LentiCRISPRv2-mCherry Citations (53)
Originally described in: LentiCRISPRv2-mCherryUnpublished
Articles Citing LentiCRISPRv2-mCherry
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| Breast cancer survival predicted by TP53 mutation status differs markedly depending on treatment. Ungerleider NA, Rao SG, Shahbandi A, Yee D, Niu T, Frey WD, Jackson JG. Breast Cancer Res. 2018 Oct 1;20(1):115. doi: 10.1186/s13058-018-1044-5. PubMed |
| TAF5L and TAF6L Maintain Self-Renewal of Embryonic Stem Cells via the MYC Regulatory Network. Seruggia D, Oti M, Tripathi P, Canver MC, LeBlanc L, Di Giammartino DC, Bullen MJ, Nefzger CM, Sun YBY, Farouni R, Polo JM, Pinello L, Apostolou E, Kim J, Orkin SH, Das PP. Mol Cell. 2019 Jun 20;74(6):1148-1163.e7. doi: 10.1016/j.molcel.2019.03.025. Epub 2019 Apr 17. PubMed |
| m(6)A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development. Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Immunity. 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. PubMed |
| A Genetic Map of the Response to DNA Damage in Human Cells. Olivieri M, Cho T, Alvarez-Quilon A, Li K, Schellenberg MJ, Zimmermann M, Hustedt N, Rossi SE, Adam S, Melo H, Heijink AM, Sastre-Moreno G, Moatti N, Szilard RK, McEwan A, Ling AK, Serrano-Benitez A, Ubhi T, Feng S, Pawling J, Delgado-Sainz I, Ferguson MW, Dennis JW, Brown GW, Cortes-Ledesma F, Williams RS, Martin A, Xu D, Durocher D. Cell. 2020 Jul 23;182(2):481-496.e21. doi: 10.1016/j.cell.2020.05.040. Epub 2020 Jul 9. PubMed |
| The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans. Agarwal S, Vierbuchen T, Ghosh S, Chan J, Jiang Z, Kandasamy RK, Ricci E, Fitzgerald KA. Nat Commun. 2020 Dec 11;11(1):6348. doi: 10.1038/s41467-020-20165-5. PubMed |
| The TOP vector: a new high-titer lentiviral construct for delivery of sgRNAs and transgenes to primary T cells. Humes D, Rainwater S, Overbaugh J. Mol Ther Methods Clin Dev. 2020 Oct 27;20:30-38. doi: 10.1016/j.omtm.2020.10.020. eCollection 2021 Mar 12. PubMed |
| Genome-wide association study implicates novel loci and reveals candidate effector genes for longitudinal pediatric bone accrual. Cousminer DL, Wagley Y, Pippin JA, Elhakeem A, Way GP, Pahl MC, McCormack SE, Chesi A, Mitchell JA, Kindler JM, Baird D, Hartley A, Howe L, Kalkwarf HJ, Lappe JM, Lu S, Leonard ME, Johnson ME, Hakonarson H, Gilsanz V, Shepherd JA, Oberfield SE, Greene CS, Kelly A, Lawlor DA, Voight BF, Wells AD, Zemel BS, Hankenson KD, Grant SFA. Genome Biol. 2021 Jan 4;22(1):1. doi: 10.1186/s13059-020-02207-9. PubMed |
| AQP8 is a crucial H(2)O(2) transporter in insulin-producing RINm5F cells. Kruger C, Waldeck-Weiermair M, Kaynert J, Pokrant T, Komaragiri Y, Otto O, Michel T, Elsner M. Redox Biol. 2021 Jul;43:101962. doi: 10.1016/j.redox.2021.101962. Epub 2021 Apr 1. PubMed |
| Interpretative differences of combined cytogenetic and molecular profiling highlights differences between MRC and ELN classifications of AML. Sussman RT, Manning B, Ackerman D, Bigdeli A, Pammer P, Velu PD, Luger SM, Bagg A, Carroll M, Morrissette JJD. Cancer Genet. 2021 Aug;256-257:68-76. doi: 10.1016/j.cancergen.2021.04.004. Epub 2021 Apr 16. PubMed |
Activating Mucosal-Associated Invariant T Cells Induces a Broad Antitumor Response.
Ruf B, Catania VV, Wabitsch S, Ma C, Diggs LP, Zhang Q, Heinrich B, Subramanyam V, Cui LL, Pouzolles M, Evans CN, Chari R, Sakai S, Oh S, Barry CE III, Barber DL, Greten TF.
