lentiCRISPR v2-Blast Citations (136)
Originally described in: CRISPR/Cas9-based system for loss-of-function screeningHabashy et al Unpublished
Articles Citing lentiCRISPR v2-Blast
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| Interferon regulatory factor 8 regulates caspase-1 expression to facilitate Epstein-Barr virus reactivation in response to B cell receptor stimulation and chemical induction. Lv DW, Zhang K, Li R. PLoS Pathog. 2018 Jan 22;14(1):e1006868. doi: 10.1371/journal.ppat.1006868. eCollection 2018 Jan. PubMed |
| KREMEN1 Is a Host Entry Receptor for a Major Group of Enteroviruses. Staring J, van den Hengel LG, Raaben M, Blomen VA, Carette JE, Brummelkamp TR. Cell Host Microbe. 2018 May 9;23(5):636-643.e5. doi: 10.1016/j.chom.2018.03.019. Epub 2018 Apr 19. PubMed |
| Protein kinase CK2 modulation of pyruvate kinase M isoforms augments the Warburg effect in cancer cells. Yang KM, Kim K. J Cell Biochem. 2018 Nov;119(10):8501-8510. doi: 10.1002/jcb.27078. Epub 2018 Jul 17. PubMed |
| Genome-scale CRISPR-Cas9 screen identifies druggable dependencies in TP53 wild-type Ewing sarcoma. Stolte B, Iniguez AB, Dharia NV, Robichaud AL, Conway AS, Morgan AM, Alexe G, Schauer NJ, Liu X, Bird GH, Tsherniak A, Vazquez F, Buhrlage SJ, Walensky LD, Stegmaier K. J Exp Med. 2018 Aug 6;215(8):2137-2155. doi: 10.1084/jem.20171066. Epub 2018 Jul 25. PubMed |
| Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data. Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C. Mol Cell. 2018 Sep 6;71(5):858-871.e8. doi: 10.1016/j.molcel.2018.06.044. Epub 2018 Aug 2. PubMed |
| GSK3 suppression upregulates beta-catenin and c-Myc to abrogate KRas-dependent tumors. Kazi A, Xiang S, Yang H, Delitto D, Trevino J, Jiang RHY, Ayaz M, Lawrence HR, Kennedy P, Sebti SM. Nat Commun. 2018 Dec 4;9(1):5154. doi: 10.1038/s41467-018-07644-6. PubMed |
| Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity. Latifkar A, Ling L, Hingorani A, Johansen E, Clement A, Zhang X, Hartman J, Fischbach C, Lin H, Cerione RA, Antonyak MA. Dev Cell. 2019 May 6;49(3):393-408.e7. doi: 10.1016/j.devcel.2019.03.011. Epub 2019 Apr 11. PubMed |
| GIPC proteins negatively modulate Plexind1 signaling during vascular development. Carretero-Ortega J, Chhangawala Z, Hunt S, Narvaez C, Menendez-Gonzalez J, Gay CM, Zygmunt T, Li X, Torres-Vazquez J. Elife. 2019 May 3;8. pii: 30454. doi: 10.7554/eLife.30454. PubMed |
| Physical Principles of Membrane Shape Regulation by the Glycocalyx. Shurer CR, Kuo JC, Roberts LM, Gandhi JG, Colville MJ, Enoki TA, Pan H, Su J, Noble JM, Hollander MJ, O'Donnell JP, Yin R, Pedram K, Mockl L, Kourkoutis LF, Moerner WE, Bertozzi CR, Feigenson GW, Reesink HL, Paszek MJ. Cell. 2019 Jun 13;177(7):1757-1770.e21. doi: 10.1016/j.cell.2019.04.017. Epub 2019 May 2. PubMed |
| EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis. Elias MS, Wright SC, Remenyi J, Abbott JC, Bray SE, Cole C, Edwards S, Gierlinski M, Glok M, McGrath JA, Nicholson WV, Paternoster L, Prescott AR, Have ST, Whitfield PD, Lamond AI, Brown SJ. J Allergy Clin Immunol. 2019 May 31. pii: S0091-6749(19)30741-9. doi: 10.1016/j.jaci.2019.05.024. PubMed |
| Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Nat Microbiol. 2019 Oct;4(10):1760-1769. doi: 10.1038/s41564-019-0464-z. Epub 2019 Jun 3. PubMed |
| Augmenting Immunotherapy Impact by Lowering Tumor TNF Cytotoxicity Threshold. Vredevoogd DW, Kuilman T, Ligtenberg MA, Boshuizen J, Stecker KE, de Bruijn B, Krijgsman O, Huang X, Kenski JCN, Lacroix R, Mezzadra R, Gomez-Eerland R, Yildiz M, Dagidir I, Apriamashvili G, Zandhuis N, van der Noort V, Visser NL, Blank CU, Altelaar M, Schumacher TN, Peeper DS. Cell. 2019 Jul 25;178(3):585-599.e15. doi: 10.1016/j.cell.2019.06.014. Epub 2019 Jul 11. PubMed |
| A real-time, click chemistry imaging approach reveals stimulus-specific subcellular locations of phospholipase D activity. Liang D, Wu K, Tei R, Bumpus TW, Ye J, Baskin JM. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15453-15462. doi: 10.1073/pnas.1903949116. Epub 2019 Jul 16. PubMed |
| A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis. Du C, Hansen LJ, Singh SX, Wang F, Sun R, Moure CJ, Roso K, Greer PK, Yan H, He Y. Cell Rep. 2019 Sep 17;28(12):3199-3211.e5. doi: 10.1016/j.celrep.2019.08.031. PubMed |
| Identification of FUBP1 as a Long Tail Cancer Driver and Widespread Regulator of Tumor Suppressor and Oncogene Alternative Splicing. Elman JS, Ni TK, Mengwasser KE, Jin D, Wronski A, Elledge SJ, Kuperwasser C. Cell Rep. 2019 Sep 24;28(13):3435-3449.e5. doi: 10.1016/j.celrep.2019.08.060. PubMed |
| PGC1alpha Suppresses Prostate Cancer Cell Invasion through ERRalpha Transcriptional Control. Valcarcel-Jimenez L, Macchia A, Crosas-Molist E, Schaub-Clerigue A, Camacho L, Martin-Martin N, Cicogna P, Viera-Bardon C, Fernandez-Ruiz S, Rodriguez-Hernandez I, Hermanova I, Astobiza I, Cortazar AR, Corres-Mendizabal J, Gomez-Munoz A, Sanz-Moreno V, Torrano V, Carracedo A. Cancer Res. 2019 Dec 15;79(24):6153-6165. doi: 10.1158/0008-5472.CAN-19-1231. Epub 2019 Oct 8. PubMed |
| Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer. Zhou S, Hawley JR, Soares F, Grillo G, Teng M, Madani Tonekaboni SA, Hua JT, Kron KJ, Mazrooei P, Ahmed M, Arlidge C, Yun HY, Livingstone J, Huang V, Yamaguchi TN, Espiritu SMG, Zhu Y, Severson TM, Murison A, Cameron S, Zwart W, van der Kwast T, Pugh TJ, Fraser M, Boutros PC, Bristow RG, He HH, Lupien M. Nat Commun. 2020 Jan 23;11(1):441. doi: 10.1038/s41467-020-14318-9. PubMed |
