A Needle in a Base-Stack: Cas9 Structural Biology
Type
Blog Post
...not include stem loop 3, and guide RNA nucleotides 11-20 are not resolved due to structural disorder. HNH...DNA target are essential for cleavage. Nucleotides 11-20 are disordered and don’t appear in the Figure ... editing enzymes. Nature Reviews Microbiology, 20(11), 641–656. https://doi.org/10.1038/s41579-022-00739...