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EGFP-alphasynuclein-A53T Citations (16)

Plasmid Article: Alpha-synuclein overexpression promotes aggregation of mutant huntingtin.
Furlong RA, Narain Y, Rankin J, Wyttenbach A, Rubinsztein DC Biochem J. 2000 Mar 15;346 Pt 3:577-81.
PubMed Journal

Articles Citing EGFP-alphasynuclein-A53T

Articles
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease. Baksi S, Tripathi AK, Singh N. Free Radic Biol Med. 2016 Jun 23;97:292-306. doi: 10.1016/j.freeradbiomed.2016.06.025. PubMed
alpha-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients. Dieriks BV, Park TI, Fourie C, Faull RL, Dragunow M, Curtis MA. Sci Rep. 2017 Feb 23;7:42984. doi: 10.1038/srep42984. PubMed
Accumulation of autophagosomes confers cytotoxicity. Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S. J Biol Chem. 2017 Jul 3. pii: jbc.M117.782276. doi: 10.1074/jbc.M117.782276. PubMed
New compounds identified through in silico approaches reduce the alpha-synuclein expression by inhibiting prolyl oligopeptidase in vitro. Kumar R, Bavi R, Jo MG, Arulalapperumal V, Baek A, Rampogu S, Kim MO, Lee KW. Sci Rep. 2017 Sep 7;7(1):10827. doi: 10.1038/s41598-017-11302-0. PubMed
Gintonin Mitigates MPTP-Induced Loss of Nigrostriatal Dopaminergic Neurons and Accumulation of alpha-Synuclein via the Nrf2/HO-1 Pathway. Jo MG, Ikram M, Jo MH, Yoo L, Chung KC, Nah SY, Hwang H, Rhim H, Kim MO. Mol Neurobiol. 2019 Jan;56(1):39-55. doi: 10.1007/s12035-018-1020-1. Epub 2018 Apr 19. PubMed
Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T alpha-synuclein model of Parkinson's disease. Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, Li W, Zou F. Cell Death Dis. 2018 Jun 13;9(6):700. doi: 10.1038/s41419-018-0722-7. PubMed
Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Shaltouki A, Hsieh CH, Kim MJ, Wang X. Acta Neuropathol. 2018 Oct;136(4):607-620. doi: 10.1007/s00401-018-1873-4. Epub 2018 Jun 9. PubMed
Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, Hong Y, Ford C, Luo Y, Qi X. Acta Neuropathol. 2019 Jun;137(6):939-960. doi: 10.1007/s00401-019-01993-2. Epub 2019 Mar 15. PubMed
Gene co-expression analysis of the human substantia nigra identifies BMP2 as a neurotrophic factor that can promote neurite growth in cells overexpressing wild-type or A53T alpha-synuclein. Goulding SR, Sullivan AM, O'Keeffe GW, Collins LM. Parkinsonism Relat Disord. 2019 Apr 11. pii: S1353-8020(19)30203-2. doi: 10.1016/j.parkreldis.2019.04.008. PubMed
Gene Co-expression Analysis Identifies Histone Deacetylase 5 and 9 Expression in Midbrain Dopamine Neurons and as Regulators of Neurite Growth via Bone Morphogenetic Protein Signaling. Mazzocchi M, Wyatt SL, Mercatelli D, Morari M, Morales-Prieto N, Collins LM, Sullivan AM, O'Keeffe GW. Front Cell Dev Biol. 2019 Sep 13;7:191. doi: 10.3389/fcell.2019.00191. eCollection 2019. PubMed
Negative regulation of autophagy by UBA6-BIRC6-mediated ubiquitination of LC3. Jia R, Bonifacino JS. Elife. 2019 Nov 6;8. pii: 50034. doi: 10.7554/eLife.50034. PubMed

Associated Plasmids

Unconventional secretion of alpha-Crystallin B requires the Autophagic pathway and is controlled by phosphorylation of its serine 59 residue. D'Agostino M, Scerra G, Cannata Serio M, Caporaso MG, Bonatti S, Renna M. Sci Rep. 2019 Nov 15;9(1):16892. doi: 10.1038/s41598-019-53226-x. PubMed
p38 MAPK-DRP1 signaling is involved in mitochondrial dysfunction and cell death in mutant A53T alpha-synuclein model of Parkinson's disease. Gui C, Ren Y, Chen J, Wu X, Mao K, Li H, Yu H, Zou F, Li W. Toxicol Appl Pharmacol. 2020 Feb 1;388:114874. doi: 10.1016/j.taap.2019.114874. Epub 2019 Dec 24. PubMed
Alterations in alpha-synuclein and PINK1 expression reduce neurite length and induce mitochondrial fission and Golgi fragmentation in midbrain neurons. Furlong RM, O'Keeffe GW, O'Neill C, Sullivan AM. Neurosci Lett. 2020 Feb 16;720:134777. doi: 10.1016/j.neulet.2020.134777. Epub 2020 Jan 21. PubMed
Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes alpha-synuclein degradation via transcription factor EB-dependent autophagy in mutant alpha-synucleinA53T model of Parkinson's disease. Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, Wen Y, Zou F, Li W. Aging Cell. 2020 Jun;19(6):e13163. doi: 10.1111/acel.13163. Epub 2020 May 31. PubMed
The extracellular chaperone Clusterin enhances Tau aggregate seeding in a cellular model. Yuste-Checa P, Trinkaus VA, Riera-Tur I, Imamoglu R, Schaller TF, Wang H, Dudanova I, Hipp MS, Bracher A, Hartl FU. Nat Commun. 2021 Aug 11;12(1):4863. doi: 10.1038/s41467-021-25060-1. PubMed

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