| Lipin-2 degradation elicits a proinflammatory gene signature in macrophages. Watahiki A, Shimizu K, Hoshikawa S, Chiba M, Kitamura H, Egusa H, Fukumoto S, Inuzuka H. Biochem Biophys Res Commun. 2020 Apr 2;524(2):477-483. doi: 10.1016/j.bbrc.2020.01.119. Epub 2020 Jan 31. PubMed |
| Using iRFP Genetic Labeling Technology to Track Tumorogenesis of Transplanted CRISPR/Cas9-Edited iPSC in Skeletal Muscle. Jin Y, Shen Y, Weintraub NL, Tang Y. Methods Mol Biol. 2020;2126:73-83. doi: 10.1007/978-1-0716-0364-2_7. PubMed |
| Copper is an essential regulator of the autophagic kinases ULK1/2 to drive lung adenocarcinoma. Tsang T, Posimo JM, Gudiel AA, Cicchini M, Feldser DM, Brady DC. Nat Cell Biol. 2020 Apr;22(4):412-424. doi: 10.1038/s41556-020-0481-4. Epub 2020 Mar 16. PubMed |
| Effective restoration of dystrophin expression in iPSC (Mdx)-derived muscle progenitor cells using the CRISPR/Cas9 system and homology-directed repair technology. Jin Y, Shen Y, Su X, Weintraub NL, Tang Y. Comput Struct Biotechnol J. 2020 Mar 25;18:765-773. doi: 10.1016/j.csbj.2020.03.012. eCollection 2020. PubMed |
| Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis. Lee YK, Kwon SM, Lee EB, Kim GH, Min S, Hong SM, Wang HJ, Lee DM, Choi KS, Park TJ, Yoon G. Cancers (Basel). 2020 Sep 15;12(9). pii: cancers12092632. doi: 10.3390/cancers12092632. PubMed |
| Rapid and direct control of target protein levels with VHL-recruiting dTAG molecules. Nabet B, Ferguson FM, Seong BKA, Kuljanin M, Leggett AL, Mohardt ML, Robichaud A, Conway AS, Buckley DL, Mancias JD, Bradner JE, Stegmaier K, Gray NS. Nat Commun. 2020 Sep 18;11(1):4687. doi: 10.1038/s41467-020-18377-w. PubMed |
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R, Li C.
Elife. 2020 Oct 1;9. pii: 57858. doi: 10.7554/eLife.57858.
PubMed
Associated Plasmids |
| Activation of Clustered IFNgamma Target Genes Drives Cohesin-Controlled Transcriptional Memory. Siwek W, Tehrani SSH, Mata JF, Jansen LET. Mol Cell. 2020 Nov 5;80(3):396-409.e6. doi: 10.1016/j.molcel.2020.10.005. Epub 2020 Oct 26. PubMed |
| CD73 and cN-II regulate the cellular response to chemotherapeutic and hypoxic stress in lung adenocarcinoma cells. Raza MZ, Cadassou O, Dumontet C, Cros-Perrial E, Jordheim LP. Biochim Biophys Acta Gen Subj. 2021 May;1865(5):129842. doi: 10.1016/j.bbagen.2021.129842. Epub 2021 Jan 9. PubMed |
| Targeted immunotherapy for HER2-low breast cancer with 17p loss. Li Y, Sun Y, Kulke M, Hechler T, Van der Jeught K, Dong T, He B, Miller KD, Radovich M, Schneider BP, Pahl A, Zhang X, Lu X. Sci Transl Med. 2021 Feb 10;13(580). pii: 13/580/eabc6894. doi: 10.1126/scitranslmed.abc6894. PubMed |
| A cold-stress-inducible PERK/OGT axis controls TOM70-assisted mitochondrial protein import and cristae formation. Latorre-Muro P, O'Malley KE, Bennett CF, Perry EA, Balsa E, Tavares CDJ, Jedrychowski M, Gygi SP, Puigserver P. Cell Metab. 2021 Mar 2;33(3):598-614.e7. doi: 10.1016/j.cmet.2021.01.013. Epub 2021 Feb 15. PubMed |
| Warburg Effect Is a Cancer Immune Evasion Mechanism Against Macrophage Immunosurveillance. Chen J, Cao X, Li B, Zhao Z, Chen S, Lai SWT, Muend SA, Nossa GK, Wang L, Guo W, Ye J, Lee PP, Feng M. Front Immunol. 2021 Feb 2;11:621757. doi: 10.3389/fimmu.2020.621757. eCollection 2020. PubMed |
| Role of Clathrin Light Chains in Regulating Invadopodia Formation. Mukenhirn M, Muraca F, Bucher D, Asberger E, Cappio Barazzone E, Cavalcanti-Adam EA, Boulant S. Cells. 2021 Feb 20;10(2). pii: cells10020451. doi: 10.3390/cells10020451. PubMed |
| Genome wide CRISPR screening reveals a role for sialylation in the tumorigenesis and chemoresistance of acute myeloid leukemia cells. Lee DH, Kang SH, Choi DS, Ko M, Choi E, Ahn H, Min H, Oh SJ, Lee MS, Park Y, Jin HS. Cancer Lett. 2021 Jul 10;510:37-47. doi: 10.1016/j.canlet.2021.04.006. Epub 2021 Apr 16. PubMed |
| ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. Bourgeois JS, Wang L, Rabino AF, Everitt J, Alvarez MI, Awadia S, Wittchen ES, Garcia-Mata R, Ko DC. PLoS Pathog. 2021 Jul 9;17(7):e1009713. doi: 10.1371/journal.ppat.1009713. eCollection 2021 Jul. PubMed |
| Generation of microRNA-378a-deficient hiPSC as a novel tool to study its role in human cardiomyocytes. Martyniak A, Andrysiak K, Motais B, Coste S, Podkalicka P, Ferdek P, Stepniewski J, Dulak J. J Mol Cell Cardiol. 2021 Jul 28;160:128-141. doi: 10.1016/j.yjmcc.2021.07.007. PubMed |
| GRB2 enforces homology-directed repair initiation by MRE11. Ye Z, Xu S, Shi Y, Bacolla A, Syed A, Moiani D, Tsai CL, Shen Q, Peng G, Leonard PG, Jones DE, Wang B, Tainer JA, Ahmed Z. Sci Adv. 2021 Aug 4;7(32). pii: 7/32/eabe9254. doi: 10.1126/sciadv.abe9254. Print 2021 Aug. PubMed |
| Caspases Switch off the m(6)A RNA Modification Pathway to Foster the Replication of a Ubiquitous Human Tumor Virus. Zhang K, Zhang Y, Maharjan Y, Sugiokto FG, Wan J, Li R. mBio. 2021 Aug 31;12(4):e0170621. doi: 10.1128/mBio.01706-21. Epub 2021 Aug 24. PubMed |
| TRIM15 and CYLD regulate ERK activation via lysine-63-linked polyubiquitination. Zhu G, Herlyn M, Yang X. Nat Cell Biol. 2021 Sep;23(9):978-991. doi: 10.1038/s41556-021-00732-8. Epub 2021 Sep 8. PubMed |
| Derivation of human pluripotent stem cell line via CRISPR/Cas9 mediated deletion of exon 3 LAMA2 gene (DMBi001-A-1). Jelinkova S, Martyniak A, Dulak J, Stepniewski J. Stem Cell Res. 2021 Oct;56:102529. doi: 10.1016/j.scr.2021.102529. Epub 2021 Sep 2. PubMed |
In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target.
