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Argonaute protein identity and pairing geometry determine cooperativity in mammalian RNA silencing.
Broderick JA, Salomon WE, Ryder SP, Aronin N, Zamore PD
RNA. 2011 Oct;17(10):1858-69. Epub 2011 Aug 30.
PubMed Article

Plasmids from Article

ID Plasmid Purpose  
40756mutpRL-TK 1xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40757mutpRL-TK 2xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40758mutpRL-TK 3xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40759mutpRL-TK 4xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40760mutpRL-TK 5xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40761mutpRL-TK 6xUTRTo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40762psiCheck2 3xUTRRenilla luciferase reporter containing siRNA target sites
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40763psicheck2 6xUTRRenilla luciferase reporter containing siRNA target sites
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40764psiCheck2 6xmut UTRRenilla luciferase reporter containing siRNA target sites
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40765mutpRL-TK 1x perfect to bulged siRNATo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40766mutpRL-TK 1x perfect to seed siRNATo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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40767mutpRL-TK 1x perfect to seed plus 13-16 siRNATo evaluate the efficacy of silencing and the extent of cooperativity directed by a small silencing RNA bound at one or multiple sites on an mRNA
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