lentiSAMv2 Citations (39)
Originally described in: Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. PubMed Journal
Articles Citing lentiSAMv2
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| Risk SNP-Mediated Promoter-Enhancer Switching Drives Prostate Cancer through lncRNA PCAT19. Hua JT, Ahmed M, Guo H, Zhang Y, Chen S, Soares F, Lu J, Zhou S, Wang M, Li H, Larson NB, McDonnell SK, Patel PS, Liang Y, Yao CQ, van der Kwast T, Lupien M, Feng FY, Zoubeidi A, Tsao MS, Thibodeau SN, Boutros PC, He HH. Cell. 2018 Jul 26;174(3):564-575.e18. doi: 10.1016/j.cell.2018.06.014. Epub 2018 Jul 19. PubMed |
| BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis. Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, Kanduri C, Lindahl P, Sayin VI, Bergo MO. Cell. 2019 Jul 11;178(2):330-345.e22. doi: 10.1016/j.cell.2019.06.005. Epub 2019 Jun 27. PubMed |
| Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS. Factor DC, Barbeau AM, Allan KC, Hu LR, Madhavan M, Hoang AT, Hazel KEA, Hall PA, Nisraiyya S, Najm FJ, Miller TE, Nevin ZS, Karl RT, Lima BR, Song Y, Sibert AG, Dhillon GK, Volsko C, Bartels CF, Adams DJ, Dutta R, Gallagher MD, Phu W, Kozlenkov A, Dracheva S, Scacheri PC, Tesar PJ, Corradin O. Cell. 2020 Apr 16;181(2):382-395.e21. doi: 10.1016/j.cell.2020.03.002. Epub 2020 Apr 3. PubMed |
| ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Jing Y, Wang S, Zhang W, Liu GH, Qu J. Nucleic Acids Res. 2020 Jun 19;48(11):6001-6018. doi: 10.1093/nar/gkaa425. PubMed |
| Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function. Allan KC, Hu LR, Scavuzzo MA, Morton AR, Gevorgyan AS, Cohn EF, Clayton BLL, Bederman IR, Hung S, Bartels CF, Madhavan M, Tesar PJ. Cell Stem Cell. 2021 Feb 4;28(2):257-272.e11. doi: 10.1016/j.stem.2020.09.019. Epub 2020 Oct 21. PubMed |
| A Single-Cell Transcriptomic Atlas of Human Skin Aging. Zou Z, Long X, Zhao Q, Zheng Y, Song M, Ma S, Jing Y, Wang S, He Y, Esteban CR, Yu N, Huang J, Chan P, Chen T, Izpisua Belmonte JC, Zhang W, Qu J, Liu GH. Dev Cell. 2021 Feb 8;56(3):383-397.e8. doi: 10.1016/j.devcel.2020.11.002. Epub 2020 Nov 24. PubMed |
Efficient Immune Cell Genome Engineering with Enhanced CRISPR Editing Tools.
Chan W, Gottschalk RA, Yao Y, Pomerantz JL, Germain RN.
Immunohorizons. 2021 Feb 23;5(2):117-132. doi: 10.4049/immunohorizons.2000082.
PubMed
Associated Plasmids |
| In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy. Dai M, Yan G, Wang N, Daliah G, Edick AM, Poulet S, Boudreault J, Ali S, Burgos SA, Lebrun JJ. Nat Commun. 2021 May 24;12(1):3055. doi: 10.1038/s41467-021-23316-4. PubMed |
| Pooled CRISPR screening in pancreatic cancer cells implicates co-repressor complexes as a cause of multiple drug resistance via regulation of epithelial-to-mesenchymal transition. Ramaker RC, Hardigan AA, Gordon ER, Wright CA, Myers RM, Cooper SJ. BMC Cancer. 2021 May 29;21(1):632. doi: 10.1186/s12885-021-08388-1. PubMed |
Targeted regulation of transcription in primary cells using CRISPRa and CRISPRi.
Jensen TI, Mikkelsen NS, Gao Z, Fosselteder J, Pabst G, Axelgaard E, Laustsen A, Konig S, Reinisch A, Bak RO.
Genome Res. 2021 Nov;31(11):2120-2130. doi: 10.1101/gr.275607.121. Epub 2021 Aug 18.
