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  2. CRISPR Antimicrobials

    Type
    Blog Post
    ...bacteria have poor non-homologous end joining machinery, so a CRISPR-induced double-stranded break (DSB...into the bacterial genome, and it carries CRISPR machinery targeting 1) the given resistance gene and 2) ...

  4. Plasmids 101: Stringent Regulation of Replication

    Type
    Blog Post
    ...plasmids rely on their host cell's replication machinery in order to replicate—but not always to the same..., as they only require the host's replication machinery for elongation and termination. These types of...

  5. Plasmids 101: Broad Host Range Plasmids

    Type
    Blog Post
    ... plasmids to utilize diverse host replication machinery. For instance, the ori typically contains iterons...However, if plasmids have their own replication machinery such as Rep or other initiator proteins, they ...

  6. Rett Syndrome: A History of Research and Therapeutic Outlooks

    Type
    Blog Post
    ...these approaches, such as delivery of the editing machinery to the brain, minimizing off-target editing, and...https://doi.org/10.3389/fgene.2019.00625 McGraw CM, Samaco RC, Zoghbi HY (2011) Adult Neural Function Requires...

  8. Evolution of Lab Techniques

    Type
    Blog Post
    ...generally considered first generation DNA sequencing machines (9). Today, similar technologies, sometimes referred...older technologies nanopore-based DNA sequencing machines are relatively small meaning that DNA sequencing...

  10. A Control for All Seasons

    Type
    Blog Post
    ...Submission to the British Journal of Pharmacology.” British Journal of Pharmacology, vol. 175, no. 3, Wiley, 19...

  11. Typing CRISPR Systems

    Type
    Blog Post
    ...involved in plasmid competition or can hijack machinery from other CRISPR systems to carry out various..., L., Kocalar, S., Oshiro, R., Makarova, K. S., Macrae, R. K., Koonin, E. V., & Zhang, F. (2023). Uncovering...

  12. Cancer and the Immune System: Deciphering the Relationship

    Type
    Blog Post
    ... produces modified dendritic cells (DCs) and macrophages (M1 and M2) that help create welcoming environments...over-express CD47 to escape recognition by circulating macrophages. Tumor cells also downregulate the expression...

  13. Trimmer Lab NeuroMab Collection

    Type
    Collection
    ...Neuroligin-1 Rat Mouse IgG2a 114555 Anti-MMACHC [N289/16R] MMACHC Human Mouse IgG2a 114556 Anti-SUR1 [N212...

  15. 22 Hot Plasmid Technologies from 2014

    Type
    Blog Post
    ...observations: Rapamycin is a membrane-permeable pharmacological agent that can rapidly induction heterodimerization...the Roth lab to be activated by otherwise pharmacologically inert drug-like small molecules, allowing ...

  16. 27 Hot Plasmids from 2016

    Type
    Blog Post
    ... industry, the bioethanol industry, and the pharmaceutical industry, depend on the yeast, Saccharomyces..., including fermented beer and wine, fuels, pharmaceutical ingredients, and recombinant proteins. In order...

  17. The 12 Days of CRISPR: 2021

    Type
    Blog Post
    ...prime editing systems through manipulating MMR machinery. On the fifth day of CRISPR, Addgene gave to me...

  18. New Videos: Addgene Lab Tips

    Type
    Blog Post
    ...that will keep the lab running like a well-oiled machine. Lab tip #1: Glove trick Putting on lab gloves ...

  19. Deck the Lab 2022!

    Type
    Blog Post
    ...everything from Falcon tube trees to giant paper mache Krampus performing routine lab maintenance tasks...
Showing: 101 - 120 of 250 results