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We narrowed to 66 results for: Alb

Showing: 1 - 30 of 66 results

  1. Viral Vectors 101: Systemic Capsids

    Type
    Blog Post
    Published
    Oct. 12, 2023, 1:15 p.m.
    ...transduces BALB/cJ, CBA/J, and FVB/NJ mice, with minimal liver transduction observed in both BALB/cJ and ...enhanced transgene expression, compared to AAV9, in BALB/cJ mice but is more effective than AAV9 in many ...brain endothelial cells in C57BL/6J mice, but not in BALB/cJ mice, meaning that systemic capsids that rely...rely on LY6A interactions cannot cross the BBB in BALB/cJ mice (Hordeaux et al., 2018). This results in ... called LY6C1. This protein is expressed in both BALB/cJ mice and C57BL/6J mice (Shay et al., 2023; Huang... effectively transduces cells in the CNS of both BALB/cJ and C57BL/6J mice (Shay et al., 2023). AAV-PHP.AX... in transduction efficiency between C57BL/6J and BALB/cJ mice due to its LY6C1 dependence. MDV1A and MDV1B...

  2. Beyond the Blood Brain Barrier: PHP.B Enters the Central Nervous System Via the LY6A Receptor

    Type
    Blog Post
    Published
    July 23, 2019, 12:46 p.m.
    ...following IV injection but fails to reach the CNS of BALB/cJ mice. These results were surprising because in...expression between the brains of C57BL/6J mice and BALB/cJ mice, suggesting it was a likely player in PHP.B...classic genetics approach and interbred C57BL/6J and BALB/cJ mice to map the inheritance pattern of PHP.B ...SNPs, PHP.B could bind it, but when LY6A contained BALB/cJ SNPs, binding was reduced. The Deverman group...permissive phenotype of mouse strains beside C57BL/6J and BALB/cJ, and the effects of overexpressed Ly6a on PHP.B...

  3. What's New in CRISPR - May 2019

    Type
    Blog Post
    Published
    May 28, 2019, 12:49 p.m.
    ...editors Nme2Cas9 CRISPR interference in Candida albicans E. coli genome-wide inhibition library To expand...AAV constructs CRISPR interference in Candida albicans A new CRISPR interference (CRIPSRi) platform for... for targeted gene repression in Candida albicans was developed by Rebecca Shapiro’s lab. After testing...repressed transcription of HSP90 an essential C. albicans gene. Read the paper in mSphere Find the dCas9...

  4. Science as Art

    Type
    Blog Post
    Published
    March 2, 2015, 3:13 p.m.
    ... blurring the lines between science and art was Albert G. Richards, who passed away in 2008. His work ... Smithsonian Magazine, where the editor stated “Albert G. Richards, a teacher of dental radiography, had...especially those which are now extinct. A collection of Albert G. Richards’ work is held by The Museum of Jurassic...

  5. Technique: Probe Phage Genomes for Host Binding Proteins

    Type
    Blog Post
    Published
    Sept. 29, 2016, 2:30 p.m.
    ... microbiology PhD student at the University of Alberta studying with the Szymanski lab. Reasons to study...which has recently moved from the University of Alberta in Edmonton, Canada, to the University of Georgia... microbiology PhD student at the University of Alberta studying with the Szymanski lab (though she’s tagged...

  6. With an Eye Towards the Future, We Look Back at the March for Science

    Type
    Blog Post
    Published
    Oct. 24, 2017, 1:54 p.m.
    ... justice.  Follow her on twitter @sung_vanessa. Albany, NY, USA 42.6526°N 73.7562°W – Nicholas Thompson...decided to go. At my local March for Science in Albany, NY, many tables were set up with various science...with some really great signs. The Congressman for Albany, Rep. Paul Tonko also came and spoke in support...

  8. 10 Great Guest Posts We're Thankful For

    Type
    Blog Post
    Published
    Nov. 18, 2016, 3 p.m.
    ...this post from Erik Snapp, Associate Professor at Albert Einstein College of Medicine, to learn how problematic...Adaptive, Multitasking “CRISPR-OS” In this post, Albert Cheng and Mark Wanner from the Jackson Laboratory...

