We narrowed to 9,645 results for: SUB

1. pRH3039

   Plasmid

   #210149

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151G-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151G-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151G

   Available Since

   Nov. 30, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

2. pRH3016

   Plasmid

   #210147

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-V26D-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-V26D-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   V26D

   Available Since

   Nov. 29, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

3. pRH3002

   Plasmid

   #210145

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W353R-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W353R-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W353R

   Available Since

   Nov. 29, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

4. pRH3216

   Plasmid

   #210184

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151K-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151K-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151K

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

5. pRH3040

   Plasmid

   #210150

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151R-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151R-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151R

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

6. pRH3180

   Plasmid

   #210180

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-G54R-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::ade1-G54R-GFP::tADH1 (ADE2 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   G54R

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

7. pRH3044

   Plasmid

   #210154

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151T-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151T-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151T

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

8. pRH3045

   Plasmid

   #210155

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151C-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151C-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151C

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

9. pRH3041

   Plasmid

   #210151

   Purpose

   Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151P-GFP::tADH1

   Depositor

   Randy Hampton

   Article

   Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

   Insert

   YIp ADE2-LEU2 pTDH3::lys1-W151P-GFP::tADH1 (LYS1 Budding Yeast)
   

   Expression

   Yeast

   Mutation

   W151P

   Available Since

   Nov. 27, 2023

   Availability

   Academic Institutions and Nonprofits only

   

   Enlarge

10. pRH3150

    Plasmid

    #210171

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-W64R-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-W64R-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W64R

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

11. pRH3043

    Plasmid

    #210153

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151S-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151S-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151S

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

12. pRH3148

    Plasmid

    #210170

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-D37V-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-D37V-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    D37V

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

13. pRH3215

    Plasmid

    #210183

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151I-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151I-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151I

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

14. pRH3142

    Plasmid

    #210168

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::aro7-D147G-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::aro7-D147G-GFP::tADH1 (ARO7 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    D147G

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

15. pRH3214

    Plasmid

    #210182

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151D-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151D-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151D

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

16. pRH3168

    Plasmid

    #210176

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-A195D-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-A195D-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    A195D

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

17. pRH3015

    Plasmid

    #210146

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-L29P-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-L29P-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    L29P

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

18. pRH3038

    Plasmid

    #210148

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-L146P-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-L146P-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    L146P

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

19. pRH3054

    Plasmid

    #210160

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151F-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151F-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151F

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

20. pRH3154

    Plasmid

    #210174

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-L32P-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-L32P-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    L32P

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

21. pRH3153

    Plasmid

    #210173

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-L102P-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-L102P-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    L102P

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

22. pRH3155

    Plasmid

    #210175

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-L32R-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-L32R-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    L32R

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

23. pRH3218

    Plasmid

    #210186

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151N-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151N-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151N

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

24. pRH3152

    Plasmid

    #210172

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::ade1-G54E-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::ade1-G54E-GFP::tADH1 (ADE2 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    G54E

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

25. pRH3069

    Plasmid

    #210163

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151V-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151V-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151V

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

26. pRH3047

    Plasmid

    #210157

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151H-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151H-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151H

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

27. pRH3055

    Plasmid

    #210161

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151Q-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151Q-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151Q

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

28. pRH3048

    Plasmid

    #210158

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151Y-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151Y-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151Y

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

29. pRH3053

    Plasmid

    #210159

    Purpose

    Protein quality control substrate and associated control YIp ADE2-LEU2 pTDH3::lys1-W151A-GFP::tADH1

    Depositor

    Randy Hampton

    Article

    Flagg et al Mol Biol Cell. 2023 Dec 1;34(13):ar125.

    Insert

    YIp ADE2-LEU2 pTDH3::lys1-W151A-GFP::tADH1 (LYS1 Budding Yeast)
    

    Expression

    Yeast

    Mutation

    W151A

    Available Since

    Nov. 27, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

30. acvr1l-VAAA-HA

    Plasmid

    #201905

    Purpose

    in vitro transcription of RNA encoding HA-tagged Acvr1l that contains 4 amino acid substitutions: T186V, S187A, S189A, S191A

    Depositor

    Mary Mullins

    Article

    Tajer et al Proc Natl Acad Sci U S A. 2021 Apr 13;11

    Insert

    acvr1l (acvr1l Zebrafish)
    

    Tags

    HA

    Mutation

    T186V, S187A, S189A, S191A

    Promoter

    SP6

    Available Since

    June 5, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

31. pGBT9-tepsin

    Plasmid

    #196647

    Purpose

    Expression of GAL4 DNA-binding domain (BD)-tepsin fusion protein

    Depositor

    Juan Bonifacino

    Article

    Mattera et al J Biol Chem. 2015 Dec 25;290(52):30736-4

    Insert

    tepsin (TEPSIN Human)
    

    Use

    Yeast two-hybrid vector

    Tags

    GAL4-DNA binding domain fragment

    Expression

    Yeast

    Mutation

    silent substitution in codon 199 to eliminate int…

    Available Since

    March 9, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

32. OA-1163A

    Plasmid

    #194001

    Purpose

    pBac-AedesUbiq-RfxCas13d (Codon optimized)-p10-Opie2-dsRed.