PubMed
Associated Plasmids |
| A CRISPR knockout screen reveals new regulators of canonical Wnt signaling. Evron T, Caspi M, Kazelnik M, Shor-Nareznoy Y, Armoza-Eilat S, Kariv R, Manber Z, Elkon R, Sklan EH, Rosin-Arbesfeld R. Oncogenesis. 2021 Sep 22;10(9):63. doi: 10.1038/s41389-021-00354-7. PubMed |
| SEC23A rescues SEC23B-deficient congenital dyserythropoietic anemia type II. King R, Lin Z, Balbin-Cuesta G, Myers G, Friedman A, Zhu G, McGee B, Saunders TL, Kurita R, Nakamura Y, Engel JD, Reddy P, Khoriaty R. Sci Adv. 2021 Nov 26;7(48):eabj5293. doi: 10.1126/sciadv.abj5293. Epub 2021 Nov 24. PubMed |
| Correction of a Factor VIII genomic inversion with designer-recombinases. Lansing F, Mukhametzyanova L, Rojo-Romanos T, Iwasawa K, Kimura M, Paszkowski-Rogacz M, Karpinski J, Grass T, Sonntag J, Schneider PM, Gunes C, Hoersten J, Schmitt LT, Rodriguez-Muela N, Knofler R, Takebe T, Buchholz F. Nat Commun. 2022 Jan 20;13(1):422. doi: 10.1038/s41467-022-28080-7. PubMed |
CRISPR activation and interference screens decode stimulation responses in primary human T cells.
Schmidt R, Steinhart Z, Layeghi M, Freimer JW, Bueno R, Nguyen VQ, Blaeschke F, Ye CJ, Marson A.
Science. 2022 Feb 4;375(6580):eabj4008. doi: 10.1126/science.abj4008. Epub 2022 Feb 4.
PubMed
Associated Plasmids |
| A genome-wide CRISPR activation screen reveals Hexokinase 1 as a critical factor in promoting resistance to multi-kinase inhibitors in hepatocellular carcinoma cells. Sofer S, Lamkiewicz K, Armoza Eilat S, Partouche S, Marz M, Moskovits N, Stemmer SM, Shlomai A, Sklan EH. FASEB J. 2022 Mar;36(3):e22191. doi: 10.1096/fj.202101507RR. PubMed |
| CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity. Joung J, Kirchgatterer PC, Singh A, Cho JH, Nety SP, Larson RC, Macrae RK, Deasy R, Tseng YY, Maus MV, Zhang F. Nat Commun. 2022 Mar 25;13(1):1606. doi: 10.1038/s41467-022-29205-8. PubMed |
| Transcription Factor 4 loss-of-function is associated with deficits in progenitor proliferation and cortical neuron content. Papes F, Camargo AP, de Souza JS, Carvalho VMA, Szeto RA, LaMontagne E, Teixeira JR, Avansini SH, Sanchez-Sanchez SM, Nakahara TS, Santo CN, Wu W, Yao H, Araujo BMP, Velho PENF, Haddad GG, Muotri AR. Nat Commun. 2022 May 2;13(1):2387. doi: 10.1038/s41467-022-29942-w. PubMed |
| CRISPR Activation Screening Identifies VGLL3-TEAD1-RUNX1/3 as a Transcriptional Complex for PD-L1 Expression. Wijdeven RH, Cabukusta B, Behr FM, Qiu X, Amiri D, Borras DM, Arens R, Liang Y, Neefjes J. J Immunol. 2022 Sep 1;209(5):907-915. doi: 10.4049/jimmunol.2100917. Epub 2022 Aug 3. PubMed |
| Modest increase of KIF11 expression exposes fragilities in the mitotic spindle, causing chromosomal instability. Dale KL, Armond JW, Hynds RE, Vladimirou E. J Cell Sci. 2022 Sep 1;135(17):jcs260031. doi: 10.1242/jcs.260031. Epub 2022 Aug 30. PubMed |
| LINE-1 activation in the cerebellum drives ataxia. Takahashi T, Stoiljkovic M, Song E, Gao XB, Yasumoto Y, Kudo E, Carvalho F, Kong Y, Park A, Shanabrough M, Szigeti-Buck K, Liu ZW, Kristant A, Zhang Y, Sulkowski P, Glazer PM, Kaczmarek LK, Horvath TL, Iwasaki A. Neuron. 2022 Oct 19;110(20):3278-3287.e8. doi: 10.1016/j.neuron.2022.08.011. Epub 2022 Sep 6. PubMed |
| FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation. Yang X, Zhao X, Zhu Y, Xun J, Wen Q, Pan H, Yang J, Wang J, Liang Z, Shen X, Liang Y, Lin Q, Liang H, Li M, Chen J, Jiang S, Xu J, Lu H, Zhu H. Emerg Microbes Infect. 2022 Dec;11(1):2785-2799. doi: 10.1080/22221751.2022.2140605. PubMed |
| MACC1 promotes pancreatic cancer metastasis by interacting with the EMT regulator SNAI1. Zhang X, Luo Y, Cen Y, Qiu X, Li J, Jie M, Yang S, Qin S. Cell Death Dis. 2022 Nov 4;13(11):923. doi: 10.1038/s41419-022-05285-8. PubMed |
| Resurrection of endogenous retroviruses during aging reinforces senescence. Liu X, Liu Z, Wu Z, Ren J, Fan Y, Sun L, Cao G, Niu Y, Zhang B, Ji Q, Jiang X, Wang C, Wang Q, Ji Z, Li L, Esteban CR, Yan K, Li W, Cai Y, Wang S, Zheng A, Zhang YE, Tan S, Cai Y, Song M, Lu F, Tang F, Ji W, Zhou Q, Belmonte JCI, Zhang W, Qu J, Liu GH. Cell. 2023 Jan 19;186(2):287-304.e26. doi: 10.1016/j.cell.2022.12.017. Epub 2023 Jan 6. PubMed |
| Single-cell transcriptomic atlas of mouse cochlear aging. Sun G, Zheng Y, Fu X, Zhang W, Ren J, Ma S, Sun S, He X, Wang Q, Ji Z, Cheng F, Yan K, Liu Z, Belmonte JCI, Qu J, Wang S, Chai R, Liu GH. Protein Cell. 2023 Apr 13;14(3):180-201. doi: 10.1093/procel/pwac058. PubMed |
| Precise excision of HTLV-1 provirus with a designer-recombinase. Rojo-Romanos T, Karpinski J, Millen S, Beschorner N, Simon F, Paszkowski-Rogacz M, Lansing F, Schneider PM, Sonntag J, Hauber J, Thoma-Kress AK, Buchholz F. Mol Ther. 2023 Jul 5;31(7):2266-2285. doi: 10.1016/j.ymthe.2023.03.014. Epub 2023 Mar 17. PubMed |
| CTLA-4 tail fusion enhances CAR-T anti-tumor immunity. Zhou X, Cao H, Fang SY, Chow RD, Tang K, Majety M, Bai M, Dong MB, Renauer PA, Shang X, Suzuki K, Levchenko A, Chen S. bioRxiv. 2023 Mar 15:2023.03.14.532655. doi: 10.1101/2023.03.14.532655. Preprint. PubMed |
| Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1. Tan X, Wang X, Liao X, Wang X, Jiang Z, Liang W, Cao C, Gong D, Hu Z, Tian X. iScience. 2023 Jul 10;26(8):107315. doi: 10.1016/j.isci.2023.107315. eCollection 2023 Aug 18. PubMed |
| Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation. Jing Y, Jiang X, Ji Q, Wu Z, Wang W, Liu Z, Guillen-Garcia P, Esteban CR, Reddy P, Horvath S, Li J, Geng L, Hu Q, Wang S, Belmonte JCI, Ren J, Zhang W, Qu J, Liu GH. Cell Stem Cell. 2023 Nov 2;30(11):1452-1471.e10. doi: 10.1016/j.stem.2023.09.007. Epub 2023 Oct 12. PubMed |
| Surplus fatty acid synthesis increases oxidative stress in adipocytes and lnduces lipodystrophy. Weng L, Tang WS, Wang X, Gong Y, Liu C, Hong NN, Tao Y, Li KZ, Liu SN, Jiang W, Li Y, Yao K, Chen L, Huang H, Zhao YZ, Hu ZP, Lu Y, Ye H, Du X, Zhou H, Li P, Zhao TJ. Nat Commun. 2024 Jan 2;15(1):133. doi: 10.1038/s41467-023-44393-7. PubMed |
| The sirtuin-associated human senescence program converges on the activation of placenta-specific gene PAPPA. Bi S, Jiang X, Ji Q, Wang Z, Ren J, Wang S, Yu Y, Wang R, Liu Z, Liu J, Hu J, Sun G, Wu Z, Diao Z, Li J, Sun L, Izpisua Belmonte JC, Zhang W, Liu GH, Qu J. Dev Cell. 2024 Apr 22;59(8):991-1009.e12. doi: 10.1016/j.devcel.2024.02.008. Epub 2024 Mar 13. PubMed |
