AAVS1-Neo-M2rtTA Citations (20)
Originally described in: Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome.DeKelver RC, Choi VM, Moehle EA, Paschon DE, Hockemeyer D, Meijsing SH, Sancak Y, Cui X, Steine EJ, Miller JC, Tam P, Bartsevich VV, Meng X, Rupniewski I, Gopalan SM, Sun HC, Pitz KJ, Rock JM, Zhang L, Davis GD, Rebar EJ, Cheeseman IM, Yamamoto KR, Sabatini DM, Jaenisch R, Gregory PD, Urnov FD Genome Res. 2010 Aug;20(8):1133-42. doi: 10.1101/gr.106773.110. Epub 2010 May 27. PubMed Journal
Articles Citing AAVS1-Neo-M2rtTA
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| Application of CRISPR/Cas9 to Autophagy Research. O'Prey J, Sakamaki J, Baudot AD, New M, Van Acker T, Tooze SA, Long JS, Ryan KM. Methods Enzymol. 2017;588:79-108. doi: 10.1016/bs.mie.2016.09.076. Epub 2016 Dec 1. PubMed |
Generation and characterization of a human iPSC cell line expressing inducible Cas9 in the "safe harbor" AAVS1 locus.
Castano J, Bueno C, Jimenez-Delgado S, Roca-Ho H, Fraga MF, Fernandez AF, Nakanishi M, Torres-Ruiz R, Rodriguez-Perales S, Menendez P.
Stem Cell Res. 2017 May;21:137-140. doi: 10.1016/j.scr.2017.04.011. Epub 2017 Apr 22.
PubMed
Associated Plasmids |
| Inducible CRISPR genome editing platform in naive human embryonic stem cells reveals JARID2 function in self-renewal. Ferreccio A, Mathieu J, Detraux D, Somasundaram L, Cavanaugh C, Sopher B, Fischer K, Bello T, M Hussein A, Levy S, Cook S, Sidhu SB, Artoni F, Palpant NJ, Reinecke H, Wang Y, Paddison P, Murry C, Jayadev S, Ware C, Ruohola-Baker H. Cell Cycle. 2018;17(5):535-549. doi: 10.1080/15384101.2018.1442621. Epub 2018 Apr 5. PubMed |
Conditional gene knockout and reconstitution in human iPSCs with an inducible Cas9 system.
Wu M, Liu S, Gao Y, Bai H, Machairaki V, Li G, Chen T, Cheng L.
Stem Cell Res. 2018 May;29:6-14. doi: 10.1016/j.scr.2018.03.003. Epub 2018 Mar 10.
PubMed
Associated Plasmids |
Gene signatures of quiescent glioblastoma cells reveal mesenchymal shift and interactions with niche microenvironment.
Tejero R, Huang Y, Katsyv I, Kluge M, Lin JY, Tome-Garcia J, Daviaud N, Wang Y, Zhang B, Tsankova NM, Friedel CC, Zou H, Friedel RH.
EBioMedicine. 2019 Apr 2. pii: S2352-3964(19)30209-9. doi: 10.1016/j.ebiom.2019.03.064.
PubMed
Associated Plasmids |
| A Platform for Studying Neurodegeneration Mechanisms Using Genetically Encoded Biosensors. Ustyantseva EI, Medvedev SP, Vetchinova AS, Minina JM, Illarioshkin SN, Zakian SM. Biochemistry (Mosc). 2019 Mar;84(3):299-309. doi: 10.1134/S000629791903012X. PubMed |
| Loss of the transcription factor MAFB limits beta-cell derivation from human PSCs. Russell R, Carnese PP, Hennings TG, Walker EM, Russ HA, Liu JS, Giacometti S, Stein R, Hebrok M. Nat Commun. 2020 Jun 2;11(1):2742. doi: 10.1038/s41467-020-16550-9. PubMed |
| Generation of two gene edited iPSC-lines carrying a DOX-inducible NGN2 expression cassette with and without GFP in the AAVS1 locus. Schmid B, Holst B, Poulsen U, Jorring I, Clausen C, Rasmussen M, Mau-Holzmann UA, Steeg R, Nuthall H, Ebneth A, Cabrera-Socorro A. Stem Cell Res. 2021 Apr;52:102240. doi: 10.1016/j.scr.2021.102240. Epub 2021 Feb 11. PubMed |
An early cell shape transition drives evolutionary expansion of the human forebrain.
Benito-Kwiecinski S, Giandomenico SL, Sutcliffe M, Riis ES, Freire-Pritchett P, Kelava I, Wunderlich S, Martin U, Wray GA, McDole K, Lancaster MA.
Cell. 2021 Apr 15;184(8):2084-2102.e19. doi: 10.1016/j.cell.2021.02.050. Epub 2021 Mar 24.
