Mouse Modeling, Part 2: Breeding and Crossing Mice
Type
Blog Post
... if the mutations are on the same chromosome. Homologous chromosomes recombine during meiosis, creating...homologous chromosomes in the parental generation, they are likely to stay on separate chromosomes in future...function when hemizygous, meaning that only one chromosome needs to contain the transgene in order to see...distance between the two loci of interest on the chromosome, the less likely crossing over is to occur between... which would get both mutations onto the same chromosome. Until crossing over occurs between the two loci...