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The serine protease TMPRSS6 is required to sense iron deficiency.
Du X, She E, Gelbart T, Truksa J, Lee P, Xia Y, Khovananth K, Mudd S, Mann N, Moresco EM, Beutler E, Beutler B Science. 2008 May 23. 320(5879):1088-92.