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We narrowed to 729 results for: NSI

Showing: 201 - 210 of 729 results

  1. Bringing Sustainable Practices to the Lab: Innovations

    Type
    Blog Post
    Published
    March 7, 2019, 2:39 p.m.
    ...before you even receive the product? How can we consider the environmental impact of those processes? Who...laboratory products that emphasizes Accountability, Consistency, and Transparency. This label scores products...might sound risky in terms of contamination, but consider flow cytometers. These fluidic machines handle...through an EPA-approved process and no longer considered hazardous. Then, they use this material to produce...

  2. Viral Vectors 101: Systemic Capsids

    Type
    Blog Post
    Published
    Oct. 12, 2023, 1:15 p.m.
    ...goes beyond such restrictions, you may want to consider a systemic capsid for your AAV.   Systemic capsids... definition of systemic capsids. After some consideration, we offer this definition: A systemic capsid...capsids are engineered, as well as highlight some considerations for their use. Then, we’ll provide information...and/or its intermediate engineered precursor. Considering systemic capsids for your research? While systemic...payload — there are a few additional, specific considerations you’ll need to be aware of before starting ...choice on which systemic capsid to use. Factors to consider include the delivery method, mouse strain, target...recommend you check out Caltech’s CLOVER Center’s extensive repository of published systemic AAV experiments...

  3. A new platform for fast functional characterization of potentially cancerous mutations

    Type
    Blog Post
    Published
    May 7, 2019, 12:39 p.m.
    ...time consuming and expensive, especially when done in vivo. There are also sensitivity issues when attempting...them remain uncharacterized. This represents a considerable barrier to furthering research and developing...Atlas (TCGA), a catalog of genetic mutations responsible for cancer from genomics data, and large-scale...

  4. A Needle in a Base-Stack: Cas9 Structural Biology

    Type
    Blog Post
    Published
    June 4, 2024, 1:15 p.m.
    ...offer more information on these regions.   Cas9’s transition from weak, random binding to precision gene editing.... This cap is where the DNA:RNA heteroduplex transitions back to DNA duplex, and it’s the reason guide...RuvC loop caps the heteroduplex and marks the transition back to a DNA duplex. sgRNA, dark blue; target...DNA strand, and Cas9 bends the DNA helix by transitioning between the open and closed conformations. This... spots—to these questions. Each new structural insight also spurs the next generation of engineered CRISPR...

  5. An Addgene Co-op: The Intersection of Fun, Friendship, and Work

    Type
    Blog Post
    Published
    June 29, 2023, 7 p.m.
    ...  Joining the Addgene crew!  This pattern was consistent: everyone I spoke with at Addgene, no matter ...been done at Addgene before. This meant I was responsible for establishing a new report and routine across..., and make the occasional TikTok. I was also responsible for typical entry level tasks such as stuffing...connections with coworkers seem, in retrospect, nonsensical. I have found the people at Addgene have become...

  6. Plasmids 101: Gene, enhancer, and promoter trapping

    Type
    Blog Post
    Published
    May 2, 2023, 1 p.m.
    ...need to be inside of a gene’s open reading frame, in fact, they can be activated a considerable distance... These reporters have historically been used extensively in fly, mouse, and yeast models. Why traps are... endogenous gene expression are all factors to consider. Once you’ve decided on the type of trap, there...

  7. Advice for Choosing a Research Project

    Type
    Blog Post
    Published
    April 17, 2014, 2:45 p.m.
    ...interests. We've outlined some important factors to consider and summarize helpful advice from the successful...Achieve Success in Academia". Important factors to consider when choosing a research project After joining... your professional brand. It offers colleagues insight into your interests and will determine how you ...fungal biology.” Connie Cepko advises students to consider their goal of PhD training when selecting a research...

  8. Celebrate Open Data Day with Addgene’s AAV Data Hub!

    Type
    Blog Post
    Published
    March 5, 2020, 2:15 p.m.
    ...Addgene blog Important Considerations When Using AAVs Three Key Considerations For Precise Neuronal Targeting...experiment, read our blog post on important considerations when using AAVs. Experimental results: These...Frontiers in Neuroanatomy and summarized some considerations for precise neuronal targeting using AAV on...

  9. Donations from Addgene to Yield Answers for Rare Disease Researchers

    Type
    Blog Post
    Published
    Sept. 15, 2015, 2:30 p.m.
    ... genetic condition leaves patients incredibly sensitive to sunlight and prone to developing metastatic... into XP genes and other genes involved in photosensitivity in melanocytes with the goal of understanding...explore the functional differences among mutations responsible for the disease known as Alternating Hemiplegia...disorder.” In 2012, researchers identified the gene responsible for the disease as ATP1A3. The gene encodes a...

  10. Advice for Moving Into Sales After Your Science Postdoc

    Type
    Blog Post
    Published
    Aug. 21, 2014, 3:15 p.m.
    ...next and what options lie ahead of me? Like a considerable number of researchers, I had high hopes of securing...thought they would focus on “Has this person been consistent throughout their career?”, "Have they sought ...interviewed for 1 hour so having a broad enough insight was going to help me push both my scientific and...promotions or further education may allow you to transition into various realms of business.  Thank you ...
Showing: 201 - 210 of 729 results