Structural details of helix-mediated multimerization of the conserved region of TDP-43 C-terminal domain.
Rizuan A, Shenoy J, Mohanty P, Dos Passos PM, Mercado Ortiz JF, Bai L, Viswanathan R, Zaborowksy J, Wang SH, Johnson V, Mamede LD, Titus AR, Ayala YM, Ghirlando R, Mittal J, Fawzi NL
Nat Commun. 2025 Nov 26;16(1):10528. doi: 10.1038/s41467-025-65546-w.
(Link opens in a new window)
PubMed
(Link opens in a new window)
Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 248845 | TDP-43_CTD_13S→E_S317C | Expresses 6xHis-tagged C-terminal domain of TDP-43 with 13S→E and S317C. |
| 248859 | TDP-43_CTD_13S→E_S273C | Expresses 6xHis-tagged C-terminal domain of TDP-43 with 13S→E and S273C. |
| 248864 | TDP-43_CTD_S273C | Expresses MBP-tagged C-terminal domain of TDP-43 with S273C. |
| 248867 | TDP-43_CTD_12S→E_S305C | Expresses MBP-tagged C-terminal domain of TDP-43 with 12S→E and S305C. |
| 248868 | TDP-43_CTD_12S→E_S305C/A326P | Expresses MBP-tagged C-terminal domain of TDP-43 with 12S→E, S305C and A326P. |
| 248869 | TDP-43_CTD_F313A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with F313A. |
| 248870 | TDP-43_CTD_F316A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with F316A. |
| 248871 | TDP-43_CTD_S317A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with S317A. |
| 248872 | TDP-43_CTD_I318A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with I318A. |
| 248873 | TDP-43_CTD_N319A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with N319A. |
| 248874 | TDP-43_CTD_M322A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with M322A. |
| 248875 | TDP-43_CTD_M323A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with M323A. |
| 248878 | TDP-43_CTD_Q327A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with Q327A. |
| 248880 | TDP-43_CTD_Q331A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with Q331A. |
| 248881 | TDP-43_CTD_S332A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with S332A. |
| 248882 | TDP-43_CTD_S333A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with S333A. |
| 248883 | TDP-43_CTD_W334A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with W334A. |
| 248884 | TDP-43_CTD_M336A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with M336A. |
| 248885 | TDP-43_CTD_M337A | Edit Expresses 6xHis-tagged C-terminal domain of TDP-43 with M337A. |
| 248886 | TDP-43_CTD_M339A | Edit Expresses 6xHis-tagged C-terminal domain of TDP-43 with M339A. |
| 248887 | TDP-43_CTD_L340A | Edit Expresses 6xHis-tagged C-terminal domain of TDP-43 with L340A. |
| 248888 | TDP-43_CTD_S342A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with S342A. |
| 248889 | TDP-43_CTD_Q343A | Expresses 6xHis-tagged C-terminal domain of TDP-43 with Q343A. |