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Getting start with mouse models? Here, we break down how to cross mice to create double knockout lines and Cre-lox lines.

The tumor microenvironment is the cellular milieu that surrounds a tumor and contains immune cells, blood vessels, cells, and signaling molecules. What goes on in the cancer microenvironment affects and is affected and can either promote or repress tumor growth.

Check out Addgene's 5 favorite science comics, have a laugh, and relax from the stresses of your lab work.

This post discusses takeaways from, and tools presented at, the Deaminet 2026 conference, focusing on base editors, prime editors, and translational work.

Learn all about how to use a new plasmid for RNAi in C. elegans, tools for proximity labeling, RNA-based methods for detecting viral outbreaks, and tools for characterizing protein domain binding specificities.

CRISPR plasmids that create double strand breaks in DNA.

CRISPR nickase plasmids for the generation of single-strand breaks.

Find out more about the different homology directed repair pathways and how to design HDR templates for CRISPR editing.