...Center for Rett Syndrome research. With a shared passion for facilitating research and discovery, Addgene...The Rett Syndrome Research Trust (RSRT) has an ambitious goal of curing Rett Syndrome and Addgene is ...biology tools so that both veteran and new Rett researchers can find the reagents and resources they need...blog post describes the history of Rett Syndrome research, the role of the MECP2 gene, and highlights some...respectively. One of the main challenges facing Rett researchers is how to deliver the precise amount of protein...brain cell to restore physiological levels. Much research is now focused on therapeutic strategies that ...expertise to develop a viable therapeutic, the researchers developed adeno-associated viral (AAV) vectors...

...they research, how they conduct their research, and in some cases, if they conduct their research. Even... Joanne Kamens, Marcy Patrick, Aliyah Weinstein, Fabienne Furt, and Quintin Marcelino for their helpful... Marc Zimmer’s recent book, The State of Science: What the Future Holds and the Scientists Making It ...inherent brokenness of scientific publishing and research funding. I’ve been aware of these problems since...

...Science. In the last decade, researchers have brought issues in reproducible research to the forefront in the...that published research is difficult to replicate.  Why is replicating previous research findings so difficult...embargoed while the research is ongoing, but all registries do require that research plans become public...findings could not be replicated by other researchers.There is both theoretical and empirical evidence... difficult to do?  There are four reasons that research can be difficult to replicate. Unclear methods...methods. Unreported flexibility and questionable research practices In an attempt to present only the most...several different ways, and other questionable research practices (QRPs) can quickly lead us to find statistically...

... academic researchers themselves(44% of postdocs in the life sciences name faculty-research as their preferred...and the Early Career Researchers in Publishing panel, focused on showing researchers that they can take ... recently attended and sponsored the Future of Research (FOR) Boston Symposium 2015. I personally participated...incredibly important to the stability of the biological research enterprise going forward, in this post I’ll point...from the symposium. The goal of the Future of Research Symposium On the FOR website, the FOR Boston 2015...determine what data is required for the academic research community to develop a plan to make postdoctoral...outcomes, and increase diversity in the academic research environment. The “how many?” question lies at ...

...meaning they come ready made to accelerate your research.   Why distribute virus? Plasmid distribution...distribution is booming, but, over the years, many researchers we’ve met with have asked if we can help them share...distribution came up time and time again with many researchers lamenting the viral production process while ... We’re reducing this frustration and getting researchers to the experiments they’re interested in faster...processes of viral production and testing so that researchers can use our educational resources and experience... decide to produce virus on their own.Harvard researcher Connie Cepko has been helping us with AAV testing... will further enable scientists and accelerate research." What viral preps are available now? There...

...accelerating this research by helping to make new cancer resources easily accessible to the research community...funding or as much attention collectively from researchers. Scientists, however, have yet to slay the beast...This is why recent work in the field of cancer research has focused on picking apart the complex cellular...improvements in computer modeling have enabled researchers to begin discovering and designing molecules ...specifically to their mutated residues. For Ras researchers, one of the most exciting and relatively new ...clinically relevant as possible. Connecting the research community - Addgene's cancer collection pages ...remain. One of the biggest challenges facing researchers today is the complexity of the pathways involved...

...columns.  The data in any column are searchable and you can search by any part of the data. For example...you're looking for. Search using the box highlighted in red above. When searching, it is worth trying ...dedication to resource sharing has led us to develop a searchable and sortable datatable that contains validated...and dCas9-FokI. This table is both sortable and searchable, which can help exclude the data that you are...that were used for activation in a human system, search for ‘sapiens activate’ to filter the table and ...

...Hays, a researcher at the University of California Berkeley. It’s been half a year since the march for science...seems to break everyday. Many researchers and supporters of science marched to advocate for scientist participation...Below I present perspectives on the March for Science from researchers all over North America. I hope that...cuts to important research funding.  So when I saw that there was going to be a march in support of science...and to tell the stories behind our research.  That's why I marched for science in D.C. "Scientists shouldn't...participate in one of the satellite Marches for Science (my local march was in Nashville, TN, USA). I had...122.0652°W – Steph Hays When I marched for science in May, I marched to advocate for the process we use...

...discipline for annotation and archiving of data are likely to improve research. What is published is typically... Jim Woodgett is Director of Research at the Lunenfeld-Tanenbaum Research Institute at Mount Sinai Hospital...Funded Scientific Research (February 22, 2013)  Who Will Pay for Public Access to Research Data? - by Francine...its data access and sharing policy. Since early March, the open access publisher has required authors ...to where readers may locate data supporting the research reported in PLOS publications. The policy was ...rather it was the result of consultations between researchers and publishers. Nonetheless, the initial release...Perhaps least compelling of these were those from researchers who wanted more time to mine their own data, ...

...advantage. It wasn’t until I wrote a blog post about a research paper that explored how scientists connect on ...started, but now I’m using social media to help my research and my career. Here are three examples of how ...especially like the pointers on how to use LinkedIn to research potential future employers and to arrange informational...shows quick ways social media can fit into a researcher’s work day. It’s also important to remember that...schedule. Has social media helped you advance your research or career? Share your story in the comments below...