| Genome-wide in vivo CRISPR screen identifies TGFbeta3 as actionable biomarker of palbociclib resistance in triple negative breast cancer. Poulet S, Dai M, Wang N, Yan G, Boudreault J, Daliah G, Guillevin A, Nguyen H, Galal S, Ali S, Lebrun JJ. Mol Cancer. 2024 Jun 3;23(1):118. doi: 10.1186/s12943-024-02029-4. PubMed |
| Direct cardiac reprogramming via combined CRISPRa-mediated endogenous Gata4 activation and exogenous Mef2c and Tbx5 expression. Huang P, Xu J, Keepers B, Xie Y, Near D, Xu Y, Hua JR, Spurlock B, Ricketts S, Liu J, Wang L, Qian L. Mol Ther Nucleic Acids. 2024 Nov 15;35(4):102390. doi: 10.1016/j.omtn.2024.102390. eCollection 2024 Dec 10. PubMed |
| Lethal co-expression intolerance underlies the mutually exclusive expression of ASCL1 and NEUROD1 in SCLC cells. Watanabe H, Inoue Y, Tsuchiya K, Asada K, Suzuki M, Ogawa H, Tanahashi M, Watanabe T, Matsuura S, Yasuda K, Ohnishi I, Imokawa S, Yasui H, Karayama M, Suzuki Y, Hozumi H, Furuhashi K, Enomoto N, Fujisawa T, Funai K, Shinmura K, Sugimura H, Inui N, Suda T. NPJ Precis Oncol. 2025 Mar 13;9(1):74. doi: 10.1038/s41698-025-00860-6. PubMed |
| RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3. Yang X, Zhu Y, Zhao X, Xun J, Wang X, Cheng Y, Xiong S, Yu X, Li S, Wang D, Hu Z, Shen Y, Jiang S, Lu H, Wang G, Zhu H. Cell Commun Signal. 2025 May 13;23(1):222. doi: 10.1186/s12964-025-02221-z. PubMed |
| Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity. Su G, Chen B, Song Y, Yin Q, Wang W, Zhao X, Fan S, Lian J, Li D, Bi J, Li P, Zhao Z, Zhang L, Shi J, Lu W. Nat Commun. 2025 Jul 1;16(1):5540. doi: 10.1038/s41467-025-60389-x. PubMed |
| A methyl-to-acetyl switch in H3K27 drives metabolic reprogramming and resistance to BRAF(V600E) inhibition in melanoma. Zhou J, Chai X, Zhu Y, Huang Z, Lin T, Hu Z, Chen G, Luo C, Cui R, Sheng J. Neoplasia. 2025 Oct;68:101223. doi: 10.1016/j.neo.2025.101223. Epub 2025 Aug 23. PubMed |
| Post-transcriptional control of KRAS: functional roles of 5'UTR RNA G-quadruplexes, long noncoding RNA, and hnRNPA1. Cortolezzis Y, Othman Z, Agostini F, Ibrahim I, Picco R, Salgado GF, Di Giorgio E, Xodo LE. Nucleic Acids Res. 2025 Sep 5;53(17):gkaf886. doi: 10.1093/nar/gkaf886. PubMed |
| PRDM16 regulates smooth muscle cell identity and atherosclerotic plaque composition. Tan JME, Cheng L, Calhoun RP, Weller AH, Drareni K, Fong S, Barbara E, Lim HW, Xue C, Winter H, Auguste G, Miller CL, Reilly MP, Maegdefessel L, Lutgens E, Seale P. Nat Cardiovasc Res. 2025 Nov;4(11):1573-1588. doi: 10.1038/s44161-025-00737-8. Epub 2025 Oct 17. PubMed |
| Reversion of passaged nucleus pulposus cells to notochordal-type cells by FoxA2 upregulation. Ashraf S, Montgomery-Song A, Thom C, Davison Kotler E, Chan B, Zelinka A, Santerre P, Kandel R. NPJ Regen Med. 2025 Oct 31;10(1):49. doi: 10.1038/s41536-025-00437-8. PubMed |
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