The AMPK-Related Kinases SIK1 and SIK3 Mediate Key Tumor-Suppressive Effects of LKB1 in NSCLC.
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ
Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26. PubMed Article
Hollstein PE, Eichner LJ, Brun SN, Kamireddy A, Svensson RU, Vera LI, Ross DS, Rymoff TJ, Hutchins A, Galvez HM, Williams AE, Shokhirev MN, Screaton RA, Berdeaux R, Shaw RJ
Cancer Discov. 2019 Nov;9(11):1606-1627. doi: 10.1158/2159-8290.CD-18-1261. Epub 2019 Jul 26. PubMed Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 138661 | pSECC-sgTom | Expresses a Tomato-targeting sgRNA, Cas9, and Cre-recombinase |
| 138663 | pSECC-sgLKB1-A | Expresses a mouse LKB1-targeting sgRNA, Cas9, and Cre-recombinase |
| 138665 | pSECC-sgSIK1-A | Expresses a mouse SIK1-targeting sgRNA, Cas9, and Cre-recombinase |
| 138666 | pSECC-sgSIK1-B | Expresses a mouse SIK1-targeting sgRNA, Cas9, and Cre-recombinase |
| 138668 | pSECC-sgSIK1-D | Expresses a mouse SIK1-targeting sgRNA, Cas9, and Cre-recombinase |
| 138669 | pSECC-sgSIK1-E | Expresses a mouse SIK1-targeting sgRNA, Cas9, and Cre-recombinase |
| 138670 | pSECC-sgSIK2-A | Expresses a mouse SIK2-targeting sgRNA, Cas9, and Cre-recombinase |
| 138671 | pSECC-sgSIK2-B | Expresses a mouse SIK2-targeting sgRNA, Cas9, and Cre-recombinase |
| 138672 | pSECC-sgSIK3-A | Expresses a mouse SIK3-targeting sgRNA, Cas9, and Cre-recombinase |
| 138673 | pSECC-sgSIK3-B | Expresses a mouse SIK3-targeting sgRNA, Cas9, and Cre-recombinase |
| 138674 | pSECC-sgSIK3-C | Expresses a mouse SIK3-targeting sgRNA, Cas9, and Cre-recombinase |
| 138675 | pSECC-sgSIK3-D | Expresses a mouse SIK3-targeting sgRNA, Cas9, and Cre-recombinase |
| 138676 | pSECC-sgMARK4-A | Expresses a mouse MARK4-targeting sgRNA, Cas9, and Cre-recombinase |
| 138677 | pSECC-sgMARK4-B | Expresses a mouse MARK4-targeting sgRNA, Cas9, and Cre-recombinase |
| 138678 | pLenti-Blast-sgNT | Expresses a Non-targeting sgRNA and Cas9 |
| 138679 | pLenti-Blast-sgSIK1-B | Expresses a mouse SIK1-targeting sgRNA and Cas9 |
| 138680 | pLenti-Blast-sgSIK1-D | Expresses a mouse SIK1-targeting sgRNA and Cas9 |
| 138681 | pLenti-Puro-sgNT | Expresses a non-targeting sgRNA and Cas9 |
| 138682 | pLenti-Puro-sgSIK3-A | Expresses a mouse SIK3-targeting sgRNA and Cas9 |
| 138683 | pLenti-Puro-sgSIK3-C | Expresses a mouse SIK3-targeting sgRNA and Cas9 |
| 138684 | pLenti-Puro-sgAMPKa1 | Expresses a human AMPKa1-targeting sgRNA and Cas9 |
| 138685 | pLenti-Puro-sgAMPKa2 | Expresses a human AMPKa2-targeting sgRNA and Cas9 |
| 138686 | pLenti-Puro-sgBRSK1 | Expresses a human BRSK1-targeting sgRNA and Cas9 |
| 138687 | pLenti-Puro-sgBRSK2 | Expresses a human BRSK2-targeting sgRNA and Cas9 |
| 138688 | pLenti-Puro-sgMARK1 | Expresses a human MARK1-targeting sgRNA and Cas9 |
| 138689 | pLenti-Puro-sgMARK2 | Expresses a human MARK2-targeting sgRNA and Cas9 |
| 138690 | pLenti-Puro-sgMARK3 | Expresses a human MARK3-targeting sgRNA and Cas9 |
| 138691 | pLenti-Puro-sgMARK4 | Expresses a human MARK4-targeting sgRNA and Cas9 |
| 138692 | pLenti-Puro-sgNUAK1 | Expresses a human NUAK1-targeting sgRNA and Cas9 |
| 138693 | pLenti-Puro-sgNUAK2 | Expresses a human NUAK2-targeting sgRNA and Cas9 |
| 138694 | pLenti-Puro-sgSNRK | Expresses a human SNRK-targeting sgRNA and Cas9 |
| 138695 | pLenti-Puro-SIK1 | Expresses a human SIK1-targeting sgRNA and Cas9 |
| 138696 | pLenti-Puro-SIK2 | Expresses a human SIK2-targeting sgRNA and Cas9 |
| 138697 | pLenti-Puro-SIK3 | Expresses a human SIK3-targeting sgRNA and Cas9 |
| 138698 | pLenti-Hygro-sgTom | Expresses a tomato-targeting sgRNA and Cas9 |
| 138699 | pLenti-Hygro-sgSIK3 | Expresses a human SIK3-targeting sgRNA and Cas9 |
| 138700 | pLenti-Blast-sgCRTC2-1 | Expresses a human CRTC2-targeting sgRNA and Cas9 |
| 138701 | pLenti-Blast-sgCRTC2-2 | Expresses a human CRTC2-targeting sgRNA and Cas9 |
| 138702 | pLenti-Neo-sgCRTC2-1 | Expresses a human CRTC2-targeting sgRNA and Cas9 |
| 138703 | pLenti-Neo-sgCRTC2-2 | Expresses a human CRTC2-targeting sgRNA and Cas9 |
| 138704 | pLenti-Blast-sgAMPKa1 | Expresses a human AMPKa1-targeting sgRNA and Cas9 |
| 138705 | pLenti-Blast-sgBRSK1 | Expresses a human BRSK1-targeting sgRNA and Cas9 |
| 138706 | pLenti-Blast-sgMARK3 | Expresses a human MARK3-targeting sgRNA and Cas9 |
| 138707 | pLenti-Blast-sgMARK4 | Expresses a human MARK4-targeting sgRNA and Cas9 |
| 138708 | pLenti-Blast-sgSIK2 | Expresses a human SIK2-targeting sgRNA and Cas9 |