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3336 pcDNA3 Bcl-2 Citations (26)

Originally described in: BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.
Yamamoto K, Ichijo H, Korsmeyer SJ Mol Cell Biol 1999 Dec;19(12):8469-78.

Articles Citing 3336 pcDNA3 Bcl-2

MAC-related mitochondrial pathway in oroxylin-A-induced apoptosis in human hepatocellular carcinoma HepG2 cells. Liu W, Mu R, Nie FF, Yang Y, Wang J, Dai QS, Lu N, Qi Q, Rong JJ, Hu R, Wang XT, You QD, Guo QL. Cancer Lett. 2009 Nov 1;284(2):198-207. doi: 10.1016/j.canlet.2009.04.021. Epub 2009 May 26. PubMed
Cisplatin overcomes Bcl-2-mediated resistance to apoptosis via preferential engagement of Bak: critical role of Noxa-mediated lipid peroxidation. Kutuk O, Arisan ED, Tezil T, Shoshan MC, Basaga H. Carcinogenesis. 2009 Sep;30(9):1517-27. doi: 10.1093/carcin/bgp165. Epub 2009 Jul 3. PubMed
Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas. Sarosiek KA, Malumbres R, Nechushtan H, Gentles AJ, Avisar E, Lossos IS. Blood. 2010 Jan 21;115(3):570-80. doi: 10.1182/blood-2009-08-239996. Epub 2009 Nov 20. PubMed
Role of mitogen-activated protein kinase in Zn-BC-AM PDT-induced apoptosis in nasopharyngeal carcinoma cells. Koon HK, Chan PS, Wu ZG, Wong RN, Lung ML, Chang CK, Mak NK. Cell Biochem Funct. 2010 Apr;28(3):239-48. doi: 10.1002/cbf.1650. PubMed
Different apoptotic effects of wogonin via induction of H(2)O(2) generation and Ca(2+) overload in malignant hepatoma and normal hepatic cells. Wei L, Lu N, Dai Q, Rong J, Chen Y, Li Z, You Q, Guo Q. J Cell Biochem. 2010 Dec 15;111(6):1629-41. doi: 10.1002/jcb.22898. PubMed
Cisplatin increases B-cell-lymphoma-2 expression via activation of protein kinase C and Akt2 in endometrial cancer cells. Rouette A, Parent S, Girouard J, Leblanc V, Asselin E. Int J Cancer. 2012 Apr 15;130(8):1755-67. doi: 10.1002/ijc.26183. Epub 2011 Aug 5. PubMed
The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma. Bhalla S, Evens AM, Dai B, Prachand S, Gordon LI, Gartenhaus RB. Blood. 2011 Jul 28;118(4):1052-61. doi: 10.1182/blood-2011-03-340109. Epub 2011 May 31. PubMed
Helenalin bypasses Bcl-2-mediated cell death resistance by inhibiting NF-kappaB and promoting reactive oxygen species generation. Hoffmann R, von Schwarzenberg K, Lopez-Anton N, Rudy A, Wanner G, Dirsch VM, Vollmar AM. Biochem Pharmacol. 2011 Sep 1;82(5):453-63. doi: 10.1016/j.bcp.2011.05.029. Epub 2011 Jun 2. PubMed
Downregulation of BCL2 by miRNAs augments drug-induced apoptosis--a combined computational and experimental approach. Singh R, Saini N. J Cell Sci. 2012 Mar 15;125(Pt 6):1568-78. doi: 10.1242/jcs.095976. Epub 2012 Feb 10. PubMed
Targeted BCL2 inhibition effectively inhibits neuroblastoma tumour growth. Lamers F, Schild L, den Hartog IJ, Ebus ME, Westerhout EM, Ora I, Koster J, Versteeg R, Caron HN, Molenaar JJ. Eur J Cancer. 2012 Nov;48(16):3093-103. doi: 10.1016/j.ejca.2012.01.037. Epub 2012 Feb 25. PubMed
A novel role for Bcl-2 in regulation of cellular calcium extrusion. Ferdek PE, Gerasimenko JV, Peng S, Tepikin AV, Petersen OH, Gerasimenko OV. Curr Biol. 2012 Jul 10;22(13):1241-6. doi: 10.1016/j.cub.2012.05.002. Epub 2012 Jun 14. PubMed
Prodigiosin activates endoplasmic reticulum stress cell death pathway in human breast carcinoma cell lines. Pan MY, Shen YC, Lu CH, Yang SY, Ho TF, Peng YT, Chang CC. Toxicol Appl Pharmacol. 2012 Dec 15;265(3):325-34. doi: 10.1016/j.taap.2012.08.034. Epub 2012 Sep 12. PubMed
Subamolide B Isolated from Medicinal Plant Cinnamomum subavenium Induces Cytotoxicity in Human Cutaneous Squamous Cell Carcinoma Cells through Mitochondrial and CHOP-Dependent Cell Death Pathways. Yang SY, Wang HM, Wu TW, Chen YJ, Shieh JJ, Lin JH, Ho TF, Luo RJ, Chen CY, Chang CC. Evid Based Complement Alternat Med. 2013;2013:630415. doi: 10.1155/2013/630415. Epub 2013 Mar 13. PubMed