Wang X, Tokheim C, Gu SS, Wang B, Tang Q, Li Y, Traugh N, Zeng Z, Zhang Y, Li Z, Zhang B, Fu J, Xiao T, Li W, Meyer CA, Chu J, Jiang P, Cejas P, Lim K, Long H, Brown M, Liu XS.
Cell. 2021 Oct 14;184(21):5357-5374.e22. doi: 10.1016/j.cell.2021.09.006. Epub 2021 Sep 27.
PubMed
Associated Plasmids |
| Cooperative methylation of human tRNA3Lys at positions A58 and U54 drives the early and late steps of HIV-1 replication. Fukuda H, Chujo T, Wei FY, Shi SL, Hirayama M, Kaitsuka T, Yamamoto T, Oshiumi H, Tomizawa K. Nucleic Acids Res. 2021 Nov 18;49(20):11855-11867. doi: 10.1093/nar/gkab879. PubMed |
| The SETDB1-TRIM28 Complex Suppresses Antitumor Immunity. Lin J, Guo D, Liu H, Zhou W, Wang C, Muller I, Kossenkov AV, Drapkin R, Bitler BG, Helin K, Zhang R. Cancer Immunol Res. 2021 Dec;9(12):1413-1424. doi: 10.1158/2326-6066.CIR-21-0754. PubMed |
| Systematic decomposition of sequence determinants governing CRISPR/Cas9 specificity. Fu R, He W, Dou J, Villarreal OD, Bedford E, Wang H, Hou C, Zhang L, Wang Y, Ma D, Chen Y, Gao X, Depken M, Xu H. Nat Commun. 2022 Jan 25;13(1):474. doi: 10.1038/s41467-022-28028-x. PubMed |
Sparse dictionary learning recovers pleiotropy from human cell fitness screens.
Pan J, Kwon JJ, Talamas JA, Borah AA, Vazquez F, Boehm JS, Tsherniak A, Zitnik M, McFarland JM, Hahn WC.
Cell Syst. 2022 Jan 21. pii: S2405-4712(21)00488-9. doi: 10.1016/j.cels.2021.12.005.
PubMed
Associated Plasmids |
| Acetate Improves the Killing of Streptococcus pneumoniae by Alveolar Macrophages via NLRP3 Inflammasome and Glycolysis-HIF-1alpha Axis. Machado MG, Patente TA, Rouille Y, Heumel S, Melo EM, Deruyter L, Pourcet B, Sencio V, Teixeira MM, Trottein F. Front Immunol. 2022 Jan 20;13:773261. doi: 10.3389/fimmu.2022.773261. eCollection 2022. PubMed |
| Drug screening and genome editing in human pancreatic cancer organoids identifies drug-gene interactions and candidates for off-label treatment. Hirt CK, Booij TH, Grob L, Simmler P, Toussaint NC, Keller D, Taube D, Ludwig V, Goryachkin A, Pauli C, Lenggenhager D, Stekhoven DJ, Stirnimann CU, Endhardt K, Ringnalda F, Villiger L, Siebenhuner A, Karkampouna S, De Menna M, Beshay J, Klett H, Kruithof-de Julio M, Schuler J, Schwank G. Cell Genom. 2022 Feb;2(2):100095. doi: 10.1016/j.xgen.2022.100095. PubMed |
| Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness. Fanfone D, Wu Z, Mammi J, Berthenet K, Neves D, Weber K, Halaburkova A, Virard F, Bunel F, Jamard C, Hernandez-Vargas H, Tait SWG, Hennino A, Ichim G. Elife. 2022 Mar 8;11. pii: 73150. doi: 10.7554/eLife.73150. PubMed |
| Metformin Combining PD-1 Inhibitor Enhanced Anti-Tumor Efficacy in STK11 Mutant Lung Cancer Through AXIN-1-Dependent Inhibition of STING Ubiquitination. Wang Z, Lu C, Zhang K, Lin C, Wu F, Tang X, Wu D, Dou Y, Han R, Wang Y, Hou C, Ouyang Q, Feng M, He Y, Li L. Front Mol Biosci. 2022 Feb 23;9:780200. doi: 10.3389/fmolb.2022.780200. eCollection 2022. PubMed |
| Functional Genomic Analysis of CDK4 and CDK6 Gene Dependency across Human Cancer Cell Lines. Zhang Z, Golomb L, Meyerson M. Cancer Res. 2022 Jun 6;82(11):2171-2184. doi: 10.1158/0008-5472.CAN-21-2428. PubMed |
| Antithetic effect of interferon-alpha on cell-free and cell-to-cell HIV-1 infection. Kumata R, Iwanami S, Mar KB, Kakizoe Y, Misawa N, Nakaoka S, Koyanagi Y, Perelson AS, Schoggins JW, Iwami S, Sato K. PLoS Comput Biol. 2022 Apr 25;18(4):e1010053. doi: 10.1371/journal.pcbi.1010053. eCollection 2022 Apr. PubMed |
| Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity. Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Nat Commun. 2022 Apr 29;13(1):2350. doi: 10.1038/s41467-022-29730-6. PubMed |
| The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis. Erttmann SF, Swacha P, Aung KM, Brindefalk B, Jiang H, Hartlova A, Uhlin BE, Wai SN, Gekara NO. Immunity. 2022 May 10;55(5):847-861.e10. doi: 10.1016/j.immuni.2022.04.006. PubMed |
| RNF31 inhibition sensitizes tumors to bystander killing by innate and adaptive immune cells. Zhang Z, Kong X, Ligtenberg MA, van Hal-van Veen SE, Visser NL, de Bruijn B, Stecker K, van der Helm PW, Kuilman T, Hoefsmit EP, Vredevoogd DW, Apriamashvili G, Baars B, Voest EE, Klarenbeek S, Altelaar M, Peeper DS. Cell Rep Med. 2022 Jun 21;3(6):100655. doi: 10.1016/j.xcrm.2022.100655. Epub 2022 Jun 9. PubMed |
| A nucleation barrier spring-loads the CBM signalosome for binary activation. Rodriguez Gama A, Miller T, Lange JJ, Unruh JR, Halfmann R. Elife. 2022 Jun 21;11:e79826. doi: 10.7554/eLife.79826. PubMed |
| Recruitment of the CoREST transcription repressor complexes by Nerve Growth factor IB-like receptor (Nurr1/NR4A2) mediates silencing of HIV in microglial cells. Ye F, Alvarez-Carbonell D, Nguyen K, Leskov K, Garcia-Mesa Y, Sreeram S, Valadkhan S, Karn J. PLoS Pathog. 2022 Jul 7;18(7):e1010110. doi: 10.1371/journal.ppat.1010110. eCollection 2022 Jul. PubMed |
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex.