PubMed
Associated Plasmids |
| Protocol for genome-scale CRISPR screening in engineered lineage reporter hPSCs to study cell fate determination. Zhou Z, Ma L, Zhang X. STAR Protoc. 2021 May 20;2(2):100548. doi: 10.1016/j.xpro.2021.100548. eCollection 2021 Jun 18. PubMed |
| Generation of Transgenic Rat Embryonic Stem Cells Using the CRISPR/Cpf1 System for Inducible Gene Knockout. Sherstyuk VV, Zakian SM. Biochemistry (Mosc). 2021 Jul;86(7):843-851. doi: 10.1134/S0006297921070051. PubMed |
| Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection. Parent AV, Faleo G, Chavez J, Saxton M, Berrios DI, Kerper NR, Tang Q, Hebrok M. Cell Rep. 2021 Aug 17;36(7):109538. doi: 10.1016/j.celrep.2021.109538. PubMed |
| Establishment of a human induced pluripotent stem cell neuronal model for identification of modulators of A53T alpha-synuclein levels and aggregation. Vajhoj C, Schmid B, Alik A, Melki R, Fog K, Holst B, Stummann TC. PLoS One. 2021 Dec 21;16(12):e0261536. doi: 10.1371/journal.pone.0261536. eCollection 2021. PubMed |
| Oxidative stress monitoring in iPSC-derived motor neurons using genetically encoded biosensors of H2O2. Ustyantseva E, Pavlova SV, Malakhova AA, Ustyantsev K, Zakian SM, Medvedev SP. Sci Rep. 2022 May 27;12(1):8928. doi: 10.1038/s41598-022-12807-z. PubMed |
| Detection of ER Stress in iPSC-Derived Neurons Carrying the p.N370S Mutation in the GBA1 Gene. Yarkova ES, Grigor'eva EV, Medvedev SP, Tarasevich DA, Pavlova SV, Valetdinova KR, Minina JM, Zakian SM, Malakhova AA. Biomedicines. 2024 Mar 27;12(4):744. doi: 10.3390/biomedicines12040744. PubMed |
| A dynamic in vitro model of Down syndrome neurogenesis with trisomy 21 gene dosage correction. Bansal P, Banda EC, Glatt-Deeley HR, Stoddard CE, Linsley JW, Arora N, Deleschaux C, Ahern DT, Kondaveeti Y, Massey RE, Nicouleau M, Wang S, Sabariego-Navarro M, Dierssen M, Finkbeiner S, Pinter SF. Sci Adv. 2024 Jun 7;10(23):eadj0385. doi: 10.1126/sciadv.adj0385. Epub 2024 Jun 7. PubMed |
| Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure. Lisowski P, Lickfett S, Rybak-Wolf A, Menacho C, Le S, Pentimalli TM, Notopoulou S, Dykstra W, Oehler D, Lopez-Calcerrada S, Mlody B, Otto M, Wu H, Richter Y, Roth P, Anand R, Kulka LAM, Meierhofer D, Glazar P, Legnini I, Telugu NS, Hahn T, Neuendorf N, Miller DC, Boddrich A, Polzin A, Mayatepek E, Diecke S, Olzscha H, Kirstein J, Ugalde C, Petrakis S, Cambridge S, Rajewsky N, Kuhn R, Wanker EE, Priller J, Metzger JJ, Prigione A. Nat Commun. 2024 Aug 22;15(1):7027. doi: 10.1038/s41467-024-51216-w. PubMed |
| Transgenic iPSC Lines with Genetically Encoded MitoTimer to Study Mitochondrial Biogenesis in Dopaminergic Neurons with Tauopathy. Nadtochy JA, Medvedev SP, Grigor'eva EV, Pavlova SV, Minina JM, Chechushkov AV, Malakhova AA, Kovalenko LV, Zakian SM. Biomedicines. 2025 Feb 21;13(3):550. doi: 10.3390/biomedicines13030550. PubMed |
| The Influence of Cohesin on the Short-Scale Dynamics of Intact and Damaged Chromatin in Different Phases of the Cell Cycle. Viushkov VS, Lomov NA, Kalitina PO, Potashnikova DM, Shtompel AS, Ulianov SV, Razin SV, Rubtsov MA. Int J Mol Sci. 2025 Sep 11;26(18):8837. doi: 10.3390/ijms26188837. PubMed |
| ZMYND11 functions in bimodal regulation of latent genes and brain-like splicing to safeguard corticogenesis. Chang X, Li W, Matsui S, Huynh C, Erickson C, Guo F, Cederquist GY, Studer L, Iwafuchi M, Shillington A, Chronis C, Tchieu J. Nat Commun. 2025 Oct 9;16(1):9010. doi: 10.1038/s41467-025-64063-0. PubMed |
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