...Plasmids Adeno-Associated Virus versus Adenovirus Adenoviruses (AdV) are part of the Adenoviridae family...deficient and depend on other viruses such as adenovirus or herpes simplex virus to replicate in the host...family. AAVs were discovered as a contaminant of adenovirus preparations, which is how they got their name...VA for replication. For more information about adenovirus, read our Adenoviral Vector Guide . Recombinant...for rAAV vector production needs to express the adenovirus E1 gene, which is crucial for efficient AAV replication...Mizukami, H., Ozawa, K., & Colosi, P. (2004). The adenovirus E1A and E1B19K genes provide a helper function...