TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells.
Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP
Nucleic Acids Res. 2014 Jun;42(11):6956-71. doi: 10.1093/nar/gku372. Epub 2014 May 29.
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Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 83568 | pIRES-hrGFP II-TET1 | Expresses TET1 in mammalian cells |
| 83569 | pIRES-hrGFP II-mTET1 | Expresses TET1 with a mutated catalytic domain in mammalian cells |
| 83570 | pIRES-hrGFP II-TET1_CD | Expresses the catalytic domain of TET1 in mammalian cells |
| 83571 | pIRES-hrGFP II-mTET1_CD | Expresses a mutant catalytic domain of TET1 in mammalian cells |