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pcDNA3-Flag mTOR wt Citations (19)

Plasmid Article: The FKBP12-rapamycin-binding domain is required for FKBP12-rapamycin-associated protein kinase activity and G1 progression.
Vilella-Bach M, Nuzzi P, Fang Y, Chen J J Biol Chem. 1999 Feb 12. 274(7):4266-72.
PubMed Journal

Articles Citing pcDNA3-Flag mTOR wt

Coordinated targeting of the EGFR signaling axis by microRNA-27a*. Wu X, Bhayani MK, Dodge CT, Nicoloso MS, Chen Y, Yan X, Adachi M, Thomas L, Galer CE, Jiffar T, Pickering CR, Kupferman ME, Myers JN, Calin GA, Lai SY. Oncotarget. 2013 Sep;4(9):1388-98. PubMed
Convergent regulation of the lysosomal two-pore channel-2 by Mg(2)(+), NAADP, PI(3,5)P(2) and multiple protein kinases. Jha A, Ahuja M, Patel S, Brailoiu E, Muallem S. EMBO J. 2014 Mar 3;33(5):501-11. doi: 10.1002/embj.201387035. Epub 2014 Feb 5. PubMed
A diverse array of cancer-associated MTOR mutations are hyperactivating and can predict rapamycin sensitivity. Grabiner BC, Nardi V, Birsoy K, Possemato R, Shen K, Sinha S, Jordan A, Beck AH, Sabatini DM. Cancer Discov. 2014 May;4(5):554-63. doi: 10.1158/2159-8290.CD-13-0929. Epub 2014 Mar 14. PubMed

Associated Plasmids

ATG4B promotes colorectal cancer growth independent of autophagic flux. Liu PF, Leung CM, Chang YH, Cheng JS, Chen JJ, Weng CJ, Tsai KW, Hsu CJ, Liu YC, Hsu PC, Pan HW, Shu CW. Autophagy. 2014 Aug;10(8):1454-65. doi: 10.4161/auto.29556. Epub 2014 Jun 12. PubMed
Molecular switch role of Akt in Polygonatum odoratum lectin-induced apoptosis and autophagy in human non-small cell lung cancer A549 cells. Li C, Chen J, Lu B, Shi Z, Wang H, Zhang B, Zhao K, Qi W, Bao J, Wang Y. PLoS One. 2014 Jul 3;9(7):e101526. doi: 10.1371/journal.pone.0101526. eCollection 2014. PubMed
Annexin A1 Preferentially Predicts Poor Prognosis of Basal-Like Breast Cancer Patients by Activating mTOR-S6 Signaling. Bhardwaj A, Ganesan N, Tachibana K, Rajapakshe K, Albarracin CT, Gunaratne PH, Coarfa C, Bedrosian I. PLoS One. 2015 May 22;10(5):e0127678. doi: 10.1371/journal.pone.0127678. eCollection 2015. PubMed
HSF1 critically attunes proteotoxic stress sensing by mTORC1 to combat stress and promote growth. Su KH, Cao J, Tang Z, Dai S, He Y, Sampson SB, Benjamin IJ, Dai C. Nat Cell Biol. 2016 May;18(5):527-39. doi: 10.1038/ncb3335. Epub 2016 Apr 4. PubMed
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets. Chen YB, Xu J, Skanderup AJ, Dong Y, Brannon AR, Wang L, Won HH, Wang PI, Nanjangud GJ, Jungbluth AA, Li W, Ojeda V, Hakimi AA, Voss MH, Schultz N, Motzer RJ, Russo P, Cheng EH, Giancotti FG, Lee W, Berger MF, Tickoo SK, Reuter VE, Hsieh JJ. Nat Commun. 2016 Oct 7;7:13131. doi: 10.1038/ncomms13131. PubMed
Diminished DYRK2 sensitizes hormone receptor-positive breast cancer to everolimus by the escape from degrading mTOR. Mimoto R, Nihira NT, Hirooka S, Takeyama H, Yoshida K. Cancer Lett. 2017 Jan 1;384:27-38. doi: 10.1016/j.canlet.2016.10.015. Epub 2016 Oct 13. PubMed
MNK Controls mTORC1:Substrate Association through Regulation of TELO2 Binding with mTORC1. Brown MC, Gromeier M. Cell Rep. 2017 Feb 7;18(6):1444-1457. doi: 10.1016/j.celrep.2017.01.023. PubMed
mTORC2 Regulates Amino Acid Metabolism in Cancer by Phosphorylation of the Cystine-Glutamate Antiporter xCT. Gu Y, Albuquerque CP, Braas D, Zhang W, Villa GR, Bi J, Ikegami S, Masui K, Gini B, Yang H, Gahman TC, Shiau AK, Cloughesy TF, Christofk HR, Zhou H, Guan KL, Mischel PS. Mol Cell. 2017 Jul 6;67(1):128-138.e7. doi: 10.1016/j.molcel.2017.05.030. Epub 2017 Jun 22. PubMed
Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation. Bruning U, Morales-Rodriguez F, Kalucka J, Goveia J, Taverna F, Queiroz KCS, Dubois C, Cantelmo AR, Chen R, Loroch S, Timmerman E, Caixeta V, Bloch K, Conradi LC, Treps L, Staes A, Gevaert K, Tee A, Dewerchin M, Semenkovich CF, Impens F, Schilling B, Verdin E, Swinnen JV, Meier JL, Kulkarni RA, Sickmann A, Ghesquiere B, Schoonjans L, Li X, Mazzone M, Carmeliet P. Cell Metab. 2018 Dec 4;28(6):866-880.e15. doi: 10.1016/j.cmet.2018.07.019. Epub 2018 Aug 23. PubMed
mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53. Jung SH, Hwang HJ, Kang D, Park HA, Lee HC, Jeong D, Lee K, Park HJ, Ko YG, Lee JS. Oncogene. 2019 Mar;38(10):1639-1650. doi: 10.1038/s41388-018-0521-8. Epub 2018 Oct 18. PubMed
Celastrol induces ubiquitin-dependent degradation of mTOR in breast cancer cells. Li X, Zhu G, Yao X, Wang N, Hu R, Kong Q, Zhou D, Long L, Cai J, Zhou W. Onco Targets Ther. 2018 Dec 11;11:8977-8985. doi: 10.2147/OTT.S187315. eCollection 2018. PubMed
The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. Kovalski JR, Bhaduri A, Zehnder AM, Neela PH, Che Y, Wozniak GG, Khavari PA. Mol Cell. 2019 Jan 4. pii: S1097-2765(18)31031-1. doi: 10.1016/j.molcel.2018.12.001. PubMed