Critical role of anti-apoptotic Bcl-2 protein phosphorylation in mitotic death. Eichhorn JM, Sakurikar N, Alford SE, Chu R, Chambers TC. Cell Death Dis. 2013 Oct 3;4:e834. doi: 10.1038/cddis.2013.360. PubMed
Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells. Obakan P, Arisan ED, Ozfiliz P, Coker-Gurkan A, Palavan-Unsal N. Mol Biol Rep. 2014 Jan;41(1):145-54. doi: 10.1007/s11033-013-2847-1. Epub 2013 Nov 5. PubMed
Molecular analysis of functional redundancy among anti-apoptotic Bcl-2 proteins and its role in cancer cell survival. Eichhorn JM, Alford SE, Sakurikar N, Chambers TC. Exp Cell Res. 2014 Apr 1;322(2):415-24. doi: 10.1016/j.yexcr.2014.02.010. Epub 2014 Feb 17. PubMed
Oncogenic BRAF induces chronic ER stress condition resulting in increased basal autophagy and apoptotic resistance of cutaneous melanoma. Corazzari M, Rapino F, Ciccosanti F, Giglio P, Antonioli M, Conti B, Fimia GM, Lovat PE, Piacentini M. Cell Death Differ. 2015 Jun;22(6):946-58. doi: 10.1038/cdd.2014.183. Epub 2014 Nov 7. PubMed
Inhibition of PI3K signaling triggered apoptotic potential of curcumin which is hindered by Bcl-2 through activation of autophagy in MCF-7 cells. Akkoc Y, Berrak O, Arisan ED, Obakan P, Coker-Gurkan A, Palavan-Unsal N. Biomed Pharmacother. 2015 Apr;71:161-71. doi: 10.1016/j.biopha.2015.02.029. Epub 2015 Mar 4. PubMed
Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy. Liu KE, Frazier WA. PLoS One. 2015 Jun 23;10(6):e0129667. doi: 10.1371/journal.pone.0129667. eCollection 2015. PubMed
MicroRNA-345 induces apoptosis in pancreatic cancer cells through potentiation of caspase-dependent and -independent pathways. Srivastava SK, Bhardwaj A, Arora S, Tyagi N, Singh S, Andrews J, McClellan S, Wang B, Singh AP. Br J Cancer. 2015 Aug 11;113(4):660-8. doi: 10.1038/bjc.2015.252. Epub 2015 Aug 6. PubMed
The inhibition of PI3K and NFkappaB promoted curcumin-induced cell cycle arrest at G2/M via altering polyamine metabolism in Bcl-2 overexpressing MCF-7 breast cancer cells. Berrak O, Akkoc Y, Arisan ED, Coker-Gurkan A, Obakan-Yerlikaya P, Palavan-Unsal N. Biomed Pharmacother. 2016 Feb;77:150-60. doi: 10.1016/j.biopha.2015.12.007. Epub 2015 Dec 29. PubMed
Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma. Zhang H, Guo Y, Song Y, Shang C. Cancer Chemother Pharmacol. 2017 Jan;79(1):49-55. doi: 10.1007/s00280-016-3194-4. Epub 2016 Nov 22. PubMed
Inhibition of insulin-like growth factor 1 signaling synergistically enhances the tumor suppressive role of triptolide in triple-negative breast cancer cells. Wu H, Sun T, Bi R. Oncol Lett. 2019 Jul;18(1):822-829. doi: 10.3892/ol.2019.10356. Epub 2019 May 14. PubMed
Blockade of STAT3 Signaling Contributes to Anticancer Effect of 5-Acetyloxy-6,7,8,4'-Tetra-Methoxyflavone, a Tangeretin Derivative, on Human Glioblastoma Multiforme Cells. Cheng YP, Li S, Chuang WL, Li CH, Chen GJ, Chang CC, Or CR, Lin PY, Chang CC. Int J Mol Sci. 2019 Jul 9;20(13). pii: ijms20133366. doi: 10.3390/ijms20133366. PubMed
Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo. Akieda Y, Ogamino S, Furuie H, Ishitani S, Akiyoshi R, Nogami J, Masuda T, Shimizu N, Ohkawa Y, Ishitani T. Nat Commun. 2019 Oct 17;10(1):4710. doi: 10.1038/s41467-019-12609-4. PubMed
Hyaluronidase-Expressing Salmonella Effectively Targets Tumor-Associated Hyaluronic Acid in Pancreatic Ductal Adenocarcinoma. Ebelt ND, Zuniga E, Passi KB, Sobocinski LJ, Manuel ER. Mol Cancer Ther. 2019 Nov 6. pii: 1535-7163.MCT-19-0556. doi: 10.1158/1535-7163.MCT-19-0556. PubMed

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