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Designer indicators for two-photon recording of subthreshold voltage dynamics.

Land MA, Galdamez M, Villette V, Zhu J, Lu X, Marosi M, Yang S, Foran G, McDonald AJ, Dong X, Zaabout E, Liu H, Liu Z, Colbert KL, Lai S, Shorey M, Lourdiane ASG, Ayon A, Bradley J, Mailhes-Hamon C, Natan RG, Zhong J, Kroeger R, Law RG, Hakam N, Smith CL, Hu M, Tabb S, Bathellier B, Dudok B, Ji N, Bourdieu L, Reimer J, St-Pierre F
Nat Methods. 2026 Apr 15. doi: 10.1038/s41592-026-03043-8. (Link opens in a new window) PubMed (Link opens in a new window) Article

Plasmids from Article

ID Plasmid Purpose
246616pAAV-EF1a-DIO-JEDI3sub-Kv-WPREDouble floxed soma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector expressed under the mammalian promoter (EF1a)
246617pAAV-EF1a-DIO-JEDI3sub-WPREDouble floxed genetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector under the control of the mammalian promoter (EF1a)
246618pAAV-hSyn-JEDI3sub-Kv-WPRESoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector for neuron -specific expression using the promoter hSyn
246619pAAV-hSyn-JEDI3sub-WPREGenetically encoded voltage indicator (GEVI) JEDI3sub in an AAV production vector for neuron -specific expression using the promoter hSyn
246620pAAV-Ef1a-fDIO-JEDI3sub-WPREFlp dependent genetically encoded voltage indicator (GEVI) JEDI3sub in an AAV production vector under the control of the mammalian promoter (EF1a)
246621pTol2-HuC(elavl3)-JEDI3subGenetically encoded voltage indicator (GEVI) JEDI3sub under the HuC(elavl3) promoter for pan neuronal expression in zebrafish
246622pTol2-HuC(elavl3)-JEDI3sub-KvSoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3sub under the HuC(elavl3) promoter for pan neuronal expression in zebrafish
246623pJFRC7-JEDI3subGenetically encoded voltage indicator (GEVI) JEDI3sub under the promoter hsp70 for Drosophila (insect) expression
246624pAAV-CaMKIIa-JEDI3sub-WPREGenetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa
246625pAAV-CaMKIIa-JEDI3sub-Kv-WPRESoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3sub in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa
246626pcDNA3.1/Puro-CAG-JEDI3sub-CyOFP1Genetically encoded voltage indicator (GEVI) JEDI3sub with a 3xGSS linked CyOFP1 expressed under a strong mammalian promoter (CAG)
246627pcDNA3.1/Puro-CAG-JEDI3subGenetically encoded voltage indicator (GEVI) JEDI3sub expressed under strong mammalian promoter (CAG)
246628pcDNA3.1/Puro-CAG-JEDI3sub-mBeRFP(E6F)Genetically encoded voltage indicator (GEVI) JEDI3sub with a 3xGSS linked mBeRFP E6F expressed under a strong mammalian promoter (CAG)
246629pAAV-EF1a-DIO-JEDI3hyp-Kv-WPREDouble floxed soma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector expressed under the mammalian promoter (EF1a)
246630pAAV-EF1a-DIO-JEDI3hyp-WPREDouble floxed genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector under the control of the mammalian promoter (EF1a)
246631pAAV-hSyn-JEDI3hyp-Kv-WPRESoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for neuron -specific expression using the promoter hSyn
246632pAAV-hSyn-JEDI3hyp-WPREGenetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for neuron -specific expression using the promoter hSyn
246633pAAV-Ef1a-fDIO-JEDI3hyp-WPREFlp dependent genetically encoded voltage indicator (GEVI) JEDI3hyp in an AAV production vector under the control of the mammalian promoter (EF1a)
246634pTol2-HuC(elavl3)-JEDI3hypGenetically encoded voltage indicator (GEVI) JEDI3hyp under the HuC(elavl3) promoter for pan neuronal expression in zebrafish
246635pTol2-HuC(elavl3)-JEDI3hyp-KvSoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3hyp under the HuC(elavl3) promoter for pan neuronal expression in zebrafish
246636pJFRC7-JEDI3hypGenetically encoded voltage indicator (GEVI) JEDI3hyp under the promoter hsp70 for Drosophila (insect) expression
246637pAAV-CaMKIIa-JEDI3hyp-WPREGenetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa
246638pAAV-CaMKIIa-JEDI3hyp-Kv-WPRESoma and AIS-localized genetically encoded voltage indicator (GEVI) JEDI3hyp in AAV production vector for expression in excitatory glutamatergic neurons using the promoter CaMKIIa
246639pcDNA3.1/Puro-CAG-JEDI3hyp-CyOFP1Genetically encoded voltage indicator (GEVI) JEDI3hyp with a 3xGSS linked CyOFP1 expressed under a strong mammalian promoter (CAG)
246640pcDNA3.1/Puro-CAG-JEDI3hypGenetically encoded voltage indicator (GEVI) JEDI3hyp expressed under strong mammalian promoter (CAG)
246641pcDNA3.1/Puro-CAG-JEDI3hyp-mBeRFP(E6F)Genetically encoded voltage indicator (GEVI) JEDI3hyp with a 3xGSS linked mBeRFP E6F expressed under a strong mammalian promoter (CAG)

Antibodies from Article