Kwon JJ, Hajian B, Bian Y, Young LC, Amor AJ, Fuller JR, Fraley CV, Sykes AM, So J, Pan J, Baker L, Lee SJ, Wheeler DB, Mayhew DL, Persky NS, Yang X, Root DE, Barsotti AM, Stamford AW, Perry CK, Burgin A, McCormick F, Lemke CT, Hahn WC, Aguirre AJ.
Nature. 2022 Jul 13. pii: 10.1038/s41586-022-04928-2. doi: 10.1038/s41586-022-04928-2.
PubMed
Associated Plasmids |
| The Mutational Landscape of Cancer's Vulnerability to Ionizing Radiation. Gopal P, Yard BD, Petty A, Lal JC, Bera TK, Hoang TQ, Buhimschi AD, Abazeed ME. Clin Cancer Res. 2022 Dec 15;28(24):5343-5358. doi: 10.1158/1078-0432.CCR-22-1914. PubMed |
| Epigenetic silencing by the SMC5/6 complex mediates HIV-1 latency. Irwan ID, Bogerd HP, Cullen BR. Nat Microbiol. 2022 Dec;7(12):2101-2113. doi: 10.1038/s41564-022-01264-z. Epub 2022 Nov 14. PubMed |
| KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition. Pan Y, Han H, Hu H, Wang H, Song Y, Hao Y, Tong X, Patel AS, Misirlioglu S, Tang S, Huang HY, Geng K, Chen T, Karatza A, Sherman F, Labbe KE, Yang F, Chafitz A, Peng C, Guo C, Moreira AL, Velcheti V, Lau SCM, Sui P, Chen H, Diehl JA, Rustgi AK, Bass AJ, Poirier JT, Zhang X, Ji H, Zhang H, Wong KK. Cancer Cell. 2023 Jan 9;41(1):88-105.e8. doi: 10.1016/j.ccell.2022.11.015. Epub 2022 Dec 15. PubMed |
| Generation of human induced pluripotent stem cell lines with HMOX1 promoter polymorphism and CRISPR/Cas9-mediated deletion of exon 50 of DMD gene. Polak K, Stepniewski J, Sciezynska A, Podgorska A, Dulak J, Florczyk-Soluch U. Stem Cell Res. 2023 Feb;66:103004. doi: 10.1016/j.scr.2022.103004. Epub 2022 Dec 13. PubMed |
| The HAPSTR2 retrogene buffers stress signaling and resilience in mammals. Amici DR, Cingoz H, Alasady MJ, Alhayek S, Phoumyvong CM, Sahni N, Yi SS, Mendillo ML. Nat Commun. 2023 Jan 11;14(1):152. doi: 10.1038/s41467-022-35697-1. PubMed |
| The ETS transcription factor ETV6 constrains the transcriptional activity of EWS-FLI to promote Ewing sarcoma. Lu DY, Ellegast JM, Ross KN, Malone CF, Lin S, Mabe NW, Dharia NV, Meyer A, Conway A, Su AH, Selich-Anderson J, Taslim C, Byrum AK, Seong BKA, Adane B, Gray NS, Rivera MN, Lessnick SL, Stegmaier K. Nat Cell Biol. 2023 Feb;25(2):285-297. doi: 10.1038/s41556-022-01059-8. Epub 2023 Jan 19. PubMed |
| Retrospective identification of intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Raj A. bioRxiv. 2023 Feb 10:2023.02.10.527870. doi: 10.1101/2023.02.10.527870. Preprint. PubMed |
| Genome-Scale CRISPR Screening Reveals Host Factors Required for Ribosome Formation and Viral Replication. Ohlson MB, Eitson JL, Wells AI, Kumar A, Jang S, Ni C, Xing C, Buszczak M, Schoggins JW. mBio. 2023 Apr 25;14(2):e0012723. doi: 10.1128/mbio.00127-23. Epub 2023 Feb 21. PubMed |
| An adverse tumor-protective effect of IDO1 inhibition. Kenski JCN, Huang X, Vredevoogd DW, de Bruijn B, Traets JJH, Ibanez-Molero S, Schieven SM, van Vliet A, Krijgsman O, Kuilman T, Pozniak J, Loayza-Puch F, Terry AM, Muller J, Logtenberg MEW, de Bruijn M, Levy P, Korner PR, Goding CR, Schumacher TN, Marine JC, Agami R, Peeper DS. Cell Rep Med. 2023 Feb 21;4(2):100941. doi: 10.1016/j.xcrm.2023.100941. PubMed |
| A neurodevelopmental epigenetic programme mediated by SMARCD3-DAB1-Reelin signalling is hijacked to promote medulloblastoma metastasis. Zou H, Poore B, Brown EE, Qian J, Xie B, Asimakidou E, Razskazovskiy V, Ayrapetian D, Sharma V, Xia S, Liu F, Chen A, Guan Y, Li Z, Wanggou S, Saulnier O, Ly M, Fellows-Mayle W, Xi G, Tomita T, Resnick AC, Mack SC, Raabe EH, Eberhart CG, Sun D, Stronach BE, Agnihotri S, Kohanbash G, Lu S, Herrup K, Rich JN, Gittes GK, Broniscer A, Hu Z, Li X, Pollack IF, Friedlander RM, Hainer SJ, Taylor MD, Hu B. Nat Cell Biol. 2023 Mar;25(3):493-507. doi: 10.1038/s41556-023-01093-0. Epub 2023 Feb 27. PubMed |
| HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer. Khalil MI, Yang C, Vu L, Chadha S, Nabors H, Welbon C, James CD, Morgan IM, Spanos WC, Pyeon D. PLoS Pathog. 2023 Mar 3;19(3):e1011171. doi: 10.1371/journal.ppat.1011171. eCollection 2023 Mar. PubMed |
| Genotype-phenotype mapping of a patient-derived lung cancer organoid biobank identifies NKX2-1-defined Wnt dependency in lung adenocarcinoma. Ebisudani T, Hamamoto J, Togasaki K, Mitsuishi A, Sugihara K, Shinozaki T, Fukushima T, Kawasaki K, Seino T, Oda M, Hanyu H, Toshimitsu K, Emoto K, Hayashi Y, Asakura K, Johnson TA, Terai H, Ikemura S, Kawada I, Ishii M, Hishida T, Asamura H, Soejima K, Nakagawa H, Fujii M, Fukunaga K, Yasuda H, Sato T. Cell Rep. 2023 Mar 28;42(3):112212. doi: 10.1016/j.celrep.2023.112212. Epub 2023 Mar 6. PubMed |
| PP6 regulation of Aurora A-TPX2 limits NDC80 phosphorylation and mitotic spindle size. Sobajima T, Kowalczyk KM, Skylakakis S, Hayward D, Fulcher LJ, Neary C, Batley C, Kurlekar S, Roberts E, Gruneberg U, Barr FA. J Cell Biol. 2023 May 1;222(5):e202205117. doi: 10.1083/jcb.202205117. Epub 2023 Mar 10. PubMed |
| Protein supersaturation powers innate immune signaling. Rodriguez Gama A, Miller T, Lange JJ, Wu J, Song X, Venkatesan S, Unruh JR, Bradford D, Halfmann R. bioRxiv. 2023 Mar 21:2023.03.20.533581. doi: 10.1101/2023.03.20.533581. Preprint. PubMed |
| CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. Cell Rep. 2023 Apr 25;42(4):112316. doi: 10.1016/j.celrep.2023.112316. Epub 2023 Mar 29. PubMed |
Interrogating bromodomain inhibitor resistance in KMT2A-rearranged leukemia through combinatorial CRISPR screens.
