O'Donnell R, Drew Y, Curtin NJ, Sharma Saha S. Cancers (Basel). 2020 Jul 17;12(7). pii: cancers12071939. doi: 10.3390/cancers12071939. PubMed
The RNA transport factor PHAX is required for proper histone H2AX expression and DNA damage response. Machitani M, Taniguchi I, McCloskey A, Suzuki T, Ohno M. RNA. 2020 Nov;26(11):1716-1725. doi: 10.1261/rna.074625.120. Epub 2020 Aug 5. PubMed
Metastasis Suppressor NME1 Modulates Choice of Double-Strand Break Repair Pathways in Melanoma Cells by Enhancing Alternative NHEJ while Inhibiting NHEJ and HR. Puts G, Jarrett S, Leonard M, Matsangos N, Snyder D, Wang Y, Vincent R, Portney B, Abbotts R, McLaughlin L, Zalzman M, Rassool F, Kaetzel D. Int J Mol Sci. 2020 Aug 17;21(16). pii: ijms21165896. doi: 10.3390/ijms21165896. PubMed
TGFbetaR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment. Le BV, Podszywalow-Bartnicka P, Maifrede S, Sullivan-Reed K, Nieborowska-Skorska M, Golovine K, Yao JC, Nejati R, Cai KQ, Caruso LB, Swatler J, Dabrowski M, Lian Z, Valent P, Paietta EM, Levine RL, Fernandez HF, Tallman MS, Litzow MR, Huang J, Challen GA, Link D, Tempera I, Wasik MA, Piwocka K, Skorski T. Cell Rep. 2020 Oct 6;33(1):108221. doi: 10.1016/j.celrep.2020.108221. PubMed
ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions. Hu K, Li Y, Wu W, Xie L, Yan H, Cai Y, Chen D, Jiang Q, Lin L, Chen Z, Liao JY, Zhang Y, Koeffler HP, Yin D, Song E. Adv Sci (Weinh). 2020 Sep 3;7(20):2000157. doi: 10.1002/advs.202000157. eCollection 2020 Oct. PubMed
Advanced Prostate Cancer with ATM Loss: PARP and ATR Inhibitors. Neeb A, Herranz N, Arce-Gallego S, Miranda S, Buroni L, Yuan W, Athie A, Casals T, Carmichael J, Rodrigues DN, Gurel B, Rescigno P, Rekowski J, Welti J, Riisnaes R, Gil V, Ning J, Wagner V, Casanova-Salas I, Cordoba S, Castro N, Fenor de la Maza MD, Seed G, Chandran K, Ferreira A, Figueiredo I, Bertan C, Bianchini D, Aversa C, Paschalis A, Gonzalez M, Morales-Barrera R, Suarez C, Carles J, Swain A, Sharp A, Gil J, Serra V, Lord C, Carreira S, Mateo J, de Bono JS. Eur Urol. 2021 Feb;79(2):200-211. doi: 10.1016/j.eururo.2020.10.029. Epub 2020 Nov 8. PubMed
EGFRvIII expression and isocitrate dehydrogenase mutations in patients with glioma. Taher MM, Dairi G, Butt EM, Al-Quthami K, Al-Khalidi H, Jastania RA, Nageeti TH, Bogari NM, Athar M, Al-Allaf FA, Valerie K. Oncol Lett. 2020 Dec;20(6):384. doi: 10.3892/ol.2020.12247. Epub 2020 Oct 23. PubMed
Age-associated deficient recruitment of 53BP1 in G1 cells directs DNA double-strand break repair to BRCA1/CtIP-mediated DNA-end resection. Anglada T, Genesca A, Martin M. Aging (Albany NY). 2020 Dec 27;12(24):24872-24893. doi: 10.18632/aging.202419. Epub 2020 Dec 27. PubMed
Loss of TGFbeta signaling increases alternative end-joining DNA repair that sensitizes to genotoxic therapies across cancer types. Liu Q, Palomero L, Moore J, Guix I, Espin R, Aytes A, Mao JH, Paulovich AG, Whiteaker JR, Ivey RG, Iliakis G, Luo D, Chalmers AJ, Murnane J, Pujana MA, Barcellos-Hoff MH. Sci Transl Med. 2021 Feb 10;13(580). pii: 13/580/eabc4465. doi: 10.1126/scitranslmed.abc4465. PubMed
WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. Kaur A, Lim JYS, Sepramaniam S, Patnaik S, Harmston N, Lee MA, Petretto E, Virshup DM, Madan B. EMBO Mol Med. 2021 Apr 9;13(4):e13349. doi: 10.15252/emmm.202013349. Epub 2021 Mar 4. PubMed
CDK1 inhibitor controls G2/M phase transition and reverses DNA damage sensitivity. Sunada S, Saito H, Zhang D, Xu Z, Miki Y. Biochem Biophys Res Commun. 2021 Apr 23;550:56-61. doi: 10.1016/j.bbrc.2021.02.117. Epub 2021 Mar 5. PubMed
