Targeting HIV-1 with CRISPR: Shock and Kill or Cut it Out?
Type
Blog Post
...common diseases.
References
Zhang Y, Yin C, Zhang T, Li F, Yang W, Kaminski R, Fagan PR, Putatunda R, Young...viral reservoirs, and CRISPR may be the way to accomplish this tough job! Kamel Khalili’s lab at Temple...infected cells, an idea that became much more realistic with the advent of CRISPR.
Using CRISPR/Cas9 SAM...enough T-cells could be reached to ablate a well-established viral reservoir.
A second challenge for CRISPR...developing resistance.
Shortly after Kaminski et al. published their results, Wang et al. showed that HIV-1 could...