Wright S, Hu J, Wang H, Hyle J, Zhang Y, Du G, Konopleva MY, Kornblau SM, Djekidel MN, Rosikiewicz W, Xu B, Lu R, Yang JJ, Li C.
Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2220134120. doi: 10.1073/pnas.2220134120. Epub 2023 Apr 10.
PubMed
Associated Plasmids |
| Nicotinamide N-methyltransferase (NNMT) regulates the glucocorticoid signaling pathway during the early phase of adipogenesis. Roberti A, Tejedor JR, Diaz-Moreno I, Lopez V, Santamarina-Ojeda P, Perez RF, Urdinguio RG, Concellon C, Martinez-Chantar ML, Fernandez-Morera JL, Diaz-Quintana A, Del Amo V, Fernandez AF, Fraga MF. Sci Rep. 2023 May 22;13(1):8293. doi: 10.1038/s41598-023-34916-z. PubMed |
| CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins. Chen M, Li J, Zhang L, Wang L, Cheng C, Ji H, Altilia S, Ding X, Cai G, Altomare D, Shtutman M, Byrum SD, Mackintosh SG, Feoktistov A, Soshnikova N, Mogila VA, Tatarskiy V, Erokhin M, Chetverina D, Prawira A, Ni Y, Urban S, McInnes C, Broude EV, Roninson IB. Nucleic Acids Res. 2023 Aug 11;51(14):7288-7313. doi: 10.1093/nar/gkad538. PubMed |
| METTL1 promotes tumorigenesis through tRNA-derived fragment biogenesis in prostate cancer. Garcia-Vilchez R, Anazco-Guenkova AM, Dietmann S, Lopez J, Moron-Calvente V, D'Ambrosi S, Nombela P, Zamacola K, Mendizabal I, Garcia-Longarte S, Zabala-Letona A, Astobiza I, Fernandez S, Paniagua A, Miguel-Lopez B, Marchand V, Alonso-Lopez D, Merkel A, Garcia-Tunon I, Ugalde-Olano A, Loizaga-Iriarte A, Lacasa-Viscasillas I, Unda M, Azkargorta M, Elortza F, Barcena L, Gonzalez-Lopez M, Aransay AM, Di Domenico T, Sanchez-Martin MA, De Las Rivas J, Guil S, Motorin Y, Helm M, Pandolfi PP, Carracedo A, Blanco S. Mol Cancer. 2023 Jul 29;22(1):119. doi: 10.1186/s12943-023-01809-8. PubMed |
| MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis. Phadnis VV, Snider J, Varadharajan V, Ramachandiran I, Deik AA, Lai ZW, Kunchok T, Eaton EN, Sebastiany C, Lyakisheva A, Vaccaro KD, Allen J, Yao Z, Wong V, Geng B, Weiskopf K, Clish CB, Brown JM, Stagljar I, Weinberg RA, Henry WS. Cell Rep. 2023 Sep 26;42(9):113023. doi: 10.1016/j.celrep.2023.113023. Epub 2023 Sep 8. PubMed |
Global analysis of suppressor mutations that rescue human genetic defects.
Unlu B, Pons C, Ho UL, Batte A, Aloy P, van Leeuwen J.
Genome Med. 2023 Oct 12;15(1):78. doi: 10.1186/s13073-023-01232-0.
PubMed
Associated Plasmids |
| CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression. Terry AR, Nogueira V, Rho H, Ramakrishnan G, Li J, Kang S, Pathmasiri KC, Bhat SA, Jiang L, Kuchay S, Cologna SM, Hay N. Cell Metab. 2023 Nov 7;35(11):2060-2076.e9. doi: 10.1016/j.cmet.2023.09.012. Epub 2023 Oct 17. PubMed |
| A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression. Liu Y, John P, Nishitani K, Cui J, Nishimura CD, Christin JR, Couturier N, Ren X, Wei Y, Pulanco MC, Galbo PM Jr, Zhang X, Fu W, Cui W, Bartholdy BA, Zheng D, Lauvau G, Fineberg SA, Oktay MH, Zang X, Guo W. Dev Cell. 2023 Dec 4;58(23):2700-2717.e12. doi: 10.1016/j.devcel.2023.10.010. Epub 2023 Nov 13. PubMed |
| Copy-back viral genomes induce a cellular stress response that interferes with viral protein expression without affecting antiviral immunity. Gonzalez Aparicio LJ, Yang Y, Hackbart M, Lopez CB. PLoS Biol. 2023 Nov 20;21(11):e3002381. doi: 10.1371/journal.pbio.3002381. eCollection 2023 Nov. PubMed |
| Cell fusion upregulates PD-L1 expression for evasion from immunosurveillance. Tajima Y, Shibasaki F, Masai H. Cancer Gene Ther. 2024 Jan;31(1):158-173. doi: 10.1038/s41417-023-00693-0. Epub 2023 Nov 21. PubMed |
| The ELAVL3/MYCN positive feedback loop provides a therapeutic target for neuroendocrine prostate cancer. Ji Y, Zhang W, Shen K, Su R, Liu X, Ma Z, Liu B, Hu C, Xue Y, Xin Z, Yang Y, Li A, Jiang Z, Jing N, Zhu HH, Dong L, Zhu Y, Dong B, Pan J, Wang Q, Xue W. Nat Commun. 2023 Nov 28;14(1):7794. doi: 10.1038/s41467-023-43676-3. PubMed |
Synonymous codon usage regulates translation initiation.
Barrington CL, Galindo G, Koch AL, Horton ER, Morrison EJ, Tisa S, Stasevich TJ, Rissland OS.
Cell Rep. 2023 Dec 26;42(12):113413. doi: 10.1016/j.celrep.2023.113413. Epub 2023 Dec 12.