Cancer Immunol Res. 2021 Jun 30. pii: 2326-6066.CIR-20-0925. doi: 10.1158/2326-6066.CIR-20-0925.
PubMed
Associated Plasmids |
| Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis. Jeffery NN, Davidson C, Peslak SA, Kingsley PD, Nakamura Y, Palis J, Bulger M. Epigenetics Chromatin. 2021 Jul 30;14(1):37. doi: 10.1186/s13072-021-00408-5. PubMed |
Targeting the coronavirus nucleocapsid protein through GSK-3 inhibition.
Liu X, Verma A, Garcia G Jr, Ramage H, Lucas A, Myers RL, Michaelson JJ, Coryell W, Kumar A, Charney AW, Kazanietz MG, Rader DJ, Ritchie MD, Berrettini WH, Schultz DC, Cherry S, Damoiseaux R, Arumugaswami V, Klein PS.
Proc Natl Acad Sci U S A. 2021 Oct 19;118(42). pii: 2113401118. doi: 10.1073/pnas.2113401118. Epub 2021 Sep 30.
PubMed
Associated Plasmids |
| NR4A1 regulates expression of immediate early genes, suppressing replication stress in cancer. Guo H, Golczer G, Wittner BS, Langenbucher A, Zachariah M, Dubash TD, Hong X, Comaills V, Burr R, Ebright RY, Horwitz E, Vuille JA, Hajizadeh S, Wiley DF, Reeves BA, Zhang JM, Niederhoffer KL, Lu C, Wesley B, Ho U, Nieman LT, Toner M, Vasudevan S, Zou L, Mostoslavsky R, Maheswaran S, Lawrence MS, Haber DA. Mol Cell. 2021 Oct 7;81(19):4041-4058.e15. doi: 10.1016/j.molcel.2021.09.016. PubMed |
| LIN28B alters ribosomal dynamics to promote metastasis in MYCN-driven malignancy. Missios P, da Rocha EL, Pearson DS, Philipp J, Aleman MM, Pirouz M, Farache D, Franses JW, Kubaczka C, Tsanov KM, Jha DK, Pepe-Mooney B, Powers JT, Gregory RI, Lee AS, Dominguez D, Ting DT, Daley GQ. J Clin Invest. 2021 Nov 15;131(22). pii: 145142. doi: 10.1172/JCI145142. PubMed |
| Focused ultrasound excites cortical neurons via mechanosensitive calcium accumulation and ion channel amplification. Yoo S, Mittelstein DR, Hurt RC, Lacroix J, Shapiro MG. Nat Commun. 2022 Jan 25;13(1):493. doi: 10.1038/s41467-022-28040-1. PubMed |
| RAS activation induces synthetic lethality of MEK inhibition with mitochondrial oxidative metabolism in acute myeloid leukemia. Decroocq J, Birsen R, Montersino C, Chaskar P, Mano J, Poulain L, Friedrich C, Alary AS, Guermouche H, Sahal A, Fouquet G, Gotanegre M, Simonetta F, Mouche S, Gestraud P, Lescure A, Del Nery E, Bosc C, Grenier A, Mazed F, Mondesir J, Chapuis N, Ho L, Boughalem A, Lelorc'h M, Gobeaux C, Fontenay M, Recher C, Vey N, Guille A, Birnbaum D, Hermine O, Radford-Weiss I, Tsantoulis P, Collette Y, Castellano R, Sarry JE, Pasmant E, Bouscary D, Kosmider O, Tamburini J. Leukemia. 2022 May;36(5):1237-1252. doi: 10.1038/s41375-022-01541-0. Epub 2022 Mar 30. PubMed |
| Trans-Seq maps a selective mammalian retinotectal synapse instructed by Nephronectin. Tsai NY, Wang F, Toma K, Yin C, Takatoh J, Pai EL, Wu K, Matcham AC, Yin L, Dang EJ, Marciano DK, Rubenstein JL, Wang F, Ullian EM, Duan X. Nat Neurosci. 2022 May;25(5):659-674. doi: 10.1038/s41593-022-01068-8. Epub 2022 May 6. PubMed |
| Ectopic JAK-STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance. Deng S, Wang C, Wang Y, Xu Y, Li X, Johnson NA, Mukherji A, Lo UG, Xu L, Gonzalez J, Metang LA, Ye J, Tirado CR, Rodarte K, Zhou Y, Xie Z, Arana C, Annamalai V, Liu X, Vander Griend DJ, Strand D, Hsieh JT, Li B, Raj G, Wang T, Mu P. Nat Cancer. 2022 Sep;3(9):1071-1087. doi: 10.1038/s43018-022-00431-9. Epub 2022 Sep 5. PubMed |
