Hot Plasmids and Viral Preps - May 2021
Type
Blog Post
Published
May 18, 2021, 1:15 p.m.
...antibodies targeting fourteen aminoacyl tRNA synthetases (aaRS) have been created, characterized, and validated...
Figure 2: Specific binding of scFVs to cognate aaRS antigens as measured by suspension bead assay. Image... the Gräslund lab. Recent findings suggest that aaRSs are involved in inflammation and autoimmune diseases...antibody tools could be used to study the role of aaRSs in these processes.
To create the antibody toolbox...would be in their native conformation. Because many aaRSs exist within a multi-tRNA synthetase complex, the...whether the generated antibodies could bind these aaRSs. They found the antibodies were able to immunoprecipitate...