PubMed
Associated Plasmids |
| The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer. Khalil MI, Yang C, Vu L, Chadha S, Nabors H, James CD, Morgan IM, Pyeon D. J Virol. 2024 Feb 20;98(2):e0172623. doi: 10.1128/jvi.01726-23. Epub 2024 Jan 16. PubMed |
| Weakened APC/C activity at mitotic exit drives cancer vulnerability to KIF18A inhibition. Gliech CR, Yeow ZY, Tapias-Gomez D, Yang Y, Huang Z, Tijhuis AE, Spierings DC, Foijer F, Chung G, Tamayo N, Bahrami-Nejad Z, Collins P, Nguyen TT, Plata Stapper A, Hughes PE, Payton M, Holland AJ. EMBO J. 2024 Mar;43(5):666-694. doi: 10.1038/s44318-024-00031-6. Epub 2024 Jan 26. PubMed |
| Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells. Jain N, Goyal Y, Dunagin MC, Cote CJ, Mellis IA, Emert B, Jiang CL, Dardani IP, Reffsin S, Arnett M, Yang W, Raj A. Cell Syst. 2024 Feb 21;15(2):109-133.e10. doi: 10.1016/j.cels.2024.01.001. Epub 2024 Feb 8. PubMed |
| Machine learning-based prediction models to guide the selection of Cas9 variants for efficient gene editing. Li J, Wu P, Cao Z, Huang G, Lu Z, Yan J, Zhang H, Zhou Y, Liu R, Chen H, Ma L, Luo M. Cell Rep. 2024 Feb 27;43(2):113765. doi: 10.1016/j.celrep.2024.113765. Epub 2024 Feb 14. PubMed |
| Tissue-location-specific transcription programs drive tumor dependencies in colon cancer. Yang L, Tu L, Bisht S, Mao Y, Petkovich D, Thursby SJ, Liang J, Patel N, Yen RC, Largent T, Zahnow C, Brock M, Gabrielson K, Salimian KJ, Baylin SB, Easwaran H. Nat Commun. 2024 Feb 15;15(1):1384. doi: 10.1038/s41467-024-45605-4. PubMed |
| Tunable DNMT1 degradation reveals DNMT1/DNMT3B synergy in DNA methylation and genome organization. Scelfo A, Barra V, Abdennur N, Spracklin G, Busato F, Salinas-Luypaert C, Bonaiti E, Velasco G, Bonhomme F, Chipont A, Tijhuis AE, Spierings DCJ, Guerin C, Arimondo P, Francastel C, Foijer F, Tost J, Mirny L, Fachinetti D. J Cell Biol. 2024 Apr 1;223(4):e202307026. doi: 10.1083/jcb.202307026. Epub 2024 Feb 20. PubMed |
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.
Ramos S, Hartenian E, Santos JC, Walch P, Broz P.
EMBO J. 2024 Apr;43(7):1164-1186. doi: 10.1038/s44318-024-00055-y. Epub 2024 Feb 23.
PubMed
Associated Plasmids |
| A tangible method to assess native ferroptosis suppressor activity. Nakamura T, Ito J, Mourao ASD, Wahida A, Nakagawa K, Mishima E, Conrad M. Cell Rep Methods. 2024 Mar 25;4(3):100710. doi: 10.1016/j.crmeth.2024.100710. Epub 2024 Feb 24. PubMed |
| eEF1A2 promotes PTEN-GSK3beta-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Treekitkarnmongkol W, Solis LM, Sankaran D, Gagea M, Singh PK, Mistry R, Nguyen T, Kai K, Liu J, Sasai K, Jitsumori Y, Liu J, Nagao N, Stossi F, Mancini MA, Wistuba II, Thompson AM, Lee JM, Cadinanos J, Wong KK, Abbott CM, Sahin AA, Liu S, Katayama H, Sen S. Sci Signal. 2024 Mar 5;17(826):eadh4475. doi: 10.1126/scisignal.adh4475. Epub 2024 Mar 5. PubMed |
| A SWI/SNF-dependent transcriptional regulation mediated by POU2AF2/C11orf53 at enhancer. Szczepanski A, Tsuboyama N, Lyu H, Wang P, Beytullahoglu O, Zhang T, Singer BD, Yue F, Zhao Z, Wang L. Nat Commun. 2024 Mar 7;15(1):2067. doi: 10.1038/s41467-024-46492-5. PubMed |
| Genome-wide CRISPR activation screen identifies JADE3 as an antiviral activator of NF-kB-dependent IFITM3 expression. Munir M, Embry A, Doench JG, Heaton NS, Wilen CB, Orchard RC. J Biol Chem. 2024 Apr;300(4):107153. doi: 10.1016/j.jbc.2024.107153. Epub 2024 Mar 9. PubMed |
| Global and single-nucleotide resolution detection of 7-methylguanosine in RNA. D'Ambrosi S, Garcia-Vilchez R, Kedra D, Vitali P, Macias-Camara N, Barcena L, Gonzalez-Lopez M, Aransay AM, Dietmann S, Hurtado A, Blanco S. RNA Biol. 2024 Jan;21(1):1-18. doi: 10.1080/15476286.2024.2337493. Epub 2024 Apr 2. PubMed |
| Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells. Yamaguchi K, Chen X, Rodgers B, Miura F, Bashtrykov P, Bonhomme F, Salinas-Luypaert C, Haxholli D, Gutekunst N, Aygenli BO, Ferry L, Kirsh O, Laisne M, Scelfo A, Ugur E, Arimondo PB, Leonhardt H, Kanemaki MT, Bartke T, Fachinetti D, Jeltsch A, Ito T, Defossez PA. Nat Commun. 2024 Apr 5;15(1):2960. doi: 10.1038/s41467-024-47314-4. PubMed |
| The Scribble/SGEF/Dlg1 complex regulates the stability of apical junctions in epithelial cells. Rabino A, Awadia S, Ali N, Edson A, Garcia-Mata R. bioRxiv [Preprint]. 2024 Mar 27:2024.03.26.586884. doi: 10.1101/2024.03.26.586884. PubMed |
| Regulation by the RNA-binding protein Unkempt at its effector interface. Shah K, He S, Turner DJ, Corbo J, Rebbani K, Dominguez D, Bateman JM, Cheloufi S, Igreja C, Valkov E, Murn J. Nat Commun. 2024 Apr 11;15(1):3159. doi: 10.1038/s41467-024-47449-4. PubMed |
Positive selection CRISPR screens reveal a druggable pocket in an oligosaccharyltransferase required for inflammatory signaling to NF-kappaB.
Lampson BL, Ramiotarez AS, Baro M, He L, Hegde M, Koduri V, Pfaff JL, Hanna RE, Kowal J, Shirole NH, He Y, Doench JG, Contessa JN, Locher KP, Kaelin WG Jr.
Cell. 2024 Apr 25;187(9):2209-2223.e16. doi: 10.1016/j.cell.2024.03.022.