| Liquid-liquid phase separation facilitates the biogenesis of secretory storage granules. Parchure A, Tian M, Stalder D, Boyer CK, Bearrows SC, Rohli KE, Zhang J, Rivera-Molina F, Ramazanov BR, Mahata SK, Wang Y, Stephens SB, Gershlick DC, von Blume J. J Cell Biol. 2022 Dec 5;221(12):e202206132. doi: 10.1083/jcb.202206132. Epub 2022 Sep 29. PubMed |
| Deletion of SNX9 alleviates CD8 T cell exhaustion for effective cellular cancer immunotherapy. Trefny MP, Kirchhammer N, Auf der Maur P, Natoli M, Schmid D, Germann M, Fernandez Rodriguez L, Herzig P, Lotscher J, Akrami M, Stinchcombe JC, Stanczak MA, Zingg A, Buchi M, Roux J, Marone R, Don L, Lardinois D, Wiese M, Jeker LT, Bentires-Alj M, Rossy J, Thommen DS, Griffiths GM, Laubli H, Hess C, Zippelius A. Nat Commun. 2023 Feb 2;14(1):86. doi: 10.1038/s41467-022-35583-w. PubMed |
| The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis. Li Y, Gao J, Zhao D, Guan X, Morris SC, Finkelman FD, Huang H. J Allergy Clin Immunol. 2023 Jul;152(1):195-204.e3. doi: 10.1016/j.jaci.2023.01.031. Epub 2023 Feb 18. PubMed |
| N-acetylcysteine overcomes NF1 loss-driven resistance to PI3Kalpha inhibition in breast cancer. Auf der Maur P, Trefny MP, Baumann Z, Vulin M, Correia AL, Diepenbruck M, Kramer N, Volkmann K, Preca BT, Ramos P, Leroy C, Eichlisberger T, Buczak K, Zilli F, Okamoto R, Rad R, Jensen MR, Fritsch C, Zippelius A, Stadler MB, Bentires-Alj M. Cell Rep Med. 2023 Apr 18;4(4):101002. doi: 10.1016/j.xcrm.2023.101002. Epub 2023 Apr 11. PubMed |
| Maintenance of a short-lived protein required for long-term memory involves cycles of transcription and local translation. Das S, Lituma PJ, Castillo PE, Singer RH. Neuron. 2023 Jul 5;111(13):2051-2064.e6. doi: 10.1016/j.neuron.2023.04.005. Epub 2023 Apr 25. PubMed |
| FGFR2 mutations promote endometrial cancer progression through dual engagement of EGFR and Notch signalling pathways. Dixit G, Gonzalez-Bosquet J, Skurski J, Devor EJ, Dickerson EB, Nothnick WB, Issuree PD, Leslie KK, Maretzky T. Clin Transl Med. 2023 May;13(5):e1223. doi: 10.1002/ctm2.1223. PubMed |
| The phospholipid transporter PITPNC1 links KRAS to MYC to prevent autophagy in lung and pancreatic cancer. Entrialgo-Cadierno R, Cueto-Urena C, Welch C, Feliu I, Macaya I, Vera L, Morales X, Michelina SV, Scaparone P, Lopez I, Darbo E, Erice O, Vallejo A, Moreno H, Goni-Salaverri A, Lara-Astiaso D, Halberg N, Cortes-Dominguez I, Guruceaga E, Ambrogio C, Lecanda F, Vicent S. Mol Cancer. 2023 May 20;22(1):86. doi: 10.1186/s12943-023-01788-w. PubMed |
| Combined loss of CDH1 and downstream regulatory sequences drive early-onset diffuse gastric cancer and increase penetrance of hereditary diffuse gastric cancer. Sao Jose C, Garcia-Pelaez J, Ferreira M, Arrieta O, Andre A, Martins N, Solis S, Martinez-Benitez B, Ordonez-Sanchez ML, Rodriguez-Torres M, Sommer AK, Te Paske IBAW, Caldas C, Tischkowitz M, Tusie MT, Hoogerbrugge N, Demidov G, de Voer RM, Laurie S, Oliveira C. Gastric Cancer. 2023 Sep;26(5):653-666. doi: 10.1007/s10120-023-01395-0. Epub 2023 May 30. PubMed |
| Nonviral base editing of KCNJ13 mutation preserves vision in a model of inherited retinal channelopathy. Kabra M, Shahi PK, Wang Y, Sinha D, Spillane A, Newby GA, Saxena S, Tong Y, Chang Y, Abdeen AA, Edwards KL, Theisen CO, Liu DR, Gamm DM, Gong S, Saha K, Pattnaik BR. J Clin Invest. 2023 Oct 2;133(19):e171356. doi: 10.1172/JCI171356. PubMed |
Tumor-associated macrophages trigger MAIT cell dysfunction at the HCC invasive margin.
