Hot Plasmids September 2018 - Optogenetics, RNA Localization, Fluorescent Protein, and Base-editing Tools
Type
Blog Post
...modulate cellular dynamics with light by modifying EB1. EB1 normally sits on microtubules to attract other...involved in their growth and extension. Now, they split EB1 into two halves (Fig. 1): one containing the microtubule...LOVTRAP domains. When both halves of the modified EB1 protein are overexpressed in cells, microtubule growth...to conformational changes, and as a consequence, EB1 protein function is inactivated by the separation... cancer cell line equipped with photodissociable EB1 could be stopped in areas with blue light - a finding...