PubMed
Associated Plasmids |
| Senescence of human pancreatic beta cells enhances functional maturation through chromatin reorganization and promotes interferon responsiveness. Patra M, Klochendler A, Condiotti R, Kaffe B, Elgavish S, Drawshy Z, Avrahami D, Narita M, Hofree M, Drier Y, Meshorer E, Dor Y, Ben-Porath I. Nucleic Acids Res. 2024 Jun 24;52(11):6298-6316. doi: 10.1093/nar/gkae313. PubMed |
| The immune response to RNA suppresses nucleic acid synthesis by limiting ribose 5-phosphate. Bhattacharjee P, Wang D, Anderson D, Buckler JN, de Geus E, Yan F, Polekhina G, Schittenhelm R, Creek DJ, Harris LD, Sadler AJ. EMBO J. 2024 Jul;43(13):2636-2660. doi: 10.1038/s44318-024-00100-w. Epub 2024 May 22. PubMed |
| CRISPR-Cas and CRISPR-based screening system for precise gene editing and targeted cancer therapy. Qin M, Deng C, Wen L, Luo G, Meng Y. J Transl Med. 2024 May 30;22(1):516. doi: 10.1186/s12967-024-05235-2. PubMed |
| Necroptosis stimulates interferon-mediated protective anti-tumor immunity. Rucker AJ, Park CS, Li QJ, Moseman EA, Chan FK. Cell Death Dis. 2024 Jun 10;15(6):403. doi: 10.1038/s41419-024-06801-8. PubMed |
| A non-canonical role for a small nucleolar RNA in ribosome biogenesis and senescence. Cheng Y, Wang S, Zhang H, Lee JS, Ni C, Guo J, Chen E, Wang S, Acharya A, Chang TC, Buszczak M, Zhu H, Mendell JT. Cell. 2024 Aug 22;187(17):4770-4789.e23. doi: 10.1016/j.cell.2024.06.019. Epub 2024 Jul 8. PubMed |
| SART3 reads methylarginine-marked glycine- and arginine-rich motifs. Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT. Cell Rep. 2024 Jul 23;43(7):114459. doi: 10.1016/j.celrep.2024.114459. Epub 2024 Jul 9. PubMed |
| The neonatal Fc receptor (FcRn) is a pan-arterivirus receptor. Shaw TM, Huey D, Mousa-Makky M, Compaleo J, Nennig K, Shah AP, Jiang F, Qiu X, Klipsic D, Rowland RRR, Slukvin II, Sullender ME, Baldridge MT, Li H, Warren CJ, Bailey AL. Nat Commun. 2024 Aug 7;15(1):6726. doi: 10.1038/s41467-024-51142-x. PubMed |
| Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms. Kang S, Antoniewicz MR, Hay N. Nat Commun. 2024 Aug 8;15(1):6777. doi: 10.1038/s41467-024-51117-y. PubMed |
| Phosphorylation of the selective autophagy receptor TAX1BP1 by TBK1 and IKBKE/IKKi promotes ATG8-family protein-dependent clearance of MAVS aggregates. White J, Choi YB, Zhang J, Vo MT, He C, Shaikh K, Harhaj EW. Autophagy. 2025 Jan;21(1):160-177. doi: 10.1080/15548627.2024.2394306. Epub 2024 Sep 10. PubMed |
| In vivo CRISPR screens identify a dual function of MEN1 in regulating tumor-microenvironment interactions. Su P, Liu Y, Chen T, Xue Y, Zeng Y, Zhu G, Chen S, Teng M, Ci X, Guo M, He MY, Hao J, Chu V, Xu W, Wang S, Mehdipour P, Xu X, Marhon SA, Soares F, Pham NA, Wu BX, Her PH, Feng S, Alshamlan N, Khalil M, Krishnan R, Yu F, Chen C, Burrows F, Hakem R, Lupien M, Harding S, Lok BH, O'Brien C, Berlin A, De Carvalho DD, Brooks DG, Schramek D, Tsao MS, He HH. Nat Genet. 2024 Sep;56(9):1890-1902. doi: 10.1038/s41588-024-01874-9. Epub 2024 Sep 3. PubMed |
| IRF2 loss is associated with reduced MHC I pathway transcripts in subsets of most human cancers and causes resistance to checkpoint immunotherapy in human and mouse melanomas. Sari G, Dhatchinamoorthy K, Orellano-Ariza L, Ferreira LM, Brehm MA, Rock K. Res Sq [Preprint]. 2024 Sep 2:rs.3.rs-4997954. doi: 10.21203/rs.3.rs-4997954/v1. PubMed |
| Generation of a fluorescent hESC reporter line (Kle033-A-1) for the isolation of distinct midbrain progenitor cell types. Sif Asgrimsdottir E, Arenas E. Stem Cell Res. 2024 Dec;81:103523. doi: 10.1016/j.scr.2024.103523. Epub 2024 Aug 12. PubMed |
| Inhibiting EZH2 targets atypical teratoid rhabdoid tumor by triggering viral mimicry via both RNA and DNA sensing pathways. Feng S, Marhon SA, Sokolowski DJ, D'Costa A, Soares F, Mehdipour P, Ishak C, Loo Yau H, Ettayebi I, Patel PS, Chen R, Liu J, Zuzarte PC, Ho KC, Ho B, Ning S, Huang A, Arrowsmith CH, Wilson MD, Simpson JT, De Carvalho DD. Nat Commun. 2024 Oct 29;15(1):9321. doi: 10.1038/s41467-024-53515-8. PubMed |
Transsulfuration pathway activation attenuates oxidative stress and ferroptosis in sickle primary erythroblasts and transgenic mice.
Xi C, Pang J, Xue W, Cui Y, Jiang N, Zhi W, Shi H, Horuzsko A, Pace BS, Zhu X.
Commun Biol. 2025 Jan 6;8(1):15. doi: 10.1038/s42003-024-07424-7.
PubMed
Associated Plasmids |
| Deacetylated SNAP47 recruits HOPS to facilitate autophagosome-lysosome fusion independent of STX17. Jian F, Wang S, Tian W, Chen Y, Wang S, Li Y, Ma C, Rong Y. Nat Commun. 2025 Jan 9;16(1):543. doi: 10.1038/s41467-025-55906-x. PubMed |
| Vaccine-induced T cell receptor T cell therapy targeting a glioblastoma stemness antigen. Chih YC, Dietsch AC, Koopmann P, Ma X, Agardy DA, Zhao B, De Roia A, Kourtesakis A, Kilian M, Kramer C, Suwala AK, Stenzinger M, Boenig H, Blum A, Pienkowski VM, Aman K, Becker JP, Feldmann H, Bunse T, Harbottle R, Riemer AB, Liu HK, Etminan N, Sahm F, Ratliff M, Wick W, Platten M, Green EW, Bunse L. Nat Commun. 2025 Feb 1;16(1):1262. doi: 10.1038/s41467-025-56547-w. PubMed |
The essential clathrin adapter protein complex-2 is tumor suppressive specifically in vivo.
Zimmerman SP, DeGraw LB, Counter CM.
Nat Commun. 2025 Mar 6;16(1):2254. doi: 10.1038/s41467-025-57521-2.