Ruf B, Bruhns M, Babaei S, Kedei N, Ma L, Revsine M, Benmebarek MR, Ma C, Heinrich B, Subramanyam V, Qi J, Wabitsch S, Green BL, Bauer KC, Myojin Y, Greten LT, McCallen JD, Huang P, Trehan R, Wang X, Nur A, Murphy Soika DQ, Pouzolles M, Evans CN, Chari R, Kleiner DE, Telford W, Dadkhah K, Ruchinskas A, Stovroff MK, Kang J, Oza K, Ruchirawat M, Kroemer A, Wang XW, Claassen M, Korangy F, Greten TF.
Cell. 2023 Aug 17;186(17):3686-3705.e32. doi: 10.1016/j.cell.2023.07.026.
PubMed
Associated Plasmids |
| Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2. Littleton SH, Trang KB, Volpe CM, Cook K, DeBruyne N, Ann Maguire J, Ann Weidekamp M, Boehm K, Chesi A, Pippin JA, Anderson SA, Wells AD, Pahl MC, Grant SFA. bioRxiv [Preprint]. 2023 Aug 22:2023.08.21.553157. doi: 10.1101/2023.08.21.553157. PubMed |
| Systematic identification of gene combinations to target in innate immune cells to enhance T cell activation. Xia L, Komissarova A, Jacover A, Shovman Y, Arcila-Barrera S, Tornovsky-Babeay S, Jaya Prakashan MM, Nasereddin A, Plaschkes I, Nevo Y, Shiff I, Yosefov-Levi O, Izhiman T, Medvedev E, Eilon E, Wilensky A, Yona S, Parnas O. Nat Commun. 2023 Oct 9;14(1):6295. doi: 10.1038/s41467-023-41792-8. PubMed |
| The expression profile and tumorigenic mechanisms of CD97 (ADGRE5) in glioblastoma render it a targetable vulnerability. Ravn-Boess N, Roy N, Hattori T, Bready D, Donaldson H, Lawson C, Lapierre C, Korman A, Rodrick T, Liu E, Frenster JD, Stephan G, Wilcox J, Corrado AD, Cai J, Ronnen R, Wang S, Haddock S, Sabio Ortiz J, Mishkit O, Khodadadi-Jamayran A, Tsirigos A, Fenyo D, Zagzag D, Drube J, Hoffmann C, Perna F, Jones DR, Possemato R, Koide A, Koide S, Park CY, Placantonakis DG. Cell Rep. 2023 Nov 28;42(11):113374. doi: 10.1016/j.celrep.2023.113374. Epub 2023 Nov 8. PubMed |
Structural and mechanistic insights into disease-associated endolysosomal exonucleases PLD3 and PLD4.
Yuan M, Peng L, Huang D, Gavin A, Luan F, Tran J, Feng Z, Zhu X, Matteson J, Wilson IA, Nemazee D.
Structure. 2024 Jun 6;32(6):766-779.e7. doi: 10.1016/j.str.2024.02.019. Epub 2024 Mar 26.
PubMed
Associated Plasmids |
Engineering human pluripotent stem cell lines to evade xenogeneic transplantation barriers.
Pizzato HA, Alonso-Guallart P, Woods J, Connelly JP, Fehniger TA, Atkinson JP, Pruett-Miller SM, Monsma FJ Jr, Bhattacharya D.
Stem Cell Reports. 2023 Dec 22:S2213-6711(23)00496-4. doi: 10.1016/j.stemcr.2023.12.003.
PubMed
Associated Plasmids
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Uncovering receptor-ligand interactions using a high-avidity CRISPR activation screening platform.
Yang L, Sheets TP, Feng Y, Yu G, Bajgain P, Hsu KS, So D, Seaman S, Lee J, Lin L, Evans CN, Guest MR, Chari R, St Croix B.
Sci Adv. 2024 Feb 16;10(7):eadj2445. doi: 10.1126/sciadv.adj2445. Epub 2024 Feb 14.