  9. Screening for Successful Genome Editing with Digital PCR

    Type
    Blog Post
    Published
    March 30, 2017, 2:30 p.m.
    ...Findlay, a Postdoctoral Fellow at the University of Alberta. If you’re like many researchers these days, you...currently a Postdoctoral Fellow at the University of Alberta. He is interested in everything molecular biology...

  10. Nanoblades: Tiny CRISPR Ninjas for Genome Editing Difficult Cells

    Type
    Blog Post
    Published
    Sept. 26, 2019, 12:50 p.m.
    ... (Tyr) gene in mouse zygotes, which results in albinism in mice. Of the eight mice born from Tyr Nanoblade... editing efficiencies of the chimeric and fully albino mice ranging from 11% to 100%, a level similar ...

  11. Savvy Advocates Needed to Navigate a Scientific Enterprise in Flux

    Type
    Blog Post
    Published
    Sept. 13, 2016, 2:30 p.m.
    ...have been well documented over the past 2 years (Alberts et al, PNAS 2014; Taylor, eLife, 2016). Several...Follow David on Twitter @driglar.   References: 1. Alberts, Bruce, et al. "Rescuing US biomedical research...

  12. Tips for Screening with Yeast Two Hybrid Systems

    Type
    Blog Post
    Published
    Oct. 22, 2015, 2:30 p.m.
    ...organisms, including bacteria, alternative fungi (C. albicans, pC2HB) (7) and mammalian cells. If the problem...two-hybrid system for the pathogenic fungus Candida albicans. Nucleic Acids Res. 2010;38(19):e184. Pubmed PMID...

  13. Avoiding the Dark Side of Fluorescent Protein Fusions with mOX FPs

    Type
    Blog Post
    Published
    Oct. 27, 2015, 3 p.m.
    ...Health and he is currently an Associate Professor at Albert Einstein College of Medicine in the Department ...Costantini received her PhD in Biomedical Research from Albert Einstein College of Medicine. Her doctoral research...

  15. Quick Guide to Near-Infrared Fluorescent Proteins

    Type
    Blog Post
    Published
    Oct. 5, 2021, 1:15 p.m.
    ...blogger Daria Shcherbakova, a faculty member at Albert Einstein College of Medicine. Several sets of near-infrared...blogger! Daria Shcherbakova is a faculty member at Albert Einstein College of Medicine. Her expertise is ...

  16. Hot Plasmids: Spring 2025

    Type
    Blog Post
    Published
    June 3, 2025, 1:15 p.m.
    ... of GABAergic interneurons — those marked by parvalbumin (PV), somatostatin (SST), vasoactive intestinal...under the control of the BiPVe3 enhancer and parvalbumin (PV) immunostaining (green), in the primary somatosensory...

  17. A Control for All Seasons

    Type
    Blog Post
    Published
    Oct. 5, 2023, 1:15 p.m.
    ...factors, consider using one of the alternative, albeit less ideal, verification approaches discussed in...generally sticky proteins such as bovine serum albumin. Secondary antibodies can also react with endogenous...

  18. Addgene's 20th Anniversary Party

    Type
    Blog Post
    Published
    June 11, 2024, 1:15 p.m.
    ...moments we captured over the years, including an album of Addgenie pet photos. The famous Addgene jacket...

  19. Call for Guest Bloggers

    Type
    Blog Post
    Published
    March 2, 2016, 3 p.m.
    ...CRISPR/Cas9   Erik L. Snapp, Associate Professor at Albert Einstein College of Medicine. Post: When is a Monomer...

  20. Editor's Choice, September 2016

    Type
    Blog Post
    Published
    Oct. 7, 2016, 4 p.m.
    ... blogger Jessica Sacher from the University of Alberta and describes a technique you can use to find phage...

  22. What's New in CRISPR - March 2020

    Type
    Blog Post
    Published
    March 10, 2020, 1:15 p.m.
    ...(Casilio-ME) is a methylation editing tool from Albert Cheng’s lab that enhances RNA-guided methylcytosine...
Showing: 1 - 30 of 66 results