Targeting HR Repair as a Synthetic Lethal Approach to Increase DNA Damage Sensitivity by a RAD52 Inhibitor in BRCA2-Deficient Cancer Cells. Tseng WC, Chen CY, Chern CY, Wang CA, Lee WC, Chi YC, Cheng SF, Kuo YT, Chiu YC, Tseng ST, Lin PY, Liou SJ, Li YC, Chen CC. Int J Mol Sci. 2021 Apr 23;22(9). pii: ijms22094422. doi: 10.3390/ijms22094422. PubMed
SMARCAD1-mediated active replication fork stability maintains genome integrity. Lo CSY, van Toorn M, Gaggioli V, Paes Dias M, Zhu Y, Manolika EM, Zhao W, van der Does M, Mukherjee C, G S C Souto Goncalves J, van Royen ME, French PJ, Demmers J, Smal I, Lans H, Wheeler D, Jonkers J, Chaudhuri AR, Marteijn JA, Taneja N. Sci Adv. 2021 May 5;7(19). pii: 7/19/eabe7804. doi: 10.1126/sciadv.abe7804. Print 2021 May. PubMed
RNA transcripts stimulate homologous recombination by forming DR-loops. Ouyang J, Yadav T, Zhang JM, Yang H, Rheinbay E, Guo H, Haber DA, Lan L, Zou L. Nature. 2021 Jun;594(7862):283-288. doi: 10.1038/s41586-021-03538-8. Epub 2021 May 12. PubMed
Altered replication stress response due to CARD14 mutations promotes recombination-induced revertant mosaicism. Miyauchi T, Suzuki S, Takeda M, Peh JT, Aiba M, Natsuga K, Fujita Y, Takeichi T, Sakamoto T, Akiyama M, Shimizu H, Nomura T. Am J Hum Genet. 2021 Jun 3;108(6):1026-1039. doi: 10.1016/j.ajhg.2021.04.021. Epub 2021 May 17. PubMed
ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer. Deng J, Thennavan A, Dolgalev I, Chen T, Li J, Marzio A, Poirier JT, Peng D, Bulatovic M, Mukhopadhyay S, Silver H, Papadopoulos E, Pyon V, Thakurdin C, Han H, Li F, Li S, Ding H, Hu H, Pan Y, Weerasekara V, Jiang B, Wang ES, Ahearn I, Philips M, Papagiannakopoulos T, Tsirigos A, Rothenberg E, Gainor J, Freeman GJ, Rudin CM, Gray NS, Hammerman PS, Pagano M, Heymach JV, Perou CM, Bardeesy N, Wong KK. Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6. Epub 2021 May 17. PubMed
Long noncoding RNA NIHCOLE promotes ligation efficiency of DNA double-strand breaks in hepatocellular carcinoma. Unfried JP, Marin-Baquero M, Rivera-Calzada A, Razquin N, Martin-Cuevas EM, de Braganca S, Aicart-Ramos C, McCoy C, Prats-Mari L, Arribas-Bosacoma R, Lee L, Caruso S, Zucman-Rossi J, Sangro B, Williams G, Moreno-Herrero F, Llorca O, Lees-Miller SP, Fortes P. Cancer Res. 2021 Jul 28. pii: 0008-5472.CAN-21-0463. doi: 10.1158/0008-5472.CAN-21-0463. PubMed
Pim kinase inhibitor co-treatment decreases alternative non-homologous end-joining DNA repair and genomic instability induced by topoisomerase 2 inhibitors in cells with FLT3 internal tandem duplication. Scarpa M, Kapoor S, Tvedte ES, Doshi KA, Zou YS, Singh P, Lee JK, Chatterjee A, Ali MKM, Bromley RE, Hotopp JCD, Rassool FV, Baer MR. Oncotarget. 2021 Aug 31;12(18):1763-1779. doi: 10.18632/oncotarget.28042. eCollection 2021 Aug 31. PubMed
ATR inhibition reverses the resistance of homologous recombination deficient MGMT(low)/MMR(proficient) cancer cells to temozolomide. El Touny LH, Hose C, Connelly J, Harris E, Monks A, Dull AB, Wilsker DF, Hollingshead MG, Gottholm-Ahalt M, Alcoser SY, Mullendore ME, Parchment RE, Doroshow JH, Teicher BA, Rapisarda A. Oncotarget. 2021 Oct 12;12(21):2114-2130. doi: 10.18632/oncotarget.28090. eCollection 2021 Oct 12. PubMed
Aberrant Transcript Usage Is Associated with Homologous Recombination Deficiency and Predicts Therapeutic Response. Kang HG, Hwangbo H, Kim MJ, Kim S, Lee EJ, Park MJ, Kim JW, Kim BG, Cho EH, Chang S, Lee JY, Choi JK. Cancer Res. 2022 Jan 1;82(1):142-154. doi: 10.1158/0008-5472.CAN-21-2023. Epub 2021 Oct 28. PubMed
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