Mouse Modeling, Part 2: Breeding and Crossing Mice
Type
Blog Post
... for introducing one modification into the mouse genome, they are not commonly used to introduce multiple...opposed to ordering control mice from a stock center. This serves as a better control since the experimental...series, we covered techniques that can be used to introduce genetic modifications into mouse embryos. But ...knockout lines and Cre-lox lines, and how to properly control for genetically engineered mice in your experiment...mutations. This is because as more mutations are introduced into a single embryo, the likelihood that a mouse...genetic engineering should be used to separately introduce each mutation independently into different mice...not a waste. Best practice is to use littermate controls in your experiment - use mice that were bred in...