...school students to publish peer-reviewed scientific research. You’ll meet some of the folks behind the journal...and Outro - Interview with high school student researchers Arooba Ahmed, Jiachen Lee, and Jillian Parker...

...and Accelerate Research Discoveries) Challenge provides grants for rare disease research. This year is ...rare disease research. Congratulations to the winners! Below, we highlight their research and how they... founded with the mission to support and drive research into CCDS. The brain and muscles have a high metabolic...-36 release,” says Dr. Mark Mellett, a senior researcher at University Hospital Zurich. IL-36 cytokines...intracellular signaling,” says Hébert. Previous research has shown that GNB1 mutations lead to increased...biosensors that would allow us to address many of our research questions,” Hébert says. In the spirit of plasmid...

...Rodríguez et al., 2011).  Genetics of SPARC Figure 1: SPARC and SPARC2 use the GAL4-UAS system along with...expression of using the SPARC system. The effector is placed downstream of the rest of the SPARC components and...Isaacman-Beck et al., 2019. Applications for SPARC SPARC technology is versatile and can be applied across...no completely genetic tools that would allow researchers to label just a fraction of a single genetically-defined...Predictive Activity through Recombinase Competition (SPARC), a genetic tool that allows for the labeling of...reliably label any post-mitotic cells in Drosophila. SPARC was developed by Thomas Clandinin’s lab, and incorporates...These sites are target sequences of PhiC31. In the SPARC system, attP sites are located on either side of...

...an improved search algorithm which was trained on key factors from past PubMed user searches, such as clicks...article. Now, search results display a bar graph of the number of papers with your search term published...over time. Creating an alert for a search term helps automate your search for new papers. An alert lets you...relevant to your search terms. Key features Semantic Scholar has several ways to focus your search results. A...year is displayed with your search results and can be used to filter your search to a specific window of ...Meta is not a traditional search engine. Instead, you create your own research feed by entering keywords...suggested related researchers, journals, and concepts to help you expand your search. Results in your ...

...prefer to use search, our updated search engine is now more powerful, intuitive, and searches across all ...s new search  Like millions of other websites, we built our new search engine atop Elasticsearch, a powerful...powerful open-source search engine that can scale to search millions of web resources and handle millions...customize the search engine, and a scoping mechanism that allows category-specific, narrow searches. We defined...example, a search scoped to plasmids shows filters for expression and vector type, while a search scoped ... a given resource, and designed the search engine to weight search results differently according to where... our website, including the recent homepage and search tool updates. Now, let’s take a look at the least...

...literature a little bit at a time. Searching for literature My go-to search engines for finding scientific... study, research article etc). There are also numerous options for narrowing down your search and sorting...you to understand the research question that will be addressed. In primary research papers, the introductions... a scientist, it is useful to make literature searching and reading a regular part of your routine. Set...number of papers each week to keep up with the research in your area. When you are in ‘writing-mode’ for...literature are Google Scholar and PubMed. You can search keywords, titles, authors, year, narrow by article...a network with an institutional subscription), archived on PubMed Central, or in preprint onBioRXIV. One...

...a small collection of plasmids for coronavirus research, including a handful of plasmids that have been...many available to scientists in industry. Since March 2020, we have received over 13,000 plasmids requests...plasmids have been used to accelerate COVID-19 research in other labs. Spike protein, variants, and pseudotyping...This plasmid was later used by another team of researchers for neutralization assays, part of a study that...spike variants. You can learn more about their research in this article. To see other plasmids for SARS-CoV...became a great starting point for SARS-CoV-2 researchers to investigate how the virus interacts with human...epithelial cells (Biering et al., 2021). In their search, they found mucins have an important role in viral...

...You've done the research, analyzed your data, and made your tables and figures. Now it's time to write...Phrasebank is a resource for phrases commonly used in research papers or dissertations. Phrases are categorized... to be edited to suit your particular field of research.   Citations tools DOI Citation Formatter Just...check out this related blog post: Early Career Researcher Toolbox: Finding Relevant Papers. These are only...for writing scientific manuscripts: literature searching, reading, and organizing Tips for writing a scientific...

...Sophisticated search You can search for specific plasmids on our website using the search bar found at ...to your research interests. We do this by promoting citation, supporting sophisticated search, and curating... Addgene in a way that another researcher finds useful, that researcher will be able to easily find the...You can search for plasmids by name, PI, Addgene ID number, or keyword. Although an initial search might...can narrow your search results using the filters found on the right side of the search page. A great breakdown...H-index for instance), but these rely upon other researchers being able to find their publications in the ...act directly associates you with a network of researchers who may be working on similar projects and should...

...and make sure they have been barcoded with a unique ID number (1D barcode as shown below). This number...all of these samples have the 2D barcodes mentioned above. These barcodes identify what type of sample is... can all be extrapolated from the 2D barcode and LIMS: Barcoded Tube Plate Freezer Rack Freezer Tubes...A1 through H12. Each plate is also barcoded with a 10 digit barcode and then assigned to a location in...every barcode on every tube contains information about that tube’s appropriate location. The barcode also...plated onto a petri dish plate that is also barcoded. The barcodes on both of these are scanned into our LIMS...within your lab, we highly recommend using barcodes! Barcoded tubes are easily accessible and can be made...