    Depositor

    Omar Akbari

    Article

    Dalla Benetta et al CRISPR J. 2023 Dec;6(6):543-556. doi: 10

    Insert

    Uniq-CasRx (Codon optimized)
    

    Expression

    Insect

    Available Since

    Jan. 17, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

33. OA-1050T

    Plasmid

    #191374

    Purpose

    pBac-AedesUbiq-RfxCas13d-p10-Opie2-dsRed.

    Depositor

    Omar Akbari

    Article

    Dalla Benetta et al CRISPR J. 2023 Dec;6(6):543-556. doi: 10

    Insert

    Uniq-CasRx
    

    Expression

    Insect

    Available Since

    Jan. 17, 2023

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

34. pNHT7

    Plasmid

    #186753

    Purpose

    A basic cloning vector for inserting genes with 5' and 3' UTRs for later subcloning via Golden Gate assembly.

    Depositor

    Bo Wang

    Article

    Hall et al Cell Rep Methods. 2022 Sep 20;2(10):1002

    Type

    Empty backbone

    Use

    Synthetic Biology; Cloning backbone

    Promoter

    T7

    Available Since

    Oct. 24, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

35. pFX-SECFP-Sec61β

    Plasmid

    #174465

    Purpose

    Express SECFP with endoplasmic reticulum-targeting sequence in mammalian cells

    Depositor

    Yusuke Ohba

    Article

    Kashiwagi et al Cell Struct Funct. 2019 Dec 26;44(2):183

    Insert

    SECFP with endoplasmic reticulum-targeting sequence
    

    Tags

    Sec61 subunit beta

    Expression

    Mammalian

    Promoter

    CMV

    Available Since

    Feb. 18, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

36. pFX-Sirius-Sec61β

    Plasmid

    #174464

    Purpose

    Express Sirius with endoplasmic reticulum-targeting sequence in mammalian cells

    Depositor

    Yusuke Ohba

    Article

    Kashiwagi et al Cell Struct Funct. 2019 Dec 26;44(2):183

    Insert

    Sirius with endoplasmic reticulum-targeting sequence
    

    Tags

    Sec61 subunit beta

    Expression

    Mammalian

    Promoter

    CMV

    Available Since

    Feb. 18, 2022

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

37. EGFP-RanGAP

    Plasmid

    #175235

    Purpose

    Bacterial expression and purification, high affinity SUMOylation substrate

    Depositor

    Michael Rosen

    Article

    Peeples et al Nat Chem Biol. 2021 Jun;17(6):693-702. d

    Insert

    RANGAP1 (RANGAP1 Human)
    

    Expression

    Bacterial

    Promoter

    tac

    Available Since

    Oct. 18, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

38. pLyGo-Bs-4

    Plasmid

    #163142

    Purpose

    pLyGo cloning vector for a sequence of interest (LPMO) in B. subtilis. Vector encoding the BatLPMO10 signal peptide and the LyGo cassette (SapI-ccdB-SapI)

    Depositor

    Morten Norholm

    Article

    Hernandez-Rollan et al ACS Synth Biol. 2021 Apr 16;10(4):897-90

    Type

    Empty backbone

    Use

    Synthetic Biology

    Expression

    Bacterial

    Promoter

    PamyL-PamyQ-PcryIIIA-cryIIIAstab49

    Available Since

    July 30, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

39. p1.2-Zeo-hVKORC1

    Plasmid

    #162776

    Purpose

    Human vitamin K oxidoreductase expression

    Depositor

    Ivan Vorobiev

    Article

    Kovnir et al Acta Naturae. 2018 Jan-Mar;10(1):51-65.

    Insert

    VKORC1 vitamin K epoxide reductase complex subunit 1 (VKORC1 Human)
    

    Expression

    Mammalian

    Promoter

    CHO EEF1A1 (Translation Elongation Factor 1 Alpha…

    Available Since

    July 23, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge

40. EGFP–acVHH–PB

    Plasmid

    #169685

    Purpose

    An anti-caffeine nanobody responds to caffeine to induce dimerization of a phospholipid-binding polybasic domain with subsequent plasma membrane translocation.

    Depositor

    Yubin Zhou

    Article

    Wang et al Adv Sci (Weinh). 2020 Dec 13;8(3):200214

    Insert

    anti-caffeine nanobody
    

    Tags

    modified STIM1-PB tag

    Expression

    Mammalian

    Promoter

    CMV

    Available Since

    July 21, 2021

    Availability

    Academic Institutions and Nonprofits only

    

    Enlarge