PubMed
Associated Plasmids |
| ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer. Xu Y, Yang Y, Wang Z, Sjostrom M, Jiang Y, Tang Y, Cheng S, Deng S, Wang C, Gonzalez J, Johnson NA, Li X, Li X, Metang LA, Mukherji A, Xu Q, Tirado CR, Wainwright G, Yu X, Barnes S, Hofstad M, Chen Y, Zhu H, Hanker AB, Raj GV, Zhu G, He HH, Wang Z, Arteaga CL, Liang H, Feng FY, Wang Y, Wang T, Mu P. Cancer Discov. 2024 Aug 2;14(8):1496-1521. doi: 10.1158/2159-8290.CD-23-0539. PubMed |
| Ago2/CAV1 interaction potentiates metastasis via controlling Ago2 localization and miRNA action. Lin MC, Kuo WH, Chen SY, Hsu JY, Lu LY, Wang CC, Chen YJ, Tsai JS, Li HJ. EMBO Rep. 2024 May;25(5):2441-2478. doi: 10.1038/s44319-024-00132-7. Epub 2024 Apr 22. PubMed |
| Spatiotemporal proteomic profiling of cellular responses to NLRP3 agonists. Hollingsworth LR, Veeraraghavan P, Paulo JA, Harper JW, Rauch I. bioRxiv [Preprint]. 2024 Apr 20:2024.04.19.590338. doi: 10.1101/2024.04.19.590338. PubMed |
| Non-esterified fatty acid palmitate facilitates oxidative endoplasmic reticulum stress and apoptosis of beta-cells by upregulating ERO-1alpha expression. Sharifi S, Yamamoto T, Zeug A, Elsner M, Avezov E, Mehmeti I. Redox Biol. 2024 Jul;73:103170. doi: 10.1016/j.redox.2024.103170. Epub 2024 Apr 27. PubMed |
| Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2. Littleton SH, Trang KB, Volpe CM, Cook K, DeBruyne N, Maguire JA, Weidekamp MA, Hodge KM, Boehm K, Lu S, Chesi A, Bradfield JP, Pippin JA, Anderson SA, Wells AD, Pahl MC, Grant SFA. Cell Genom. 2024 May 8;4(5):100556. doi: 10.1016/j.xgen.2024.100556. Epub 2024 May 1. PubMed |
| An essential role for EROS in redox-dependent endothelial signal transduction. Waldeck-Weiermair M, Das AA, Covington TA, Yadav S, Kaynert J, Guo R, Balendran P, Thulabandu VR, Pandey AK, Spyropoulos F, Thomas DC, Michel T. Redox Biol. 2024 Jul;73:103214. doi: 10.1016/j.redox.2024.103214. Epub 2024 May 24. PubMed |
| Mis-splicing of Mitotic Regulators Sensitizes SF3B1-Mutated Human HSCs to CHK1 Inhibition. Sarchi M, Clough CA, Crosse EI, Kim J, Baquero Galvis LD, Aydinyan N, Wellington R, Yang F, Galli A, Creamer JP, Stewart S, Bradley RK, Malcovati L, Doulatov S. Blood Cancer Discov. 2024 Sep 3;5(5):353-370. doi: 10.1158/2643-3230.BCD-23-0230. PubMed |
| Variant-to-function mapping of late-onset Alzheimer's disease GWAS signals in human microglial cell models implicates RTFDC1 at the CASS4 locus. Burton EA, Argenziano M, Cook K, Ridler M, Lu S, Su C, Manduchi E, Littleton SH, Leonard ME, Hodge KM, Wang LS, Schellenberg GD, Johnson ME, Pahl MC, Pippin JA, Wells AD, Anderson SA, Brown CD, Grant SFA, Chesi A. bioRxiv [Preprint]. 2024 Aug 22:2024.08.22.609230. doi: 10.1101/2024.08.22.609230. PubMed |
| Tau is a receptor with low affinity for glucocorticoids and is required for glucocorticoid-induced bone loss. Fu W, Chen M, Wang K, Chen Y, Cui Y, Xie Y, Lei ZN, Hu W, Sun G, Huang G, He C, Fretz J, Hettinghouse A, Liu R, Cai X, Zhang M, Chen Y, Jiang N, He M, Wiznia DH, Xu H, Chen ZS, Chen L, Tang K, Zhou H, Liu CJ. Cell Res. 2025 Jan;35(1):23-44. doi: 10.1038/s41422-024-01016-0. Epub 2025 Jan 2. PubMed |
