Scalable and multiplexed recorders of gene regulation dynamics across weeks.
Zheng L, Shi D, Yan Y, Zhou B, Lim J, Hou Y, An B, Adhinarta JK, Lin M, Ko B, Joesten WC, Gautam M, Huez EDM, Kim EC, Klyder EG, Chang B, Pitchiaya S, Roberts MT, Cai DJ, Boyden ES, Wei D, Lio P, Linghu C
Nature. 2026 Jan 26. doi: 10.1038/s41586-026-10156-9.
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Article
Plasmids from Article
| ID | Plasmid | Purpose |
|---|---|---|
| 239423 | pAAV-UbC-CytoTape-HA | CytoTape structural monomer for CytoTape fiber formation and elongation for cell culture applications |
| 239424 | pAAV-Arc-CytoTape-V5 | CytoTape signal monomer for recording SARE-ArcMin promoter transcriptional activity |
| 239425 | pAAV-N-RAM-CytoTape-V5 | CytoTape signal monomer for recording Npas4 protein activity |
| 239426 | pAAV-HSE-CytoTape-V5 | CytoTape signal monomer for recording HSE promoter transcriptional activity |
| 239427 | pAAV-F-RAM-CytoTape-V5 | CytoTape signal monomer for recording Fos protein activity |
| 239428 | pAAV-Egr1-CytoTape-V5 | CytoTape signal monomer for recording Egr1 promoter transcriptional activity |
| 239429 | pAAV-c-fos-CytoTape-V5 | CytoTape signal monomer for recording c-fos promoter transcriptional activity |
| 239430 | pAAV-CRE-CytoTape-V5 | CytoTape signal monomer for recording phosphorylated CREB protein activity |
| 239616 | pAAV-UbC-CytoTape-HaloTag | CytoTape timestamp monomer (HaloTag fused to CytoTape-HA) for encoding time along the CytoTape fiber for cell culture applications. |
| 250670 | pAAV-UbC-CytoTape-vivo-HA | CytoTape-vivo structural monomer for CytoTape-vivo fiber formation and elongation for mouse brain in vivo applications |
| 250671 | pAAV-TRE3G-XRI-FLAG | Timestamp monomer for encoding time along the CytoTape-vivo fiber for mouse brain in vivo applications. |
| 250672 | pAAV-hSyn-rtTA3G-TetOn3G | Drive Tet-ON activator expression from human synapsin promoter for doxycycline-inducible transgene activation |
| 252514 | pAAV-TRE3G-CytoTape-FLAG | Timestamp monomer based on CytoTape for encoding time along protein tape recorder for mouse brain in vivo applications |