Associated Plasmids

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR. Zhang X, Chen W, Gao Q, Yang J, Yan X, Zhao H, Su L, Yang M, Gao C, Yao Y, Inoki K, Li D, Shao R, Wang S, Sahoo N, Kudo F, Eguchi T, Ruan B, Xu H. PLoS Biol. 2019 May 21;17(5):e3000252. doi: 10.1371/journal.pbio.3000252. eCollection 2019 May. PubMed
Pentapeptide Protects INS-1 Cells From hIAPP-Mediated Apoptosis by Enhancing Autophagy Through mTOR Pathway. Lin J, Jiao A, Lv W, Zhang C, Shi Y, Yang Z, Sun N, Li X, Zhang J. Front Pharmacol. 2019 Aug 9;10:896. doi: 10.3389/fphar.2019.00896. eCollection 2019. PubMed
Rheb1-Independent Activation of mTORC1 in Mammary Tumors Occurs through Activating Mutations in mTOR. Xiao B, Zuo D, Hirukawa A, Cardiff RD, Lamb R, Sonenberg N, Muller WJ. Cell Rep. 2020 Apr 28;31(4):107571. doi: 10.1016/j.celrep.2020.107571. PubMed
Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease. Kim D, Park G, Huuhtanen J, Lundgren S, Khajuria RK, Hurtado AM, Munoz-Calleja C, Cardenoso L, Gomez-Garcia de Soria V, Chen-Liang TH, Eldfors S, Ellonen P, Hannula S, Kankainen M, Bruck O, Kreutzman A, Salmenniemi U, Lonnberg T, Jerez A, Itala-Remes M, Myllymaki M, Keranen MAI, Mustjoki S. Nat Commun. 2020 May 7;11(1):2246. doi: 10.1038/s41467-020-16115-w. PubMed

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