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...cells expressing Fcγ receptors binds to IgG and release cytotoxins that kill the target cell. If the pathogen...antibodies and eosinophils, where the eosinophils release cytotoxins via degranulation.  Antibody-dependent...

... or have a simple pathology. In these cases, preliminary identification of potential targets by CRISPR...researchers to select and generate physiologically relevant models. In complex diseases, it can aid in generation...

...traps? Traps – gene, enhancer, and promoter – all rely on the random integration of a reporter construct... effective tools but neglect some biologically relevant situations. Tissue-specific genes – the genes...

...LitSuggest Tool Following the “rabbit hole” of related cell lines when annotating a cell line Community... helpful information on the known features and relevant literature, or to decide which line is best for...

...'s more than 50 antibodies target neuroscience-related proteins, but we recently added several broadly...into your protein of interest and recognized by reliable antibodies. It is derived from the C-terminal ...

...there are so many bad managers? New managers are rarely chosen because they have demonstrated skill at ...better with some variety in their job. Good relationships with clients and colleagues Sometimes this means...

...scheduling Diverse opportunities to do science related jobs that require no bench work Better resources... important first step. Developing mentoring relationships, especially with peer mentors, to discuss your...

...chimera may have different binding properties (Morelock 1994). While in the majority of cases the differences...doi.org/10.1016/b978-0-08-097037-0.00017-8     Morelock, M. M., Rothlein, R., Bright, S. M., Robinson,...

...even by introducing a person that the audience can relate to. It doesn’t need to be anything fancy; it just... anthropomorphized animals, or even seemingly unrelated stories that they then tuck the science into. ...

...   Biological Processes  If you’re feeling relieved that you’re working with native proteins instead...instead of denatured ones - well, don’t relax just yet. Proteins often change shapes and epitope accessibility...

... produce two biosensors that could quickly and reliably detect HMOs. Fatima’s first design is a whole ...enzyme breaks down the HMO of interest, the lactose released activates expression of GFP from the lac operon...

...determine if our tubes were permeable to the CO2 released from dry ice, and whether this affected the pH...tested whether venting the tubes prior to thaw released the CO2 from the headspace, thus mitigating the...

...give researchers the ability to monitor glutamate release from neurons and other brain cells in vivo. Glutamate...differentiating between synaptic vs. extrasynaptic glutamate release. Building on the previous generation of the SF-...

...viral vectors. Here are some of the AAV we have released in the last few months. You can also browse our...coming soon! These vectors listed below should be released at Addgene in the next 6 months, pending quality...

...current research, Sheen aims to identify new genes related to PZA-resistance by using different approaches...microorganisms, biomarkers, and recently, cancer research related to space medicine. Now he aims on tracking pollution...

...Meetings are for talking, not reading: Send around relevant documents, like proposals to review or project...discussions can happen “off-line” with just one or two relevant people. How often do you need to meet? Use trial...

...process had just been discovered, the mechanism was barely understood.” Doench’s graduate work helped expand...regulatory process. This early research is still relevant to his work at the Broad Institute today, where...

... is sufficient to use a spectrum for a closely related protein, if you know that your protein of interest...lecture at iBiology. Commonly used filter sets & relevant fluorescent proteins Commonly used filter sets...

...bacteria, plasmids used for stable transfections rarely contain an ORI since the integrated DNA will be... Stably transfected cells may be considered an entirely new cell line from that of the original parental...

...cannot convince others that it is important and relevant to them.   When you think about it, virtually ... to forget that you have a much bigger job than merely telling your audience about the work you've done...