...found that a cytosine base editor (CBE) with rat APOBEC1 causes genome-wide deamination of RNA cytosines...engineered two CBE variants with mutations in the rat APOBEC1 that decreases the number of off-target RNA edits...

... expression of TAK 1, an enzyme that controls apoptosis and regulates transcription. Without TKA1, cells...cells proliferate and cannot undergo apoptosis, thus multiplying uncontrollably and building up tumors....

...Varenicline has been further modified to create ultrapotent PSEMS (uPSEMs) that have drastically increased... A, Basu J, Michaelides M, Sternson S (2019) Ultrapotent chemogenetics for research and potential clinical...

... myidp.sciencecareers.org mentioned museums. Indianapolis is home to one of "The world’s biggest and best...children’s museum", The Children's Museum of Indianapolis. I drove passed these dinosaurs every day. They...

...fusion dynamics of mitochondria in healthy and apoptotic cells (9). PA-FPs have helped to revolutionize...is blocked during the Bax activation phase of apoptosis." J Cell Biol 164.4 (2004): 493-499. PubMed PMID...

...TCCCGTCTCTGGCCATGAcctcctctaatggatcTCATTCCAACGGTGTGCA apoa4 TAL3022 & TAL3025 TGGCAGGACCAACCAATGcccagcatggacctggTGAAAAATGCTTTCTGGA apoa4-like TAL3023...TGAAGGTTCTTGTGGTGCtcacacttgctgtggtTACAGGTAAGAAACTAAA apoeb TAL3402 & TAL3403 TGCCAGGCTCGTAGCCTGttccaggctgatgccccTCAGCCCAGATGGGAGGA...

...on the surfaces of the water bath as the water evaporates from the tub. Disinfectant may be added to prevent...cover on the top of the water bath to prevent evaporation and maintain the desired temperature. This also...

...OZ528 OPEN OPEN cACCCTCCTCgtggtGCTGGTGGCc apoeb (apolipoprotein Eb) OZ529 and OZ530 OPEN OPEN gCCCCTCAGCccagatgGGAGGAGATg...

... singapore...

...directed DNA Demethylation: Guest blogger Daniel M. Sapozhnikov tells us how to use dCas9 (with no modifications...

...rate of off-target genome edits compared to rat APOBEC1. Now, they’ve engineered SECURE adenine base editor...

...proliferation, survival, differentiation, and apoptosis. For each of these 17 pathways, they identified...

... as well. This tag is not suitable for use in apoptotic cells as Caspase3/7 both cleave after the DVPD...

...it for a while and he eventually calmed down, apologised and admitted he’d been under a lot of pressure...

...Excitation of Distinct Neural Populations. Nathan Klapoetke et al. Nature Methods. 2014 Feb 9. (PubMed). Read...

...  After using mCherry for FACS sorting of the weaponized T-cells (CAR-T cells) - and then delivering them...

...(which had been lost for an age) fight in the Napoleonic Wars and against something even more sinister...

...race is to develop resistance to these chemical weapons. Conveniently, plasmids carrying genes for the...

...Harvard Medical School. Follow her on Twitter @jessicapolka.     References 1. Kanabrocki, J. A., Quackenbush...

...ones listed previously). E3/E1B suppresses both apoptosis and the host immune response to the virus to allow...