PubMed
Associated Plasmids |
| Heritable maintenance of chromatin modifications confers transcriptional memory of interferon-gamma signaling. Mikulski P, Tehrani SSH, Kogan A, Abdul-Zani I, Shell E, James L, Ryan BJ, Jansen LET. Nat Struct Mol Biol. 2025 Apr 4. doi: 10.1038/s41594-025-01522-8. PubMed |
| Lysosomal lipid peroxidation contributes to ferroptosis induction via lysosomal membrane permeabilization. Saimoto Y, Kusakabe D, Morimoto K, Matsuoka Y, Kozakura E, Kato N, Tsunematsu K, Umeno T, Kiyotani T, Matsumoto S, Tsuji M, Hirayama T, Nagasawa H, Uchida K, Karasawa S, Jutanom M, Yamada KI. Nat Commun. 2025 Apr 15;16(1):3554. doi: 10.1038/s41467-025-58909-w. PubMed |
| Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation. Teng M, Guo J, Xu X, Ci X, Mo Y, Kohen Y, Ni Z, Chen S, Guo WY, Bakht M, Ku S, Sigouros M, Luo W, Macarios CM, Xia Z, Chen M, Ul Haq S, Yang W, Berlin A, van der Kwast T, Ellis L, Zoubeidi A, Zheng G, Ming J, Wang Y, Cui H, Lok BH, Raught B, Beltran H, Qin J, He HH. Cancer Cell. 2025 May 12;43(5):891-904.e10. doi: 10.1016/j.ccell.2025.03.027. Epub 2025 Apr 17. PubMed |
| Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis. Kahn BM, Ng RWS, Kim IK, Eskandarian C, Chen CO, Huang B, Lucas A, Li L, Maillard I, Stanger BZ. Cancer Discov. 2025 Sep 4;15(9):1949-1968. doi: 10.1158/2159-8290.CD-24-1847. PubMed |
| The use of sialic acids as attachment factors is a common feature of Enterovirus-D species. Filhol T, Mac Kain A, Joffret M-L, Jouvenet N, Caval V, Bessaud M. J Virol. 2025 Jun 17;99(6):e0042925. doi: 10.1128/jvi.00429-25. Epub 2025 May 13. PubMed |
| Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities. Chen QS, Cai RZ, Wang Y, Liang GH, Zhang KM, Yang XY, Yang D, Zhao DC, Zhu XF, Deng R, Tang J. Mol Cancer. 2025 May 13;24(1):141. doi: 10.1186/s12943-025-02342-6. PubMed |
| CD81 is a receptor for equine arteritis virus (family: Arteriviridae). Maloney SM, Shaw TM, Nennig KM, Larsen MS, Shah A, Kumar A, Marcotrigiano J, Grove J, Snijder EJ, Kirchdoerfer RN, Bailey AL. mBio. 2025 Jul 9;16(7):e0062325. doi: 10.1128/mbio.00623-25. Epub 2025 May 27. PubMed |
| Cocrystal structure reveals the mechanism of FSP1 inhibition by FSEN1. Zhang S, Megarioti AH, Hendricks JM, Zhou J, Sun Q, Jia D, Olzmann JA. Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2505197122. doi: 10.1073/pnas.2505197122. Epub 2025 May 29. PubMed |
| WIP1 mutations suppress DNA damage triggered bypass of the mitotic timer. Sobajima T, Fulcher LJ, Batley C, Alsop SJ, Veakins J, Barr FA. EMBO J. 2025 Aug;44(15):4378-4405. doi: 10.1038/s44318-025-00495-0. Epub 2025 Jun 23. PubMed |
Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids.
Broderick K, Moutaoufik MT, Saccon T, Malty R, Amin S, Phanse S, Joseph TP, Zilocchi M, Hosseinnia A, Istace Z, Hajikarimlou M, Abrar S, Fisher J, Brassard R, Perera R, Kumar A, Aoki H, Rahmatbakhsh M, Jessulat M, Kobasa D, Dehne F, Prasad B, Gagarinova A, Joanne Lemieux M, Cochrane A, Houry WA, Aly KA, Golshani A, Babu M.
Nat Commun. 2025 Jul 1;16(1):5784. doi: 10.1038/s41467-025-60949-1.
PubMed
Associated Plasmids |
| Hippo pathway controls biopterin metabolism to shield adjacent cells from ferroptosis in lung cancer. Li H, Kanamori Y, Nita A, Maeda A, Zhang T, Kikuchi K, Yamada H, Toyomoto T, Saleh MF, Niimura M, Hinokuma H, Shimoda M, Ikeda K, Suzuki M, Komohara Y, Kurotaki D, Sawa T, Moroishi T. EMBO Rep. 2025 Aug;26(16):4124-4152. doi: 10.1038/s44319-025-00515-4. Epub 2025 Jul 7. PubMed |
| SUCLG1 deficiency-induced histone succinylation impairs oncogene expression in acute myeloid leukemia. Gao M, Shi M, Ding H, Xu L, Zhao N, Wang L, Huang S, Jiang H, Bourova-Flin E, Mi J, Khochbin S, Iuso D, Zhu X. Cell Rep. 2025 Aug 26;44(8):116147. doi: 10.1016/j.celrep.2025.116147. Epub 2025 Aug 12. PubMed |
| Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer. Hong D, Lyu Y, Nayak R, Becker JS, Booker MA, Masuzawa K, Devos Z, Wang T, Saito S, Liu Q, Li Y, Li Z, Knelson EH, Thai T, Duplaquet L, Laimon YN, Roberti De Oliveira G, Signoretti S, Doench JG, Barbie DA, Tolystorukov MY, Qi J, Bernstein BE, Ge Y, Oser MG. Dev Cell. 2025 Dec 15;60(24):3462-3479.e13. doi: 10.1016/j.devcel.2025.07.023. Epub 2025 Aug 26. PubMed |
| The aflatoxin B(1)-induced formamidopyrimidine adduct is repaired by transcription-coupled nucleotide excision repair in human cells. Laverty DJ, Tomar R, Erlich S, Stone MP, Nagel ZD. NAR Cancer. 2025 Sep 3;7(3):zcaf030. doi: 10.1093/narcan/zcaf030. eCollection 2025 Sep. PubMed |
| Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer. Sheehan C, Hu L, Cognet G, Croley G, Nguyen TT, Thomas-Toth A, Agovino D, Jonker PB, Sadullozoda M, Ziolkowski LM, Martin JK, Beutel AK, Dano R, Khan MA, Halbrook CJ, Macleod KF, Weber CR, LaBelle JL, Muir A. bioRxiv [Preprint]. 2025 Sep 8:2025.09.04.673818. doi: 10.1101/2025.09.04.673818. PubMed |
| ABCC4 impairs the clearance of plasma LDL cholesterol through suppressing LDLR expression in the liver. Chen J, Huang H, Chen C, Xia G, Huang H, Xiong Y, Luo P, Chen Y, Li J, Wen L, Li L, Lin J, Xu G, Ji C, Tian W, Zhou J, Wei P, Shen C, Wang X. Commun Biol. 2025 Oct 2;8(1):1414. doi: 10.1038/s42003-025-08818-x. PubMed |
| Deciphering acquired resistance mechanisms to sustained auxin-inducible protein degradation in cells and mice. Hyle J, Liu Z, Fields S, Yang J, Chen X, Qi W, Zhang Q, Cho BK, Goo YA, Li X, Sublett J, Li Q, He L, Klein J, Xu P, Pruett-Miller SM, Xu B, Li C. bioRxiv [Preprint]. 2025 Sep 23:2025.09.21.677607. doi: 10.1101/2025.09.21.677607. PubMed |
| Atypical contribution of caspase-3 to melanoma cancer cell motility by regulation of coronin 1B activity. Berthenet K, Diazzi S, Jamard C, Stopa KB, Gil C, Dragan S, Fanfone D, Nguyen TT, Al N, Virard F, Meurette O, Popgeorgiev N, Hernandez-Vargas H, Ablain J, Ichim G. Cell Death Dis. 2025 Oct 6;16(1):690. doi: 10.1038/s41419-025-07952-y. PubMed |
| MEK5/ERK5 inhibition sensitizes NRAS-mutant melanoma to MAPK-targeted therapy by preventing Cyclin D/CDK4-mediated G1/S progression. Paudel R, Goller S, Deutzmann F, Gillitzer A, Meder K, Knorz A, Schrama D, Goebeler M, Schmidt M. Cell Death Dis. 2025 Oct 6;16(1):689. doi: 10.1038/s41419-025-08036-7. PubMed |
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