| A fetal oncogene NUAK2 is an emerging therapeutic target in glioblastoma. Jo H, Dalvi A, Yang W, Morozova E, Munoz S, Glasgow SM. bioRxiv [Preprint]. 2025 Jan 2:2024.12.31.630965. doi: 10.1101/2024.12.31.630965. PubMed |
| Increasing RB1 Expression by Targeting EZH2 in Triple-Negative Breast Cancer. Yang R, Fei L, Xue Y, Zhang Y, Hu Q, Guo L, Wei Y, Wu Q. J Cell Mol Med. 2025 Mar;29(5):e70384. doi: 10.1111/jcmm.70384. PubMed |
| Transport and InsP(8) gating mechanisms of the human inorganic phosphate exporter XPR1. Zhu Q, Yaggi MF, Jork N, Jessen HJ, Diver MM. Nat Commun. 2025 Mar 20;16(1):2770. doi: 10.1038/s41467-025-58076-y. PubMed |
| Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth. Fidelito G, Todorovski I, Cluse L, Vervoort SJ, Taylor RA, Watt MJ. Cell Rep. 2025 Apr 22;44(4):115470. doi: 10.1016/j.celrep.2025.115470. Epub 2025 Mar 26. PubMed |
| CDX2 downregulation regulates intrinsic WNT pathway activation, dictating metastasis in APC and CTNNB1 wildtype colorectal cancer. Wouters VM, Helderman RFCPA, Cameron K, van der Hooff SR, Torang A, van den Bergh S, Jackstadt R, Sansom OJ, van Neerven SM, Medema JP. Oncogene. 2025 Jul;44(25):2091-2102. doi: 10.1038/s41388-025-03365-5. Epub 2025 Apr 6. PubMed |
| SAMSN1 causes sepsis immunosuppression by inducing macrophages to express coinhibitory molecules that cause T-cell exhaustion via KEAP1-NRF2 signaling. Li Y, Li T, Xiao F, Wang L, Liao X, Zhang W, Kang Y. Chin Med J (Engl). 2025 Jul 5;138(13):1607-1620. doi: 10.1097/CM9.0000000000003606. Epub 2025 Apr 27. PubMed |
| The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated beta-catenin degradation and through a mechanism independent of changes in beta-catenin abundance. McKenna JK, Wu Y, Sonkusre P, Sinclear CK, Chari R, Lebensohn AM. PLoS Genet. 2025 May 27;21(5):e1011677. doi: 10.1371/journal.pgen.1011677. eCollection 2025 May. PubMed |
| AAV-dCas9 vector unsilences paternal Ube3a in neurons by impeding Ube3a-ATS transcription. Wolter JM, James LM, Boeshore SL, Mao H, McCoy ES, Ryan DF, Fragola G, Taylor-Blake B, Stein JL, Zylka MJ. Commun Biol. 2025 Sep 2;8(1):1332. doi: 10.1038/s42003-025-08794-2. PubMed |
| Gliomas phenocopy an inborn error of metabolism to drive neuronal activity and tumor growth. Abdullah KG, Miki K, Edgar CK, Wu SA, Xiao Y, Savani MR, Ghoche MT, Kotermanski SE, Huang YT, Traylor JI, Guo L, Gunn K, Hicks WH, Shi DD, Tang M, Levitt MM, El-Shami M, Oken S, Manoj N, Smith BC, Puliyappadamba VT, Kaphle P, Shipman T, West RE, Liang C, Patel TR, Hatanpaa KJ, Raj P, Ma S, Ksendzovsky A, Nolin TD, Lega BC, Zinn PO, Kuhn BJ, Clark NM, Williams C, Mani DR, Gillette MA, Calzado MA, Xu L, Zacharias LG, Cai F, Mathews TP, Losman JA, Richardson TE, Levi B, Monje M, Gibson JR, Khan OH, Agnihotri S, Huber KM, Chamberland S, DeBerardinis RJ, McBrayer SK. bioRxiv [Preprint]. 2025 Sep 18:2025.09.15.676412. doi: 10.1101/2025.09.15.676412. PubMed |
| 3-in-one (PD-1)CAR Tregs: A bioengineered cellular therapy for target engagement, activation, and immunosuppression with reparative potential. Dong S, Zhang T, Zhai Y, Naatz LC, Carlson NG, Rose JW, Evavold B, Chen M. iScience. 2025 Oct 3;28(11):113677. doi: 10.1016/j.isci.2025.113677. eCollection 2025 Nov 21. PubMed |
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